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Protein

RNA binding protein fox-1 homolog 1

Gene

Rbfox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.4 Publications

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • protein C-terminus binding Source: MGI

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • nervous system development Source: GO_Central
  • neuromuscular process controlling balance Source: MGI
  • regulation of alternative mRNA splicing, via spliceosome Source: MGI
  • regulation of skeletal muscle cell differentiation Source: MGI
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 1
Alternative name(s):
Ataxin-2-binding protein 1
Fox-1 homolog A
Gene namesi
Name:Rbfox1
Synonyms:A2bp, A2bp1, Fox1
ORF Names:MNCb-3035
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1926224 Rbfox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814811 – 396RNA binding protein fox-1 homolog 1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316Asymmetric dimethylarginineCombined sources1
Modified residuei387Omega-N-methylarginineCombined sources1
Isoform 3 (identifier: Q9JJ43-3)
Modified residuei337Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9JJ43
PeptideAtlasiQ9JJ43
PRIDEiQ9JJ43

PTM databases

iPTMnetiQ9JJ43
PhosphoSitePlusiQ9JJ43

Expressioni

Tissue specificityi

Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo.3 Publications

Gene expression databases

BgeeiENSMUSG00000008658 Expressed in 199 organ(s), highest expression level in caudate-putamen
CleanExiMM_A2BP1
GenevisibleiQ9JJ43 MM

Interactioni

Subunit structurei

Binds to the C-terminus of ATXN2.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117Interaction with RNABy similarity1
Sitei125Interaction with RNABy similarity1
Sitei126Interaction with RNABy similarity1
Sitei150Interaction with RNABy similarity1
Sitei155Interaction with RNABy similarity1
Sitei159Interaction with RNABy similarity1
Sitei183Interaction with RNABy similarity1
Sitei193Interaction with RNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234568, 1 interactor
IntActiQ9JJ43, 2 interactors
MINTiQ9JJ43
STRINGi10090.ENSMUSP00000049970

Structurei

3D structure databases

ProteinModelPortaliQ9JJ43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 192RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiKOG0125 Eukaryota
ENOG4111WJT LUCA
GeneTreeiENSGT00390000013767
HOVERGENiHBG000044
InParanoidiQ9JJ43
KOiK14946
OMAiLVYTSAX
OrthoDBiEOG091G15X5
PhylomeDBiQ9JJ43
TreeFamiTF315942

Family and domain databases

CDDicd12407 RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR034237 FOX1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JJ43-1) [UniParc]FASTAAdd to basket
Also known as: A016

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP
60 70 80 90 100
EYTGQTTVPD HTLNLYPPTQ THSEQSADTS AQTVSGTATQ TDDAAPTDGQ
110 120 130 140 150
PQTQPSENTE SKSQPKRLHV SNIPFRFRDP DLRQMFGQFG KILDVEIIFN
160 170 180 190 200
ERGSKGFGFV TFENSADADR AREKLHGTVV EGRKIEVNNA TARVMTNKKT
210 220 230 240 250
VNPYTNGWKL NPVVGAVYSP DFYAGTVLLC QANQEGSSMY SGPSSLVYTS
260 270 280 290 300
AMPGFPYPAA TAAAAYRGAH LRGRGRTVYN TFRAAAPPPP IPAYGGVVYQ
310 320 330 340 350
DGFYGADIYG GYAAYRYAQP TPATAAAYSD SYGRVYAADP YHHTLAPAPT
360 370 380 390
YGVGAMNAFA PLTDAKTRSH ADDVGLVLSS LQASIYRGGY NRFAPY
Length:396
Mass (Da):42,678
Last modified:February 5, 2008 - v3
Checksum:iE64DBA6FE6A062ED
GO
Isoform 2 (identifier: Q9JJ43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:376
Mass (Da):40,492
Checksum:i77C56FE98817B9F2
GO
Isoform 3 (identifier: Q9JJ43-3) [UniParc]FASTAAdd to basket
Also known as: A713

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHSYGVPMIVPAAPYFPGLMQ
     301-309: DGFYGADIY → EPVYGNKLLQ

Show »
Length:417
Mass (Da):44,729
Checksum:i95D41CFA0A1D5535
GO
Isoform 4 (identifier: Q9JJ43-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-224: Missing.

Show »
Length:378
Mass (Da):40,713
Checksum:i966076D6E685A9C6
GO
Isoform 5 (identifier: Q9JJ43-5) [UniParc]FASTAAdd to basket
Also known as: 2, A030

The sequence of this isoform differs from the canonical sequence as follows:
     331-396: SYGRVYAADP...RGGYNRFAPY → RNQFVFVATD...LQPPPTALVP

Show »
Length:373
Mass (Da):40,288
Checksum:iC20687C2777B463C
GO
Isoform 6 (identifier: Q9JJ43-6) [UniParc]FASTAAdd to basket
Also known as: 4, A715

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHSYGVPMIVPAAPYFPGLMQ
     301-309: DGFYGADIY → EPVYGNKLLQ
     331-396: SYGRVYAADP...RGGYNRFAPY → RNQFVFVATD...LQPPPTALVP

Show »
Length:394
Mass (Da):42,338
Checksum:i905CCB2924E570F4
GO
Isoform 7 (identifier: Q9JJ43-7) [UniParc]FASTAAdd to basket
Also known as: 5, A704

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHSYGVPMIVPAAPYFPGLMQ
     156-186: Missing.
     301-309: DGFYGADIY → EPVYGNKLLQ
     331-396: SYGRVYAADP...RGGYNRFAPY → RNQFVFVATD...LQPPPTALVP

Show »
Length:363
Mass (Da):38,919
Checksum:iE8A44FBE429F8741
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK79A0A2R8VK79_MOUSE
RNA binding protein fox-1 homolog
Rbfox1
396Annotation score:
A0A2R8VI79A0A2R8VI79_MOUSE
RNA binding protein fox-1 homolog
Rbfox1
358Annotation score:
A0A2R8W6K5A0A2R8W6K5_MOUSE
RNA-binding protein fox-1 homolog 1
Rbfox1
289Annotation score:
A0A2R8VHB5A0A2R8VHB5_MOUSE
RNA-binding protein fox-1 homolog 1
Rbfox1
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60D → G in BAA95079 (Ref. 4) Curated1
Sequence conflicti124P → PFR in AAF78292 (PubMed:10814712).Curated1
Sequence conflicti136F → FS in AAF78292 (PubMed:10814712).Curated1
Sequence conflicti261T → S in AAL83425 (Ref. 3) Curated1
Sequence conflicti278V → G in AAL83425 (Ref. 3) Curated1
Sequence conflicti282F → L in AAL83425 (Ref. 3) Curated1
Sequence conflicti369S → G in BAA95079 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0308791 – 20Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0308801 – 9MNCEREQLR → MLASQGVLLHSYGVPMIVPA APYFPGLMQ in isoform 3, isoform 6 and isoform 7. 3 Publications9
Alternative sequenceiVSP_030881156 – 186Missing in isoform 7. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_030882207 – 224Missing in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_030883301 – 309DGFYGADIY → EPVYGNKLLQ in isoform 3, isoform 6 and isoform 7. 3 Publications9
Alternative sequenceiVSP_030884331 – 396SYGRV…RFAPY → RNQFVFVATDEISCNTSAVT DEFMLPTPTTTHLLQPPPTA LVP in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107204 mRNA Translation: AAF78292.1
AY659954 mRNA Translation: AAV74337.1
AY659955 mRNA Translation: AAV74338.1
AY659956 mRNA Translation: AAV74339.1
AY659957 mRNA Translation: AAV74340.1
AY659958 mRNA Translation: AAV74341.1
AF191501 mRNA Translation: AAL83425.1
AB041596 mRNA Translation: BAA95079.1
AK134833 mRNA Translation: BAE22304.1
BC059002 mRNA Translation: AAH59002.1
CCDSiCCDS27936.1 [Q9JJ43-3]
CCDS37245.1 [Q9JJ43-1]
RefSeqiNP_067452.2, NM_021477.5 [Q9JJ43-1]
NP_899011.2, NM_183188.2 [Q9JJ43-3]
XP_006522251.1, XM_006522188.1
XP_006522252.1, XM_006522189.3 [Q9JJ43-6]
XP_006522253.1, XM_006522190.1 [Q9JJ43-4]
XP_006522255.1, XM_006522192.3 [Q9JJ43-2]
XP_011244213.1, XM_011245911.2 [Q9JJ43-1]
XP_011244218.1, XM_011245916.1 [Q9JJ43-5]
XP_017172487.1, XM_017316998.1
XP_017172491.1, XM_017317002.1 [Q9JJ43-5]
UniGeneiMm.370334

Genome annotation databases

EnsembliENSMUST00000056416; ENSMUSP00000049970; ENSMUSG00000008658 [Q9JJ43-1]
ENSMUST00000115841; ENSMUSP00000111507; ENSMUSG00000008658 [Q9JJ43-1]
ENSMUST00000229741; ENSMUSP00000155364; ENSMUSG00000008658 [Q9JJ43-3]
GeneIDi268859
KEGGimmu:268859
UCSCiuc007ycb.2 mouse [Q9JJ43-1]
uc007ycc.2 mouse [Q9JJ43-4]
uc007ycf.2 mouse [Q9JJ43-3]
uc007ycg.2 mouse [Q9JJ43-6]
uc007ych.2 mouse [Q9JJ43-7]
uc007yci.2 mouse [Q9JJ43-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107204 mRNA Translation: AAF78292.1
AY659954 mRNA Translation: AAV74337.1
AY659955 mRNA Translation: AAV74338.1
AY659956 mRNA Translation: AAV74339.1
AY659957 mRNA Translation: AAV74340.1
AY659958 mRNA Translation: AAV74341.1
AF191501 mRNA Translation: AAL83425.1
AB041596 mRNA Translation: BAA95079.1
AK134833 mRNA Translation: BAE22304.1
BC059002 mRNA Translation: AAH59002.1
CCDSiCCDS27936.1 [Q9JJ43-3]
CCDS37245.1 [Q9JJ43-1]
RefSeqiNP_067452.2, NM_021477.5 [Q9JJ43-1]
NP_899011.2, NM_183188.2 [Q9JJ43-3]
XP_006522251.1, XM_006522188.1
XP_006522252.1, XM_006522189.3 [Q9JJ43-6]
XP_006522253.1, XM_006522190.1 [Q9JJ43-4]
XP_006522255.1, XM_006522192.3 [Q9JJ43-2]
XP_011244213.1, XM_011245911.2 [Q9JJ43-1]
XP_011244218.1, XM_011245916.1 [Q9JJ43-5]
XP_017172487.1, XM_017316998.1
XP_017172491.1, XM_017317002.1 [Q9JJ43-5]
UniGeneiMm.370334

3D structure databases

ProteinModelPortaliQ9JJ43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234568, 1 interactor
IntActiQ9JJ43, 2 interactors
MINTiQ9JJ43
STRINGi10090.ENSMUSP00000049970

PTM databases

iPTMnetiQ9JJ43
PhosphoSitePlusiQ9JJ43

Proteomic databases

PaxDbiQ9JJ43
PeptideAtlasiQ9JJ43
PRIDEiQ9JJ43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056416; ENSMUSP00000049970; ENSMUSG00000008658 [Q9JJ43-1]
ENSMUST00000115841; ENSMUSP00000111507; ENSMUSG00000008658 [Q9JJ43-1]
ENSMUST00000229741; ENSMUSP00000155364; ENSMUSG00000008658 [Q9JJ43-3]
GeneIDi268859
KEGGimmu:268859
UCSCiuc007ycb.2 mouse [Q9JJ43-1]
uc007ycc.2 mouse [Q9JJ43-4]
uc007ycf.2 mouse [Q9JJ43-3]
uc007ycg.2 mouse [Q9JJ43-6]
uc007ych.2 mouse [Q9JJ43-7]
uc007yci.2 mouse [Q9JJ43-5]

Organism-specific databases

CTDi54715
MGIiMGI:1926224 Rbfox1

Phylogenomic databases

eggNOGiKOG0125 Eukaryota
ENOG4111WJT LUCA
GeneTreeiENSGT00390000013767
HOVERGENiHBG000044
InParanoidiQ9JJ43
KOiK14946
OMAiLVYTSAX
OrthoDBiEOG091G15X5
PhylomeDBiQ9JJ43
TreeFamiTF315942

Miscellaneous databases

ChiTaRSiRbfox1 mouse
PROiPR:Q9JJ43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008658 Expressed in 199 organ(s), highest expression level in caudate-putamen
CleanExiMM_A2BP1
GenevisibleiQ9JJ43 MM

Family and domain databases

CDDicd12407 RRM_FOX1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR025670 Fox-1_C_dom
IPR034237 FOX1_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR017325 RNA-bd_Fox-1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF12414 Fox-1_C, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037932 Ataxin_2_bd_A2BP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFOX1_MOUSE
AccessioniPrimary (citable) accession number: Q9JJ43
Secondary accession number(s): Q3UYA8
, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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