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UniProtKB - Q9JIS1 (RIMS2_RAT)

Entry version 166 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Regulating synaptic membrane exocytosis protein 2

Gene

Rims2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri86 – 142FYVE-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 2
Alternative name(s):
Rab-3-interacting molecule 2
Short name:
RIM 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rims2
Synonyms:Rim2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...RGDi		620001, Rims2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902031 – 1555Regulating synaptic membrane exocytosis protein 2Add BLAST1555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei369PhosphoserineBy similarity1
Modified residuei611PhosphothreonineBy similarity1
Modified residuei713PhosphoserineBy similarity1
Modified residuei716PhosphoserineBy similarity1
Modified residuei1106PhosphoserineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1543PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9JIS1

PRoteomics IDEntifications database

More...PRIDEi		Q9JIS1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9JIS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9JIS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000004201, Expressed in brain and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9JIS1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9JIS1, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with PCLO.

Part of a ternary complex involving PCLO and EPAC2.

Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding.

Interacts with TSPOAP1 and RIMBP2.

Interacts with PPFIA3 and PPFIA4.

Interacts via its zinc finger with the first C2 domain of UNC13A.

Forms a complex consisting of UNC13A, RIMS2 and RAB3A.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		250611, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9JIS1

Database of interacting proteins

More...DIPi		DIP-29192N

Protein interaction database and analysis system

More...IntActi		Q9JIS1, 2 interactors

Molecular INTeraction database

More...MINTi		Q9JIS1

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000045165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11555
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9JIS1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9JIS1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9JIS1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 154RabBDPROSITE-ProRule annotationAdd BLAST129
Domaini590 – 676PDZPROSITE-ProRule annotationAdd BLAST87
Domaini743 – 866C2 1PROSITE-ProRule annotationAdd BLAST124
Domaini1401 – 1519C2 2PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1194 – 1315Ser-richAdd BLAST122

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri86 – 142FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2060, Eukaryota
KOG3799, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_071205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9JIS1

Database of Orthologous Groups

More...OrthoDBi		109268at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR030631, RIM2
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR12157, PTHR12157, 1 hit
PTHR12157:SF15, PTHR12157:SF15, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF17820, PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 10 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JIS1-1) [UniParc]FASTAAdd to basket
Also known as: RIM2-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII QAVMDRQKKE 
        60         70         80         90        100
EEKEQSVLKK LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF 
       110        120        130        140        150
ADGCGHNCSY CQTKFCARCG GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW 
       160        170        180        190        200
FYNSGSNTPQ QPDQKALRGL RSEEAPQEKK AKLHEQTQFQ GPPGDSSVPA 
       210        220        230        240        250
VERGRAHGLT RQDSIKNGSG MKHQIASDMP SDRKRSPSVS RDQNRRYDQS 
       260        270        280        290        300
EEREEYSQYV PSDSTMPRSP SDYADRRSQR EPQFYEEPDH LNYRDSNRRG 
       310        320        330        340        350
HRHSKEYIVD DEDVESRDEY ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE 
       360        370        380        390        400
EQMRIHAEVS RARHERRHSD VSLANAELED SRISLLRMDR PSRQRSVSER 
       410        420        430        440        450
RAAMENQRSY SMERTREAQG QSSYPQRTTN HSPPTPRRSP IPLDRPELRR 
       460        470        480        490        500
ADSLRKQHHL DPSSAVRKTK REKMETMLRN DSLSSDQSES VRPPPPRPHK 
       510        520        530        540        550
SKKGGKMRQV SLSSSEEELA STPEYTSCDD VEIESESVGE KGDMEYSWLE 
       560        570        580        590        600
HASWHSSEAS PMSLHPVTWQ PSKDGDRLIG RILLNKRLKD GSVPRDSGAM 
       610        620        630        640        650
LGLKVVGGKM TESGRLCAFI TKVKKGSLAD TVGHLRPGDE VLEWNGRLLQ 
       660        670        680        690        700
GATFEEVYNI ILESKPEPQV ELVVSRPIGD MPRIPDSTHA QLESSSSSFE 
       710        720        730        740        750
SQKMDRPSIS VTSPMSPGML RDVPQFLSGQ LSSQSLSRRT TPFVPRVQIK 
       760        770        780        790        800
LWFDKVGHQL IVTILGAKDL PSREDGRPRN PYVKIYFLPD RSDKNKRRTK 
       810        820        830        840        850
TVKKTLEPKW NQTFIYSPVH RREFRERMLE ITLWDQARVR EEESEFLGEI 
       860        870        880        890        900
LIELETALLD DEPHWYKLQT HDVSSLPLPH PSPYMPRRQL HGESPTRRLQ 
       910        920        930        940        950
RSKRISDSEV SDYDCEDGVG VVSDYRHDGR DLQSSTLSVP EQVMSSNHCS 
       960        970        980        990       1000
PSGSPHRVDV IGRTRSWSPS VPPPQRNVEQ GLRGTRATGH YNTISRMDRH 
      1010       1020       1030       1040       1050
RVMDDHYSSE RDSHFLTLPR SRHRQTSEHH HRDGRDCEAA DRQPYHRSRS 
      1060       1070       1080       1090       1100
TEQRPLLERT TTRSRSSERA DTNLMRSMPS LMTGRSAPPS PALSRSHPRT 
      1110       1120       1130       1140       1150
GSVQTSPSST PVTGRRGRQL PQLPPKGTLE RMITEDMDST RKRNSGAMDI 
      1160       1170       1180       1190       1200
EERNRQMKLN KYKQVAGSDP RLEQDYHSKY RSGWDPHRGA DTVSTKSSDS 
      1210       1220       1230       1240       1250
DVSDVSAVSR TSSASRFSST SYMSVQSERP RGNRKISVFT SKMQSRQMGV 
      1260       1270       1280       1290       1300
SGKSMAKSTS ISGDMCSLEK NDGSQSDTAV GALGTSGKKR RSSIGAKMVA 
      1310       1320       1330       1340       1350
IVGLSRKSRS ASQLSQTEGG GKKLRSTVQR STETGLAVEM RNWMTRQASR 
      1360       1370       1380       1390       1400
ESTDGSMNSY SSEGNLIFPG VRLASDSQFS DFLDGLGPAQ LVGRQTLATP 
      1410       1420       1430       1440       1450
AMGDIQVGMM DKKGQLEVEI IRARGLVVKP GSKTLPAPYV KVYLLDNGVC 
      1460       1470       1480       1490       1500
IAKKKTKVAR KTLEPLYQQL LSFEESPQGK VLQIIVWGDY GRMDHKSFMG 
      1510       1520       1530       1540       1550
VAQILLDELE LSNMVIGWFK LFPPSSLVDP TLAPLTRRAS QSSLESSTGP 

SYSRS
Length:1,555
Mass (Da):175,913
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD76967BB36D9704E
GO
Isoform 2 (identifier: Q9JIS1-2) [UniParc]FASTAAdd to basket
Also known as: RIM2-2B

The sequence of this isoform differs from the canonical sequence as follows:
     544-564: MEYSWLEHASWHSSEASPMSL → SQKGKRKTSE...LNEERSHSDE
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,399
Mass (Da):158,946
Checksum:i3F1550E3D52D237B
GO
Isoform 3 (identifier: Q9JIS1-3) [UniParc]FASTAAdd to basket
Also known as: RIM2-4C

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1013-1034: Missing.
     1132-1318: Missing.

Show »
Length:1,330
Mass (Da):151,045
Checksum:i485906E1F668FC73
GO
Isoform 4 (identifier: Q9JIS1-4) [UniParc]FASTAAdd to basket
Also known as: RIM2-5C, RIM2-2A, RIM2-3B, RIM2-4A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,352
Mass (Da):153,719
Checksum:i5E1E6F0F42DFEA9C
GO
Isoform 5 (identifier: Q9JIS1-5) [UniParc]FASTAAdd to basket
Also known as: RIM2-3A

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1318: Missing.

Show »
Length:1,368
Mass (Da):155,560
Checksum:iCE08E16F0B383A11
GO
Isoform 6 (identifier: Q9JIS1-6) [UniParc]FASTAAdd to basket
Also known as: RIM2-4B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1035-1094: Missing.
     1132-1318: Missing.

Show »
Length:1,292
Mass (Da):146,934
Checksum:iE15B2C2B25452094
GO
Isoform 7 (identifier: Q9JIS1-7) [UniParc]FASTAAdd to basket
Also known as: RIM2-beta, RIM2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: MSAPLGPRGR...HQIASDMPSD → MQFETLRQVC...ELFGQTLNNA

Show »
Length:1,363
Mass (Da):154,503
Checksum:iC100863603514145
GO
Isoform 8 (identifier: Q9JIS1-8) [UniParc]FASTAAdd to basket
Also known as: RIM2-5B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1146: MITEDMDSTRKRNSG → S

Show »
Length:1,525
Mass (Da):172,436
Checksum:iD4930D6D2F03CF21
GO
Isoform 9 (identifier: Q9JIS1-9) [UniParc]FASTAAdd to basket
Also known as: RIM2-5A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.

Show »
Length:1,539
Mass (Da):174,072
Checksum:i12882D2F4EE0AE8C
GO
Isoform 10 (identifier: Q9JIS1-10) [UniParc]FASTAAdd to basket
Also known as: RIM2-gamma, NIM2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1270: Missing.
     1271-1317: NDGSQSDTAV...SRSASQLSQT → MGRQGLGGTG...CMNSLEEDEG

Show »
Length:285
Mass (Da):30,944
Checksum:iDBE7F39B93C4616C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LNC5F1LNC5_RAT
Regulating synaptic membrane exocyt...
Rims2
1,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096P6M3A0A096P6M3_RAT
Regulating synaptic membrane exocyt...
Rims2
1,498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096P6M8A0A096P6M8_RAT
Regulating synaptic membrane exocyt...
Rims2
1,525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081921 – 1270Missing in isoform 10. 1 PublicationAdd BLAST1270
Alternative sequenceiVSP_0081851 – 232MSAPL…DMPSD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 7. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_008186544 – 564MEYSW…SPMSL → SQKGKRKTSEQAVWSDSNTR SERQKKVMYSGGHSLDEDLE WSEPQTKDSGVDTCSSTTLN EERSHSDE in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_008187733 – 748Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 8 and isoform 9. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0081881013 – 1034Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0081911035 – 1094Missing in isoform 6. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0081891132 – 1318Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_0081901132 – 1146MITED…KRNSG → S in isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0081931271 – 1317NDGSQ…QLSQT → MGRQGLGGTGAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEDEG in isoform 10. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF199322 mRNA Translation: AAF81644.1
AF199323 mRNA Translation: AAF81645.1
AF199324 mRNA Translation: AAF81646.1
AF199325 mRNA Translation: AAF81647.1
AF199326 mRNA Translation: AAF81648.1
AF199327 mRNA Translation: AAF81649.1
AF199328 mRNA Translation: AAF81650.1
AF199329 mRNA Translation: AAF81651.1
AF199330 mRNA Translation: AAF81652.1
AF199331 mRNA Translation: AAF81653.1
AF199332 mRNA Translation: AAF81654.1
AF199335 mRNA Translation: AAF81657.1
AF548738 mRNA Translation: AAN59930.1

NCBI Reference Sequences

More...RefSeqi		NP_446397.1, NM_053945.2 [Q9JIS1-1]
NP_665888.1, NM_145881.2 [Q9JIS1-10]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201 [Q9JIS1-10]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:116839

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199322 mRNA Translation: AAF81644.1
AF199323 mRNA Translation: AAF81645.1
AF199324 mRNA Translation: AAF81646.1
AF199325 mRNA Translation: AAF81647.1
AF199326 mRNA Translation: AAF81648.1
AF199327 mRNA Translation: AAF81649.1
AF199328 mRNA Translation: AAF81650.1
AF199329 mRNA Translation: AAF81651.1
AF199330 mRNA Translation: AAF81652.1
AF199331 mRNA Translation: AAF81653.1
AF199332 mRNA Translation: AAF81654.1
AF199335 mRNA Translation: AAF81657.1
AF548738 mRNA Translation: AAN59930.1
RefSeqiNP_446397.1, NM_053945.2 [Q9JIS1-1]
NP_665888.1, NM_145881.2 [Q9JIS1-10]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A20NMR-A83-142[»]
2BWQX-ray1.41A725-869[»]
2CJSX-ray1.78C83-142[»]
BMRBiQ9JIS1
SMRiQ9JIS1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi250611, 4 interactors
CORUMiQ9JIS1
DIPiDIP-29192N
IntActiQ9JIS1, 2 interactors
MINTiQ9JIS1
STRINGi10116.ENSRNOP00000045165

PTM databases

iPTMnetiQ9JIS1
PhosphoSitePlusiQ9JIS1

Proteomic databases

PaxDbiQ9JIS1
PRIDEiQ9JIS1

Genome annotation databases

EnsembliENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201 [Q9JIS1-10]
GeneIDi116839
KEGGirno:116839

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9699
RGDi620001, Rims2

Phylogenomic databases

eggNOGiKOG2060, Eukaryota
KOG3799, Eukaryota
GeneTreeiENSGT00940000155236
HOGENOMiCLU_071205_0_0_1
InParanoidiQ9JIS1
OrthoDBi109268at2759

Miscellaneous databases

EvolutionaryTraceiQ9JIS1

Protein Ontology

More...PROi		PR:Q9JIS1

Gene expression databases

BgeeiENSRNOG00000004201, Expressed in brain and 21 other tissues
ExpressionAtlasiQ9JIS1, baseline and differential
GenevisibleiQ9JIS1, RN

Family and domain databases

Gene3Di2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR030631, RIM2
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR12157, PTHR12157, 1 hit
PTHR12157:SF15, PTHR12157:SF15, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF17820, PDZ_6, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JIS1
Secondary accession number(s): Q8CIX2
, Q9JHJ6, Q9JIR2, Q9JIR5, Q9JIR6, Q9JIR7, Q9JIR8, Q9JIR9, Q9JIS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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