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UniProtKB - Q9JJC8 (NIPA2_MOUSE)

Entry version 130 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Magnesium transporter NIPA2

Gene

Nipa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a selective Mg2+ transporter.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.31 mM for magnesium ions1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    • magnesium ion transport Source: UniProtKB
    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processIon transport, Transport
    LigandMagnesium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-MMU-5223345, Miscellaneous transport and binding events

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Magnesium transporter NIPA2
    Alternative name(s):
    Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Nipa2
    ORF Names:MNCb-2146
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...    MGIi    		MGI:1913918, Nipa2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularSequence analysis9
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
    Topological domaini31 – 56CytoplasmicSequence analysisAdd BLAST26
    Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
    Topological domaini78ExtracellularSequence analysis1
    Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
    Topological domaini100 – 107CytoplasmicSequence analysis8
    Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
    Topological domaini129 – 149ExtracellularSequence analysisAdd BLAST21
    Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
    Topological domaini171 – 175CytoplasmicSequence analysis5
    Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
    Topological domaini197 – 215ExtracellularSequence analysisAdd BLAST19
    Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
    Topological domaini237 – 246CytoplasmicSequence analysis10
    Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
    Topological domaini268 – 278ExtracellularSequence analysisAdd BLAST11
    Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
    Topological domaini300 – 359CytoplasmicSequence analysisAdd BLAST60

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917441 – 359Magnesium transporter NIPA2Add BLAST359

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9JJC8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9JJC8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9JJC8

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9JJC8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9JJC8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed at high levels in the kidney.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by low magnesium ion levels.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSMUSG00000030452, Expressed in epithelium of small intestine and 288 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9JJC8, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...    IntActi    		Q9JJC8, 1 interactor

    Molecular INTeraction database

    More...    MINTi    		Q9JJC8

    STRING: functional protein association networks

    More...    STRINGi    		10090.ENSMUSP00000114020

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9JJC8, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG2922, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155651

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_012349_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9JJC8

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		KNPLAWI

    Database of Orthologous Groups

    More...    OrthoDBi    		754939at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9JJC8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313214

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR008521, Mg_trans_NIPA

    The PANTHER Classification System

    More...    PANTHERi    		PTHR12570, PTHR12570, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF05653, Mg_trans_NIPA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9JJC8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSLGRGKYDF YIGLGLAMTS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG 
            60         70         80         90        100
    HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS 
           110        120        130        140        150
    SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG 
           160        170        180        190        200
    FVVFATFVVI VALIFIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG 
           210        220        230        240        250
    IAIKELLAGK PVLQHPLAWI LLFSLVVCVS TQINYLNRAL DIFNTSIVTP 
           260        270        280        290        300
    IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 
           310        320        330        340        350
    DVSFSLASLP VSFRKDEKAM NGNLSSMYEV LNNNEDDLPC GIEHTGENIS 

    RRNGNLPSF
    Length:359
    Mass (Da):39,091
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAFFAA474D414253
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    D3Z682D3Z682_MOUSE
    Magnesium transporter NIPA2
    Nipa2
    		130Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D3YUE5D3YUE5_MOUSE
    Magnesium transporter NIPA2
    Nipa2
    		127Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		BK001121 mRNA Translation: DAA01178.1
    AB041581 mRNA Translation: BAA95065.1
    AK028734 mRNA Translation: BAC26089.1
    AK041427 mRNA Translation: BAC30943.1
    AK076051 mRNA Translation: BAC36149.1
    AK154755 mRNA Translation: BAE32806.1
    BC038499 mRNA Translation: AAH38499.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS21316.1

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001243059.1, NM_001256130.1
    NP_001243060.1, NM_001256131.1
    NP_001243061.1, NM_001256132.1
    NP_001243062.1, NM_001256133.1
    NP_076136.2, NM_023647.6
    XP_006541387.1, XM_006541324.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452
    ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452
    ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452
    ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		93790

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		mmu:93790

    UCSC genome browser

    More...    UCSCi    		uc009hdp.2, mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		BK001121 mRNA Translation: DAA01178.1
    AB041581 mRNA Translation: BAA95065.1
    AK028734 mRNA Translation: BAC26089.1
    AK041427 mRNA Translation: BAC30943.1
    AK076051 mRNA Translation: BAC36149.1
    AK154755 mRNA Translation: BAE32806.1
    BC038499 mRNA Translation: AAH38499.1
    CCDSiCCDS21316.1
    RefSeqiNP_001243059.1, NM_001256130.1
    NP_001243060.1, NM_001256131.1
    NP_001243061.1, NM_001256132.1
    NP_001243062.1, NM_001256133.1
    NP_076136.2, NM_023647.6
    XP_006541387.1, XM_006541324.3

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    IntActiQ9JJC8, 1 interactor
    MINTiQ9JJC8
    STRINGi10090.ENSMUSP00000114020

    PTM databases

    iPTMnetiQ9JJC8
    PhosphoSitePlusiQ9JJC8

    Proteomic databases

    MaxQBiQ9JJC8
    PaxDbiQ9JJC8
    PRIDEiQ9JJC8

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		22214, 39 antibodies

    Genome annotation databases

    EnsembliENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452
    ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452
    ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452
    ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452
    GeneIDi93790
    KEGGimmu:93790
    UCSCiuc009hdp.2, mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		81614
    MGIiMGI:1913918, Nipa2

    Phylogenomic databases

    eggNOGiKOG2922, Eukaryota
    GeneTreeiENSGT00940000155651
    HOGENOMiCLU_012349_1_1_1
    InParanoidiQ9JJC8
    OMAiKNPLAWI
    OrthoDBi754939at2759
    PhylomeDBiQ9JJC8
    TreeFamiTF313214

    Enzyme and pathway databases

    ReactomeiR-MMU-5223345, Miscellaneous transport and binding events

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		93790, 0 hits in 19 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		Nipa2, mouse

    Protein Ontology

    More...    PROi    		PR:Q9JJC8
    RNActiQ9JJC8, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSMUSG00000030452, Expressed in epithelium of small intestine and 288 other tissues
    GenevisibleiQ9JJC8, MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR008521, Mg_trans_NIPA
    PANTHERiPTHR12570, PTHR12570, 1 hit
    PfamiView protein in Pfam
    PF05653, Mg_trans_NIPA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPA2_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJC8
    Secondary accession number(s): Q3U3I0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 1, 2000
    Last modified: December 2, 2020
    This is version 130 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
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