Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Signal peptide peptidase-like 2A

Gene

Sppl2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei355By similarity1
Active sitei416By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5357905 Regulation of TNFR1 signaling

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A22.007

Transport Classification Database

More...
TCDBi
1.A.54.3.1 the presenilin er ca(2+) leak channel (presenilin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide peptidase-like 2ABy similarity (EC:3.4.23.-)
Short name:
SPP-like 2ABy similarity
Short name:
SPPL2aBy similarity
Alternative name(s):
Intramembrane protease 3By similarity
Short name:
IMP-3By similarity
Presenilin-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sppl2aBy similarityImported
Synonyms:Imp3By similarity, Psl2
ORF Names:MNCb-3763
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913802 Sppl2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 175LumenalSequence analysisBy similarityAdd BLAST150
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 224CytoplasmicSequence analysisAdd BLAST28
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 247LumenalSequence analysis2
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 288CytoplasmicSequence analysisAdd BLAST20
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 315LumenalSequence analysis6
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 344CytoplasmicSequence analysis8
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 403LumenalBy similarityAdd BLAST38
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 440CytoplasmicSequence analysisAdd BLAST16
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 463LumenalSequence analysis2
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 523CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi498Y → A: Inhibits lysosomal/late endosomal targeting. 1 Publication1
Mutagenesisi506Y → A: Does not inhibit lysosomal/late endosomal targeting. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25By similarityAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007391126 – 523Signal peptide peptidase-like 2AAdd BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JJF9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JJF9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9JJF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJF9

PeptideAtlas

More...
PeptideAtlasi
Q9JJF9

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJF9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JJF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJF9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9JJF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027366 Expressed in 284 organ(s), highest expression level in right colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JJF9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JJF9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITM2B.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JJF9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9JJF9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JJF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 155PAAdd BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi466 – 468PAL3
Motifi498 – 501YXXo lysosomal targeting motif4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP (By similarity). The C-terminal tail is necessary for lysosomal transport (PubMed:21896273).By similarity1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2442 Eukaryota
ENOG410ZP52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJF9

KEGG Orthology (KO)

More...
KOi
K09596

Identification of Orthologs from Complete Genome Data

More...
OMAi
WGTCHFL

Database of Orthologous Groups

More...
OrthoDBi
535101at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319186

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033151 SPPL2a

The PANTHER Classification System

More...
PANTHERi
PTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02225 PA, 1 hit
PF04258 Peptidase_A22B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00730 PSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JJF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLHSLHAP AAALLWSCLL GLAAAQEAIL HASTNGVSSL SKDYCMYYNN
60 70 80 90 100
NWTRLPSSLE NATSLSLMNL TGTALCHLSD IPPDGIRNKA VVVHWGPCHF
110 120 130 140 150
LEKARIAQEG GAAALLIANN SVLIPSSRNK STFQNVTVLI AVITQKDFKD
160 170 180 190 200
MKETLGDDIT VKMYSPSWPN FDYTLVVIFV IAVFTVALGG YWSGLIELEN
210 220 230 240 250
MKSVEDAEDR ETRKKKDDYL TFSPLTVVVF VVICCIMIVL LYFFYRWLVY
260 270 280 290 300
VMIAIFCIAS SMSLYNCLSA LIHRMPCGQC TILCCGKNIK VSLIFLSGLC
310 320 330 340 350
ISVAVVWAVF RNEDRWAWIL QDILGIAFCL NLIKTMKLPN FMSCVILLGL
360 370 380 390 400
LLIYDVFFVF ITPFITKNGE SIMVELAAGP FENAEKLPVV IRVPKLMGYS
410 420 430 440 450
VMSVCSVPVS VLGFGDIIVP GLLIAYCRRF DVQTGSSIYY ISSTIAYAVG
460 470 480 490 500
MIITFVVLMV MKTGQPALLY LVPCTLITVS VVAWSRKEMK KFWKGSSYQV
510 520
MDHLDYSTNE ENPVTTDEQI VQQ
Length:523
Mass (Da):58,129
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA15109A71FCF25C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RJQ8F6RJQ8_MOUSE
Signal peptide peptidase-like 2A
Sppl2a
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74A → P in AAH26578 (PubMed:19468303).Curated1
Sequence conflicti331 – 333NLI → PKV in AAH26578 (PubMed:19468303).Curated3
Sequence conflicti502D → G in BAA95032 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041547 mRNA Translation: BAA95032.1
AL732330 Genomic DNA No translation available.
AL928836 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28169.1
BC026578 mRNA Translation: AAH26578.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16690.1

NCBI Reference Sequences

More...
RefSeqi
NP_075709.2, NM_023220.2
XP_011238039.1, XM_011239737.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028844; ENSMUSP00000028844; ENSMUSG00000027366

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66552

UCSC genome browser

More...
UCSCi
uc008mej.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041547 mRNA Translation: BAA95032.1
AL732330 Genomic DNA No translation available.
AL928836 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28169.1
BC026578 mRNA Translation: AAH26578.1
CCDSiCCDS16690.1
RefSeqiNP_075709.2, NM_023220.2
XP_011238039.1, XM_011239737.2

3D structure databases

SMRiQ9JJF9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JJF9, 2 interactors
MINTiQ9JJF9
STRINGi10090.ENSMUSP00000028844

Chemistry databases

ChEMBLiCHEMBL4105948

Protein family/group databases

MEROPSiA22.007
TCDBi1.A.54.3.1 the presenilin er ca(2+) leak channel (presenilin) family

PTM databases

iPTMnetiQ9JJF9
PhosphoSitePlusiQ9JJF9
SwissPalmiQ9JJF9

Proteomic databases

EPDiQ9JJF9
jPOSTiQ9JJF9
MaxQBiQ9JJF9
PaxDbiQ9JJF9
PeptideAtlasiQ9JJF9
PRIDEiQ9JJF9

Genome annotation databases

EnsembliENSMUST00000028844; ENSMUSP00000028844; ENSMUSG00000027366
GeneIDi66552
KEGGimmu:66552
UCSCiuc008mej.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84888
MGIiMGI:1913802 Sppl2a

Phylogenomic databases

eggNOGiKOG2442 Eukaryota
ENOG410ZP52 LUCA
GeneTreeiENSGT00940000157722
HOGENOMiHOG000231496
InParanoidiQ9JJF9
KOiK09596
OMAiWGTCHFL
OrthoDBi535101at2759
TreeFamiTF319186

Enzyme and pathway databases

ReactomeiR-MMU-5357905 Regulation of TNFR1 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sppl2a mouse

Protein Ontology

More...
PROi
PR:Q9JJF9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027366 Expressed in 284 organ(s), highest expression level in right colon
ExpressionAtlasiQ9JJF9 baseline and differential
GenevisibleiQ9JJF9 MM

Family and domain databases

InterProiView protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033151 SPPL2a
PANTHERiPTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04258 Peptidase_A22B, 1 hit
SMARTiView protein in SMART
SM00730 PSN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP2A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJF9
Secondary accession number(s): A2AI51, Q8R354
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again