Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-L2

Gene

Ccnl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.By similarity

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L2
Alternative name(s):
Cyclin Ania-6b
Paneth cell-enhanced expression protein
Short name:
PCEE
Gene namesi
Name:Ccnl2
Synonyms:Ania6b
ORF Names:MNCb-5160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1927119 Ccnl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804881 – 518Cyclin-L2Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei328PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei348PhosphoserineBy similarity1
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JJA7
PaxDbiQ9JJA7
PeptideAtlasiQ9JJA7
PRIDEiQ9JJA7

PTM databases

iPTMnetiQ9JJA7
PhosphoSitePlusiQ9JJA7

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000029068 Expressed in 322 organ(s), highest expression level in spleen
CleanExiMM_CCNL2
ExpressionAtlasiQ9JJA7 baseline and differential
GenevisibleiQ9JJA7 MM

Interactioni

Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.By similarity1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-350 Cyclin L2-CDK11B(p110) complex
CPX-353 Cyclin L2-CDK11B(p58) complex
IntActiQ9JJA7, 1 interactor
MINTiQ9JJA7
STRINGi10090.ENSMUSP00000030944

Structurei

3D structure databases

ProteinModelPortaliQ9JJA7
SMRiQ9JJA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 183Cyclin-like 1Add BLAST103
Regioni196 – 280Cyclin-like 2Add BLAST85
Regioni382 – 420RSAdd BLAST39

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOVERGENiHBG056044
InParanoidiQ9JJA7
OMAiYRKSKDC
OrthoDBiEOG091G0BW9
PhylomeDBiQ9JJA7
TreeFamiTF101011

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JJA7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAGAAG LMAPASAACS SGSAGAAPGS QGVLIGDRLY SGVLITLENC
60 70 80 90 100
LLPDDKLRFT PSMSSGLDVD TETGLRVVGC ELIQAAGILL RLPQVAMATG
110 120 130 140 150
QVLFQRFFYT KSFVKHSMEH VSMACVHLAS KIEEAPRRIR DVINVFHRLR
160 170 180 190 200
HLREKKKPVP LVLDQEYVNL KNQIIKAERR VLKELGFCVH VKHPHKIIVM
210 220 230 240 250
YLQVLECERN QHLVQTAWNY MNDSLRTDVF VRFQPESIAC ACIYLAARTL
260 270 280 290 300
EIPLPNRPHW FLLFGATEEE IQEICFKILQ LYTRKKVDLT HLESEVEKRK
310 320 330 340 350
HAIEEAKARA KGLLPGTAPG LDSAAGFSPA PKLESPKEGK GGKPSPPSGK
360 370 380 390 400
SAKRKMEGPK KAQGHSPVNG LLKGQESRSQ SRSREQSYSR SPSRSASPKR
410 420 430 440 450
RKSDSGSTSG GSKSQSRSRS RSDSPPRQVH RGAPYKGSEV RGSRKSKDCK
460 470 480 490 500
YLTQKPHKSR SRSSSRSRSR SRERTDNSGK YKKKSHYYRD QRRERSRSYE
510
RTGHRYERDH PGHSRHRR
Length:518
Mass (Da):58,005
Last modified:October 1, 2000 - v1
Checksum:iC93AEE68682CDBA5
GO
Isoform 2 (identifier: Q9JJA7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-224: NYMNDS → VASEGK
     225-518: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:224
Mass (Da):24,578
Checksum:i744000F7C7D3084E
GO
Isoform 3 (identifier: Q9JJA7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-518: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):24,006
Checksum:i584E197FA66E601D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RXL0F6RXL0_MOUSE
Cyclin-L2
Ccnl2
93Annotation score:

Sequence cautioni

The sequence AAC52504 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC52504 differs from that shown. Reason: Erroneous termination at position 519. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16S → A in BAE41413 (PubMed:16141072).Curated1
Sequence conflicti16S → A in BAE33556 (PubMed:16141072).Curated1
Sequence conflicti16S → A in EDL15040 (Ref. 6) Curated1
Sequence conflicti16S → A in AAI32296 (PubMed:15489334).Curated1
Sequence conflicti131K → R in BAC26255 (PubMed:16141072).Curated1
Sequence conflicti282Y → F in AAH03773 (PubMed:15489334).Curated1
Sequence conflicti317T → S in EDL15040 (Ref. 6) Curated1
Sequence conflicti317T → S in AAH03773 (PubMed:15489334).Curated1
Sequence conflicti317T → S in AAI32296 (PubMed:15489334).Curated1
Sequence conflicti334E → VE in AAH03773 (PubMed:15489334).Curated1
Sequence conflicti334E → VE in AAH83055 (PubMed:15489334).Curated1
Sequence conflicti334E → VE in AAC52504 (PubMed:8838426).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016133219 – 518Missing in isoform 3. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_016134219 – 224NYMNDS → VASEGK in isoform 2. 3 Publications6
Alternative sequenceiVSP_016135225 – 518Missing in isoform 2. 3 PublicationsAdd BLAST294

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211859 mRNA Translation: AAF23011.1
AY337018 mRNA Translation: AAQ01205.1
AB041605 mRNA Translation: BAA95088.1
AK007552 mRNA Translation: BAB25103.1
AK029033 mRNA Translation: BAC26255.1
AK048244 mRNA Translation: BAE43334.1
AK156037 mRNA Translation: BAE33556.1
AK169857 mRNA Translation: BAE41413.1
AL670236 Genomic DNA Translation: CAM18388.1
CH466594 Genomic DNA Translation: EDL15040.1
BC003773 mRNA Translation: AAH03773.2
BC023747 mRNA No translation available.
BC083055 mRNA Translation: AAH83055.1
BC132295 mRNA Translation: AAI32296.1
U37351 mRNA Translation: AAC52504.1 Sequence problems.
CCDSiCCDS19042.1 [Q9JJA7-1]
RefSeqiNP_997561.1, NM_207678.1 [Q9JJA7-1]
UniGeneiMm.23492

Genome annotation databases

EnsembliENSMUST00000030944; ENSMUSP00000030944; ENSMUSG00000029068 [Q9JJA7-1]
GeneIDi56036
KEGGimmu:56036
UCSCiuc008wev.1 mouse [Q9JJA7-3]
uc008wew.1 mouse [Q9JJA7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211859 mRNA Translation: AAF23011.1
AY337018 mRNA Translation: AAQ01205.1
AB041605 mRNA Translation: BAA95088.1
AK007552 mRNA Translation: BAB25103.1
AK029033 mRNA Translation: BAC26255.1
AK048244 mRNA Translation: BAE43334.1
AK156037 mRNA Translation: BAE33556.1
AK169857 mRNA Translation: BAE41413.1
AL670236 Genomic DNA Translation: CAM18388.1
CH466594 Genomic DNA Translation: EDL15040.1
BC003773 mRNA Translation: AAH03773.2
BC023747 mRNA No translation available.
BC083055 mRNA Translation: AAH83055.1
BC132295 mRNA Translation: AAI32296.1
U37351 mRNA Translation: AAC52504.1 Sequence problems.
CCDSiCCDS19042.1 [Q9JJA7-1]
RefSeqiNP_997561.1, NM_207678.1 [Q9JJA7-1]
UniGeneiMm.23492

3D structure databases

ProteinModelPortaliQ9JJA7
SMRiQ9JJA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-350 Cyclin L2-CDK11B(p110) complex
CPX-353 Cyclin L2-CDK11B(p58) complex
IntActiQ9JJA7, 1 interactor
MINTiQ9JJA7
STRINGi10090.ENSMUSP00000030944

PTM databases

iPTMnetiQ9JJA7
PhosphoSitePlusiQ9JJA7

Proteomic databases

EPDiQ9JJA7
PaxDbiQ9JJA7
PeptideAtlasiQ9JJA7
PRIDEiQ9JJA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030944; ENSMUSP00000030944; ENSMUSG00000029068 [Q9JJA7-1]
GeneIDi56036
KEGGimmu:56036
UCSCiuc008wev.1 mouse [Q9JJA7-3]
uc008wew.1 mouse [Q9JJA7-1]

Organism-specific databases

CTDi81669
MGIiMGI:1927119 Ccnl2

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOVERGENiHBG056044
InParanoidiQ9JJA7
OMAiYRKSKDC
OrthoDBiEOG091G0BW9
PhylomeDBiQ9JJA7
TreeFamiTF101011

Miscellaneous databases

ChiTaRSiCcnl2 mouse
PROiPR:Q9JJA7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029068 Expressed in 322 organ(s), highest expression level in spleen
CleanExiMM_CCNL2
ExpressionAtlasiQ9JJA7 baseline and differential
GenevisibleiQ9JJA7 MM

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCCNL2_MOUSE
AccessioniPrimary (citable) accession number: Q9JJA7
Secondary accession number(s): A2AD95
, A2RSY2, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9QXH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again