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Protein

EF-hand and coiled-coil domain-containing protein 1

Gene

Efcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand and coiled-coil domain-containing protein 1
Alternative name(s):
Coiled-coil domain-containing protein 48
Gene namesi
Name:Efcc1
Synonyms:Ccdc48
ORF Names:MNCb-4779
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3611451 Efcc1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003423421 – 558EF-hand and coiled-coil domain-containing protein 1Add BLAST558

Proteomic databases

PaxDbiQ9JJF6
PRIDEiQ9JJF6

PTM databases

iPTMnetiQ9JJF6
PhosphoSitePlusiQ9JJF6

Expressioni

Gene expression databases

BgeeiENSMUSG00000068263 Expressed in 46 organ(s), highest expression level in blood
ExpressionAtlasiQ9JJF6 baseline and differential

Structurei

3D structure databases

SMRiQ9JJF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 78EF-handPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili179 – 304Sequence analysisAdd BLAST126
Coiled coili453 – 495Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 169Poly-Arg10
Compositional biasi368 – 373Poly-Glu6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH78 Eukaryota
ENOG410Y9W3 LUCA
GeneTreeiENSGT00680000100042
HOGENOMiHOG000090223
HOVERGENiHBG078065
InParanoidiQ9JJF6
OMAiLMTYFGH
PhylomeDBiQ9JJF6
TreeFamiTF330736

Family and domain databases

InterProiView protein in InterPro
IPR031601 CCD48
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF15799 CCD48, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JJF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESSAGDPYR RPARRTQWLL SALAHHYGLD RGVENEIVVL ATGLDQYLQE
60 70 80 90 100
VFHHLDCRGA GRLPRADFRA LCAVLGLNAD GETATEDANS AEAASTNPAA
110 120 130 140 150
GMIAGGDADV REEARLALRA DPPELTFRQF HARLCGYFSS RAGPRLPRGA
160 170 180 190 200
LSEHIETQIR LRRPRRRRRP GSPSLHGGAY GERVAHLEEE NSSLRELVED
210 220 230 240 250
LRAALQSSDA RCLALQVGLW KSQSDIPEAA AHELQRAQGA LAEAEARARR
260 270 280 290 300
LQRGQVEVRL RTEEARQAVR RSLHRVRELE ALARRVPCLQ RQVQRLEAEL
310 320 330 340 350
RGYRSEGPQL LTPQQASPRP GNRNGEPTAG GTRDSDTTPE GVQRSDSRDT
360 370 380 390 400
DEEDEQLFRS VEGQAASEEE EEERWQEKPG RPQAHGEVPL VQPSGCVSRC
410 420 430 440 450
DDQTAETLKA SFGHCDGAEH ICTLELETHV TRLGEQLQTL GTPEEEAELQ
460 470 480 490 500
QMVEAEHLRL ELQMVETERV RLSLLEEKLV DVLQLLQRLR DLNISKRALG
510 520 530 540 550
KMLLNALDRN PSQEGTCGTL AILDTLHQAL VGCELLQRNP SAPASTAPAH

TNPFLISC
Length:558
Mass (Da):61,881
Last modified:July 13, 2010 - v2
Checksum:iC83E160F53B86FE3
GO
Isoform 2 (identifier: Q9JJF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-558: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,943
Checksum:i7761BD57400027CA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ84A0A0A0MQ84_MOUSE
EF-hand and coiled-coil domain-cont...
Efcc1
559Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039450305 – 558Missing in isoform 2. 1 PublicationAdd BLAST254

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041550 mRNA Translation: BAA95035.1
AC158626 Genomic DNA No translation available.
CCDSiCCDS51840.1 [Q9JJF6-1]
RefSeqiNP_001153169.1, NM_001159697.1 [Q9JJF6-1]
XP_017177180.1, XM_017321691.1 [Q9JJF6-1]
UniGeneiMm.333229

Genome annotation databases

EnsembliENSMUST00000159570; ENSMUSP00000138649; ENSMUSG00000068263 [Q9JJF6-1]
GeneIDi58229
KEGGimmu:58229
UCSCiuc009ctu.1 mouse [Q9JJF6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041550 mRNA Translation: BAA95035.1
AC158626 Genomic DNA No translation available.
CCDSiCCDS51840.1 [Q9JJF6-1]
RefSeqiNP_001153169.1, NM_001159697.1 [Q9JJF6-1]
XP_017177180.1, XM_017321691.1 [Q9JJF6-1]
UniGeneiMm.333229

3D structure databases

SMRiQ9JJF6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9JJF6
PhosphoSitePlusiQ9JJF6

Proteomic databases

PaxDbiQ9JJF6
PRIDEiQ9JJF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159570; ENSMUSP00000138649; ENSMUSG00000068263 [Q9JJF6-1]
GeneIDi58229
KEGGimmu:58229
UCSCiuc009ctu.1 mouse [Q9JJF6-1]

Organism-specific databases

CTDi79825
MGIiMGI:3611451 Efcc1

Phylogenomic databases

eggNOGiENOG410IH78 Eukaryota
ENOG410Y9W3 LUCA
GeneTreeiENSGT00680000100042
HOGENOMiHOG000090223
HOVERGENiHBG078065
InParanoidiQ9JJF6
OMAiLMTYFGH
PhylomeDBiQ9JJF6
TreeFamiTF330736

Miscellaneous databases

PROiPR:Q9JJF6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068263 Expressed in 46 organ(s), highest expression level in blood
ExpressionAtlasiQ9JJF6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR031601 CCD48
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF15799 CCD48, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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