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Entry version 151 (02 Jun 2021)
Sequence version 2 (04 Mar 2015)
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Protein

Heterogeneous nuclear ribonucleoprotein D0

Gene

Hnrnpd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processBiological rhythms

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein D0
Short name:
hnRNP D0
Alternative name(s):
AU-rich element RNA-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hnrnpd
Synonyms:Auf1, Hnrpd
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14
  • UP000234681 Componentsi: Chromosome 14, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
620365, Hnrnpd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818512 – 353Heterogeneous nuclear ribonucleoprotein D0Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei78PhosphoserineCombined sources1
Modified residuei80PhosphoserineBy similarity1
Modified residuei81PhosphoserineCombined sources1
Modified residuei89PhosphothreonineBy similarity1
Modified residuei117N6-methyllysineBy similarity1
Modified residuei125PhosphothreonineBy similarity1
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei163N6-acetyllysineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei191PhosphothreonineBy similarity1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei241N6-acetyllysineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1
Modified residuei269PhosphoserineBy similarity1
Modified residuei270Omega-N-methylarginineBy similarity1
Modified residuei276Omega-N-methylarginineBy similarity1
Modified residuei278Omega-N-methylarginineBy similarity1
Modified residuei280Omega-N-methylarginineBy similarity1
Modified residuei343Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei343Dimethylated arginine; alternateBy similarity1
Modified residuei343Omega-N-methylarginine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates its phosphorylation.1 Publication
Arg-343 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JJ54

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JJ54

PRoteomics IDEntifications database

More...
PRIDEi
Q9JJ54

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JJ54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JJ54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002292, Expressed in thymus and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JJ54, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP.

Interacts with IGF2BP2.

Interacts with GTPBP1.

Interacts with EIF4G1; the interaction requires RNA.

Interacts with EIF3B and RPS3.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249454, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9JJ54, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000046491

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JJ54

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 177RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini180 – 259RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 89DisorderedSequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 89Basic and acidic residuesSequence analysisAdd BLAST25

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0118, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158010

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JJ54

Identification of Orthologs from Complete Genome Data

More...
OMAi
QQQWGGR

Database of Orthologous Groups

More...
OrthoDBi
1055256at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314808

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012956, CARG-binding_factor_N
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08143, CBFNT, 1 hit
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9JJ54-1) [UniParc]FASTAAdd to basket
Also known as: p45

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAAAQGAAAA AGSGSGGGSA
60 70 80 90 100
PGGTEGGSTE AEGAKIDASK NEEDEGHSNS SPRHTEAATA QREEWKMFIG
110 120 130 140 150
GLSWDTTKKD LKDYFSKFGD VVDCTLKLDP ITGRSRGFGF VLFKESESVD
160 170 180 190 200
KVMDQKEHKL NGKVIDPKRA KAMKTKEPVK KIFVGGLSPD TPEEKIREYF
210 220 230 240 250
GGFGEVESIE LPMDNKTNKR RGFCFITFKE EEPVKKIMEK KYHNVGLSKC
260 270 280 290 300
EIKVAMSKEQ YQQQQQWGSR GGFAGRARGR GGGPSQNWNQ GYSNYWNQGY
310 320 330 340 350
GSYGYNSQGY GGYGGYDYTG YNSYYGYGDY SNQQSGYGKV SRRGGHQNSY

KPY
Length:353
Mass (Da):38,218
Last modified:March 4, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C21381A6B4A199F
GO
Isoform 2 (identifier: Q9JJ54-2) [UniParc]FASTAAdd to basket
Also known as: p42

The sequence of this isoform differs from the canonical sequence as follows:
     77-95: Missing.

Show »
Length:334
Mass (Da):36,042
Checksum:iE391A9B5F116AC60
GO
Isoform 3 (identifier: Q9JJ54-3) [UniParc]FASTAAdd to basket
Also known as: p40

The sequence of this isoform differs from the canonical sequence as follows:
     283-332: GPSQNWNQGYSNYWNQGYGSYGYNSQGYGGYGGYDYTGYNSYYGYGDYSN → D

Show »
Length:304
Mass (Da):32,672
Checksum:i6991CEF5913C56AF
GO
Isoform 4 (identifier: Q9JJ54-4) [UniParc]FASTAAdd to basket
Also known as: p37

The sequence of this isoform differs from the canonical sequence as follows:
     77-95: Missing.
     283-332: GPSQNWNQGYSNYWNQGYGSYGYNSQGYGGYGGYDYTGYNSYYGYGDYSN → D

Show »
Length:285
Mass (Da):30,496
Checksum:iBF3BCA2717A2FC58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51P → A in BAB03465 (Ref. 1) Curated1
Sequence conflicti51P → A in BAB03466 (Ref. 1) Curated1
Sequence conflicti51P → A in BAB03467 (Ref. 1) Curated1
Sequence conflicti51P → A in BAB03468 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00583677 – 95Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005837283 – 332GPSQN…GDYSN → D in isoform 3 and isoform 4. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046615 mRNA Translation: BAB03465.1
AB046616 mRNA Translation: BAB03466.1
AB046617 mRNA Translation: BAB03467.1
AB046618 mRNA Translation: BAB03468.1
AABR06077578 Genomic DNA No translation available.
CH474022 Genomic DNA Translation: EDL99590.1
X16933 mRNA Translation: CAA34808.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S09017

NCBI Reference Sequences

More...
RefSeqi
NP_001076008.1, NM_001082539.1 [Q9JJ54-2]
NP_001076009.1, NM_001082540.1 [Q9JJ54-3]
NP_001076010.1, NM_001082541.1 [Q9JJ54-4]
NP_077380.2, NM_024404.2 [Q9JJ54-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000003158; ENSRNOP00000003158; ENSRNOG00000002292 [Q9JJ54-3]
ENSRNOT00000003173; ENSRNOP00000003173; ENSRNOG00000002292 [Q9JJ54-2]
ENSRNOT00000047840; ENSRNOP00000046491; ENSRNOG00000002292 [Q9JJ54-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:79256

UCSC genome browser

More...
UCSCi
RGD:620365, rat [Q9JJ54-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046615 mRNA Translation: BAB03465.1
AB046616 mRNA Translation: BAB03466.1
AB046617 mRNA Translation: BAB03467.1
AB046618 mRNA Translation: BAB03468.1
AABR06077578 Genomic DNA No translation available.
CH474022 Genomic DNA Translation: EDL99590.1
X16933 mRNA Translation: CAA34808.1
PIRiS09017
RefSeqiNP_001076008.1, NM_001082539.1 [Q9JJ54-2]
NP_001076009.1, NM_001082540.1 [Q9JJ54-3]
NP_001076010.1, NM_001082541.1 [Q9JJ54-4]
NP_077380.2, NM_024404.2 [Q9JJ54-1]

3D structure databases

SMRiQ9JJ54
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi249454, 3 interactors
IntActiQ9JJ54, 4 interactors
STRINGi10116.ENSRNOP00000046491

PTM databases

iPTMnetiQ9JJ54
PhosphoSitePlusiQ9JJ54

Proteomic databases

jPOSTiQ9JJ54
PaxDbiQ9JJ54
PRIDEiQ9JJ54

Genome annotation databases

EnsembliENSRNOT00000003158; ENSRNOP00000003158; ENSRNOG00000002292 [Q9JJ54-3]
ENSRNOT00000003173; ENSRNOP00000003173; ENSRNOG00000002292 [Q9JJ54-2]
ENSRNOT00000047840; ENSRNOP00000046491; ENSRNOG00000002292 [Q9JJ54-1]
GeneIDi79256
KEGGirno:79256
UCSCiRGD:620365, rat [Q9JJ54-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3184
RGDi620365, Hnrnpd

Phylogenomic databases

eggNOGiKOG0118, Eukaryota
GeneTreeiENSGT00940000158010
InParanoidiQ9JJ54
OMAiQQQWGGR
OrthoDBi1055256at2759
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-RNO-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9JJ54

Gene expression databases

BgeeiENSRNOG00000002292, Expressed in thymus and 21 other tissues
GenevisibleiQ9JJ54, RN

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956, CARG-binding_factor_N
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF08143, CBFNT, 1 hit
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPD_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JJ54
Secondary accession number(s): G3V9G2
, P17132, Q9JJ51, Q9JJ52, Q9JJ53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 4, 2015
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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