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Entry version 163 (17 Jun 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Regulating synaptic membrane exocytosis protein 2

Gene

Rims2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri86 – 142FYVE-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 2
Alternative name(s):
Rab-3-interacting molecule 2
Short name:
RIM 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rims2
Synonyms:Rim2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
620001 Rims2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902031 – 1555Regulating synaptic membrane exocytosis protein 2Add BLAST1555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei369PhosphoserineBy similarity1
Modified residuei611PhosphothreonineBy similarity1
Modified residuei713PhosphoserineBy similarity1
Modified residuei716PhosphoserineBy similarity1
Modified residuei1106PhosphoserineCombined sources1
Modified residuei1200PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1543PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JIS1

PRoteomics IDEntifications database

More...
PRIDEi
Q9JIS1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JIS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JIS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004201 Expressed in brain and 8 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JIS1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JIS1 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with PCLO.

Part of a ternary complex involving PCLO and EPAC2.

Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding.

Interacts with TSPOAP1 and RIMBP2.

Interacts with PPFIA3 and PPFIA4.

Interacts via its zinc finger with the first C2 domain of UNC13A.

Forms a complex consisting of UNC13A, RIMS2 and RAB3A.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9JIS1

Database of interacting proteins

More...
DIPi
DIP-29192N

Protein interaction database and analysis system

More...
IntActi
Q9JIS1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9JIS1

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000045165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11555
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JIS1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9JIS1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 154RabBDPROSITE-ProRule annotationAdd BLAST129
Domaini590 – 676PDZPROSITE-ProRule annotationAdd BLAST87
Domaini743 – 866C2 1PROSITE-ProRule annotationAdd BLAST124
Domaini1401 – 1519C2 2PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1194 – 1315Ser-richAdd BLAST122

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri86 – 142FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060 Eukaryota
KOG3799 Eukaryota
ENOG4111MA5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_071205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JIS1

KEGG Orthology (KO)

More...
KOi
K15297

Database of Orthologous Groups

More...
OrthoDBi
109268at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030631 RIM2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157 PTHR12157, 1 hit
PTHR12157:SF15 PTHR12157:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF17820 PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 10 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JIS1-1) [UniParc]FASTAAdd to basket
Also known as: RIM2-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII QAVMDRQKKE
60 70 80 90 100
EEKEQSVLKK LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF
110 120 130 140 150
ADGCGHNCSY CQTKFCARCG GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW
160 170 180 190 200
FYNSGSNTPQ QPDQKALRGL RSEEAPQEKK AKLHEQTQFQ GPPGDSSVPA
210 220 230 240 250
VERGRAHGLT RQDSIKNGSG MKHQIASDMP SDRKRSPSVS RDQNRRYDQS
260 270 280 290 300
EEREEYSQYV PSDSTMPRSP SDYADRRSQR EPQFYEEPDH LNYRDSNRRG
310 320 330 340 350
HRHSKEYIVD DEDVESRDEY ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE
360 370 380 390 400
EQMRIHAEVS RARHERRHSD VSLANAELED SRISLLRMDR PSRQRSVSER
410 420 430 440 450
RAAMENQRSY SMERTREAQG QSSYPQRTTN HSPPTPRRSP IPLDRPELRR
460 470 480 490 500
ADSLRKQHHL DPSSAVRKTK REKMETMLRN DSLSSDQSES VRPPPPRPHK
510 520 530 540 550
SKKGGKMRQV SLSSSEEELA STPEYTSCDD VEIESESVGE KGDMEYSWLE
560 570 580 590 600
HASWHSSEAS PMSLHPVTWQ PSKDGDRLIG RILLNKRLKD GSVPRDSGAM
610 620 630 640 650
LGLKVVGGKM TESGRLCAFI TKVKKGSLAD TVGHLRPGDE VLEWNGRLLQ
660 670 680 690 700
GATFEEVYNI ILESKPEPQV ELVVSRPIGD MPRIPDSTHA QLESSSSSFE
710 720 730 740 750
SQKMDRPSIS VTSPMSPGML RDVPQFLSGQ LSSQSLSRRT TPFVPRVQIK
760 770 780 790 800
LWFDKVGHQL IVTILGAKDL PSREDGRPRN PYVKIYFLPD RSDKNKRRTK
810 820 830 840 850
TVKKTLEPKW NQTFIYSPVH RREFRERMLE ITLWDQARVR EEESEFLGEI
860 870 880 890 900
LIELETALLD DEPHWYKLQT HDVSSLPLPH PSPYMPRRQL HGESPTRRLQ
910 920 930 940 950
RSKRISDSEV SDYDCEDGVG VVSDYRHDGR DLQSSTLSVP EQVMSSNHCS
960 970 980 990 1000
PSGSPHRVDV IGRTRSWSPS VPPPQRNVEQ GLRGTRATGH YNTISRMDRH
1010 1020 1030 1040 1050
RVMDDHYSSE RDSHFLTLPR SRHRQTSEHH HRDGRDCEAA DRQPYHRSRS
1060 1070 1080 1090 1100
TEQRPLLERT TTRSRSSERA DTNLMRSMPS LMTGRSAPPS PALSRSHPRT
1110 1120 1130 1140 1150
GSVQTSPSST PVTGRRGRQL PQLPPKGTLE RMITEDMDST RKRNSGAMDI
1160 1170 1180 1190 1200
EERNRQMKLN KYKQVAGSDP RLEQDYHSKY RSGWDPHRGA DTVSTKSSDS
1210 1220 1230 1240 1250
DVSDVSAVSR TSSASRFSST SYMSVQSERP RGNRKISVFT SKMQSRQMGV
1260 1270 1280 1290 1300
SGKSMAKSTS ISGDMCSLEK NDGSQSDTAV GALGTSGKKR RSSIGAKMVA
1310 1320 1330 1340 1350
IVGLSRKSRS ASQLSQTEGG GKKLRSTVQR STETGLAVEM RNWMTRQASR
1360 1370 1380 1390 1400
ESTDGSMNSY SSEGNLIFPG VRLASDSQFS DFLDGLGPAQ LVGRQTLATP
1410 1420 1430 1440 1450
AMGDIQVGMM DKKGQLEVEI IRARGLVVKP GSKTLPAPYV KVYLLDNGVC
1460 1470 1480 1490 1500
IAKKKTKVAR KTLEPLYQQL LSFEESPQGK VLQIIVWGDY GRMDHKSFMG
1510 1520 1530 1540 1550
VAQILLDELE LSNMVIGWFK LFPPSSLVDP TLAPLTRRAS QSSLESSTGP

SYSRS
Length:1,555
Mass (Da):175,913
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD76967BB36D9704E
GO
Isoform 2 (identifier: Q9JIS1-2) [UniParc]FASTAAdd to basket
Also known as: RIM2-2B

The sequence of this isoform differs from the canonical sequence as follows:
     544-564: MEYSWLEHASWHSSEASPMSL → SQKGKRKTSE...LNEERSHSDE
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,399
Mass (Da):158,946
Checksum:i3F1550E3D52D237B
GO
Isoform 3 (identifier: Q9JIS1-3) [UniParc]FASTAAdd to basket
Also known as: RIM2-4C

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1013-1034: Missing.
     1132-1318: Missing.

Show »
Length:1,330
Mass (Da):151,045
Checksum:i485906E1F668FC73
GO
Isoform 4 (identifier: Q9JIS1-4) [UniParc]FASTAAdd to basket
Also known as: RIM2-5C, RIM2-2A, RIM2-3B, RIM2-4A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1318: Missing.

Show »
Length:1,352
Mass (Da):153,719
Checksum:i5E1E6F0F42DFEA9C
GO
Isoform 5 (identifier: Q9JIS1-5) [UniParc]FASTAAdd to basket
Also known as: RIM2-3A

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1318: Missing.

Show »
Length:1,368
Mass (Da):155,560
Checksum:iCE08E16F0B383A11
GO
Isoform 6 (identifier: Q9JIS1-6) [UniParc]FASTAAdd to basket
Also known as: RIM2-4B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1035-1094: Missing.
     1132-1318: Missing.

Show »
Length:1,292
Mass (Da):146,934
Checksum:iE15B2C2B25452094
GO
Isoform 7 (identifier: Q9JIS1-7) [UniParc]FASTAAdd to basket
Also known as: RIM2-beta, RIM2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: MSAPLGPRGR...HQIASDMPSD → MQFETLRQVC...ELFGQTLNNA

Show »
Length:1,363
Mass (Da):154,503
Checksum:iC100863603514145
GO
Isoform 8 (identifier: Q9JIS1-8) [UniParc]FASTAAdd to basket
Also known as: RIM2-5B

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.
     1132-1146: MITEDMDSTRKRNSG → S

Show »
Length:1,525
Mass (Da):172,436
Checksum:iD4930D6D2F03CF21
GO
Isoform 9 (identifier: Q9JIS1-9) [UniParc]FASTAAdd to basket
Also known as: RIM2-5A

The sequence of this isoform differs from the canonical sequence as follows:
     733-748: Missing.

Show »
Length:1,539
Mass (Da):174,072
Checksum:i12882D2F4EE0AE8C
GO
Isoform 10 (identifier: Q9JIS1-10) [UniParc]FASTAAdd to basket
Also known as: RIM2-gamma, NIM2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1270: Missing.
     1271-1317: NDGSQSDTAV...SRSASQLSQT → MGRQGLGGTG...CMNSLEEDEG

Show »
Length:285
Mass (Da):30,944
Checksum:iDBE7F39B93C4616C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LNC5F1LNC5_RAT
Regulating synaptic membrane exocyt...
Rims2
1,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096P6M3A0A096P6M3_RAT
Regulating synaptic membrane exocyt...
Rims2
1,498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096P6M8A0A096P6M8_RAT
Regulating synaptic membrane exocyt...
Rims2
1,525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081921 – 1270Missing in isoform 10. 1 PublicationAdd BLAST1270
Alternative sequenceiVSP_0081851 – 232MSAPL…DMPSD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 7. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_008186544 – 564MEYSW…SPMSL → SQKGKRKTSEQAVWSDSNTR SERQKKVMYSGGHSLDEDLE WSEPQTKDSGVDTCSSTTLN EERSHSDE in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_008187733 – 748Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 8 and isoform 9. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0081881013 – 1034Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0081911035 – 1094Missing in isoform 6. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0081891132 – 1318Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_0081901132 – 1146MITED…KRNSG → S in isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0081931271 – 1317NDGSQ…QLSQT → MGRQGLGGTGAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEDEG in isoform 10. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF199322 mRNA Translation: AAF81644.1
AF199323 mRNA Translation: AAF81645.1
AF199324 mRNA Translation: AAF81646.1
AF199325 mRNA Translation: AAF81647.1
AF199326 mRNA Translation: AAF81648.1
AF199327 mRNA Translation: AAF81649.1
AF199328 mRNA Translation: AAF81650.1
AF199329 mRNA Translation: AAF81651.1
AF199330 mRNA Translation: AAF81652.1
AF199331 mRNA Translation: AAF81653.1
AF199332 mRNA Translation: AAF81654.1
AF199335 mRNA Translation: AAF81657.1
AF548738 mRNA Translation: AAN59930.1

NCBI Reference Sequences

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RefSeqi
NP_446397.1, NM_053945.2 [Q9JIS1-1]
NP_665888.1, NM_145881.2 [Q9JIS1-10]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201 [Q9JIS1-10]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116839

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:116839

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199322 mRNA Translation: AAF81644.1
AF199323 mRNA Translation: AAF81645.1
AF199324 mRNA Translation: AAF81646.1
AF199325 mRNA Translation: AAF81647.1
AF199326 mRNA Translation: AAF81648.1
AF199327 mRNA Translation: AAF81649.1
AF199328 mRNA Translation: AAF81650.1
AF199329 mRNA Translation: AAF81651.1
AF199330 mRNA Translation: AAF81652.1
AF199331 mRNA Translation: AAF81653.1
AF199332 mRNA Translation: AAF81654.1
AF199335 mRNA Translation: AAF81657.1
AF548738 mRNA Translation: AAN59930.1
RefSeqiNP_446397.1, NM_053945.2 [Q9JIS1-1]
NP_665888.1, NM_145881.2 [Q9JIS1-10]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A20NMR-A83-142[»]
2BWQX-ray1.41A725-869[»]
2CJSX-ray1.78C83-142[»]
SMRiQ9JIS1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiQ9JIS1
DIPiDIP-29192N
IntActiQ9JIS1, 2 interactors
MINTiQ9JIS1
STRINGi10116.ENSRNOP00000045165

PTM databases

iPTMnetiQ9JIS1
PhosphoSitePlusiQ9JIS1

Proteomic databases

PaxDbiQ9JIS1
PRIDEiQ9JIS1

Genome annotation databases

EnsembliENSRNOT00000006393; ENSRNOP00000006393; ENSRNOG00000004201 [Q9JIS1-10]
GeneIDi116839
KEGGirno:116839

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9699
RGDi620001 Rims2

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
KOG3799 Eukaryota
ENOG4111MA5 LUCA
GeneTreeiENSGT00940000155236
HOGENOMiCLU_071205_0_0_1
InParanoidiQ9JIS1
KOiK15297
OrthoDBi109268at2759

Miscellaneous databases

EvolutionaryTraceiQ9JIS1

Protein Ontology

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PROi
PR:Q9JIS1

Gene expression databases

BgeeiENSRNOG00000004201 Expressed in brain and 8 other tissues
ExpressionAtlasiQ9JIS1 baseline and differential
GenevisibleiQ9JIS1 RN

Family and domain databases

Gene3Di2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030631 RIM2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12157 PTHR12157, 1 hit
PTHR12157:SF15 PTHR12157:SF15, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF17820 PDZ_6, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JIS1
Secondary accession number(s): Q8CIX2
, Q9JHJ6, Q9JIR2, Q9JIR5, Q9JIR6, Q9JIR7, Q9JIR8, Q9JIR9, Q9JIS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: June 17, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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