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Protein

Pannexin-1

Gene

Panx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels. May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: MGI
  • calcium channel activity Source: UniProtKB
  • channel activity Source: MGI
  • gap junction channel activity Source: MGI
  • gap junction hemi-channel activity Source: UniProtKB
  • ion channel binding Source: MGI
  • leak channel activity Source: UniProtKB
  • protease binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • scaffold protein binding Source: MGI
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-1
Gene namesi
Name:Panx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1860055 Panx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini62 – 106ExtracellularSequence analysisAdd BLAST45
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini128 – 216CytoplasmicSequence analysisAdd BLAST89
Transmembranei217 – 237HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini238 – 277ExtracellularSequence analysisAdd BLAST40
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini299 – 426CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40C → A: Abolishes S-nitrosylation; when associated with Ala-346. 1 Publication1
Mutagenesisi254N → Q: Impairs glycosylation. 1 Publication1
Mutagenesisi346C → A: Abolishes S-nitrosylation; when associated with Ala-40. 1 Publication1
Mutagenesisi426C → A: No effect on S-nitrosylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084851 – 426Pannexin-1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40S-nitrosocysteine1 Publication1
Glycosylationi254N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei346S-nitrosocysteine1 Publication1

Post-translational modificationi

N-glycosylation may play a role in cell surface targeting.1 Publication
S-nitrosylation inhibits channel currents and ATP release.1 Publication

Keywords - PTMi

Glycoprotein, S-nitrosylation

Proteomic databases

EPDiQ9JIP4
MaxQBiQ9JIP4
PaxDbiQ9JIP4
PRIDEiQ9JIP4

PTM databases

iPTMnetiQ9JIP4
PhosphoSitePlusiQ9JIP4

Expressioni

Tissue specificityi

Widely expressed, including in cartilage, skin, spleen and brain.

Gene expression databases

BgeeiENSMUSG00000031934 Expressed in 236 organ(s), highest expression level in thymus
CleanExiMM_PANX1
ExpressionAtlasiQ9JIP4 baseline and differential
GenevisibleiQ9JIP4 MM

Interactioni

Subunit structurei

Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnab3P973822EBI-6272917,EBI-7261133

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JIP4, 4 interactors
MINTiQ9JIP4
STRINGi10090.ENSMUSP00000126405

Structurei

3D structure databases

SMRiQ9JIP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00390000009703
HOGENOMiHOG000063721
HOVERGENiHBG053497
InParanoidiQ9JIP4
KOiK03443
OMAiDRFQCKL
OrthoDBiEOG091G086D
PhylomeDBiQ9JIP4
TreeFamiTF333142

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JIP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIAHLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI
60 70 80 90 100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KSSLQSESGN
110 120 130 140 150
LPLWLHKFFP YILLLFAILL YLPALFWRFS AAPHLCSDLK FIMEELDKVY
160 170 180 190 200
NRAIKAAKSA RDLDLRDGPG PPGVTENVGQ SLWEISESHF KYPIVEQYLK
210 220 230 240 250
TKKNSSHLIM KYISCRLVTF VVILLACIYL SYYFSLSSLS DEFLCSIKSG
260 270 280 290 300
VLKNDSTIPD RFQCKLIAVG IFQLLSLINL IVYALLIPVV VYTFFIPFRQ
310 320 330 340 350
KTDILKVYEI LPTFDVLHFK SEGYNDLSLY NLFLEENISE LKSYKCLKVL
360 370 380 390 400
ENIKSNGQGI DPMLLLTNLG MIKMDIIDGK IPTSLQTKGE DQGSQRVEFK
410 420
DLDLSSEAAA NNGEKNSRQR LLNPSC
Length:426
Mass (Da):48,167
Last modified:July 27, 2011 - v3
Checksum:i86AF6167C5D39565
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1PL19B1PL19_MOUSE
Pannexin-1
Panx1
112Annotation score:
E9PY07E9PY07_MOUSE
Pannexin-1
Panx1
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296I → T in AAF75838 (PubMed:10898987).Curated1
Sequence conflicti409A → R in AAF75838 (PubMed:10898987).Curated1
Sequence conflicti422 – 426LNPSC → CESVLLMVSFLNFKPVTSVA DAPLLDL in AAF75838 (PubMed:10898987).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207817 mRNA Translation: AAF75838.1
AK014033 mRNA Translation: BAB29125.1
AK053871 mRNA Translation: BAC35567.1
AK089764 mRNA Translation: BAC40956.1
CH466522 Genomic DNA Translation: EDL25014.1
BC049074 mRNA Translation: AAH49074.1
CCDSiCCDS22832.1
RefSeqiNP_062355.2, NM_019482.2
UniGeneiMm.142253

Genome annotation databases

EnsembliENSMUST00000164273; ENSMUSP00000126405; ENSMUSG00000031934
GeneIDi55991
KEGGimmu:55991
UCSCiuc009ofi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207817 mRNA Translation: AAF75838.1
AK014033 mRNA Translation: BAB29125.1
AK053871 mRNA Translation: BAC35567.1
AK089764 mRNA Translation: BAC40956.1
CH466522 Genomic DNA Translation: EDL25014.1
BC049074 mRNA Translation: AAH49074.1
CCDSiCCDS22832.1
RefSeqiNP_062355.2, NM_019482.2
UniGeneiMm.142253

3D structure databases

SMRiQ9JIP4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIP4, 4 interactors
MINTiQ9JIP4
STRINGi10090.ENSMUSP00000126405

PTM databases

iPTMnetiQ9JIP4
PhosphoSitePlusiQ9JIP4

Proteomic databases

EPDiQ9JIP4
MaxQBiQ9JIP4
PaxDbiQ9JIP4
PRIDEiQ9JIP4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164273; ENSMUSP00000126405; ENSMUSG00000031934
GeneIDi55991
KEGGimmu:55991
UCSCiuc009ofi.1 mouse

Organism-specific databases

CTDi24145
MGIiMGI:1860055 Panx1

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00390000009703
HOGENOMiHOG000063721
HOVERGENiHBG053497
InParanoidiQ9JIP4
KOiK03443
OMAiDRFQCKL
OrthoDBiEOG091G086D
PhylomeDBiQ9JIP4
TreeFamiTF333142

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-844456 The NLRP3 inflammasome

Miscellaneous databases

ChiTaRSiPanx1 mouse
PROiPR:Q9JIP4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031934 Expressed in 236 organ(s), highest expression level in thymus
CleanExiMM_PANX1
ExpressionAtlasiQ9JIP4 baseline and differential
GenevisibleiQ9JIP4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
IPR039099 Pannexin
PANTHERiPTHR15759 PTHR15759, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPANX1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP4
Secondary accession number(s): Q5RL18, Q9CXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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