UniProtKB - Q9JIX8 (ACINU_MOUSE)
Apoptotic chromatin condensation inducer in the nucleus
Acin1
Functioni
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity).
By similarityGO - Molecular functioni
- nucleic acid binding Source: InterPro
GO - Biological processi
- apoptotic chromosome condensation Source: UniProtKB
- apoptotic process Source: MGI
- erythrocyte differentiation Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of monocyte differentiation Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptotic chromatin condensation inducer in the nucleusShort name: Acinus |
Gene namesi | Name:Acin1 Synonyms:Acinus |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1891824, Acin1 |
VEuPathDBi | HostDB:ENSMUSG00000022185 |
Subcellular locationi
Nucleus
- Nucleus By similarity
- Nucleus speckle By similarity
- nucleoplasm By similarity
Note: Phosphorylation on Ser-1179 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear speck Source: UniProtKB
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- ASAP complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064437 | 1 – 1338 | Apoptotic chromatin condensation inducer in the nucleusAdd BLAST | 1338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 132 | PhosphoserineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 169 | PhosphoserineBy similarity | 1 | |
Modified residuei | 208 | PhosphoserineBy similarity | 1 | |
Modified residuei | 210 | PhosphoserineBy similarity | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | PhosphoserineBy similarity | 1 | |
Modified residuei | 253 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 267 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity | ||
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Cross-linki | 318 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 332 | PhosphoserineBy similarity | 1 | |
Modified residuei | 369 | PhosphoserineBy similarity | 1 | |
Cross-linki | 378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 387 | PhosphoserineCombined sources | 1 | |
Modified residuei | 389 | PhosphoserineCombined sources | 1 | |
Modified residuei | 391 | PhosphoserineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 | |
Modified residuei | 417 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 423 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 454 | PhosphoserineCombined sources | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 479 | PhosphoserineCombined sources | 1 | |
Modified residuei | 491 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | PhosphoserineCombined sources | 1 | |
Modified residuei | 561 | PhosphoserineBy similarity | 1 | |
Modified residuei | 654 | N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity | 1 | |
Modified residuei | 654 | N6,N6-dimethyllysine; by EHMT2; alternateBy similarity | 1 | |
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 657 | PhosphoserineBy similarity | 1 | |
Modified residuei | 710 | PhosphoserineCombined sources | 1 | |
Modified residuei | 729 | PhosphoserineBy similarity | 1 | |
Cross-linki | 732 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 825 | PhosphoserineBy similarity | 1 | |
Modified residuei | 838 | PhosphoserineCombined sources | 1 | |
Modified residuei | 861 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 861 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 879 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 895 | PhosphoserineBy similarity | 1 | |
Modified residuei | 898 | PhosphoserineCombined sources | 1 | |
Cross-linki | 969 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 975 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 986 | PhosphoserineCombined sources | 1 | |
Modified residuei | 989 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1003 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1046 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1106 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1179 | Phosphoserine; by SRPK2 and PKB/AKT1By similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1093 – 1094 | Cleavage; by caspase-3By similarity | 2 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | non-CPTAC-3629 |
EPDi | Q9JIX8 |
jPOSTi | Q9JIX8 |
MaxQBi | Q9JIX8 |
PaxDbi | Q9JIX8 |
PeptideAtlasi | Q9JIX8 |
PRIDEi | Q9JIX8 |
ProteomicsDBi | 285927 [Q9JIX8-1] 285928 [Q9JIX8-2] 285929 [Q9JIX8-3] 285930 [Q9JIX8-4] |
PTM databases
iPTMneti | Q9JIX8 |
PhosphoSitePlusi | Q9JIX8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022185, Expressed in brain and 295 other tissues |
ExpressionAtlasi | Q9JIX8, baseline and differential |
Genevisiblei | Q9JIX8, MM |
Interactioni
Subunit structurei
Found in a mRNA splicing-dependent exon junction complex (EJC).
Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex.
Interacts with API5.
Interacts with SRPK2 in a phosphorylation-dependent manner (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 207849, 8 interactors |
IntActi | Q9JIX8, 8 interactors |
MINTi | Q9JIX8 |
STRINGi | 10090.ENSMUSP00000022793 |
Miscellaneous databases
RNActi | Q9JIX8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 106 | SAPPROSITE-ProRule annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 155 – 866 | DisorderedSequence analysisAdd BLAST | 712 | |
Regioni | 892 – 950 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 1104 – 1214 | DisorderedSequence analysisAdd BLAST | 111 | |
Regioni | 1209 – 1236 | Sufficient for interaction with RNPS1 and SAP18 and formation of th ASAP complexBy similarityAdd BLAST | 28 | |
Regioni | 1226 – 1338 | DisorderedSequence analysisAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 155 – 175 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 185 – 205 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 206 – 234 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 241 – 268 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 269 – 292 | Acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 293 – 360 | Basic and acidic residuesSequence analysisAdd BLAST | 68 | |
Compositional biasi | 361 – 388 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 475 – 491 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 502 – 516 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 546 – 565 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 570 – 612 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 617 – 643 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 644 – 674 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 756 – 782 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 800 – 819 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 892 – 915 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1113 – 1130 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1131 – 1176 | Basic and acidic residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 1177 – 1191 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1192 – 1214 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1236 – 1319 | Basic and acidic residuesSequence analysisAdd BLAST | 84 |
Phylogenomic databases
eggNOGi | KOG2416, Eukaryota |
GeneTreei | ENSGT00710000106790 |
HOGENOMi | CLU_482284_0_0_1 |
InParanoidi | Q9JIX8 |
OMAi | DYHKGIR |
TreeFami | TF320727 |
Family and domain databases
CDDi | cd12432, RRM_ACINU, 1 hit |
Gene3Di | 1.10.720.30, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034257, Acinus_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR032552, RSB_motif IPR003034, SAP_dom IPR036361, SAP_dom_sf |
Pfami | View protein in Pfam PF16294, RSB_motif, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWGRKRPNSS GETRGILSGN RGVDYGSGRG QSGPFEGRWR KLPKMPEAVG
60 70 80 90 100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK
110 120 130 140 150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ
160 170 180 190 200
RLEREAREAA ELEEASAESE DEMTHPEGVA SLLPPDFQSS LNRPELELST
210 220 230 240 250
HSPRKSSSFS EEKGESDDEK PRKGERRSSR VRQAKSKLPE YSQTAEEEED
260 270 280 290 300
QETPSRNLRV RADRNLKIEE EEEEEEEEED DDDEEEEEVD EAQKSREAEA
310 320 330 340 350
PTLKQFEDEE GEERTRAKPE KVVDEKPLNI RSQEKGELEK GGRVTRSQEE
360 370 380 390 400
ARRSHLARQQ QEKETQIVSL PQEENEVKSS QSLEEKSQSP SPPPLPEDLE
410 420 430 440 450
KAPVVLQPEQ IVSEEETPPP LLTKEASSPP THIQLQEEME PVEGPAPPVL
460 470 480 490 500
IQLSPPNTDA GAREPLASPH PAQLLRSLSP LSGTTDTKAE SPAGRVSDES
510 520 530 540 550
VLPLAQKSSL PECSTQKGVE SEREKSAPLP LTVEEFAPAK GITEEPMKKQ
560 570 580 590 600
SLEQKEGRRA SHALFPEHSG KQSADSSSSR SSSPSSSSSP SRSPSPDSVA
610 620 630 640 650
SRPQSSPGSK QRDGAQARVH ANPHERPKMG SRSTSESRSR SRSRSRSASS
660 670 680 690 700
SSRKSLSPGV SRDSNTSYTE TKDPSCGQEA AAPSGPQLQV LEPKEKAPTF
710 720 730 740 750
SASVRGRHLS HPEPEQQHVI QRLQPEQGSP KKCEAEEAEP PAATQPQTSE
760 770 780 790 800
TQISHLLESE RTHHTVEEKE EVTMDTSENR PENEVPEPPL PVADQVSNDE
810 820 830 840 850
RPEGGAEEEE KKESSMPKSF KRKISVVSAT KGVQAGNSDT EGGQPGRKRR
860 870 880 890 900
WGASTAATQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED
910 920 930 940 950
ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE KEPEAELPAP
960 970 980 990 1000
PQVSVEVALP PPVEHEVKKV TLGDTLTRRS ISQQKSGVSI TIDDPVRTAQ
1010 1020 1030 1040 1050
VPSPPRGKIS NIVHISNLVR PFTLGQLKEL LGRTGTLVEE AFWIDKIKSH
1060 1070 1080 1090 1100
CFVTYSTVEE AVATRTALHG VKWPQSNPKF LCADYAEQDE LDYHRGLLVD
1110 1120 1130 1140 1150
RPSETKAEEQ GAPRPLHPPP PPPVQPPPHP RAEQREQERA VREQWAERER
1160 1170 1180 1190 1200
EMERRERTRS EREWDRDKVR EGPRSRSRSR DRRRKERAKS KEKKSEKKEK
1210 1220 1230 1240 1250
AQEEPPAKLL DDLFRKTKAA PCIYWLPLTE SQIVQKEAEQ AERAKEREKR
1260 1270 1280 1290 1300
RKEREEEEQK EREKEAERER NRQLEREKRR EHSRERERDR ERERDRGDRE
1310 1320 1330
RERERDRDRG RERDRRDTKR HSRSRSRSTP VRDRGGRR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8JJ91 | B8JJ91_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 634 | Annotation score: | ||
Q52KR6 | Q52KR6_MOUSE | Acin1 protein | Acin1 | 552 | Annotation score: | ||
B8JJ92 | B8JJ92_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 580 | Annotation score: | ||
F6RJ39 | F6RJ39_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 1,272 | Annotation score: | ||
F6Q8C0 | F6Q8C0_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 141 | Annotation score: | ||
B8JJ89 | B8JJ89_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 256 | Annotation score: | ||
B8JJ90 | B8JJ90_MOUSE | Apoptotic chromatin condensation in... | Acin1 | 221 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 244 | T → A in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 515 | T → A in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 536 | F → L in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 557 | G → D in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 568 | H → Y in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 599 | V → A in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 729 | S → I in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 757 | L → P in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 773 | T → A in AAD56723 (PubMed:10490026).Curated | 1 | |
Sequence conflicti | 829 | Missing in BAB28030 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 896 | R → Q in AAD56723 (PubMed:10490026).Curated | 1 | |
Sequence conflicti | 896 | R → Q in AAD56727 (PubMed:10490026).Curated | 1 | |
Sequence conflicti | 896 | R → Q in AAF89661 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1035 | G → R in BAB28030 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004031 | 1 – 773 | Missing in isoform 3. 1 PublicationAdd BLAST | 773 | |
Alternative sequenceiVSP_004030 | 1 – 757 | Missing in isoform 2. 2 PublicationsAdd BLAST | 757 | |
Alternative sequenceiVSP_004032 | 164 – 204 | EASAE…THSPR → G in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_004033 | 758 – 766 | ESERTHHTV → MMFSDSRAG in isoform 2. 2 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124725 mRNA Translation: AAD56723.1 AF124729 mRNA Translation: AAD56727.1 AF168782 mRNA Translation: AAF89661.1 Frameshift. CT009512 Genomic DNA No translation available. AK011698 mRNA No translation available. AK012099 mRNA Translation: BAB28030.1 AK012337 mRNA Translation: BAB28171.3 AK050467 mRNA Translation: BAC34272.1 |
CCDSi | CCDS27097.1 [Q9JIX8-1] CCDS49492.1 [Q9JIX8-2] CCDS56957.1 [Q9JIX8-3] CCDS88664.1 [Q9JIX8-4] |
RefSeqi | NP_001078942.2, NM_001085473.2 NP_001229534.1, NM_001242605.1 [Q9JIX8-3] NP_062513.3, NM_019567.3 NP_075679.2, NM_023190.3 [Q9JIX8-1] XP_006519361.1, XM_006519298.3 XP_006519367.1, XM_006519304.3 [Q9JIX8-3] |
Genome annotation databases
Ensembli | ENSMUST00000022793; ENSMUSP00000022793; ENSMUSG00000022185 [Q9JIX8-1] ENSMUST00000111484; ENSMUSP00000107109; ENSMUSG00000022185 [Q9JIX8-4] ENSMUST00000126166; ENSMUSP00000114546; ENSMUSG00000022185 [Q9JIX8-3] ENSMUST00000148754; ENSMUSP00000122003; ENSMUSG00000022185 [Q9JIX8-2] ENSMUST00000167015; ENSMUSP00000125776; ENSMUSG00000022185 [Q9JIX8-2] |
GeneIDi | 56215 |
KEGGi | mmu:56215 |
UCSCi | uc007twr.2, mouse [Q9JIX8-3] uc007twv.2, mouse [Q9JIX8-1] uc007twx.2, mouse [Q9JIX8-4] uc011zld.1, mouse [Q9JIX8-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124725 mRNA Translation: AAD56723.1 AF124729 mRNA Translation: AAD56727.1 AF168782 mRNA Translation: AAF89661.1 Frameshift. CT009512 Genomic DNA No translation available. AK011698 mRNA No translation available. AK012099 mRNA Translation: BAB28030.1 AK012337 mRNA Translation: BAB28171.3 AK050467 mRNA Translation: BAC34272.1 |
CCDSi | CCDS27097.1 [Q9JIX8-1] CCDS49492.1 [Q9JIX8-2] CCDS56957.1 [Q9JIX8-3] CCDS88664.1 [Q9JIX8-4] |
RefSeqi | NP_001078942.2, NM_001085473.2 NP_001229534.1, NM_001242605.1 [Q9JIX8-3] NP_062513.3, NM_019567.3 NP_075679.2, NM_023190.3 [Q9JIX8-1] XP_006519361.1, XM_006519298.3 XP_006519367.1, XM_006519304.3 [Q9JIX8-3] |
3D structure databases
AlphaFoldDBi | Q9JIX8 |
SMRi | Q9JIX8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207849, 8 interactors |
IntActi | Q9JIX8, 8 interactors |
MINTi | Q9JIX8 |
STRINGi | 10090.ENSMUSP00000022793 |
PTM databases
iPTMneti | Q9JIX8 |
PhosphoSitePlusi | Q9JIX8 |
Proteomic databases
CPTACi | non-CPTAC-3629 |
EPDi | Q9JIX8 |
jPOSTi | Q9JIX8 |
MaxQBi | Q9JIX8 |
PaxDbi | Q9JIX8 |
PeptideAtlasi | Q9JIX8 |
PRIDEi | Q9JIX8 |
ProteomicsDBi | 285927 [Q9JIX8-1] 285928 [Q9JIX8-2] 285929 [Q9JIX8-3] 285930 [Q9JIX8-4] |
Protocols and materials databases
Antibodypediai | 63, 523 antibodies from 35 providers |
DNASUi | 56215 |
Genome annotation databases
Ensembli | ENSMUST00000022793; ENSMUSP00000022793; ENSMUSG00000022185 [Q9JIX8-1] ENSMUST00000111484; ENSMUSP00000107109; ENSMUSG00000022185 [Q9JIX8-4] ENSMUST00000126166; ENSMUSP00000114546; ENSMUSG00000022185 [Q9JIX8-3] ENSMUST00000148754; ENSMUSP00000122003; ENSMUSG00000022185 [Q9JIX8-2] ENSMUST00000167015; ENSMUSP00000125776; ENSMUSG00000022185 [Q9JIX8-2] |
GeneIDi | 56215 |
KEGGi | mmu:56215 |
UCSCi | uc007twr.2, mouse [Q9JIX8-3] uc007twv.2, mouse [Q9JIX8-1] uc007twx.2, mouse [Q9JIX8-4] uc011zld.1, mouse [Q9JIX8-2] |
Organism-specific databases
CTDi | 22985 |
MGIi | MGI:1891824, Acin1 |
VEuPathDBi | HostDB:ENSMUSG00000022185 |
Phylogenomic databases
eggNOGi | KOG2416, Eukaryota |
GeneTreei | ENSGT00710000106790 |
HOGENOMi | CLU_482284_0_0_1 |
InParanoidi | Q9JIX8 |
OMAi | DYHKGIR |
TreeFami | TF320727 |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins |
Miscellaneous databases
BioGRID-ORCSi | 56215, 12 hits in 76 CRISPR screens |
ChiTaRSi | Acin1, mouse |
PROi | PR:Q9JIX8 |
RNActi | Q9JIX8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022185, Expressed in brain and 295 other tissues |
ExpressionAtlasi | Q9JIX8, baseline and differential |
Genevisiblei | Q9JIX8, MM |
Family and domain databases
CDDi | cd12432, RRM_ACINU, 1 hit |
Gene3Di | 1.10.720.30, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR034257, Acinus_RRM IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR032552, RSB_motif IPR003034, SAP_dom IPR036361, SAP_dom_sf |
Pfami | View protein in Pfam PF16294, RSB_motif, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACINU_MOUSE | |
Accessioni | Q9JIX8Primary (citable) accession number: Q9JIX8 Secondary accession number(s): B8JJ87 Q9R047 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot