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Protein

5-hydroxytryptamine receptor 3B

Gene

Htr3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to growth factor stimulus Source: RGD
  • positive regulation of ion transmembrane transporter activity Source: RGD

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.9.2.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3B
Short name:
5-HT3-B
Short name:
5-HT3B
Alternative name(s):
Serotonin receptor 3B
Gene namesi
Name:Htr3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61820 Htr3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 255Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini256 – 266CytoplasmicSequence analysisAdd BLAST11
Transmembranei267 – 284Helical; Name=2Sequence analysisAdd BLAST18
Topological domaini285 – 295ExtracellularSequence analysisAdd BLAST11
Transmembranei296 – 324Helical; Name=3Sequence analysisAdd BLAST29
Topological domaini325 – 410CytoplasmicSequence analysisAdd BLAST86
Transmembranei411 – 434Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini435 – 437ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094116

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031229122 – 4375-hydroxytryptamine receptor 3BAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 165By similarity

Post-translational modificationi

N-glycosylation is required for membrane localization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JJ16
PRIDEiQ9JJ16

Expressioni

Tissue specificityi

Expressed in peripheral neurons, but not in neurons of the central nervous system.1 Publication

Inductioni

By nerve growth factor in PC12 cells.1 Publication

Interactioni

Subunit structurei

Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.2 Publications

Protein-protein interaction databases

ComplexPortaliCPX-277 5-hydroxytryptamine-3A/B receptor complex
STRINGi10116.ENSRNOP00000009574

Chemistry databases

BindingDBiQ9JJ16

Structurei

3D structure databases

ProteinModelPortaliQ9JJ16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 409HA-stretchAdd BLAST33

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
HOGENOMiHOG000241519
HOVERGENiHBG106638
InParanoidiQ9JJ16
KOiK04819
PhylomeDBiQ9JJ16

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR008132 5HT3_rcpt
IPR008134 5HT3_rcpt_B
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01710 5HT3BRECEPTR
PR01708 5HT3RECEPTOR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JJ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLWSCLLV AVVGILGTAT PQPGNSSLHR LTRQLLQQYH KEVRPVYNWA
60 70 80 90 100
EATTVYLDLC VHAVLDVDVQ NQKLKTSMWY REVWNDEFLS WNSSLFDDIQ
110 120 130 140 150
EISLPLSAIW APDIIINEFV DVERSPDLPY VYVNSSGTIR NHKPIQVVSA
160 170 180 190 200
CSLQTYAFPF DIQNCSLTFN SILHTVEDID LGFLRNQEDI ENDKRSFLND
210 220 230 240 250
SEWQLLSVTS TYHIRQSSAG DFAQIRFNVV IRRCPLAYVV SLLIPSIFLM
260 270 280 290 300
LVDLGSFYLP PNCRARIVFK TNVLVGYTVF RVNMSDEVPR SAGCTSLIGV
310 320 330 340 350
FFTVCMALLV LSLSKSILLI KFLYEERHSE QERPLMCLRG DSDANESRLY
360 370 380 390 400
LRAPCAEDTE SPVRQEHQVP SDTLKDFWFQ LQSINNSLRT RDQVYQKEVE
410 420 430
WLAILCHFDQ LLFRIYLAVL GLYTVTLCSL WALWSRM
Length:437
Mass (Da):50,336
Last modified:October 1, 2000 - v1
Checksum:i633C2F4175FDB55A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194K → E in AAG30903 (PubMed:10854267).Curated1
Sequence conflicti217S → N in AAG30903 (PubMed:10854267).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155044 mRNA Translation: AAF73283.1
AF303447 mRNA Translation: AAG30903.1
RefSeqiNP_071525.1, NM_022189.1
UniGeneiRn.87106

Genome annotation databases

GeneIDi58963
KEGGirno:58963
UCSCiRGD:61820 rat

Similar proteinsi

Entry informationi

Entry namei5HT3B_RAT
AccessioniPrimary (citable) accession number: Q9JJ16
Secondary accession number(s): Q9ERJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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