Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 111 (12 Aug 2020)
Sequence version 2 (01 May 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Coiled-coil domain-containing protein 86

Gene

Ccdc86

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 86
Alternative name(s):
Cytokine-induced protein with coiled-coil domain
Short name:
mCyclon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc86
Synonyms:Cyclon, D19Ertd678e
ORF Names:MNCb-4327
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277220, Ccdc86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860931 – 426Coiled-coil domain-containing protein 86Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei59PhosphoserineBy similarity1
Modified residuei66PhosphothreonineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei408Citrulline1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JJ89

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JJ89

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9JJ89

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJ89

PeptideAtlas

More...
PeptideAtlasi
Q9JJ89

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJ89

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JJ89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJ89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Also expressed in heart, liver, kidney.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interleukin-3 (IL3).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024732, Expressed in embryo and 291 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JJ89, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
224366, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9JJ89, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9JJ89

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025639

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JJ89, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JJ89

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili346 – 389Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 265Pro-richAdd BLAST213

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017281

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_065828_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJ89

KEGG Orthology (KO)

More...
KOi
K14822

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSQMLQD

Database of Orthologous Groups

More...
OrthoDBi
1470010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JJ89

TreeFam database of animal gene trees

More...
TreeFami
TF325663

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026570, CCDC86
IPR005579, Cgr1-like

The PANTHER Classification System

More...
PANTHERi
PTHR13557, PTHR13557, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03879, Cgr1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9JJ89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTPLRRSRR LEGLKPLSPE NLPVPEVSRA KRALVDFKSN SEETGELKST
60 70 80 90 100
RVPPLSLPSP GPQPETSPGS PCPPLSLPSP GPQPETSPGS PCPPLSLPSP
110 120 130 140 150
GPQPETSPGS PCPPLSLPSP GPQPETSPGS PCPPLSLPSP GPQPEASPGS
160 170 180 190 200
PGPRQDADDG SPQRQPEPHP GSLQPHQDLG LESPAGQTES SPESPQREQP
210 220 230 240 250
SKLPPPQGEL DSEAAHAKEE VIPGSPEPCP GQQAPGPEPS QPAQELTVQA
260 270 280 290 300
PSSPERQLEP GKLPPAGETV TESLNLKKRV IASPQAPASK KLKEKEELPV
310 320 330 340 350
IPKGKPKSGR VWKDRSKKRF SQMVQDKPLR TSWQRKMKER QERKLAKDFA
360 370 380 390 400
RHLEEEKQRR RQEKKERRAE NLRRRLENER KAEIVQVIRN PAKLKKAKKK
410 420
QLRSIEKRDT LALLQKQPPQ RPVAKV
Length:426
Mass (Da):46,487
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A4014176E1F1B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → L in BAA95108 (Ref. 2) Curated1
Sequence conflicti92C → F in BAC37282 (PubMed:16141072).Curated1
Sequence conflicti92C → F in BAC37260 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ501252 mRNA Translation: ABF68613.1
AB041663 mRNA Translation: BAA95108.1
AK078407 mRNA Translation: BAC37260.1
AK078455 mRNA Translation: BAC37282.1
AK088727 mRNA Translation: BAC40530.1
BC043326 mRNA Translation: AAH43326.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29593.1

NCBI Reference Sequences

More...
RefSeqi
NP_076220.2, NM_023731.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025639; ENSMUSP00000025639; ENSMUSG00000024732

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108673

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:108673

UCSC genome browser

More...
UCSCi
uc008grj.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ501252 mRNA Translation: ABF68613.1
AB041663 mRNA Translation: BAA95108.1
AK078407 mRNA Translation: BAC37260.1
AK078455 mRNA Translation: BAC37282.1
AK088727 mRNA Translation: BAC40530.1
BC043326 mRNA Translation: AAH43326.1
CCDSiCCDS29593.1
RefSeqiNP_076220.2, NM_023731.3

3D structure databases

SMRiQ9JJ89
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi224366, 1 interactor
IntActiQ9JJ89, 2 interactors
MINTiQ9JJ89
STRINGi10090.ENSMUSP00000025639

PTM databases

iPTMnetiQ9JJ89
PhosphoSitePlusiQ9JJ89

Proteomic databases

EPDiQ9JJ89
jPOSTiQ9JJ89
MaxQBiQ9JJ89
PaxDbiQ9JJ89
PeptideAtlasiQ9JJ89
PRIDEiQ9JJ89

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
43508, 46 antibodies

Genome annotation databases

EnsembliENSMUST00000025639; ENSMUSP00000025639; ENSMUSG00000024732
GeneIDi108673
KEGGimmu:108673
UCSCiuc008grj.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79080
MGIiMGI:1277220, Ccdc86

Phylogenomic databases

eggNOGiKOG4538, Eukaryota
GeneTreeiENSGT00390000017281
HOGENOMiCLU_065828_0_0_1
InParanoidiQ9JJ89
KOiK14822
OMAiFSQMLQD
OrthoDBi1470010at2759
PhylomeDBiQ9JJ89
TreeFamiTF325663

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
108673, 7 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ccdc86, mouse

Protein Ontology

More...
PROi
PR:Q9JJ89
RNActiQ9JJ89, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024732, Expressed in embryo and 291 other tissues
GenevisibleiQ9JJ89, MM

Family and domain databases

InterProiView protein in InterPro
IPR026570, CCDC86
IPR005579, Cgr1-like
PANTHERiPTHR13557, PTHR13557, 1 hit
PfamiView protein in Pfam
PF03879, Cgr1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD86_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJ89
Secondary accession number(s): Q8BGH9, Q8C2F2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: August 12, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again