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Entry version 130 (16 Oct 2019)
Sequence version 3 (14 May 2014)
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Protein

DNA excision repair protein ERCC-6-like 2

Gene

Ercc6l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in early DNA damage response.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi147 – 154ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA excision repair protein ERCC-6-like 2 (EC:3.6.4.-)
Alternative name(s):
DNA repair and recombination protein RAD26-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ercc6l2
Synonyms:Rad26l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923501 Ercc6l2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260871 – 1537DNA excision repair protein ERCC-6-like 2Add BLAST1537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei968PhosphoserineCombined sources1
Modified residuei971PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JIM3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JIM3

PRoteomics IDEntifications database

More...
PRIDEi
Q9JIM3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JIM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JIM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021470 Expressed in 261 organ(s), highest expression level in metanephric cortical collecting duct

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JIM3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JIM3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NEK6.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093392

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 319Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST186
Domaini510 – 660Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi270 – 273DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0387 Eukaryota
ENOG410XP4Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074171

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JIM3

KEGG Orthology (KO)

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KOi
K20098

Identification of Orthologs from Complete Genome Data

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OMAi
QTRYFEG

Database of Orthologous Groups

More...
OrthoDBi
372069at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR029256 Heliccase-ass-bd
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
PF14773 VIGSSK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JIM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDISAPQSRA DSRKDRWCPG ERCLAPSLDN KKLCEASIKS ITVDGNGKPF
60 70 80 90 100
AVVLYPDFQE KTIPLQRLQE VKSTKDYSRS LIFDDKDLEK PYFPDRKIPS
110 120 130 140 150
LASAFQLSED GDSIPYTINR YLRDYQREGA QFLYRHYIEG RGCILGDDMG
160 170 180 190 200
LGKTIQVISF LAAVLHKKGT REDIENNMPE FLLKSMKKKP PSTAKKMFLI
210 220 230 240 250
VAPLSVLYNW KDELDTWGYF RVTVLHGSKK DNELLRLKQR KCEIALTTYE
260 270 280 290 300
TLRLCLEELN SLEWSAIIVD EAHRIKNPKA RVTEVMKAVK CKVRIGLTGT
310 320 330 340 350
VLQNNMKELW CVMDWAVPGL LGSRIHFKKQ FSDPVEHGQR HTATKRELAT
360 370 380 390 400
GRKAMHRLAK KMSGWFLRRT KTLIKGQLPK KEDRMVYCSL TDFQKAVYQT
410 420 430 440 450
VLETEDVALI LTSSQPCTCG SGQKRRKCCY KTNSRGDTVR TLCLSYLTVL
460 470 480 490 500
QKVANHVALL QAASTSKHQE TVIKRICDRV FSRFPDFVQK SKDAAFETLS
510 520 530 540 550
DPKYSGKMKV LQQLLNHFRK QRDKVLLFSF STKLLDVLQQ YCMASGLDYR
560 570 580 590 600
RLDGSTKSEE RLKIVKEFNS SQDVNICLVS TMAGGLGLNF VGANVVILFD
610 620 630 640 650
PTWNPANDLQ AVDRAYRIGQ CRDVKVLRLI SLGTVEEIMY LRQVYKQQLH
660 670 680 690 700
CVVVGSENAK RYFEAVQGSK EHRGELFGVH NLFKLRSQGS CLTRDILERE
710 720 730 740 750
GQVEAGIMTA TTWLKGEPSA QELETPRDPD CQEPTDVCEL YSDISDEESV
760 770 780 790 800
GHSLGKTDKH KFSDTSRTPG FPAQLTLLQC GFSKLFEAKY KSDQDGDGNP
810 820 830 840 850
VPSDGSSDEQ PMCLSAEARQ AARQKTWDSV CTSEHQKSDN IQTPDEKCVS
860 870 880 890 900
DKSEKTLEQN VSSESDDETK DHRTAGHHCM GQGDTESEDS DVIFPTQYPT
910 920 930 940 950
QRIPKNHIRF KLLLGESEDS EAENPVKVNH GDDRQNSGRG NGPVPNLLCL
960 970 980 990 1000
ENMTSKSVRK RKGTDDISDE SDDIDMFPKS RIRKQRATTS LKFKRKKENK
1010 1020 1030 1040 1050
RKLDNSPVTA KEANQVCAAD GDRSSQVIED FSSSDDNLSL SHLSFTKLSH
1060 1070 1080 1090 1100
RAETVKDKIS LSPKLPGPDK KNNTFISRKP PSFLNEGVIS QEQICNSMDK
1110 1120 1130 1140 1150
ILDGVQEVAY IHSNQNVIGS SRAENHMSRW ATRDVFELKQ FSQLPANVAV
1160 1170 1180 1190 1200
CSSKTYKTQV KANIVSPTEK DQPPSDGGIS SPLYVSHPVV QKKKDVYRTN
1210 1220 1230 1240 1250
HTTFIIGETP RGIRRKQFEE MASYYKLPVK EFAEQVTRAT SEERQKMLRD
1260 1270 1280 1290 1300
FYSLQHPEVK EFFVNSASEL IKSVHKKEER VRNKSKEKES LLKENPSNDS
1310 1320 1330 1340 1350
TLSCYDSTNK MSQVYNRKIC EGKSVRSQNH VFHREDTFSS DAEINKSPVS
1360 1370 1380 1390 1400
FTEELHSERK DHTPKDTTTV FCPNSNSEAL EAELGNSPGR QWDLTGACGS
1410 1420 1430 1440 1450
RNRPLFKLRN KRVENPGSEN TPEDGLLGDT SILNDLFKSH GEGPTQLPKN
1460 1470 1480 1490 1500
VLSGPVAKAK QKPKDFWDIL NEQNDDSLSK LTDLAVIETL CTKAPSTSAS
1510 1520 1530
KRKDELEASL WKANEKFLWK TLSSDVDDES ISNTERE
Note: Gene prediction based on partial EST data.
Length:1,537
Mass (Da):173,873
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6980D5307FB2FF22
GO
Isoform 2 (identifier: Q9JIM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     699-699: R → V
     700-1537: Missing.

Show »
Length:699
Mass (Da):79,899
Checksum:i0BA3912C697A7A39
GO
Isoform 3 (identifier: Q9JIM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-156: TINRYLRDYQ...DDMGLGKTIQ → MPGSRPTCRA...PRSPAQTPAK
     583-1537: Missing.

Show »
Length:467
Mass (Da):53,069
Checksum:i741071999B26B78D
GO
Isoform 4 (identifier: Q9JIM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-273: SLEWSAIIVDEAH → RQTFCSSHHEHAS
     274-1537: Missing.

Show »
Length:273
Mass (Da):31,463
Checksum:iAC88934DF0E97D6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SJP9F6SJP9_MOUSE
DNA excision repair protein ERCC-6-...
Ercc6l2 0610007P08Rik
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JL31G8JL31_MOUSE
DNA excision repair protein ERCC-6-...
Ercc6l2 0610007P08Rik
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TW36F6TW36_MOUSE
DNA excision repair protein ERCC-6-...
Ercc6l2 0610007P08Rik
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QPI9E9QPI9_MOUSE
DNA excision repair protein ERCC-6-...
Ercc6l2 0610007P08Rik
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26917 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH32964 differs from that shown. Reason: Frameshift.Curated
The sequence AAH75679 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB24414 differs from that shown. The first 10 codons may be found on an alternative exon not observed on any other cDNA/EST.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18C → M in BAC38652 (PubMed:16141072).Curated1
Sequence conflicti26P → Q in BAC28927 (PubMed:16141072).Curated1
Sequence conflicti86K → E in AAF73858 (Ref. 3) Curated1
Sequence conflicti301V → I in AAF73858 (Ref. 3) Curated1
Sequence conflicti453V → I in AAF73858 (Ref. 3) Curated1
Sequence conflicti453V → I in AAH32964 (PubMed:15489334).Curated1
Sequence conflicti581T → P in BAC28927 (PubMed:16141072).Curated1
Sequence conflicti1294E → R in BAB24414 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546701 – 116Missing in isoform 3. 2 PublicationsAdd BLAST116
Alternative sequenceiVSP_054671117 – 156TINRY…GKTIQ → MPGSRPTCRALLAAESGGAA GCLPLARWTSPPRSPAQTPA K in isoform 3. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_054672261 – 273SLEWS…VDEAH → RQTFCSSHHEHAS in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_054673274 – 1537Missing in isoform 4. 1 PublicationAdd BLAST1264
Alternative sequenceiVSP_054674583 – 1537Missing in isoform 3. 2 PublicationsAdd BLAST955
Alternative sequenceiVSP_054675699R → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_054676700 – 1537Missing in isoform 2. 1 PublicationAdd BLAST838

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002307 mRNA Translation: BAB22002.1
AK006112 mRNA Translation: BAB24414.1 Sequence problems.
AK035054 mRNA Translation: BAC28927.1
AK082850 mRNA Translation: BAC38652.1
AC154248 Genomic DNA No translation available.
AF217319 mRNA Translation: AAF73858.1
BC026917 mRNA Translation: AAH26917.1 Different initiation.
BC032964 mRNA Translation: AAH32964.1 Frameshift.
BC075679 mRNA Translation: AAH75679.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36701.1 [Q9JIM3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001013626.2, NM_001013608.2 [Q9JIM3-1]
NP_075996.2, NM_023507.3 [Q9JIM3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000067821; ENSMUSP00000069488; ENSMUSG00000021470 [Q9JIM3-2]
ENSMUST00000144763; ENSMUSP00000152142; ENSMUSG00000021470 [Q9JIM3-4]
ENSMUST00000238465; ENSMUSP00000158755; ENSMUSG00000021470 [Q9JIM3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
76251

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:76251

UCSC genome browser

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UCSCi
uc007qyb.2 mouse [Q9JIM3-3]
uc007qyc.2 mouse [Q9JIM3-2]
uc007qye.2 mouse [Q9JIM3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002307 mRNA Translation: BAB22002.1
AK006112 mRNA Translation: BAB24414.1 Sequence problems.
AK035054 mRNA Translation: BAC28927.1
AK082850 mRNA Translation: BAC38652.1
AC154248 Genomic DNA No translation available.
AF217319 mRNA Translation: AAF73858.1
BC026917 mRNA Translation: AAH26917.1 Different initiation.
BC032964 mRNA Translation: AAH32964.1 Frameshift.
BC075679 mRNA Translation: AAH75679.1 Different initiation.
CCDSiCCDS36701.1 [Q9JIM3-2]
RefSeqiNP_001013626.2, NM_001013608.2 [Q9JIM3-1]
NP_075996.2, NM_023507.3 [Q9JIM3-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093392

PTM databases

iPTMnetiQ9JIM3
PhosphoSitePlusiQ9JIM3

Proteomic databases

EPDiQ9JIM3
PaxDbiQ9JIM3
PRIDEiQ9JIM3

Genome annotation databases

EnsembliENSMUST00000067821; ENSMUSP00000069488; ENSMUSG00000021470 [Q9JIM3-2]
ENSMUST00000144763; ENSMUSP00000152142; ENSMUSG00000021470 [Q9JIM3-4]
ENSMUST00000238465; ENSMUSP00000158755; ENSMUSG00000021470 [Q9JIM3-1]
GeneIDi76251
KEGGimmu:76251
UCSCiuc007qyb.2 mouse [Q9JIM3-3]
uc007qyc.2 mouse [Q9JIM3-2]
uc007qye.2 mouse [Q9JIM3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
375748
MGIiMGI:1923501 Ercc6l2

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00940000161328
HOGENOMiHOG000074171
InParanoidiQ9JIM3
KOiK20098
OMAiQTRYFEG
OrthoDBi372069at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ercc6l2 mouse

Protein Ontology

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PROi
PR:Q9JIM3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021470 Expressed in 261 organ(s), highest expression level in metanephric cortical collecting duct
ExpressionAtlasiQ9JIM3 baseline and differential
GenevisibleiQ9JIM3 MM

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR029256 Heliccase-ass-bd
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
PF14773 VIGSSK, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiER6L2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JIM3
Secondary accession number(s): E9Q4J6
, Q6DI94, Q8BIV4, Q8BM40, Q8K267, Q8R2Z6, Q9DA70, Q9DD01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 14, 2014
Last modified: October 16, 2019
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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