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Protein

Kv channel-interacting protein 1

Gene

Kcnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents (PubMed:14572458). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi146 – 1571PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi194 – 2052PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Metal-binding, Potassium

Enzyme and pathway databases

ReactomeiR-MMU-5576894 Phase 1 - inactivation of fast Na+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Kv channel-interacting protein 1
Short name:
KChIP1
Alternative name(s):
A-type potassium channel modulatory protein 1
Potassium channel-interacting protein 1
Gene namesi
Name:Kcnip1
Synonyms:Kchip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917607 Kcnip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738191 – 227Kv channel-interacting protein 1Add BLAST227

Proteomic databases

PaxDbiQ9JJ57
PRIDEiQ9JJ57

Expressioni

Tissue specificityi

Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.2 Publications

Gene expression databases

BgeeiENSMUSG00000053519 Expressed in 159 organ(s), highest expression level in habenula
CleanExiMM_KCNIP1
ExpressionAtlasiQ9JJ57 baseline and differential
GenevisibleiQ9JJ57 MM

Interactioni

Subunit structurei

Component of heteromultimeric potassium channels (PubMed:19713751). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19713751). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity). Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-3262 Kv4.3-KChIP1 channel complex
STRINGi10090.ENSMUSP00000104964

Structurei

3D structure databases

ProteinModelPortaliQ9JJ57
SMRiQ9JJ57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 94EF-hand 1; degeneratePROSITE-ProRule annotationAdd BLAST57
Domaini97 – 132EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini133 – 168EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini181 – 216EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 227Interaction with KCND2By similarityAdd BLAST14

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOVERGENiHBG108179
InParanoidiQ9JJ57
OMAiTDAPKQH
OrthoDBiEOG091G11T4
PhylomeDBiQ9JJ57
TreeFamiTF318560

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9JJ57-1) [UniParc]FASTAAdd to basket
Also known as: A, Kchip1.2, KCHIP1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL
60 70 80 90 100
EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEETFKQIYA QFFPHGDAST
110 120 130 140 150
YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD
160 170 180 190 200
GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI
210 220
VTLDEFLESC QEDDNIMRSL QLFQNVM
Length:227
Mass (Da):26,831
Last modified:August 16, 2005 - v2
Checksum:i9256B5239A13B126
GO
Isoform 2 (identifier: Q9JJ57-2) [UniParc]FASTAAdd to basket
Also known as: Kchip1.1, KCHP1a

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Show »
Length:216
Mass (Da):25,258
Checksum:iA9F32A1932B6B747
GO
Isoform 3 (identifier: Q9JJ57-3) [UniParc]FASTAAdd to basket
Also known as: Kchip1.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:188
Mass (Da):22,093
Checksum:i16D9A84482FA00AD
GO
Isoform 4 (identifier: Q9JJ57-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGAVMGTFSSLQTKQRRP → MSSCSKRCRLGFVKFAQTIFKLITGTL

Show »
Length:236
Mass (Da):27,873
Checksum:i1A17AA636755B0CD
GO

Sequence cautioni

The sequence AAN77492 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147I → L in AAL12488 (PubMed:14572458).Curated1
Sequence conflicti185H → R in AAT68468 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0150451 – 39Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0150461 – 18MGAVM…KQRRP → MSSCSKRCRLGFVKFAQTIF KLITGTL in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_01504721 – 31Missing in isoform 2. 5 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050525 mRNA Translation: AAL12488.1
AY050526 mRNA Translation: AAL12489.1
AB075041 mRNA Translation: BAB78543.1
AY171234 mRNA Translation: AAN77492.1 Different initiation.
AY647242 mRNA Translation: AAT68468.1
AK081845 mRNA Translation: BAC38347.1
AK045948 mRNA Translation: BAC32543.1
AK046398 mRNA Translation: BAC32705.1
AL669814, AL731867 Genomic DNA Translation: CAI25675.1
AL669814, AL731867 Genomic DNA Translation: CAI25676.1
AL731867, AL669814 Genomic DNA Translation: CAI26003.1
AL669814 Genomic DNA Translation: CAI25682.1
AL731867, AL669814 Genomic DNA Translation: CAI26004.1
BC034241 mRNA Translation: AAH34241.1
AJ278534 mRNA Translation: CAC82025.1
CCDSiCCDS24537.1 [Q9JJ57-2]
CCDS56766.1 [Q9JJ57-1]
CCDS70160.1 [Q9JJ57-3]
RefSeqiNP_001177814.1, NM_001190885.1 [Q9JJ57-1]
NP_001177815.1, NM_001190886.1
NP_001277619.1, NM_001290690.1 [Q9JJ57-3]
NP_081674.2, NM_027398.3 [Q9JJ57-2]
UniGeneiMm.252514

Genome annotation databases

EnsembliENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519 [Q9JJ57-2]
ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519 [Q9JJ57-3]
ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519 [Q9JJ57-1]
GeneIDi70357
KEGGimmu:70357
UCSCiuc007ikp.2 mouse [Q9JJ57-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050525 mRNA Translation: AAL12488.1
AY050526 mRNA Translation: AAL12489.1
AB075041 mRNA Translation: BAB78543.1
AY171234 mRNA Translation: AAN77492.1 Different initiation.
AY647242 mRNA Translation: AAT68468.1
AK081845 mRNA Translation: BAC38347.1
AK045948 mRNA Translation: BAC32543.1
AK046398 mRNA Translation: BAC32705.1
AL669814, AL731867 Genomic DNA Translation: CAI25675.1
AL669814, AL731867 Genomic DNA Translation: CAI25676.1
AL731867, AL669814 Genomic DNA Translation: CAI26003.1
AL669814 Genomic DNA Translation: CAI25682.1
AL731867, AL669814 Genomic DNA Translation: CAI26004.1
BC034241 mRNA Translation: AAH34241.1
AJ278534 mRNA Translation: CAC82025.1
CCDSiCCDS24537.1 [Q9JJ57-2]
CCDS56766.1 [Q9JJ57-1]
CCDS70160.1 [Q9JJ57-3]
RefSeqiNP_001177814.1, NM_001190885.1 [Q9JJ57-1]
NP_001177815.1, NM_001190886.1
NP_001277619.1, NM_001290690.1 [Q9JJ57-3]
NP_081674.2, NM_027398.3 [Q9JJ57-2]
UniGeneiMm.252514

3D structure databases

ProteinModelPortaliQ9JJ57
SMRiQ9JJ57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3262 Kv4.3-KChIP1 channel complex
STRINGi10090.ENSMUSP00000104964

Proteomic databases

PaxDbiQ9JJ57
PRIDEiQ9JJ57

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065970; ENSMUSP00000069063; ENSMUSG00000053519 [Q9JJ57-2]
ENSMUST00000101368; ENSMUSP00000098919; ENSMUSG00000053519 [Q9JJ57-3]
ENSMUST00000109340; ENSMUSP00000104964; ENSMUSG00000053519 [Q9JJ57-1]
GeneIDi70357
KEGGimmu:70357
UCSCiuc007ikp.2 mouse [Q9JJ57-1]

Organism-specific databases

CTDi30820
MGIiMGI:1917607 Kcnip1

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOVERGENiHBG108179
InParanoidiQ9JJ57
OMAiTDAPKQH
OrthoDBiEOG091G11T4
PhylomeDBiQ9JJ57
TreeFamiTF318560

Enzyme and pathway databases

ReactomeiR-MMU-5576894 Phase 1 - inactivation of fast Na+ channels

Miscellaneous databases

PROiPR:Q9JJ57
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053519 Expressed in 159 organ(s), highest expression level in habenula
CleanExiMM_KCNIP1
ExpressionAtlasiQ9JJ57 baseline and differential
GenevisibleiQ9JJ57 MM

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKCIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJ57
Secondary accession number(s): Q5SSA3
, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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