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Entry version 150 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Voltage-dependent L-type calcium channel subunit alpha-1F

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines (By similarity).

Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei330Calcium ion selectivity and permeabilityBy similarity1
Sitei711Calcium ion selectivity and permeabilityBy similarity1
Sitei1091Calcium ion selectivity and permeabilityBy similarity1
Sitei1388Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi1475 – 1486By similarityAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Sensory transduction, Transport, Vision
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1FBy similarity
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav1.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1fImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1859639, Cacna1f

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 92CytoplasmicSequence analysisAdd BLAST92
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei93 – 111Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini112 – 129ExtracellularSequence analysisAdd BLAST18
Transmembranei130 – 149Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini150 – 161CytoplasmicSequence analysisAdd BLAST12
Transmembranei162 – 180Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini181 – 201ExtracellularSequence analysisAdd BLAST21
Transmembranei202 – 220Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini221 – 239CytoplasmicSequence analysisAdd BLAST19
Transmembranei240 – 259Helical; Name=S5 of repeat ISequence analysisAdd BLAST20
Topological domaini260 – 347ExtracellularSequence analysisAdd BLAST88
Transmembranei348 – 372Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini373 – 529CytoplasmicSequence analysisAdd BLAST157
Transmembranei530 – 549Helical; Name=S1 of repeat IISequence analysisAdd BLAST20
Topological domaini550 – 564ExtracellularSequence analysisAdd BLAST15
Transmembranei565 – 583Helical; Name=S2 of repeat IISequence analysisAdd BLAST19
Topological domaini584 – 591CytoplasmicSequence analysis8
Transmembranei592 – 610Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini611 – 620ExtracellularSequence analysis10
Transmembranei621 – 639Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini640 – 658CytoplasmicSequence analysisAdd BLAST19
Transmembranei659 – 679Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini680 – 733ExtracellularSequence analysisAdd BLAST54
Transmembranei734 – 758Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini759 – 876CytoplasmicSequence analysisAdd BLAST118
Transmembranei877 – 895Helical; Name=S1 of repeat IIISequence analysisAdd BLAST19
Topological domaini896 – 911ExtracellularSequence analysisAdd BLAST16
Transmembranei912 – 931Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini932 – 943CytoplasmicSequence analysisAdd BLAST12
Transmembranei944 – 962Helical; Name=S3 of repeat IIISequence analysisAdd BLAST19
Topological domaini963 – 968ExtracellularSequence analysis6
Transmembranei969 – 988Helical; Name=S4 of repeat IIISequence analysisAdd BLAST20
Topological domaini989 – 1007CytoplasmicSequence analysisAdd BLAST19
Transmembranei1008 – 1027Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1028 – 1117ExtracellularSequence analysisAdd BLAST90
Transmembranei1118 – 1138Helical; Name=S6 of repeat IIISequence analysisAdd BLAST21
Topological domaini1139 – 1195CytoplasmicSequence analysisAdd BLAST57
Transmembranei1196 – 1214Helical; Name=S1 of repeat IVSequence analysisAdd BLAST19
Topological domaini1215 – 1229ExtracellularSequence analysisAdd BLAST15
Transmembranei1230 – 1249Helical; Name=S2 of repeat IVSequence analysisAdd BLAST20
Topological domaini1250 – 1256CytoplasmicSequence analysis7
Transmembranei1257 – 1278Helical; Name=S3 of repeat IVSequence analysisAdd BLAST22
Topological domaini1279 – 1295ExtracellularSequence analysisAdd BLAST17
Transmembranei1296 – 1315Helical; Name=S4 of repeat IVSequence analysisAdd BLAST20
Topological domaini1316 – 1334CytoplasmicSequence analysisAdd BLAST19
Transmembranei1335 – 1354Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1355 – 1421ExtracellularSequence analysisAdd BLAST67
Transmembranei1422 – 1446Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1447 – 1982CytoplasmicSequence analysisAdd BLAST536

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176791

DrugCentral

More...
DrugCentrali
Q9JIS7

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539511 – 1985Voltage-dependent L-type calcium channel subunit alpha-1FAdd BLAST1985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9JIS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JIS7

PRoteomics IDEntifications database

More...
PRIDEi
Q9JIS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273885

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9JIS7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JIS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JIS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the inner and outer nuclear layers and the genglion cell layer of the retina.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity (By similarity).

Interacts (via IQ domain) with CABP4; in a calcium independent manner.

By similarity1 Publication

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61285N

Protein interaction database and analysis system

More...
IntActi
Q9JIS7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000111391

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9JIS7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JIS7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JIS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati79 – 375IAdd BLAST297
Repeati515 – 761IIAdd BLAST247
Repeati858 – 1140IIIAdd BLAST283
Repeati1182 – 1449IVAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56
Regioni395 – 412Binding to the beta subunitBy similarityAdd BLAST18
Regioni455 – 490DisorderedSequence analysisAdd BLAST36
Regioni766 – 834DisorderedSequence analysisAdd BLAST69
Regioni1065 – 1155Dihydropyridine bindingBy similarityAdd BLAST91
Regioni1402 – 1468Dihydropyridine bindingBy similarityAdd BLAST67
Regioni1414 – 1457Phenylalkylamine bindingBy similarityAdd BLAST44
Regioni1643 – 1729DisorderedSequence analysisAdd BLAST87
Regioni1746 – 1778DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi456 – 479Polar residuesSequence analysisAdd BLAST24
Compositional biasi768 – 782Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi809 – 831Acidic residuesSequence analysisAdd BLAST23
Compositional biasi1644 – 1666Acidic residuesSequence analysisAdd BLAST23
Compositional biasi1670 – 1687Polar residuesSequence analysisAdd BLAST18
Compositional biasi1706 – 1729Polar residuesSequence analysisAdd BLAST24
Compositional biasi1746 – 1761Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JIS7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01630, LVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9JIS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESEVGKDT TPEPSPANGT GPGPEWGLCP GPPTVGTDTS GASGLGTPRR
60 70 80 90 100
RTQHNKHKTV AVASAQRSPR ALFCLTLTNP IRRSCISIVE WKPFDILILL
110 120 130 140 150
TIFANCVALG VYIPFPEDDS NTANHNLEQV EYVFLVIFTV ETVLKIVAYG
160 170 180 190 200
LVLHPSAYIR NGWNLLDFII VVVGLFSVLL EQGPGRPGDA PHTGGKPGGF
210 220 230 240 250
DVKALRAFRV LRPLRLVSGV PSLHIVVNSI MKALVPLLHI ALLVLFVIII
260 270 280 290 300
YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR SCTLNHTECR
310 320 330 340 350
GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV
360 370 380 390 400
YFVSLVIFGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQMEED
410 420 430 440 450
LRGYLDWITQ AEELDLHDPS VDGNLASLAE EGRAGHRPQL SELTNRRRGR
460 470 480 490 500
LRWFSHSTRS THSTSSHASL PASDTGSMTD TPGDEDEEEG TMASCTRCLN
510 520 530 540 550
KIMKTRICRH FRRANRGLRA RCRRAVKSNA CYWAVLLLVF LNTLTIASEH
560 570 580 590 600
HGQPLWLTQT QEYANKVLLC LFTVEMLLKL YGLGPSVYVA SFFNRFDCFV
610 620 630 640 650
VCGGILETTL VEVGAMQPLG ISVLRCVRLL RIFKVTRHWA SLSNLVASLL
660 670 680 690 700
NSMKSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDQTHTK RSTFDTFPQA
710 720 730 740 750
LLTVFQILTG EDWNVVMYDG IMAYGGPFFP GMLVCVYFII LFICGNYILL
760 770 780 790 800
NVFLAIAVDN LASGDAGTAK DKGREKSSEG NPPKENKVLV PGGENEDAKG
810 820 830 840 850
ARSEGAAPGM EEEEEEEEEE EEEEEEEEEN GAGHVELLQE VVPKEKVVPI
860 870 880 890 900
PEGSAFFCLS QTNPLRKACH TLIHHHIFTS LILVFIILSS VSLAAEDPIR
910 920 930 940 950
AHSFRNHILG YFDYAFTSIF TVEILLKMTV FGAFLHRGSF CRSWFNLLDL
960 970 980 990 1000
LVVSVSLISF GIHSSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV
1010 1020 1030 1040 1050
AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYSCTDEAKH TLKESKGSFL
1060 1070 1080 1090 1100
IYPDGDVSRP LVRERLWVNS DFNFDNVLSA MMALFTVSTF EGWPALLYKA
1110 1120 1130 1140 1150
IDANAEDEGP IYNYHVEISV FFIVYIIIIA FFMMNIFVGF VIITFRAQGE
1160 1170 1180 1190 1200
QEYQNCELDK NQRQCVEYAL KAQPLRRYIP KNPHQYRVWA TVNSRAFEYL
1210 1220 1230 1240 1250
MFLLILLNTV ALAMQHYEQT APFNYAMDIL NMVFTGLFTI EMVLKIIAFK
1260 1270 1280 1290 1300
PKHYFADAWN TFDALIVVGS VVDIAVTEVN NGGHLGESSE DTSRISITFF
1310 1320 1330 1340 1350
RLFRVMRLVK LLSKGEGIRT LLWTFIKSFQ ALPYVALLIA MIFFIYAVIG
1360 1370 1380 1390 1400
MQMFGLVALQ DGTQINRNNN FQTFPQAVLL LFRCATGEAW QEIMLASLPG
1410 1420 1430 1440 1450
NRCDPESDFG PGEEFTCGSS FAIVYFISFF MLCAFLIINL FVAVIMDNFD
1460 1470 1480 1490 1500
YLTRDWSILG PHHLDEFKRI WSEYDPGAKG RIKHLDVVAL LRRIQPPLGF
1510 1520 1530 1540 1550
GKLCPHRVAC KRLVAMNVPL NSDGTVTFNA TLFALVRTSL KIKTEGNLDQ
1560 1570 1580 1590 1600
ANQELRMVIK KIWKRIKQKL LDEVIPPPDE EEVTVGKFYA TFLIQDYFRK
1610 1620 1630 1640 1650
FRRRKEKGLL GREAPTSTSS ALQAGLRSLQ DLGPEIRQAL TYVTEEEEEE
1660 1670 1680 1690 1700
EEAVGQEAEE EEAENNPEPY KDSIDSQPQS RWNSRISVSL PVKEKLPDSL
1710 1720 1730 1740 1750
STGPSDDDGL APNSRQPSVI QAGSQPHRRS SGVFMFTIPE EGSIQLKGTQ
1760 1770 1780 1790 1800
GQDNQNEEQE LPDWTPDLDR AGRDSFEPSP FTTSLVQQHV NGHMSTPTFA
1810 1820 1830 1840 1850
APHACRSEPS FTIQCLQRLG SCEDLPIPGT YHRGRTSGPS RAQGSWAAPP
1860 1870 1880 1890 1900
QKGRLLYAPL LLVEESTVGE GYLGKLGGPL RTFTCLQVPG AHPNPSHRKR
1910 1920 1930 1940 1950
GSADSLVEAV LISEGLGLFA QDPRFVALAK QEIADACHLT LDEMDSAASD
1960 1970 1980
LLAQRTISLY SDEESILSRF DEEDLGDEMA CVHAL
Length:1,985
Mass (Da):221,926
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC365A105614ACAD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TNI3Q7TNI3_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f Cav1.4
1,984Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVA4B1AVA4_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f
1,977Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C8Q4Q8C8Q4_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f
844Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R182S4R182_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f
431Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVA5B1AVA5_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVA6B1AVA6_MOUSE
Voltage-dependent L-type calcium ch...
Cacna1f
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF192497 mRNA Translation: AAF86764.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192497 mRNA Translation: AAF86764.1

3D structure databases

SMRiQ9JIS7
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-61285N
IntActiQ9JIS7, 1 interactor
STRINGi10090.ENSMUSP00000111391

Chemistry databases

BindingDBiQ9JIS7
ChEMBLiCHEMBL2176791
DrugCentraliQ9JIS7
GuidetoPHARMACOLOGYi531

PTM databases

GlyGeniQ9JIS7, 1 site
iPTMnetiQ9JIS7
PhosphoSitePlusiQ9JIS7

Proteomic databases

MaxQBiQ9JIS7
PaxDbiQ9JIS7
PRIDEiQ9JIS7
ProteomicsDBi273885

Organism-specific databases

MGIiMGI:1859639, Cacna1f

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
InParanoidiQ9JIS7

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9JIS7
RNActiQ9JIS7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1F_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JIS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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