Activator protein 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.8

    "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
• E-box binding Source: UniProtKBInferred from direct assayⁱ
  • "Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements."
    Aranburu A., Carlsson R., Persson C., Leanderson T.
    Biochem J 354:431-438(2001) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.8

    "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• sequence-specific DNA binding Source: MGI
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: UniProtKBInferred from direct assayⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to dexamethasone stimulus Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: MGI
• mitotic cell cycle phase transition Source: UniProtKB
• negative regulation by host of viral transcription Source: MGI
• negative regulation of cell population proliferation Source: MGI
• negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
• negative regulation of DNA binding Source: MGI
• negative regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation by host of viral transcription Source: MGI
• positive regulation of apoptotic process Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.8

    "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• positive regulation of transcription, DNA-templated Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • Ref.8

    "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis."
    Tsujimoto K., Ono T., Sato M., Nishida T., Oguma T., Tadakuma T.
    J. Biol. Chem. 280:27638-27644(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• protein-containing complex assembly Source: UniProtKBInferred from direct assayⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle phase transition Source: MGI
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: UniProtKBInferred from physical interactionⁱ
  • "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells."
    Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., Kim K.K.
    Proc Natl Acad Sci U S A 103:13074-13079(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR 
        60         70         80         90        100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE 
       110        120        130        140        150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED 
       160        170        180        190        200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ 
       210        220        230        240        250
QEQVRLLHQE KLEREQQHLR TQLLPPPAPT HHPTVIVPAP APPSSHHINV 
       260        270        280        290        300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQDKQELEE EQRRAVIVKS 
       310        320        330 
VRSCPDAHTS DTASDSEASD SDAMDQSREE PLGDGELP              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ