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Protein

Magnesium transporter NIPA2

Gene

Nipa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a selective Mg2+ transporter.1 Publication

Kineticsi

  1. KM=0.31 mM for magnesium ions1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • magnesium ion transport Source: UniProtKB

    Keywordsi

    Biological processIon transport, Transport
    LigandMagnesium

    Enzyme and pathway databases

    ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magnesium transporter NIPA2
    Alternative name(s):
    Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog
    Gene namesi
    Name:Nipa2
    ORF Names:MNCb-2146
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 7

    Organism-specific databases

    MGIiMGI:1913918 Nipa2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 9ExtracellularSequence analysis9
    Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
    Topological domaini31 – 56CytoplasmicSequence analysisAdd BLAST26
    Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
    Topological domaini78ExtracellularSequence analysis1
    Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
    Topological domaini100 – 107CytoplasmicSequence analysis8
    Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
    Topological domaini129 – 149ExtracellularSequence analysisAdd BLAST21
    Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
    Topological domaini171 – 175CytoplasmicSequence analysis5
    Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
    Topological domaini197 – 215ExtracellularSequence analysisAdd BLAST19
    Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
    Topological domaini237 – 246CytoplasmicSequence analysis10
    Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
    Topological domaini268 – 278ExtracellularSequence analysisAdd BLAST11
    Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
    Topological domaini300 – 359CytoplasmicSequence analysisAdd BLAST60

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001917441 – 359Magnesium transporter NIPA2Add BLAST359

    Proteomic databases

    MaxQBiQ9JJC8
    PaxDbiQ9JJC8
    PRIDEiQ9JJC8

    PTM databases

    iPTMnetiQ9JJC8
    PhosphoSitePlusiQ9JJC8

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high levels in the kidney.2 Publications

    Inductioni

    Up-regulated by low magnesium ion levels.1 Publication

    Gene expression databases

    BgeeiENSMUSG00000030452 Expressed in 273 organ(s), highest expression level in epithelium of small intestine
    ExpressionAtlasiQ9JJC8 baseline and differential
    GenevisibleiQ9JJC8 MM

    Interactioni

    Protein-protein interaction databases

    IntActiQ9JJC8, 1 interactor
    MINTiQ9JJC8
    STRINGi10090.ENSMUSP00000032635

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JJC8
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2922 Eukaryota
    ENOG410XNR8 LUCA
    GeneTreeiENSGT00550000074395
    HOGENOMiHOG000203962
    HOVERGENiHBG055032
    InParanoidiQ9JJC8
    KOiK22733
    OMAiKEWQHMA
    OrthoDBiEOG091G0M8A
    PhylomeDBiQ9JJC8
    TreeFamiTF313214

    Family and domain databases

    InterProiView protein in InterPro
    IPR008521 Mg_trans_NIPA
    PANTHERiPTHR12570 PTHR12570, 1 hit
    PfamiView protein in Pfam
    PF05653 Mg_trans_NIPA, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9JJC8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSLGRGKYDF YIGLGLAMTS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
    60 70 80 90 100
    HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
    110 120 130 140 150
    SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
    160 170 180 190 200
    FVVFATFVVI VALIFIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
    210 220 230 240 250
    IAIKELLAGK PVLQHPLAWI LLFSLVVCVS TQINYLNRAL DIFNTSIVTP
    260 270 280 290 300
    IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
    310 320 330 340 350
    DVSFSLASLP VSFRKDEKAM NGNLSSMYEV LNNNEDDLPC GIEHTGENIS

    RRNGNLPSF
    Length:359
    Mass (Da):39,091
    Last modified:October 1, 2000 - v1
    Checksum:iCAFFAA474D414253
    GO

    Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D3Z682D3Z682_MOUSE
    Magnesium transporter NIPA2
    Nipa2
    130Annotation score:
    D3YUE5D3YUE5_MOUSE
    Magnesium transporter NIPA2
    Nipa2
    127Annotation score:

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BK001121 mRNA Translation: DAA01178.1
    AB041581 mRNA Translation: BAA95065.1
    AK028734 mRNA Translation: BAC26089.1
    AK041427 mRNA Translation: BAC30943.1
    AK076051 mRNA Translation: BAC36149.1
    AK154755 mRNA Translation: BAE32806.1
    BC038499 mRNA Translation: AAH38499.1
    CCDSiCCDS21316.1
    RefSeqiNP_001243059.1, NM_001256130.1
    NP_001243060.1, NM_001256131.1
    NP_001243061.1, NM_001256132.1
    NP_001243062.1, NM_001256133.1
    NP_076136.2, NM_023647.6
    XP_006541387.1, XM_006541324.3
    UniGeneiMm.333893
    Mm.37249
    Mm.486878

    Genome annotation databases

    EnsembliENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452
    ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452
    ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452
    ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452
    GeneIDi93790
    KEGGimmu:93790
    UCSCiuc009hdp.2 mouse

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BK001121 mRNA Translation: DAA01178.1
    AB041581 mRNA Translation: BAA95065.1
    AK028734 mRNA Translation: BAC26089.1
    AK041427 mRNA Translation: BAC30943.1
    AK076051 mRNA Translation: BAC36149.1
    AK154755 mRNA Translation: BAE32806.1
    BC038499 mRNA Translation: AAH38499.1
    CCDSiCCDS21316.1
    RefSeqiNP_001243059.1, NM_001256130.1
    NP_001243060.1, NM_001256131.1
    NP_001243061.1, NM_001256132.1
    NP_001243062.1, NM_001256133.1
    NP_076136.2, NM_023647.6
    XP_006541387.1, XM_006541324.3
    UniGeneiMm.333893
    Mm.37249
    Mm.486878

    3D structure databases

    ProteinModelPortaliQ9JJC8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9JJC8, 1 interactor
    MINTiQ9JJC8
    STRINGi10090.ENSMUSP00000032635

    PTM databases

    iPTMnetiQ9JJC8
    PhosphoSitePlusiQ9JJC8

    Proteomic databases

    MaxQBiQ9JJC8
    PaxDbiQ9JJC8
    PRIDEiQ9JJC8

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452
    ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452
    ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452
    ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452
    GeneIDi93790
    KEGGimmu:93790
    UCSCiuc009hdp.2 mouse

    Organism-specific databases

    CTDi81614
    MGIiMGI:1913918 Nipa2

    Phylogenomic databases

    eggNOGiKOG2922 Eukaryota
    ENOG410XNR8 LUCA
    GeneTreeiENSGT00550000074395
    HOGENOMiHOG000203962
    HOVERGENiHBG055032
    InParanoidiQ9JJC8
    KOiK22733
    OMAiKEWQHMA
    OrthoDBiEOG091G0M8A
    PhylomeDBiQ9JJC8
    TreeFamiTF313214

    Enzyme and pathway databases

    ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

    Miscellaneous databases

    PROiPR:Q9JJC8
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSMUSG00000030452 Expressed in 273 organ(s), highest expression level in epithelium of small intestine
    ExpressionAtlasiQ9JJC8 baseline and differential
    GenevisibleiQ9JJC8 MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR008521 Mg_trans_NIPA
    PANTHERiPTHR12570 PTHR12570, 1 hit
    PfamiView protein in Pfam
    PF05653 Mg_trans_NIPA, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiNIPA2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JJC8
    Secondary accession number(s): Q3U3I0
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 1, 2000
    Last modified: September 12, 2018
    This is version 119 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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