UniProtKB - Q9JJC8 (NIPA2_MOUSE)
Protein
Magnesium transporter NIPA2
Gene
Nipa2
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a selective Mg2+ transporter.1 Publication
Kineticsi
- KM=0.31 mM for magnesium ions1 Publication
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: InterPro
GO - Biological processi
- magnesium ion transport Source: UniProtKB
Keywordsi
Biological process | Ion transport, Transport |
Ligand | Magnesium |
Enzyme and pathway databases
Reactomei | R-MMU-5223345, Miscellaneous transport and binding events |
Names & Taxonomyi
Protein namesi | Recommended name: Magnesium transporter NIPA2Alternative name(s): Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog |
Gene namesi | Name:Nipa2 ORF Names:MNCb-2146 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913918, Nipa2 |
Subcellular locationi
Endosome
- Early endosome 1 Publication
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Note: Recruited to the cell membrane in response to low extracellular magnesium.
Endosome
- early endosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | ExtracellularSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 56 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 78 | ExtracellularSequence analysis | 1 | |
Transmembranei | 79 – 99 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 100 – 107 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 149 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 175 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 215 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 246 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 278 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 279 – 299 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 359 | CytoplasmicSequence analysisAdd BLAST | 60 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191744 | 1 – 359 | Magnesium transporter NIPA2Add BLAST | 359 |
Proteomic databases
MaxQBi | Q9JJC8 |
PaxDbi | Q9JJC8 |
PRIDEi | Q9JJC8 |
PTM databases
iPTMneti | Q9JJC8 |
PhosphoSitePlusi | Q9JJC8 |
Expressioni
Tissue specificityi
Widely expressed. Expressed at high levels in the kidney.2 Publications
Inductioni
Up-regulated by low magnesium ion levels.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000030452, Expressed in epithelium of small intestine and 288 other tissues |
Genevisiblei | Q9JJC8, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q9JJC8, 1 interactor |
MINTi | Q9JJC8 |
STRINGi | 10090.ENSMUSP00000114020 |
Miscellaneous databases
RNActi | Q9JJC8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NIPA family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2922, Eukaryota |
GeneTreei | ENSGT00940000155651 |
HOGENOMi | CLU_012349_1_1_1 |
InParanoidi | Q9JJC8 |
OMAi | KNPLAWI |
OrthoDBi | 754939at2759 |
PhylomeDBi | Q9JJC8 |
TreeFami | TF313214 |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9JJC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLGRGKYDF YIGLGLAMTS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
60 70 80 90 100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
110 120 130 140 150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
160 170 180 190 200
FVVFATFVVI VALIFIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
210 220 230 240 250
IAIKELLAGK PVLQHPLAWI LLFSLVVCVS TQINYLNRAL DIFNTSIVTP
260 270 280 290 300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
310 320 330 340 350
DVSFSLASLP VSFRKDEKAM NGNLSSMYEV LNNNEDDLPC GIEHTGENIS
RRNGNLPSF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z682 | D3Z682_MOUSE | Magnesium transporter NIPA2 | Nipa2 | 130 | Annotation score: | ||
D3YUE5 | D3YUE5_MOUSE | Magnesium transporter NIPA2 | Nipa2 | 127 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BK001121 mRNA Translation: DAA01178.1 AB041581 mRNA Translation: BAA95065.1 AK028734 mRNA Translation: BAC26089.1 AK041427 mRNA Translation: BAC30943.1 AK076051 mRNA Translation: BAC36149.1 AK154755 mRNA Translation: BAE32806.1 BC038499 mRNA Translation: AAH38499.1 |
CCDSi | CCDS21316.1 |
RefSeqi | NP_001243059.1, NM_001256130.1 NP_001243060.1, NM_001256131.1 NP_001243061.1, NM_001256132.1 NP_001243062.1, NM_001256133.1 NP_076136.2, NM_023647.6 XP_006541387.1, XM_006541324.3 |
Genome annotation databases
Ensembli | ENSMUST00000032635; ENSMUSP00000032635; ENSMUSG00000030452 ENSMUST00000117812; ENSMUSP00000113727; ENSMUSG00000030452 ENSMUST00000119041; ENSMUSP00000112394; ENSMUSG00000030452 ENSMUST00000119201; ENSMUSP00000114020; ENSMUSG00000030452 |
GeneIDi | 93790 |
KEGGi | mmu:93790 |
UCSCi | uc009hdp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BK001121 mRNA Translation: DAA01178.1 AB041581 mRNA Translation: BAA95065.1 AK028734 mRNA Translation: BAC26089.1 AK041427 mRNA Translation: BAC30943.1 AK076051 mRNA Translation: BAC36149.1 AK154755 mRNA Translation: BAE32806.1 BC038499 mRNA Translation: AAH38499.1 |
CCDSi | CCDS21316.1 |
RefSeqi | NP_001243059.1, NM_001256130.1 NP_001243060.1, NM_001256131.1 NP_001243061.1, NM_001256132.1 NP_001243062.1, NM_001256133.1 NP_076136.2, NM_023647.6 XP_006541387.1, XM_006541324.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9JJC8, 1 interactor |
MINTi | Q9JJC8 |
STRINGi | 10090.ENSMUSP00000114020 |
PTM databases
iPTMneti | Q9JJC8 |
PhosphoSitePlusi | Q9JJC8 |
Proteomic databases
MaxQBi | Q9JJC8 |
PaxDbi | Q9JJC8 |
PRIDEi | Q9JJC8 |
Protocols and materials databases
Antibodypediai | 22214, 39 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 81614 |
MGIi | MGI:1913918, Nipa2 |
Phylogenomic databases
eggNOGi | KOG2922, Eukaryota |
GeneTreei | ENSGT00940000155651 |
HOGENOMi | CLU_012349_1_1_1 |
InParanoidi | Q9JJC8 |
OMAi | KNPLAWI |
OrthoDBi | 754939at2759 |
PhylomeDBi | Q9JJC8 |
TreeFami | TF313214 |
Enzyme and pathway databases
Reactomei | R-MMU-5223345, Miscellaneous transport and binding events |
Miscellaneous databases
BioGRID-ORCSi | 93790, 0 hits in 19 CRISPR screens |
ChiTaRSi | Nipa2, mouse |
PROi | PR:Q9JJC8 |
RNActi | Q9JJC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030452, Expressed in epithelium of small intestine and 288 other tissues |
Genevisiblei | Q9JJC8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NIPA2_MOUSE | |
Accessioni | Q9JJC8Primary (citable) accession number: Q9JJC8 Secondary accession number(s): Q3U3I0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families