UniProtKB - Q9JJ16 (5HT3B_RAT)
5-hydroxytryptamine receptor 3B
Htr3b
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
1 PublicationGO - Molecular functioni
- neurotransmitter receptor activity Source: GO_Central
- serotonin-gated cation-selective channel activity Source: RGD
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- cellular response to growth factor stimulus Source: RGD
- chemical synaptic transmission Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- positive regulation of ion transmembrane transporter activity Source: RGD
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-112314, Neurotransmitter receptors and postsynaptic signal transmission |
Protein family/group databases
TCDBi | 1.A.9.2.2, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 3BShort name: 5-HT3-B Short name: 5-HT3B Alternative name(s): Serotonin receptor 3B |
Gene namesi | Name:Htr3b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61820, Htr3b |
Subcellular locationi
Plasma membrane
Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.By similarity
Plasma Membrane
- integral component of plasma membrane Source: RGD
- postsynaptic membrane Source: InterPro
- serotonin-activated cation-selective channel complex Source: RGD
Other locations
- axon Source: RGD
- cell surface Source: RGD
- neuron projection Source: GO_Central
- neuronal cell body Source: RGD
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 235 | ExtracellularSequence analysisAdd BLAST | 214 | |
Transmembranei | 236 – 255 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 256 – 266 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 267 – 284 | Helical; Name=2Sequence analysisAdd BLAST | 18 | |
Topological domaini | 285 – 295 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 296 – 324 | Helical; Name=3Sequence analysisAdd BLAST | 29 | |
Topological domaini | 325 – 410 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Transmembranei | 411 – 434 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 435 – 437 | ExtracellularSequence analysis | 3 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000312291 | 22 – 437 | 5-hydroxytryptamine receptor 3BAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 92 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 151 ↔ 165 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JJ16 |
PTM databases
GlyGeni | Q9JJ16, 3 sites |
Expressioni
Tissue specificityi
Inductioni
Interactioni
Subunit structurei
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.
2 PublicationsProtein-protein interaction databases
ComplexPortali | CPX-277, 5-hydroxytryptamine-3A/B receptor complex |
STRINGi | 10116.ENSRNOP00000009574 |
Chemistry databases
BindingDBi | Q9JJ16 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 377 – 409 | HA-stretchAdd BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
InParanoidi | Q9JJ16 |
OrthoDBi | 611108at2759 |
PhylomeDBi | Q9JJ16 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR008132, 5HT3_rcpt IPR008134, 5HT3_rcpt_B IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01710, 5HT3BRECEPTR PR01708, 5HT3RECEPTOR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MILLWSCLLV AVVGILGTAT PQPGNSSLHR LTRQLLQQYH KEVRPVYNWA
60 70 80 90 100
EATTVYLDLC VHAVLDVDVQ NQKLKTSMWY REVWNDEFLS WNSSLFDDIQ
110 120 130 140 150
EISLPLSAIW APDIIINEFV DVERSPDLPY VYVNSSGTIR NHKPIQVVSA
160 170 180 190 200
CSLQTYAFPF DIQNCSLTFN SILHTVEDID LGFLRNQEDI ENDKRSFLND
210 220 230 240 250
SEWQLLSVTS TYHIRQSSAG DFAQIRFNVV IRRCPLAYVV SLLIPSIFLM
260 270 280 290 300
LVDLGSFYLP PNCRARIVFK TNVLVGYTVF RVNMSDEVPR SAGCTSLIGV
310 320 330 340 350
FFTVCMALLV LSLSKSILLI KFLYEERHSE QERPLMCLRG DSDANESRLY
360 370 380 390 400
LRAPCAEDTE SPVRQEHQVP SDTLKDFWFQ LQSINNSLRT RDQVYQKEVE
410 420 430
WLAILCHFDQ LLFRIYLAVL GLYTVTLCSL WALWSRM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6W4 | G3V6W4_RAT | 5-hydroxytryptamine (Serotonin) rec... | Htr3b rCG_58296 | 437 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 194 | K → E in AAG30903 (PubMed:10854267).Curated | 1 | |
Sequence conflicti | 217 | S → N in AAG30903 (PubMed:10854267).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155044 mRNA Translation: AAF73283.1 AF303447 mRNA Translation: AAG30903.1 |
RefSeqi | NP_071525.1, NM_022189.1 |
Genome annotation databases
GeneIDi | 58963 |
KEGGi | rno:58963 |
UCSCi | RGD:61820, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155044 mRNA Translation: AAF73283.1 AF303447 mRNA Translation: AAG30903.1 |
RefSeqi | NP_071525.1, NM_022189.1 |
3D structure databases
SMRi | Q9JJ16 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-277, 5-hydroxytryptamine-3A/B receptor complex |
STRINGi | 10116.ENSRNOP00000009574 |
Chemistry databases
BindingDBi | Q9JJ16 |
ChEMBLi | CHEMBL2094116 |
DrugCentrali | Q9JJ16 |
Protein family/group databases
TCDBi | 1.A.9.2.2, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
PTM databases
GlyGeni | Q9JJ16, 3 sites |
Proteomic databases
PaxDbi | Q9JJ16 |
Genome annotation databases
GeneIDi | 58963 |
KEGGi | rno:58963 |
UCSCi | RGD:61820, rat |
Organism-specific databases
CTDi | 9177 |
RGDi | 61820, Htr3b |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
InParanoidi | Q9JJ16 |
OrthoDBi | 611108at2759 |
PhylomeDBi | Q9JJ16 |
Enzyme and pathway databases
Reactomei | R-RNO-112314, Neurotransmitter receptors and postsynaptic signal transmission |
Miscellaneous databases
PROi | PR:Q9JJ16 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR008132, 5HT3_rcpt IPR008134, 5HT3_rcpt_B IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01710, 5HT3BRECEPTR PR01708, 5HT3RECEPTOR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT3B_RAT | |
Accessioni | Q9JJ16Primary (citable) accession number: Q9JJ16 Secondary accession number(s): Q9ERJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families