UniProtKB - Q9JJC8 (NIPA2_MOUSE)

BLAST

>sp|Q9JJC8|NIPA2_MOUSE Magnesium transporter NIPA2 OS=Mus musculus OX=10090 GN=Nipa2 PE=1 SV=1
MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWW
AGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSI
LGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATFVVIVALIFIFVVGPRHGQTNILV
YITICSVIGAFSVSCVKGLGIAIKELLAGKPVLQHPLAWILLFSLVVCVSTQINYLNRAL
DIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFK
DVSFSLASLPVSFRKDEKAMNGNLSSMYEVLNNNEDDLPCGIEHTGENISRRNGNLPSF

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History
Entry version 119 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Magnesium transporter NIPA2

Gene

Nipa2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as a selective Mg²⁺ transporter.1 Publication

Keywordsⁱ

Biological process	Ion transport, Transport
Ligand	Magnesium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Magnesium transporter NIPA2 Alternative name(s): Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog
Gene namesⁱ	Name:Nipa2 ORF Names:MNCb-2146
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1913918 Nipa2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 9	ExtracellularSequence analysis	9
Transmembraneⁱ	10 – 30	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	31 – 56	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	57 – 77	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	78	ExtracellularSequence analysis	1
Transmembraneⁱ	79 – 99	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	100 – 107	CytoplasmicSequence analysis	8
Transmembraneⁱ	108 – 128	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	129 – 149	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	150 – 170	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	171 – 175	CytoplasmicSequence analysis	5
Transmembraneⁱ	176 – 196	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	197 – 215	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	216 – 236	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	237 – 246	CytoplasmicSequence analysis	10
Transmembraneⁱ	247 – 267	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	268 – 278	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	279 – 299	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	300 – 359	CytoplasmicSequence analysisAdd BLAST	60

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191744	1 – 359	Magnesium transporter NIPA2Add BLAST		359

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9JJC8
PaxDbⁱ	Q9JJC8
PRIDEⁱ	Q9JJC8

PTM databases

iPTMnetⁱ	Q9JJC8
PhosphoSitePlusⁱ	Q9JJC8

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expressed at high levels in the kidney.2 Publications

Inductionⁱ

Up-regulated by low magnesium ion levels.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000030452 Expressed in 273 organ(s), highest expression level in epithelium of small intestine
ExpressionAtlasⁱ	Q9JJC8 baseline and differential
Genevisibleⁱ	Q9JJC8 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q9JJC8, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q9JJC8
STRINGⁱ	10090.ENSMUSP00000032635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JJC8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NIPA family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2922 Eukaryota ENOG410XNR8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074395
HOGENOMⁱ	HOG000203962
HOVERGENⁱ	HBG055032
InParanoidⁱ	Q9JJC8
KEGG Orthology (KO) More...KOⁱ	K22733
OMAⁱ	KEWQHMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M8A
PhylomeDBⁱ	Q9JJC8
TreeFamⁱ	TF313214

Family and domain databases

InterProⁱ	View protein in InterPro IPR008521 Mg_trans_NIPA
PANTHERⁱ	PTHR12570 PTHR12570, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05653 Mg_trans_NIPA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9JJC8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLGRGKYDF YIGLGLAMTS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG 
        60         70         80         90        100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS 
       110        120        130        140        150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG 
       160        170        180        190        200
FVVFATFVVI VALIFIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG 
       210        220        230        240        250
IAIKELLAGK PVLQHPLAWI LLFSLVVCVS TQINYLNRAL DIFNTSIVTP 
       260        270        280        290        300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 
       310        320        330        340        350
DVSFSLASLP VSFRKDEKAM NGNLSSMYEV LNNNEDDLPC GIEHTGENIS 

RRNGNLPSF

Length:359

Mass (Da):39,091

Last modified:October 1, 2000 - v1

Checksum:ⁱCAFFAA474D414253

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z682	D3Z682_MOUSE	Magnesium transporter NIPA2 Magnesium transporter NIPA2	Nipa2	130	Annotation score:
D3YUE5	D3YUE5_MOUSE	Magnesium transporter NIPA2 Magnesium transporter NIPA2	Nipa2	127	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BK001121 mRNA Translation: DAA01178.1 AB041581 mRNA Translation: BAA95065.1 AK028734 mRNA Translation: BAC26089.1 AK041427 mRNA Translation: BAC30943.1 AK076051 mRNA Translation: BAC36149.1 AK154755 mRNA Translation: BAE32806.1 BC038499 mRNA Translation: AAH38499.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21316.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001243059.1, NM_001256130.1 NP_001243060.1, NM_001256131.1 NP_001243061.1, NM_001256132.1 NP_001243062.1, NM_001256133.1 NP_076136.2, NM_023647.6 XP_006541387.1, XM_006541324.3
UniGeneⁱ	Mm.333893 Mm.37249 Mm.486878

Genome annotation databases

Ensemblⁱ	ENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452 ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452 ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452 ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452
GeneIDⁱ	93790
KEGGⁱ	mmu:93790
UCSC genome browser More...UCSCⁱ	uc009hdp.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JJC8	Nipa2 protein (Fragment)		MOUSE		118	UniRef100_Q9JJC8
Uncharacterized protein (Fragment)		MOUSE		209
UPI0002458343		MOUSE		294

Protein	Similar proteins		Species	Score	Length	Source
Q9JJC8	Magnesium transporter NIPA2		BOVIN		360	UniRef90_Q9JJC8
Magnesium transporter NIPA2		HUMAN		360
Magnesium transporter NIPA2		PONAB		360
Nipa2 protein (Fragment)		MOUSE		118
Magnesium transporter NIPA2		MYODS		440
+109

Protein	Similar proteins		Species	Score	Length	Source
Q9JJC8	Magnesium transporter NIPA2		HUMAN		360	UniRef50_Q9JJC8
Magnesium transporter NIPA2		PONAB		360
Magnesium transporter NIPA2		BOVIN		360
Nipa2 protein (Fragment)		MOUSE		118
Magnesium transporter NIPA2		MYODS		440
+385

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BK001121 mRNA Translation: DAA01178.1 AB041581 mRNA Translation: BAA95065.1 AK028734 mRNA Translation: BAC26089.1 AK041427 mRNA Translation: BAC30943.1 AK076051 mRNA Translation: BAC36149.1 AK154755 mRNA Translation: BAE32806.1 BC038499 mRNA Translation: AAH38499.1
CCDSⁱ	CCDS21316.1
RefSeqⁱ	NP_001243059.1, NM_001256130.1 NP_001243060.1, NM_001256131.1 NP_001243061.1, NM_001256132.1 NP_001243062.1, NM_001256133.1 NP_076136.2, NM_023647.6 XP_006541387.1, XM_006541324.3
UniGeneⁱ	Mm.333893 Mm.37249 Mm.486878

3D structure databases

ProteinModelPortalⁱ	Q9JJC8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9JJC8, 1 interactor
MINTⁱ	Q9JJC8
STRINGⁱ	10090.ENSMUSP00000032635

PTM databases

iPTMnetⁱ	Q9JJC8
PhosphoSitePlusⁱ	Q9JJC8

Proteomic databases

MaxQBⁱ	Q9JJC8
PaxDbⁱ	Q9JJC8
PRIDEⁱ	Q9JJC8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452 ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452 ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452 ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452
GeneIDⁱ	93790
KEGGⁱ	mmu:93790
UCSCⁱ	uc009hdp.2 mouse

Organism-specific databases

CTDⁱ	81614
MGIⁱ	MGI:1913918 Nipa2

Phylogenomic databases

eggNOGⁱ	KOG2922 Eukaryota ENOG410XNR8 LUCA
GeneTreeⁱ	ENSGT00550000074395
HOGENOMⁱ	HOG000203962
HOVERGENⁱ	HBG055032
InParanoidⁱ	Q9JJC8
KOⁱ	K22733
OMAⁱ	KEWQHMA
OrthoDBⁱ	EOG091G0M8A
PhylomeDBⁱ	Q9JJC8
TreeFamⁱ	TF313214

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JJC8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030452 Expressed in 273 organ(s), highest expression level in epithelium of small intestine
ExpressionAtlasⁱ	Q9JJC8 baseline and differential
Genevisibleⁱ	Q9JJC8 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR008521 Mg_trans_NIPA
PANTHERⁱ	PTHR12570 PTHR12570, 1 hit
Pfamⁱ	View protein in Pfam PF05653 Mg_trans_NIPA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NIPA2_MOUSE
Accessionⁱ	Q9JJC8Primary (citable) accession number: Q9JJC8 Secondary accession number(s): Q3U3I0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JJC8 (NIPA2_MOUSE)

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Magnesium transporter NIPA2

Nipa2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ