UniProtKB - Q9JIX8 (ACINU_MOUSE)

BLAST

>sp|Q9JIX8|ACINU_MOUSE Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus OX=10090 GN=Acin1 PE=1 SV=3
MWGRKRPNSSGETRGILSGNRGVDYGSGRGQSGPFEGRWRKLPKMPEAVGTDPSTSRKMA
ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA
FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMTHPEGVA
SLLPPDFQSSLNRPELELSTHSPRKSSSFSEEKGESDDEKPRKGERRSSRVRQAKSKLPE
YSQTAEEEEDQETPSRNLRVRADRNLKIEEEEEEEEEEEDDDDEEEEEVDEAQKSREAEA
PTLKQFEDEEGEERTRAKPEKVVDEKPLNIRSQEKGELEKGGRVTRSQEEARRSHLARQQ
QEKETQIVSLPQEENEVKSSQSLEEKSQSPSPPPLPEDLEKAPVVLQPEQIVSEEETPPP
LLTKEASSPPTHIQLQEEMEPVEGPAPPVLIQLSPPNTDAGAREPLASPHPAQLLRSLSP
LSGTTDTKAESPAGRVSDESVLPLAQKSSLPECSTQKGVESEREKSAPLPLTVEEFAPAK
GITEEPMKKQSLEQKEGRRASHALFPEHSGKQSADSSSSRSSSPSSSSSPSRSPSPDSVA
SRPQSSPGSKQRDGAQARVHANPHERPKMGSRSTSESRSRSRSRSRSASSSSRKSLSPGV
SRDSNTSYTETKDPSCGQEAAAPSGPQLQVLEPKEKAPTFSASVRGRHLSHPEPEQQHVI
QRLQPEQGSPKKCEAEEAEPPAATQPQTSETQISHLLESERTHHTVEEKEEVTMDTSENR
PENEVPEPPLPVADQVSNDERPEGGAEEEEKKESSMPKSFKRKISVVSATKGVQAGNSDT
EGGQPGRKRRWGASTAATQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED
ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEKEPEAELPAPPQVSVEVALP
PPVEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVR
PFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKF
LCADYAEQDELDYHRGLLVDRPSETKAEEQGAPRPLHPPPPPPVQPPPHPRAEQREQERA
VREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK
AQEEPPAKLLDDLFRKTKAAPCIYWLPLTESQIVQKEAEQAERAKEREKRRKEREEEEQK
EREKEAERERNRQLEREKRREHSRERERDRERERDRGDRERERERDRDRGRERDRRDTKR
HSRSRSRSTPVRDRGGRR

Align

Format
Add to basket Added to basket
History
Entry version 164 (07 Nov 2018)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Apoptotic chromatin condensation inducer in the nucleus

Gene

Acin1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (By similarity).By similarity

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic chromosome condensation Source: UniProtKB
apoptotic process
Source: MGI
Inferred from sequence or structural similarityⁱ
- 10490026
erythrocyte differentiation Source: UniProtKB
mRNA processing Source: UniProtKB-KW
negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
positive regulation of apoptotic process Source: UniProtKB
positive regulation of monocyte differentiation Source: UniProtKB
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, mRNA processing, mRNA splicing

Biological process

Apoptosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-111465 Apoptotic cleavage of cellular proteins

Reactomeⁱ

R-MMU-111465 Apoptotic cleavage of cellular proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptotic chromatin condensation inducer in the nucleus Short name: Acinus
Gene namesⁱ	Name:Acin1 Synonyms:Acinus
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1891824 Acin1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064437	1 – 1338	Apoptotic chromatin condensation inducer in the nucleusAdd BLAST		1338

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	132	PhosphoserineBy similarity	1
Modified residueⁱ	166	PhosphoserineBy similarity	1
Modified residueⁱ	169	PhosphoserineBy similarity	1
Modified residueⁱ	208	PhosphoserineBy similarity	1
Modified residueⁱ	210	PhosphoserineBy similarity	1
Modified residueⁱ	216	PhosphoserineCombined sources	1
Modified residueⁱ	242	PhosphoserineBy similarity	1
Modified residueⁱ	253	PhosphothreonineBy similarity	1
Cross-linkⁱ	267	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residueⁱ	295	PhosphoserineCombined sources	1
Cross-linkⁱ	318	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	369	PhosphoserineBy similarity	1
Cross-linkⁱ	378	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	387	PhosphoserineCombined sources	1
Modified residueⁱ	389	PhosphoserineCombined sources	1
Modified residueⁱ	391	PhosphoserineCombined sources	1
Modified residueⁱ	413	PhosphoserineCombined sources	1
Modified residueⁱ	417	PhosphothreonineCombined sources	1
Modified residueⁱ	423	PhosphothreonineBy similarity	1
Modified residueⁱ	454	PhosphoserineCombined sources	1
Modified residueⁱ	477	PhosphoserineCombined sources	1
Modified residueⁱ	479	PhosphoserineCombined sources	1
Modified residueⁱ	491	PhosphoserineCombined sources	1
Modified residueⁱ	497	PhosphoserineCombined sources	1
Modified residueⁱ	561	PhosphoserineBy similarity	1
Modified residueⁱ	654	N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity	1
Modified residueⁱ	654	N6,N6-dimethyllysine; by EHMT2; alternateBy similarity	1
Modified residueⁱ	655	PhosphoserineBy similarity	1
Modified residueⁱ	657	PhosphoserineBy similarity	1
Modified residueⁱ	710	PhosphoserineCombined sources	1
Modified residueⁱ	729	PhosphoserineBy similarity	1
Cross-linkⁱ	732	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	825	PhosphoserineBy similarity	1
Modified residueⁱ	838	PhosphoserineCombined sources	1
Modified residueⁱ	861	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	861	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	879	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	895	PhosphoserineBy similarity	1
Modified residueⁱ	898	PhosphoserineCombined sources	1
Cross-linkⁱ	969	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	975	PhosphothreonineBy similarity	1
Modified residueⁱ	986	PhosphoserineCombined sources	1
Modified residueⁱ	989	PhosphoserineBy similarity	1
Modified residueⁱ	1003	PhosphoserineCombined sources	1
Cross-linkⁱ	1046	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1106	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1179	Phosphoserine; by SRPK2 and PKB/AKT1By similarity	1

Post-translational modificationⁱ

Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.By similarity

Phosphorylation on Ser-1179 by SRPK2 up-regulates its stimulatory effect on cyclin A1.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	1093 – 1094	Cleavage; by caspase-3By similarity		2

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9JIX8
PeptideAtlas More...PeptideAtlasⁱ	Q9JIX8
PRIDEⁱ	Q9JIX8

PTM databases

iPTMnetⁱ	Q9JIX8
PhosphoSitePlusⁱ	Q9JIX8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022185 Expressed in 274 organ(s), highest expression level in female gonad
CleanExⁱ	MM_ACIN1
ExpressionAtlasⁱ	Q9JIX8 baseline and differential
Genevisibleⁱ	Q9JIX8 MM

Interactionⁱ

Subunit structureⁱ

Found in a mRNA splicing-dependent exon junction complex (EJC). Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) complexes consisting of RNPS1, SAP18 and different isoforms of ACIN1; the association of SAP18 seems to require a preformed RNPS1:ACIN1 complex. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	207849, 4 interactors
IntActⁱ	Q9JIX8, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9JIX8
STRINGⁱ	10090.ENSMUSP00000022793

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JIX8
SMRⁱ	Q9JIX8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 106	SAPPROSITE-ProRule annotationAdd BLAST		35

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1209 – 1236	Sufficient for interaction with RNPS1 and SAP18 and formation of th ASAP complexBy similarityAdd BLAST		28

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	142 – 443	Glu-richAdd BLAST	302
Compositional biasⁱ	569 – 667	Ser-richAdd BLAST	99
Compositional biasⁱ	1113 – 1130	Pro-richAdd BLAST	18
Compositional biasⁱ	1131 – 1338	Arg/Asp/Glu/Lys-richAdd BLAST	208

Phylogenomic databases

eggNOGⁱ	KOG2416 Eukaryota ENOG4111HR1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106790
HOVERGENⁱ	HBG050449
InParanoidⁱ	Q9JIX8
KEGG Orthology (KO) More...KOⁱ	K12875
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MO8
TreeFamⁱ	TF320727

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12432 RRM_ACINU, 1 hit
Gene3Dⁱ	1.10.720.30, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034257 Acinus_RRM IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR032552 RSB_motif IPR003034 SAP_dom IPR036361 SAP_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16294 RSB_motif, 1 hit PF02037 SAP, 1 hit
SMARTⁱ	View protein in SMART SM00513 SAP, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF68906 SSF68906, 1 hit
PROSITEⁱ	View protein in PROSITE PS50800 SAP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9JIX8-1) [UniParc]FASTA Add to basket

Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGRKRPNSS GETRGILSGN RGVDYGSGRG QSGPFEGRWR KLPKMPEAVG 
        60         70         80         90        100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK 
       110        120        130        140        150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ 
       160        170        180        190        200
RLEREAREAA ELEEASAESE DEMTHPEGVA SLLPPDFQSS LNRPELELST 
       210        220        230        240        250
HSPRKSSSFS EEKGESDDEK PRKGERRSSR VRQAKSKLPE YSQTAEEEED 
       260        270        280        290        300
QETPSRNLRV RADRNLKIEE EEEEEEEEED DDDEEEEEVD EAQKSREAEA 
       310        320        330        340        350
PTLKQFEDEE GEERTRAKPE KVVDEKPLNI RSQEKGELEK GGRVTRSQEE 
       360        370        380        390        400
ARRSHLARQQ QEKETQIVSL PQEENEVKSS QSLEEKSQSP SPPPLPEDLE 
       410        420        430        440        450
KAPVVLQPEQ IVSEEETPPP LLTKEASSPP THIQLQEEME PVEGPAPPVL 
       460        470        480        490        500
IQLSPPNTDA GAREPLASPH PAQLLRSLSP LSGTTDTKAE SPAGRVSDES 
       510        520        530        540        550
VLPLAQKSSL PECSTQKGVE SEREKSAPLP LTVEEFAPAK GITEEPMKKQ 
       560        570        580        590        600
SLEQKEGRRA SHALFPEHSG KQSADSSSSR SSSPSSSSSP SRSPSPDSVA 
       610        620        630        640        650
SRPQSSPGSK QRDGAQARVH ANPHERPKMG SRSTSESRSR SRSRSRSASS 
       660        670        680        690        700
SSRKSLSPGV SRDSNTSYTE TKDPSCGQEA AAPSGPQLQV LEPKEKAPTF 
       710        720        730        740        750
SASVRGRHLS HPEPEQQHVI QRLQPEQGSP KKCEAEEAEP PAATQPQTSE 
       760        770        780        790        800
TQISHLLESE RTHHTVEEKE EVTMDTSENR PENEVPEPPL PVADQVSNDE 
       810        820        830        840        850
RPEGGAEEEE KKESSMPKSF KRKISVVSAT KGVQAGNSDT EGGQPGRKRR 
       860        870        880        890        900
WGASTAATQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED 
       910        920        930        940        950
ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE KEPEAELPAP 
       960        970        980        990       1000
PQVSVEVALP PPVEHEVKKV TLGDTLTRRS ISQQKSGVSI TIDDPVRTAQ 
      1010       1020       1030       1040       1050
VPSPPRGKIS NIVHISNLVR PFTLGQLKEL LGRTGTLVEE AFWIDKIKSH 
      1060       1070       1080       1090       1100
CFVTYSTVEE AVATRTALHG VKWPQSNPKF LCADYAEQDE LDYHRGLLVD 
      1110       1120       1130       1140       1150
RPSETKAEEQ GAPRPLHPPP PPPVQPPPHP RAEQREQERA VREQWAERER 
      1160       1170       1180       1190       1200
EMERRERTRS EREWDRDKVR EGPRSRSRSR DRRRKERAKS KEKKSEKKEK 
      1210       1220       1230       1240       1250
AQEEPPAKLL DDLFRKTKAA PCIYWLPLTE SQIVQKEAEQ AERAKEREKR 
      1260       1270       1280       1290       1300
RKEREEEEQK EREKEAERER NRQLEREKRR EHSRERERDR ERERDRGDRE 
      1310       1320       1330 
RERERDRDRG RERDRRDTKR HSRSRSRSTP VRDRGGRR

Length:1,338

Mass (Da):150,719

Last modified:July 27, 2011 - v3

Checksum:ⁱ683E56058723C9D8

Isoform 2 (identifier: Q9JIX8-2) [UniParc]FASTA Add to basket

Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
1-757: Missing.
758-766: ESERTHHTV → MMFSDSRAG

« Hide

        10         20         30         40         50
MMFSDSRAGE EKEEVTMDTS ENRPENEVPE PPLPVADQVS NDERPEGGAE 
        60         70         80         90        100
EEEKKESSMP KSFKRKISVV SATKGVQAGN SDTEGGQPGR KRRWGASTAA 
       110        120        130        140        150
TQKKPSISIT TESLKSLIPD IKPLAGQEAV VDLHADDSRI SEDETERNGD 
       160        170        180        190        200
DGTHDKGLKI CRTVTQVVPA EGQENGQREE EEEKEPEAEL PAPPQVSVEV 
       210        220        230        240        250
ALPPPVEHEV KKVTLGDTLT RRSISQQKSG VSITIDDPVR TAQVPSPPRG 
       260        270        280        290        300
KISNIVHISN LVRPFTLGQL KELLGRTGTL VEEAFWIDKI KSHCFVTYST 
       310        320        330        340        350
VEEAVATRTA LHGVKWPQSN PKFLCADYAE QDELDYHRGL LVDRPSETKA 
       360        370        380        390        400
EEQGAPRPLH PPPPPPVQPP PHPRAEQREQ ERAVREQWAE REREMERRER 
       410        420        430        440        450
TRSEREWDRD KVREGPRSRS RSRDRRRKER AKSKEKKSEK KEKAQEEPPA 
       460        470        480        490        500
KLLDDLFRKT KAAPCIYWLP LTESQIVQKE AEQAERAKER EKRRKEREEE 
       510        520        530        540        550
EQKEREKEAE RERNRQLERE KRREHSRERE RDRERERDRG DRERERERDR 
       560        570        580 
DRGRERDRRD TKRHSRSRSR STPVRDRGGR R

Show »

Length:581

Mass (Da):67,185

Checksum:ⁱ38C74E0629009255

Isoform 3 (identifier: Q9JIX8-3) [UniParc]FASTA Add to basket

Also known as: S'

The sequence of this isoform differs from the canonical sequence as follows:
1-773: Missing.

« Hide

        10         20         30         40         50
MDTSENRPEN EVPEPPLPVA DQVSNDERPE GGAEEEEKKE SSMPKSFKRK 
        60         70         80         90        100
ISVVSATKGV QAGNSDTEGG QPGRKRRWGA STAATQKKPS ISITTESLKS 
       110        120        130        140        150
LIPDIKPLAG QEAVVDLHAD DSRISEDETE RNGDDGTHDK GLKICRTVTQ 
       160        170        180        190        200
VVPAEGQENG QREEEEEKEP EAELPAPPQV SVEVALPPPV EHEVKKVTLG 
       210        220        230        240        250
DTLTRRSISQ QKSGVSITID DPVRTAQVPS PPRGKISNIV HISNLVRPFT 
       260        270        280        290        300
LGQLKELLGR TGTLVEEAFW IDKIKSHCFV TYSTVEEAVA TRTALHGVKW 
       310        320        330        340        350
PQSNPKFLCA DYAEQDELDY HRGLLVDRPS ETKAEEQGAP RPLHPPPPPP 
       360        370        380        390        400
VQPPPHPRAE QREQERAVRE QWAEREREME RRERTRSERE WDRDKVREGP 
       410        420        430        440        450
RSRSRSRDRR RKERAKSKEK KSEKKEKAQE EPPAKLLDDL FRKTKAAPCI 
       460        470        480        490        500
YWLPLTESQI VQKEAEQAER AKEREKRRKE REEEEQKERE KEAERERNRQ 
       510        520        530        540        550
LEREKRREHS RERERDRERE RDRGDRERER ERDRDRGRER DRRDTKRHSR 
       560 
SRSRSTPVRD RGGRR

Show »

Length:565

Mass (Da):65,357

Checksum:ⁱA68FF1692E30B303

Isoform 4 (identifier: Q9JIX8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
164-204: EASAESEDEMTHPEGVASLLPPDFQSSLNRPELELSTHSPR → G

« Hide

        10         20         30         40         50
MWGRKRPNSS GETRGILSGN RGVDYGSGRG QSGPFEGRWR KLPKMPEAVG 
        60         70         80         90        100
TDPSTSRKMA ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK 
       110        120        130        140        150
RLKGALMLEN LQKHSTPHAA FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ 
       160        170        180        190        200
RLEREAREAA ELEGKSSSFS EEKGESDDEK PRKGERRSSR VRQAKSKLPE 
       210        220        230        240        250
YSQTAEEEED QETPSRNLRV RADRNLKIEE EEEEEEEEED DDDEEEEEVD 
       260        270        280        290        300
EAQKSREAEA PTLKQFEDEE GEERTRAKPE KVVDEKPLNI RSQEKGELEK 
       310        320        330        340        350
GGRVTRSQEE ARRSHLARQQ QEKETQIVSL PQEENEVKSS QSLEEKSQSP 
       360        370        380        390        400
SPPPLPEDLE KAPVVLQPEQ IVSEEETPPP LLTKEASSPP THIQLQEEME 
       410        420        430        440        450
PVEGPAPPVL IQLSPPNTDA GAREPLASPH PAQLLRSLSP LSGTTDTKAE 
       460        470        480        490        500
SPAGRVSDES VLPLAQKSSL PECSTQKGVE SEREKSAPLP LTVEEFAPAK 
       510        520        530        540        550
GITEEPMKKQ SLEQKEGRRA SHALFPEHSG KQSADSSSSR SSSPSSSSSP 
       560        570        580        590        600
SRSPSPDSVA SRPQSSPGSK QRDGAQARVH ANPHERPKMG SRSTSESRSR 
       610        620        630        640        650
SRSRSRSASS SSRKSLSPGV SRDSNTSYTE TKDPSCGQEA AAPSGPQLQV 
       660        670        680        690        700
LEPKEKAPTF SASVRGRHLS HPEPEQQHVI QRLQPEQGSP KKCEAEEAEP 
       710        720        730        740        750
PAATQPQTSE TQISHLLESE RTHHTVEEKE EVTMDTSENR PENEVPEPPL 
       760        770        780        790        800
PVADQVSNDE RPEGGAEEEE KKESSMPKSF KRKISVVSAT KGVQAGNSDT 
       810        820        830        840        850
EGGQPGRKRR WGASTAATQK KPSISITTES LKSLIPDIKP LAGQEAVVDL 
       860        870        880        890        900
HADDSRISED ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE 
       910        920        930        940        950
KEPEAELPAP PQVSVEVALP PPVEHEVKKV TLGDTLTRRS ISQQKSGVSI 
       960        970        980        990       1000
TIDDPVRTAQ VPSPPRGKIS NIVHISNLVR PFTLGQLKEL LGRTGTLVEE 
      1010       1020       1030       1040       1050
AFWIDKIKSH CFVTYSTVEE AVATRTALHG VKWPQSNPKF LCADYAEQDE 
      1060       1070       1080       1090       1100
LDYHRGLLVD RPSETKAEEQ GAPRPLHPPP PPPVQPPPHP RAEQREQERA 
      1110       1120       1130       1140       1150
VREQWAERER EMERRERTRS EREWDRDKVR EGPRSRSRSR DRRRKERAKS 
      1160       1170       1180       1190       1200
KEKKSEKKEK AQEEPPAKLL DDLFRKTKAA PCIYWLPLTE SQIVQKEAEQ 
      1210       1220       1230       1240       1250
AERAKEREKR RKEREEEEQK EREKEAERER NRQLEREKRR EHSRERERDR 
      1260       1270       1280       1290 
ERERDRGDRE RERERDRDRG RERDRRDTKR HSRSRSRSTP VRDRGGRR

Show »

Length:1,298

Mass (Da):146,302

Checksum:ⁱFFEC0D9BF7838055

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B8JJ91	B8JJ91_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	634	Annotation score:
Q52KR6	Q52KR6_MOUSE	Acin1 protein Acin1 protein (Apoptotic chromatin condensation inducer in the nucleus)	Acin1	552	Annotation score:
B8JJ92	B8JJ92_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	580	Annotation score:
F6RJ39	F6RJ39_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	1,272	Annotation score:
B8JJ89	B8JJ89_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	256	Annotation score:
F6Q8C0	F6Q8C0_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	141	Annotation score:
B8JJ90	B8JJ90_MOUSE	Apoptotic chromatin condensation in... Apoptotic chromatin condensation inducer in the nucleus	Acin1	221	Annotation score:

Sequence cautionⁱ

The sequence AAF89661 differs from that shown. Reason: Frameshift at positions 110 and 112.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	244	T → A in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	515	T → A in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	536	F → L in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	557	G → D in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	568	H → Y in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	599	V → A in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	729	S → I in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	757	L → P in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	773	T → A in AAD56723 (PubMed:10490026).Curated	1
Sequence conflictⁱ	829	Missing in BAB28030 (PubMed:16141072).Curated	1
Sequence conflictⁱ	896	R → Q in AAD56723 (PubMed:10490026).Curated	1
Sequence conflictⁱ	896	R → Q in AAD56727 (PubMed:10490026).Curated	1
Sequence conflictⁱ	896	R → Q in AAF89661 (Ref. 2) Curated	1
Sequence conflictⁱ	1035	G → R in BAB28030 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004031	1 – 773	Missing in isoform 3. 1 PublicationAdd BLAST	773
Alternative sequenceⁱVSP_004030	1 – 757	Missing in isoform 2. 2 PublicationsAdd BLAST	757
Alternative sequenceⁱVSP_004032	164 – 204	EASAE…THSPR → G in isoform 4. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_004033	758 – 766	ESERTHHTV → MMFSDSRAG in isoform 2. 2 Publications	9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124725 mRNA Translation: AAD56723.1 AF124729 mRNA Translation: AAD56727.1 AF168782 mRNA Translation: AAF89661.1 Frameshift. CT009512 Genomic DNA No translation available. AK011698 mRNA No translation available. AK012099 mRNA Translation: BAB28030.1 AK012337 mRNA Translation: BAB28171.3 AK050467 mRNA Translation: BAC34272.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27097.1 [Q9JIX8-1] CCDS49492.1 [Q9JIX8-2] CCDS56957.1 [Q9JIX8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001078942.2, NM_001085473.2 NP_001229534.1, NM_001242605.1 [Q9JIX8-3] NP_062513.3, NM_019567.3 NP_075679.2, NM_023190.3 [Q9JIX8-1] XP_006519361.1, XM_006519298.3 [Q9JIX8-4] XP_006519367.1, XM_006519304.3 [Q9JIX8-3]
UniGeneⁱ	Mm.297078

Genome annotation databases

Ensemblⁱ	ENSMUST00000022793; ENSMUSP00000022793; ENSMUSG00000022185 [Q9JIX8-1] ENSMUST00000111484; ENSMUSP00000107109; ENSMUSG00000022185 [Q9JIX8-4] ENSMUST00000126166; ENSMUSP00000114546; ENSMUSG00000022185 [Q9JIX8-3] ENSMUST00000148754; ENSMUSP00000122003; ENSMUSG00000022185 [Q9JIX8-2] ENSMUST00000167015; ENSMUSP00000125776; ENSMUSG00000022185 [Q9JIX8-2]
GeneIDⁱ	56215
KEGGⁱ	mmu:56215
UCSC genome browser More...UCSCⁱ	uc007twr.2 mouse [Q9JIX8-3] uc007twv.2 mouse [Q9JIX8-1] uc007twx.2 mouse [Q9JIX8-4] uc011zld.1 mouse [Q9JIX8-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JIX8	Apoptotic chromatin condensation inducer 1 isoform 2 (Fragment)		synthetic construct		431	UniRef100_Q9JIX8
Uncharacterized protein (Fragment)		MOUSE		139
Isoform 3 of Apoptotic chromatin condensation inducer in the nucleus		MOUSE		565
Apoptotic chromatin condensation inducer 1 isoform 2 (Fragment)		synthetic construct		433
Q9JIX8-4	Apoptotic chromatin condensation inducer in the nucleus (Fragment)		MOUSE		256	UniRef100_Q9JIX8-4

Protein	Similar proteins		Species	Score	Length	Source
Q9JIX8	Apoptotic chromatin condensation inducer 1 isoform 2 (Fragment)		synthetic construct		431	UniRef90_Q9JIX8
Uncharacterized protein (Fragment)		MOUSE		139
Apoptotic chromatin condensation inducer 1		RAT		1339
UPI000A3148E1		MUSCR		1337
UPI000A311591		MUSPA		1336
+22
Q9JIX8-4	Apoptotic chromatin condensation inducer in the nucleus (Fragment)		MOUSE		256	UniRef90_Q9JIX8-4
UPI0000501C1A		RAT		1299
UPI000A314C0F		MUSCR		1297
UPI000A3060AC		MUSPA		1296

Protein	Similar proteins		Species	Score	Length	Source
Q9JIX8	Apoptotic chromatin condensation inducer in the nucleus	)	HUMAN		1341	UniRef50_Q9UKV3
Apoptotic chromatin condensation inducer 1		SAIBB		1353
apoptotic chromatin condensation inducer in the nucleus		TARSY		1352
Uncharacterized protein		AOTNA		1351
Uncharacterized protein		Cebus capucinus imitator		1349
+454
Q9JIX8-2	Uncharacterized protein		CAVPO		635	UniRef50_Q9JIX8-2
Apoptotic chromatin condensation inducer in the nucleus		MOUSE		634
Uncharacterized protein		CERAT		631
MGC132201 protein		XENLA		639
Apoptotic chromatin condensation inducer 1		XENTR		568
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124725 mRNA Translation: AAD56723.1 AF124729 mRNA Translation: AAD56727.1 AF168782 mRNA Translation: AAF89661.1 Frameshift. CT009512 Genomic DNA No translation available. AK011698 mRNA No translation available. AK012099 mRNA Translation: BAB28030.1 AK012337 mRNA Translation: BAB28171.3 AK050467 mRNA Translation: BAC34272.1
CCDSⁱ	CCDS27097.1 [Q9JIX8-1] CCDS49492.1 [Q9JIX8-2] CCDS56957.1 [Q9JIX8-3]
RefSeqⁱ	NP_001078942.2, NM_001085473.2 NP_001229534.1, NM_001242605.1 [Q9JIX8-3] NP_062513.3, NM_019567.3 NP_075679.2, NM_023190.3 [Q9JIX8-1] XP_006519361.1, XM_006519298.3 [Q9JIX8-4] XP_006519367.1, XM_006519304.3 [Q9JIX8-3]
UniGeneⁱ	Mm.297078

3D structure databases

ProteinModelPortalⁱ	Q9JIX8
SMRⁱ	Q9JIX8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207849, 4 interactors
IntActⁱ	Q9JIX8, 9 interactors
MINTⁱ	Q9JIX8
STRINGⁱ	10090.ENSMUSP00000022793

PTM databases

iPTMnetⁱ	Q9JIX8
PhosphoSitePlusⁱ	Q9JIX8

Proteomic databases

PaxDbⁱ	Q9JIX8
PeptideAtlasⁱ	Q9JIX8
PRIDEⁱ	Q9JIX8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022793; ENSMUSP00000022793; ENSMUSG00000022185 [Q9JIX8-1] ENSMUST00000111484; ENSMUSP00000107109; ENSMUSG00000022185 [Q9JIX8-4] ENSMUST00000126166; ENSMUSP00000114546; ENSMUSG00000022185 [Q9JIX8-3] ENSMUST00000148754; ENSMUSP00000122003; ENSMUSG00000022185 [Q9JIX8-2] ENSMUST00000167015; ENSMUSP00000125776; ENSMUSG00000022185 [Q9JIX8-2]
GeneIDⁱ	56215
KEGGⁱ	mmu:56215
UCSCⁱ	uc007twr.2 mouse [Q9JIX8-3] uc007twv.2 mouse [Q9JIX8-1] uc007twx.2 mouse [Q9JIX8-4] uc011zld.1 mouse [Q9JIX8-2]

Organism-specific databases

CTDⁱ	22985
MGIⁱ	MGI:1891824 Acin1

Phylogenomic databases

eggNOGⁱ	KOG2416 Eukaryota ENOG4111HR1 LUCA
GeneTreeⁱ	ENSGT00710000106790
HOVERGENⁱ	HBG050449
InParanoidⁱ	Q9JIX8
KOⁱ	K12875
OrthoDBⁱ	EOG091G0MO8
TreeFamⁱ	TF320727

Enzyme and pathway databases

Reactomeⁱ	R-MMU-111465 Apoptotic cleavage of cellular proteins

Reactomeⁱ

R-MMU-111465 Apoptotic cleavage of cellular proteins

Miscellaneous databases

ChiTaRSⁱ	Acin1 mouse
Protein Ontology More...PROⁱ	PR:Q9JIX8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022185 Expressed in 274 organ(s), highest expression level in female gonad
CleanExⁱ	MM_ACIN1
ExpressionAtlasⁱ	Q9JIX8 baseline and differential
Genevisibleⁱ	Q9JIX8 MM

Family and domain databases

CDDⁱ	cd12432 RRM_ACINU, 1 hit
Gene3Dⁱ	1.10.720.30, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR034257 Acinus_RRM IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR032552 RSB_motif IPR003034 SAP_dom IPR036361 SAP_dom_sf
Pfamⁱ	View protein in Pfam PF16294 RSB_motif, 1 hit PF02037 SAP, 1 hit
SMARTⁱ	View protein in SMART SM00513 SAP, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF68906 SSF68906, 1 hit
PROSITEⁱ	View protein in PROSITE PS50800 SAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACINU_MOUSE
Accessionⁱ	Q9JIX8Primary (citable) accession number: Q9JIX8 Secondary accession number(s): B8JJ87 , Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JIX8 (ACINU_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Apoptotic chromatin condensation inducer in the nucleus

Acin1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ