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UniProtKB - Q9JIZ5 (Q9JIZ5_MOUSE)
Protein
Submitted name:
Activator protein 4
Gene
Tfap4
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- E-box binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- cellular response to dexamethasone stimulus Source: UniProtKB
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: MGI
- mitotic cell cycle phase transition Source: UniProtKB
- negative regulation by host of viral transcription Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- negative regulation of DNA binding Source: MGI
- negative regulation of gene expression Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation by host of viral transcription Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein-containing complex assembly Source: UniProtKB
- regulation of mitotic cell cycle phase transition Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Activator protein 4ImportedSubmitted name: Transcription factor AP4Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103239, Tfap4 |
VEuPathDBi | HostDB:ENSMUSG00000005718 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- transcription repressor complex Source: UniProtKB
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000005718, Expressed in forelimb bud and 171 other tissues |
Interactioni
Binary interactionsi
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
DIPi | DIP-59708N |
IntActi | Q9JIZ5, 6 interactors |
STRINGi | 10090.ENSMUSP00000005862 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 99 | BHLHInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 141 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 299 – 338 | DisorderedSequence analysisAdd BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 148 – 182 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 197 – 217 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 121 – 141 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 305 – 320 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 321 – 338 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0561, Eukaryota |
GeneTreei | ENSGT00390000015189 |
HOGENOMi | CLU_064747_0_0_1 |
OMAi | DQGREEP |
OrthoDBi | 1565841at2759 |
TreeFami | TF316489 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9JIZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR
60 70 80 90 100
EIANSNERRR MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE
110 120 130 140 150
QEKTRLLQQN TQLKRFIQEL SGSSPKRRRA EDKDEGIGSP DIWEDEKAED
160 170 180 190 200
LRREMIELRQ QLDKERSVRM MLEEQVRSLE AHMYPEKLKV IAQQVQLQQQ
210 220 230 240 250
QEQVRLLHQE KLEREQQHLR TQLLPPPAPT HHPTVIVPAP APPSSHHINV
260 270 280 290 300
VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQDKQELEE EQRRAVIVKS
310 320 330
VRSCPDAHTS DTASDSEASD SDAMDQSREE PLGDGELP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8W6R9 | A0A2R8W6R9_MOUSE | Transcription factor AP4 | Tfap4 | 199 | Annotation score: | ||
A0A2R8VI80 | A0A2R8VI80_MOUSE | Transcription factor AP4 | Tfap4 | 214 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161262 mRNA Translation: AAF80448.1 BC047270 mRNA Translation: AAH47270.1 BC054777 mRNA Translation: AAH54777.1 AK166424 mRNA Translation: BAE38767.1 |
RefSeqi | NP_112459.1, NM_031182.2 |
Genome annotation databases
Ensembli | ENSMUST00000005862.9; ENSMUSP00000005862.8; ENSMUSG00000005718.9 |
GeneIDi | 83383 |
KEGGi | mmu:83383 |
UCSCi | uc007xzv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF161262 mRNA Translation: AAF80448.1 BC047270 mRNA Translation: AAH47270.1 BC054777 mRNA Translation: AAH54777.1 AK166424 mRNA Translation: BAE38767.1 |
RefSeqi | NP_112459.1, NM_031182.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-59708N |
IntActi | Q9JIZ5, 6 interactors |
STRINGi | 10090.ENSMUSP00000005862 |
Proteomic databases
ProteomicsDBi | 308558 |
Protocols and materials databases
Antibodypediai | 894, 309 antibodies from 25 providers |
DNASUi | 83383 |
Genome annotation databases
Ensembli | ENSMUST00000005862.9; ENSMUSP00000005862.8; ENSMUSG00000005718.9 |
GeneIDi | 83383 |
KEGGi | mmu:83383 |
UCSCi | uc007xzv.1, mouse |
Organism-specific databases
CTDi | 7023 |
MGIi | MGI:103239, Tfap4 |
VEuPathDBi | HostDB:ENSMUSG00000005718 |
Phylogenomic databases
eggNOGi | KOG0561, Eukaryota |
GeneTreei | ENSGT00390000015189 |
HOGENOMi | CLU_064747_0_0_1 |
OMAi | DQGREEP |
OrthoDBi | 1565841at2759 |
TreeFami | TF316489 |
Miscellaneous databases
BioGRID-ORCSi | 83383, 10 hits in 76 CRISPR screens |
ChiTaRSi | Tfap4, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005718, Expressed in forelimb bud and 171 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9JIZ5_MOUSE | |
Accessioni | Q9JIZ5Primary (citable) accession number: Q9JIZ5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2000 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |