UniProtKB - Q9JIR0 (RIMB1_RAT)
Protein
Peripheral-type benzodiazepine receptor-associated protein 1
Gene
Tspoap1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- benzodiazepine receptor binding Source: ParkinsonsUK-UCL
Enzyme and pathway databases
Reactomei | R-RNO-181429 Serotonin Neurotransmitter Release Cycle R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle R-RNO-196108 Pregnenolone biosynthesis R-RNO-210500 Glutamate Neurotransmitter Release Cycle R-RNO-212676 Dopamine Neurotransmitter Release Cycle R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Peripheral-type benzodiazepine receptor-associated protein 1Short name: PRAX-1 Alternative name(s): RIMS-binding protein 1 Short name: RIM-BP1 TSPO-associated protein 1Imported |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708563 Tspoap1 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Mitochondrion
- mitochondrion Source: RGD
Other locations
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221382 | 1 – 1847 | Peripheral-type benzodiazepine receptor-associated protein 1Add BLAST | 1847 |
Proteomic databases
PaxDbi | Q9JIR0 |
PRIDEi | Q9JIR0 |
PTM databases
PhosphoSitePlusi | Q9JIR0 |
Expressioni
Tissue specificityi
Specifically expressed in brain. High expression level in the limbic system such as the nucleus accumbens, septum, and hippocampus, as well as on the cerebellum and pineal gland. Abundant in the CA1 region of the hippocampus.3 Publications
Interactioni
Subunit structurei
Interacts with TSPO (By similarity).
Interacts with RIMS1 and RIMS2.
By similarity1 PublicationGO - Molecular functioni
- benzodiazepine receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010755 |
Chemistry databases
BindingDBi | Q9JIR0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 651 – 718 | SH3 1PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 789 – 880 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 882 – 974 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 979 – 1077 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 1617 – 1685 | SH3 2PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 1756 – 1823 | SH3 3PROSITE-ProRule annotationAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1256 – 1266 | Poly-GluAdd BLAST | 11 | |
Compositional biasi | 1326 – 1335 | Poly-Glu | 10 |
Domaini
The second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.
Sequence similaritiesi
Belongs to the RIMBP family.Curated
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG3632 Eukaryota ENOG410XZ8W LUCA |
HOGENOMi | HOG000139176 |
InParanoidi | Q9JIR0 |
PhylomeDBi | Q9JIR0 |
Family and domain databases
CDDi | cd00063 FN3, 1 hit cd12012 SH3_RIM-BP_2, 1 hit cd12013 SH3_RIM-BP_3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR035753 RIM-BP_SH3_2 IPR035755 RIM-BP_SH3_3 IPR040325 RIMBP1/2/3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain |
PANTHERi | PTHR14234 PTHR14234, 1 hit |
Pfami | View protein in Pfam PF07653 SH3_2, 2 hits PF14604 SH3_9, 1 hit |
SMARTi | View protein in SMART SM00060 FN3, 3 hits SM00326 SH3, 3 hits |
SUPFAMi | SSF49265 SSF49265, 1 hit SSF50044 SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50853 FN3, 3 hits PS50002 SH3, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9JIR0-1) [UniParc]FASTAAdd to basket
Also known as: Rbp1A, RIM binding protein 1A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQLTTLPRL GDPGAMEPWA LPAWQHWTQG QGCKPGDASA SIAATPTALQ
60 70 80 90 100
VKGLRFEESS EPAGAHSPGP IRNTDPEGTE TVLPKLGQQA ESPGYSCSRL
110 120 130 140 150
EGEDAQAYKA KFNIGFGDRP NLELLRALGE LQQHCTILKE ENQMLRKSSF
160 170 180 190 200
PETEEKVRRL KRKNAELAVI AKRLEERAQK LQETNMRGGE VPLCPDPDPV
210 220 230 240 250
WSCARKALAR QRARDLSETA TALLAKDKQN AALQRECREL QARLSLVGKE
260 270 280 290 300
GPQWLHMRDF DRLLRESQRE VLRLQRQIAL RNQREPLRPA RSQGSTAPSS
310 320 330 340 350
VGAPAPGAPG ETVLEDDVES PQVVLGEPEK QLRVQQLESE LCKKRKKCES
360 370 380 390 400
LEQEARKKQR RCEELELQLR AAQNENARLV EENSRLSGKA TEKEQVEWEN
410 420 430 440 450
AELKGQLLGV TQERDSALRK SQGLQSKLES LEQVLEHMRK VAQRRQQLEE
460 470 480 490 500
EHEQARLSLQ EKQEEVRRLQ QAQAEAKREH EGAVQLLEST LDSMQARVRE
510 520 530 540 550
LEGQCRSQTE RFSLLAQELQ AFRLHPGPLD LLTSALGCNA LGDHPPPHCC
560 570 580 590 600
CSSPQPCQGS GPKDLDLPPG SPGRCTPKSS EPALATLTGV PRRTAKKAES
610 620 630 640 650
LSNSSRSESI HNSPKSCPTP EVDTASEVEE LEVDSVSLLP AAPEGHSGGG
660 670 680 690 700
ARIQVFLARY SYNPFEGPNE NPEAELPLTA GEYIYIYGNM DEDGFFEGEL
710 720 730 740 750
MDGRRGLVPS NFVERVSDDD LLSTLPRELA DSSHSSGPEL SFLSGGGGGC
760 770 780 790 800
SSGGQSSGGR SQPRPEEEAT GDELSLSPPP EGLGEPLAVP YPRHITVLKQ
810 820 830 840 850
LAHSVVLAWE LPPERVDLRG FHIFVNGELR QALGPGVPPK AVLENMDLRA
860 870 880 890 900
GPLHVSVQAL TSKGSSDPLR CCLAMGAGAG VVPSQLRIHR LTATSAEITW
910 920 930 940 950
VPGNSNLAHA VYLNGEECPP ARPSTYWATF CNLRPGTLYQ ARVEAQIPSQ
960 970 980 990 1000
GPWEPGWERP ELRAATLQFT TLPAGLPDAP LDVQAEPGPS PGIVMISWLP
1010 1020 1030 1040 1050
VTIDAAGTSN GVRVTGYAVY ADGQKIMEVA SPTAGSVLVE VSQLQLLQAC
1060 1070 1080 1090 1100
HEVTVRTMSP HGESTDSIPA PVAPALASAC QPARMSCLSP RPSPEVRTPL
1110 1120 1130 1140 1150
ASVSPGLGYT SLPLRHPVPH GTQDSPASLS TEMSKGPQEE PPVPCSQEEA
1160 1170 1180 1190 1200
GSAVHRTSEE KRAMEPTLGQ EGPDPVAPFL AKQAVECTSG DAGPTPCSTQ
1210 1220 1230 1240 1250
EELTQKEPST EVCHRGDLDS ELKLRSEKEG MSELGVHLVN SLVDHSRNSD
1260 1270 1280 1290 1300
LSDIQEEEEE EEEEEELGSR PWSFQKQVAG NSIGENGAKP QPDPSCETDS
1310 1320 1330 1340 1350
DEEILEQILE LPLQRLCSKK LFSIPEEEEE EDEEEGLGKP GPSSSSQDPS
1360 1370 1380 1390 1400
QPERALLGLD CESSQPQGPG LCPLSPELSG AREHLEDVLG VVGGNSRRRG
1410 1420 1430 1440 1450
GCSPEKLPNR KRPQDPREHC SRLLGNGGPQ TSARPVPPRD RGSLPVIEGT
1460 1470 1480 1490 1500
RVGQEPGGRG RPGLSRRCPR GPAPESSLVS CLSPKCLEIS IEYDSEDEQE
1510 1520 1530 1540 1550
VGSGGVSISS SCYPTDGEAW GTAAVGRPRG PVKVNSGSNT YLRLPAWEKG
1560 1570 1580 1590 1600
EPERRGRSAI GRTKEPPSRA TETGESRGQD NSGRRGPQRR GARVLRTGTT
1610 1620 1630 1640 1650
ELAPPRSPQE APSHQDLPLR VFVALFDYDP ISMSPNPDAG EEELPFREGQ
1660 1670 1680 1690 1700
ILKVFGDKDA DGFYRGESGG RTGYIPCNMV AEVAVDTPTG RQQLLQRGFL
1710 1720 1730 1740 1750
PPNVLTQGSG NGPSVYPSAH TPGPPPKPRR SKKVELEDPA QLCPGPPKLI
1760 1770 1780 1790 1800
HSAALKTSRP MVAAFDYNPR ENSPNMDVEA ELPFRAGDVI TVFGNMDDDG
1810 1820 1830 1840
FYYGELNGQR GLVPSNFLEG PGPEAGGLDS GTSQAESQRT RRRRVQC
Note: No experimental confirmation available.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LPI6 | F1LPI6_RAT | Peripheral-type benzodiazepine rece... | Tspoap1 | 1,845 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009211 | 1063 – 1121 | Missing in isoform 2. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03073157 Genomic DNA No translation available. AF199337 mRNA Translation: AAF81659.1 AF199338 mRNA Translation: AAF81660.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03073157 Genomic DNA No translation available. AF199337 mRNA Translation: AAF81659.1 AF199338 mRNA Translation: AAF81660.1 |
3D structure databases
SMRi | Q9JIR0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010755 |
Chemistry databases
BindingDBi | Q9JIR0 |
PTM databases
PhosphoSitePlusi | Q9JIR0 |
Proteomic databases
PaxDbi | Q9JIR0 |
PRIDEi | Q9JIR0 |
Organism-specific databases
RGDi | 708563 Tspoap1 |
Phylogenomic databases
eggNOGi | KOG3632 Eukaryota ENOG410XZ8W LUCA |
HOGENOMi | HOG000139176 |
InParanoidi | Q9JIR0 |
PhylomeDBi | Q9JIR0 |
Enzyme and pathway databases
Reactomei | R-RNO-181429 Serotonin Neurotransmitter Release Cycle R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle R-RNO-196108 Pregnenolone biosynthesis R-RNO-210500 Glutamate Neurotransmitter Release Cycle R-RNO-212676 Dopamine Neurotransmitter Release Cycle R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle |
Miscellaneous databases
PROi | PR:Q9JIR0 |
Family and domain databases
CDDi | cd00063 FN3, 1 hit cd12012 SH3_RIM-BP_2, 1 hit cd12013 SH3_RIM-BP_3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR035753 RIM-BP_SH3_2 IPR035755 RIM-BP_SH3_3 IPR040325 RIMBP1/2/3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain |
PANTHERi | PTHR14234 PTHR14234, 1 hit |
Pfami | View protein in Pfam PF07653 SH3_2, 2 hits PF14604 SH3_9, 1 hit |
SMARTi | View protein in SMART SM00060 FN3, 3 hits SM00326 SH3, 3 hits |
SUPFAMi | SSF49265 SSF49265, 1 hit SSF50044 SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50853 FN3, 3 hits PS50002 SH3, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIMB1_RAT | |
Accessioni | Q9JIR0Primary (citable) accession number: Q9JIR0 Secondary accession number(s): Q9JIQ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | January 16, 2004 | |
Last modified: | November 13, 2019 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families