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Entry version 109 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

Dync2h1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi145 – 152ATPSequence analysis8
Nucleotide bindingi1689 – 1696ATPSequence analysis8
Nucleotide bindingi1979 – 1986ATPSequence analysis8
Nucleotide bindingi2291 – 2298ATPSequence analysis8
Nucleotide bindingi2655 – 2662ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5610787, Hedgehog 'off' state
R-RNO-5620924, Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain isotype 1B
Dynein-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dync2h1
Synonyms:Dhc1b, Dlp4, Dnch2, Dnchc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
71042, Dync2h1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003187451 – 4306Cytoplasmic dynein 2 heavy chain 1Add BLAST4306

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JJ79

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJ79

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJ79

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9JJ79

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JJ79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJ79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed both in ciliated and unciliated tissues. Detected in brain and testis (at protein level).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in adult and juvenile brain.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during ciliogenesis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249321, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9JJ79

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000043252

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JJ79

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1650StemBy similarityAdd BLAST1650
Regioni1651 – 1875AAA 1By similarityAdd BLAST225
Regioni1941 – 2161AAA 2By similarityAdd BLAST221
Regioni2249 – 2505AAA 3By similarityAdd BLAST257
Regioni2617 – 2862AAA 4By similarityAdd BLAST246
Regioni2880 – 3168StalkBy similarityAdd BLAST289
Regioni3243 – 3472AAA 5By similarityAdd BLAST230
Regioni3689 – 3904AAA 6By similarityAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili669 – 696Sequence analysisAdd BLAST28
Coiled coili2896 – 2981Sequence analysisAdd BLAST86
Coiled coili3108 – 3199Sequence analysisAdd BLAST92
Coiled coili3407 – 3441Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJ79

KEGG Orthology (KO)

More...
KOi
K10414

Database of Orthologous Groups

More...
OrthoDBi
26380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JJ79

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JJ79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSLSDVRK LFLFTTTQNY FGLRPELWDQ TPLSNCPEVN NFLDDGNQML
60 70 80 90 100
LRVQRSDAGL AFSNTIDFDD TKDKVLVFFK LRPEVITDGN LHTNILVSSM
110 120 130 140 150
LESPINSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGVVLR
160 170 180 190 200
KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI EQAHRGSKQI SKERASYFKE
210 220 230 240 250
LFETIAREFY NLDSLSLLEV VDLVETTRDV VDDVWRQAEH DHYPESRMLH
260 270 280 290 300
LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH
310 320 330 340 350
LTGQVWQRYV PHPWKSEKYF PETLDRLGKR LEEVLAIRTI HEKLLYFLPA
360 370 380 390 400
SEERIVCLSR VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA
410 420 430 440 450
GKLKNYISEI QDSPQQLLQA FLKYKELVKR PTISKELMLE RETLLARLGD
460 470 480 490 500
SAKDFRLDFE NRCRGIPGDA SGPLSGKNLS EVVNNIVWVR QLELKVDDTI
510 520 530 540 550
KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR EVQSGLSDSR
560 570 580 590 600
SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI
610 620 630 640 650
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII
660 670 680 690 700
KNSKAGSGGK SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHITFC
710 720 730 740 750
EKVVILMNID LLRQQQRWKD GLQELRTGLA SVAAQGFQPS DMRAWRQHWN
760 770 780 790 800
HQLYKALEHQ YQMGLEALNE NLPEINVDLT YKQGRLQFRP PFEEIRAKYY
810 820 830 840 850
REMKRFIGIP NQFKGVGGAG DESIFSVMID RNASGFLTIY SKAEDLFRRL
860 870 880 890 900
SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP
910 920 930 940 950
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT
960 970 980 990 1000
EAMKVLTVIP QSVEEIGDTN LQYSNLQDRR PEILPLFQEA EDKNRLLRTV
1010 1020 1030 1040 1050
AGGGVETVSN LRAKWDKFEL MMESHQLMIK DQIEVMKGNV KSRLQIYYQE
1060 1070 1080 1090 1100
LDKFKARWDQ LKPGDDIIET GQQNTMDQSA KSIKEKKIEF DDLEVIRKKL
1110 1120 1130 1140 1150
VDDCHHFGLE ESNFSLAYSI SKDIESCAQI WALYEEFQQG LQEMAKEDWI
1160 1170 1180 1190 1200
TYRTKIYIFE EFLINWHERL RKVEEHSVMT VKLQSEVDRY KIIIPILKYV
1210 1220 1230 1240 1250
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASDLKDL
1260 1270 1280 1290 1300
NSRAQGEVTI REALRELDLW GVGAVFSLID YEDSQNRTIK LIKDWKDIVN
1310 1320 1330 1340 1350
QVGDNRCLLQ SLKDSPYYKG FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV
1360 1370 1380 1390 1400
YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM DIRKDSRVTT LTTHAGIRNT
1410 1420 1430 1440 1450
LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI LGQSTNPSVI
1460 1470 1480 1490 1500
QSHLKKLFAG INSVCFDEES KHITAMRSLE GEVVPFKSKV LLSNNVEAWL
1510 1520 1530 1540 1550
NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED
1560 1570 1580 1590 1600
VEDAIRDHSL HQIEAQLAAK LERYTSVDTS SEDPGNSESG ILELKLKTLI
1610 1620 1630 1640 1650
LDIIHNIDIV KQLNQAQVHT TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ
1660 1670 1680 1690 1700
YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK MGLGGNPYGP AGTGKTESVK
1710 1720 1730 1740 1750
ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV
1760 1770 1780 1790 1800
LSAVSMQIQT IQDALKNHRS VCELLGKEVE VNANSGIFIT MNPAGKGYGG
1810 1820 1830 1840 1850
RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN
1860 1870 1880 1890 1900
LSRELLTPQQ HYDWGLRALK TVLRGSGNLL RQLKKSGTKQ DVNENHIVVQ
1910 1920 1930 1940 1950
ALRLNTMSKF TFADCTRFDA LIKDVFPGID FKEVEYNELS SALKQVFEEA
1960 1970 1980 1990 2000
NYEVIPNQMK KALELYEQLR QRTGVVIVGP SGAGKSTLWR MLRAALCKIG
2010 2020 2030 2040 2050
KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ VVREPQDVSS
2060 2070 2080 2090 2100
WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS
2110 2120 2130 2140 2150
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPVEYRSN LENWIGDYFS
2160 2170 2180 2190 2200
KALQWVLKQN DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL
2210 2220 2230 2240 2250
NMKSRLEFTK EVFNWARETP PDSHRPMDTY FDCDRGQLAS YVLKKPESLT
2260 2270 2280 2290 2300
ADDFSSGHSL PVIQTPDMQR GLDYFKPWLS SETKQPFILV GPEGCGKGML
2310 2320 2330 2340 2350
LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST NTGRVYRPKD
2360 2370 2380 2390 2400
CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI
2410 2420 2430 2440 2450
QIVASMSAGG RLGRHKLTTR FTSIVRLCAV DYPEREQLQT IYGAYLEAVL
2460 2470 2480 2490 2500
HKNLKNHSIW GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT
2510 2520 2530 2540 2550
QWVLGLFRYD LEGGSSNHPL DYVLEVVAYE ARRLFRDKIV GVKELHLFDN
2560 2570 2580 2590 2600
ILTSVLQGDW GSDILDNMAD SFYVTWGAQH ISGAKIAPGQ PLPPHGKPLG
2610 2620 2630 2640 2650
KLSSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI DRVLSFPGGS
2660 2670 2680 2690 2700
LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RTDLKHVLHL
2710 2720 2730 2740 2750
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP
2760 2770 2780 2790 2800
LKDQASQDGF FGPVFNYFTY RIQQNLHIVL IMDSANLNFI INCESNPALH
2810 2820 2830 2840 2850
KKCRVLWMEG WSDSSMKKIP EMLFSEADIE EKYEKKRKDE KKKSSVDPDF
2860 2870 2880 2890 2900
IKSFLLIHES CKAYGATPSR YMTFLRVYSA ISSSKRKELL KRQSHLQAGV
2910 2920 2930 2940 2950
SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV SMQDASEQKT
2960 2970 2980 2990 3000
ELERLKHRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS
3010 3020 3030 3040 3050
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD
3060 3070 3080 3090 3100
ARNIPKEIRE SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH
3110 3120 3130 3140 3150
VLERIQPLET EQSGLELNLK KTEDRKRKLE DLLNSVGQKV SELKEKFQSR
3160 3170 3180 3190 3200
TSEAAKLEAE VSKAQETIKA AEVLISQLDR EHRRWNAQVA EIAEELATLP
3210 3220 3230 3240 3250
KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR RFLCTESEQL
3260 3270 3280 3290 3300
IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE
3310 3320 3330 3340 3350
VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY
3360 3370 3380 3390 3400
VVQIGDKIID YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG
3410 3420 3430 3440 3450
QLLALTIQHE KPDLEEQKTK LLQQEEDKKI QLARLEESLL ETLATSQGNI
3460 3470 3480 3490 3500
LENKDLIESL NQTKASSALI QDSLKESYKL QISLDRERDA YLPLAESASK
3510 3520 3530 3540 3550
MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSESTE QRIQCLVNSL
3560 3570 3580 3590 3600
KHMVYEYICR CLFKADQLMF ALHFVRGMHP EFFQENEWDT FTGVVVGDML
3610 3620 3630 3640 3650
RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPGLYQTLC FEDGTLWRTY
3660 3670 3680 3690 3700
YHHSMCEQEF PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK
3710 3720 3730 3740 3750
ELSPLPLNLK RLYKETLEIE PILIIISPGA DPSQELQELA NAERSSERYH
3760 3770 3780 3790 3800
QVAMGQGQAD LAIQMLKECA RNGDWLCLKN LHLVVSWLPV LEKELNTLQP
3810 3820 3830 3840 3850
KESFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM RTYESWTPEQ
3860 3870 3880 3890 3900
ISKKDNIHRA HALFSLAWFH AACQERRNFI PQGWTKFYEF SLSDLRAGYH
3910 3920 3930 3940 3950
VIDRLFDGSK DVQWEFVHGL LENSIYGGRI DNYFDLRVLQ SYLKQFFNSS
3960 3970 3980 3990 4000
IIDVLNQRNK KSIFPYSISL PDSCSILDYR AVIEKLPEDD KPSFFGLPAN
4010 4020 4030 4040 4050
IARSSQRMTS SQVISQLRIL GRSVTAGCKF DREIWSNELS PVLNLWKKLN
4060 4070 4080 4090 4100
QNSNLIHQKV SPPNDRQGSP ILSFIILEQF NAIRLVQSVH QSLAALSKVI
4110 4120 4130 4140 4150
RGTTLLSSEV QKLASALLNQ KCPLTWQSKW EGPEDPLQYL RGLVARTLAI
4160 4170 4180 4190 4200
QNWVEKAEKQ ALLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV
4210 4220 4230 4240 4250
ASWKGRLQEA KLQIKISGLL LEGCSFDGSR LSENQHDSPS VSSVLPCYMG
4260 4270 4280 4290 4300
WTPQGSYGPY SPDECISLPV YTSAERDCVV TNIDVPCGGN QDQWIQCGAA

LFLKNQ
Length:4,306
Mass (Da):492,218
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4AC9B7B9E7FA330
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZBB8D3ZBB8_RAT
Cytoplasmic dynein 2 heavy chain 1
Dync2h1
4,303Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1670K → R in AAC52802 (PubMed:8812413).Curated1
Sequence conflicti1715C → R in AAC52802 (PubMed:8812413).Curated1
Sequence conflicti1781V → I in BAA05503 (PubMed:7657712).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041881 mRNA Translation: BAA97048.1
U61748 mRNA Translation: AAC52802.1
D26495 mRNA Translation: BAA05503.1

Protein sequence database of the Protein Information Resource

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PIRi
I70174

NCBI Reference Sequences

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RefSeqi
NP_075413.1, NM_023024.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
65209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:65209

UCSC genome browser

More...
UCSCi
RGD:71042, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041881 mRNA Translation: BAA97048.1
U61748 mRNA Translation: AAC52802.1
D26495 mRNA Translation: BAA05503.1
PIRiI70174
RefSeqiNP_075413.1, NM_023024.1

3D structure databases

SMRiQ9JJ79
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi249321, 1 interactor
CORUMiQ9JJ79
STRINGi10116.ENSRNOP00000043252

PTM databases

CarbonylDBiQ9JJ79
iPTMnetiQ9JJ79
PhosphoSitePlusiQ9JJ79

Proteomic databases

jPOSTiQ9JJ79
PaxDbiQ9JJ79
PRIDEiQ9JJ79

Genome annotation databases

GeneIDi65209
KEGGirno:65209
UCSCiRGD:71042, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79659
RGDi71042, Dync2h1

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
InParanoidiQ9JJ79
KOiK10414
OrthoDBi26380at2759
PhylomeDBiQ9JJ79

Enzyme and pathway databases

ReactomeiR-RNO-5610787, Hedgehog 'off' state
R-RNO-5620924, Intraflagellar transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9JJ79

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 3 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJ79
Secondary accession number(s): P70576, Q63167
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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