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Protein

Mothers against decapentaplegic homolog 9

Gene

Smad9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68ZincBy similarity1
Metal bindingi113ZincBy similarity1
Metal bindingi125ZincBy similarity1
Metal bindingi130ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • bone development Source: MGI
  • cartilage development Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • hindbrain development Source: MGI
  • midbrain development Source: MGI
  • Mullerian duct regression Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • protein phosphorylation Source: MGI
  • SMAD protein signal transduction Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
  • transforming growth factor beta receptor signaling pathway Source: InterPro
  • ureteric bud development Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 9
Short name:
MAD homolog 9
Short name:
Mothers against DPP homolog 9
Alternative name(s):
SMAD family member 9
Short name:
SMAD 9
Short name:
Smad9
Smad8
Gene namesi
Name:Smad9
Synonyms:Madh8, Madh9, Smad8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1859993 Smad9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3883282

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908761 – 430Mothers against decapentaplegic homolog 9Add BLAST430

Post-translational modificationi

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase and activin type I receptor-like kinases (ALK-2, ALK-3 and ALK-6).

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JIW5
PaxDbiQ9JIW5
PRIDEiQ9JIW5

PTM databases

iPTMnetiQ9JIW5
PhosphoSitePlusiQ9JIW5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027796
CleanExiMM_SMAD9
ExpressionAtlasiQ9JIW5 baseline and differential
GenevisibleiQ9JIW5 MM

Interactioni

Subunit structurei

Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit (By similarity). Interacts with RANBP3L (By similarity).By similarity

Protein-protein interaction databases

BioGridi207765, 9 interactors
IntActiQ9JIW5, 1 interactor
MINTiQ9JIW5
STRINGi10090.ENSMUSP00000029371

Structurei

3D structure databases

ProteinModelPortaliQ9JIW5
SMRiQ9JIW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 140MH1PROSITE-ProRule annotationAdd BLAST125
Domaini236 – 430MH2PROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 49Poly-Lys7

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

eggNOGiKOG3701 Eukaryota
ENOG410XQKU LUCA
GeneTreeiENSGT00760000119091
HOGENOMiHOG000286018
HOVERGENiHBG053353
InParanoidiQ9JIW5
KOiK16791
OMAiSDFRPVC
OrthoDBiEOG091G082C
PhylomeDBiQ9JIW5
TreeFamiTF314923

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 2 hits
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JIW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPSTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG
60 70 80 90 100
AMDELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD
110 120 130 140 150
LQSHHELKPL ECCEFPFGSK QKEVCINPYH YRRVETPVLP PVLVPRHSEY
160 170 180 190 200
NPQLSLLAKF RSASLHSEPL MPHNATYPDS FQQSLCPAPP SSPGHVFPQS
210 220 230 240 250
PCPTSYPHSP GSPSESDSPY QHSDFRPVCY EEPQHWCSVA YYELNNRVGE
260 270 280 290 300
TFQASSRSVL IDGFTDPSNN RNRFCLGLLS NVNRNSTIEN TRRHIGKGVH
310 320 330 340 350
LYYVGGEVYA ECVSDSSIFV QSRNCNYQHG FHPATVCKIP SGCSLKVFNN
360 370 380 390 400
QLFAQLLAQS VHHGFEVVYE LTKMCTIRMS FVKGWGAEYH RQDVTSTPCW
410 420 430
IEIHLHGPLQ WLDKVLTQMG SPHNPISSVS
Length:430
Mass (Da):48,636
Last modified:May 10, 2005 - v2
Checksum:i3B15EC51D6A594E5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti214 – 215Missing 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175408 mRNA Translation: AAF77079.2
AY145520 mRNA Translation: AAN85445.1
CCDSiCCDS17354.1
RefSeqiNP_062356.3, NM_019483.5
XP_006501791.1, XM_006501728.3
UniGeneiMm.244353

Genome annotation databases

EnsembliENSMUST00000029371; ENSMUSP00000029371; ENSMUSG00000027796
GeneIDi55994
KEGGimmu:55994
UCSCiuc008pfv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSMAD9_MOUSE
AccessioniPrimary (citable) accession number: Q9JIW5
Secondary accession number(s): Q8CFF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 10, 2005
Last modified: July 18, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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