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Protein

Regulating synaptic membrane exocytosis protein 1

Gene

Rims1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • ion channel binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein kinase binding Source: UniProtKB
  • Rab GTPase binding Source: ParkinsonsUK-UCL
  • SH3 domain binding Source: RGD

GO - Biological processi

Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 1
Alternative name(s):
Rab-3-interacting molecule 1
Short name:
RIM 1
Gene namesi
Name:Rims1
Synonyms:Rim1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620000 Rims1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902001 – 1615Regulating synaptic membrane exocytosis protein 1Add BLAST1615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei745PhosphoserineBy similarity1
Modified residuei895PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1175PhosphoserineCombined sources1
Modified residuei1177PhosphothreonineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1233PhosphoserineCombined sources1
Modified residuei1234PhosphoserineCombined sources1
Modified residuei1262PhosphoserineBy similarity1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1339PhosphoserineCombined sources1
Modified residuei1600PhosphoserineCombined sources1
Modified residuei1603PhosphoserineCombined sources1
Modified residuei1606PhosphoserineBy similarity1
Modified residuei1615PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by BRSK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9JIR4

PTM databases

iPTMnetiQ9JIR4
PhosphoSitePlusiQ9JIR4

Expressioni

Tissue specificityi

Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at lower levels in midbrain, hindbrain and spinal cord. Detected retina and in spinal cord motor neurons.1 Publication

Interactioni

Subunit structurei

Interacts with RAB3C, RAB10, RAB26 AND RAB37 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Binds UNC13A. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1.By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ9JIR4
DIPiDIP-41432N
ELMiQ9JIR4
IntActiQ9JIR4, 8 interactors
MINTiQ9JIR4

Structurei

Secondary structure

11615
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JIR4
SMRiQ9JIR4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JIR4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 205RabBDPROSITE-ProRule annotationAdd BLAST184
Domaini619 – 705PDZPROSITE-ProRule annotationAdd BLAST87
Domaini758 – 864C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini1461 – 1563C2 2PROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi422 – 455Ala-richAdd BLAST34
Compositional biasi444 – 483Pro-richAdd BLAST40
Compositional biasi1259 – 1301Ser-richAdd BLAST43

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri133 – 193FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG058147
InParanoidiQ9JIR4
KOiK15291
PhylomeDBiQ9JIR4

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030630 RIM1
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
PANTHERiPTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JIR4-1) [UniParc]FASTAAdd to basket
Also known as: Rim1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE
60 70 80 90 100
EAMLKCVVRD MAKPAACKTP RNAESQPHQP PLNIFRCVCV PRKPSSEEGG
110 120 130 140 150
PERDWRLHQQ FESYKEQVRK IGEEARRYQG EHKDDAPTCG ICHKTKFADG
160 170 180 190 200
CGHLCSYCRT KFCARCGGRV SLRSNNEDKV VMWVCNLCRK QQEILTKSGA
210 220 230 240 250
WFFGSGPQQP SQDGTLSDTA TGAGSEVPRE KKARLQERSR SQTPLSTAAV
260 270 280 290 300
SSQDTATPGA PLHRNKGAEP SQQALGPEQK QASRSRSEPP RERKKAPGLS
310 320 330 340 350
EQNGKGGQKS ERKRVPKSVV QPGEGIADER ERKERRETRR LEKGRSQDYS
360 370 380 390 400
DRPEKRDNGR VAEDQKQRKE EEYQTRYRSD PNLARYPVKA PPEEQQMRMH
410 420 430 440 450
ARVSRARHER RHSDVALPHT EAAAAAPAEA TAGKRAPATA RVSPPESPRA
460 470 480 490 500
RAAAAQPPTE HGPPPPRPAP GPAEPPEPRV PEPLRKQGRL DPGSAVLLRK
510 520 530 540 550
AKREKAESML RNDSLSSDQS ESVRPSPPKP HRPKRGGKRR QMSVSSSEEE
560 570 580 590 600
GVSTPEYTSC EDVELESESV SEKGDLDYYW LDPATWHSRE TSPISSHPVT
610 620 630 640 650
WQPSKEGDRL IGRVILNKRT TMPKESGALL GLKVVGGKMT DLGRLGAFIT
660 670 680 690 700
KVKKGSLADV VGHLRAGDEV LEWNGKPLPG ATNEEVYNII LESKSEPQVE
710 720 730 740 750
IIVSRPIGDI PRIPESSHPP LESSSSSFES QKMERPSISV ISPTSPGALK
760 770 780 790 800
DAPQVLPGQL SVKLWYDKVG HQLIVNVLQA TDLPPRVDGR PRNPYVKMYF
810 820 830 840 850
LPDRSDKSKR RTKTVKKLLE PKWNQTFVYS HVHRRDFRER MLEITVWDQP
860 870 880 890 900
RVQDEESEFL GEILIELETA LLDDEPHWYK LQTHDESSLP LPQPSPFMPR
910 920 930 940 950
RHIHGESSSK KLQRSQRISD SDISDYEVDD GIGVVPPVGY RASARESKAT
960 970 980 990 1000
TLTVPEQQRT THHRSRSVSP HRGDDQGRPR SRLPNVPLQR SLDEIHPTRR
1010 1020 1030 1040 1050
SRSPTRHHDA SRSPADHRSR HVESQYSSEP DSELLMLPRA KRGRSAESLH
1060 1070 1080 1090 1100
MTSELQPSLD RARSASTNCL RPDTSLHSPE RERHSRKSER CSIQKQSRKG
1110 1120 1130 1140 1150
TASDADRVLP PCLSRRGYAT PRATDQPVVR GKYPTRSRSS EHSSVRTLCS
1160 1170 1180 1190 1200
MHHLAPGGSA PPSPLLLTRT HRQGSPTQSP PADTSFGSRR GRQLPQVPVR
1210 1220 1230 1240 1250
SGSIEQASLV VEERTRQMKV KVHRFKQTTG SGSSQELDHE QYSKYNIHKD
1260 1270 1280 1290 1300
QYRSCDNASA KSSDSDVSDV SAISRASSTS RLSSTSFMSE QSERPRGRIS
1310 1320 1330 1340 1350
SFTPKMQGRR MGTSGRAIIK STSVSGEIYT LERNDGSQSD TAVGTVGAGG
1360 1370 1380 1390 1400
KKRRSSLSAK VVAIVSRRSR STSQLSQTES GHKKLKSTIQ RSTETGMAAE
1410 1420 1430 1440 1450
MRKMVRQPSR ESTDGSINSY SSEGNLIFPG VRVGPDSQFS DFLDGLGPAQ
1460 1470 1480 1490 1500
LVGRQTLATP AMGDIQIGME DKKGQLEVEV IRARSLTQKP GSKSTPAPYV
1510 1520 1530 1540 1550
KVYLLENGAC IAKKKTRIAR KTLDPLYQQS LVFDESPQGK VLQVIVWGDY
1560 1570 1580 1590 1600
GRMDHKCFMG VAQILLEELD LSSMVIGWYK LFPPSSLVDP TLAPLTRRAS
1610
QSSLESSSGP PCIRS
Length:1,615
Mass (Da):179,655
Last modified:October 1, 2000 - v1
Checksum:i80E76F74BF35FB7E
GO
Isoform 2 (identifier: Q9JIR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1107-1168: Missing.

Show »
Length:1,553
Mass (Da):172,965
Checksum:iD6643997E65D03EE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JT77A0A0G2JT77_RAT
Regulating synaptic membrane exocyt...
Rims1
1,614Annotation score:
F1LYS1F1LYS1_RAT
Regulating synaptic membrane exocyt...
Rims1
1,553Annotation score:
A0A0G2K708A0A0G2K708_RAT
Regulating synaptic membrane exocyt...
Rims1
1,613Annotation score:
A0A0G2KA18A0A0G2KA18_RAT
Regulating synaptic membrane exocyt...
Rims1
1,553Annotation score:
A0A0G2KAV8A0A0G2KAV8_RAT
Regulating synaptic membrane exocyt...
Rims1
1,448Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0081721107 – 1168Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007836 mRNA Translation: AAB66703.1
AF199333 mRNA Translation: AAF81655.1
PIRiT03301
RefSeqiNP_439894.1, NM_052829.1 [Q9JIR4-2]
UniGeneiRn.10799

Genome annotation databases

GeneIDi84556
KEGGirno:84556
UCSCiRGD:620000 rat [Q9JIR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007836 mRNA Translation: AAB66703.1
AF199333 mRNA Translation: AAF81655.1
PIRiT03301
RefSeqiNP_439894.1, NM_052829.1 [Q9JIR4-2]
UniGeneiRn.10799

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUBNMR-A597-705[»]
2Q3XX-ray1.73A/B1447-1615[»]
ProteinModelPortaliQ9JIR4
SMRiQ9JIR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9JIR4
DIPiDIP-41432N
ELMiQ9JIR4
IntActiQ9JIR4, 8 interactors
MINTiQ9JIR4

PTM databases

iPTMnetiQ9JIR4
PhosphoSitePlusiQ9JIR4

Proteomic databases

PRIDEiQ9JIR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84556
KEGGirno:84556
UCSCiRGD:620000 rat [Q9JIR4-1]

Organism-specific databases

CTDi22999
RGDi620000 Rims1

Phylogenomic databases

HOVERGENiHBG058147
InParanoidiQ9JIR4
KOiK15291
PhylomeDBiQ9JIR4

Miscellaneous databases

EvolutionaryTraceiQ9JIR4
PROiPR:Q9JIR4

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030630 RIM1
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
PANTHERiPTHR12157 PTHR12157, 2 hits
PTHR12157:SF19 PTHR12157:SF19, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIMS1_RAT
AccessioniPrimary (citable) accession number: Q9JIR4
Secondary accession number(s): O35168
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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