UniProtKB - Q9JIL6 (GPC5D_MOUSE)
Protein
G-protein coupled receptor family C group 5 member D
Gene
Gprc5d
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- protein kinase activator activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- hair cycle Source: UniProtKB
- keratinization Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor family C group 5 member D |
Gene namesi | Name:Gprc5d |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1935037, Gprc5d |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular exosome Source: GO_Central
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 63 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 64 – 84 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 93 | ExtracellularSequence analysis | 9 | |
Transmembranei | 94 – 114 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 115 – 124 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 125 – 145 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 167 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 168 – 188 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 189 – 204 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 205 – 225 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 239 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 240 – 260 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 344 | CytoplasmicSequence analysisAdd BLAST | 84 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206898 | 1 – 344 | G-protein coupled receptor family C group 5 member DAdd BLAST | 344 |
Proteomic databases
PaxDbi | Q9JIL6 |
PRIDEi | Q9JIL6 |
PTM databases
PhosphoSitePlusi | Q9JIL6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030205, Expressed in skin of back and 38 other tissues |
ExpressionAtlasi | Q9JIL6, baseline and differential |
Genevisiblei | Q9JIL6, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107553 |
Miscellaneous databases
RNActi | Q9JIL6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SKRS, Eukaryota |
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_044162_0_1_1 |
InParanoidi | Q9JIL6 |
OMAi | RSCKQDC |
PhylomeDBi | Q9JIL6 |
TreeFami | TF321410 |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9JIL6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYEDCVKSTE DYYLFCDNEG PWAIVLESLA VIGIVVTILL LLAFLFLMRK
60 70 80 90 100
VQDCSQWNVL PTQFLFLLAV LGLFGLTFAF IIQLNHQTAP VRYFLFGVLF
110 120 130 140 150
AICFSCLLAH ASNLVKLVRG RVSFCWTTIL FIAIGVSLLQ TIIAIEYVTL
160 170 180 190 200
IMTRGLMFEH MTPYQLNVDF VCLLIYVLFL MALTFFVSKA TFCGPCENWK
210 220 230 240 250
QHGRLIFATV LVSIIIWVVW ISMLLRGNPQ LQRQPHWDDA VICIGLVTNA
260 270 280 290 300
WVFLLIYIIP ELSILYRSCR QECPTQGNVC QVPVYQRSFR MDTQEPTRAR
310 320 330 340
DSDGAQEDVA LTAYGTPIQL QSADPSREYL IPSATLSPQQ DAGL
Sequence cautioni
The sequence BAC20266 differs from that shown. Reason: Frameshift.Curated
The sequence BAC20267 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | I → C (Ref. 3) Curated | 1 | |
Sequence conflicti | 234 – 235 | QP → HA in BAC20266 (Ref. 3) Curated | 2 | |
Sequence conflicti | 234 – 235 | QP → HA in BAC20267 (Ref. 3) Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010009 | 299 – 300 | AR → EC in isoform 2. 3 Publications | 2 | |
Alternative sequenceiVSP_010010 | 301 – 344 | Missing in isoform 2. 3 PublicationsAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF218809 mRNA Translation: AAF72880.1 AB099816 mRNA Translation: BAC79168.1 AB025221 mRNA Translation: BAC20266.1 Frameshift. AB025222 mRNA Translation: BAC20267.1 Frameshift. |
CCDSi | CCDS39680.1 [Q9JIL6-2] CCDS57462.1 [Q9JIL6-1] |
RefSeqi | NP_001192325.1, NM_001205396.1 [Q9JIL6-1] NP_444348.1, NM_053118.1 [Q9JIL6-2] |
Genome annotation databases
Ensembli | ENSMUST00000032327; ENSMUSP00000032327; ENSMUSG00000030205 [Q9JIL6-1] ENSMUST00000111922; ENSMUSP00000107553; ENSMUSG00000030205 [Q9JIL6-2] |
GeneIDi | 93746 |
KEGGi | mmu:93746 |
UCSCi | uc009elg.1, mouse [Q9JIL6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF218809 mRNA Translation: AAF72880.1 AB099816 mRNA Translation: BAC79168.1 AB025221 mRNA Translation: BAC20266.1 Frameshift. AB025222 mRNA Translation: BAC20267.1 Frameshift. |
CCDSi | CCDS39680.1 [Q9JIL6-2] CCDS57462.1 [Q9JIL6-1] |
RefSeqi | NP_001192325.1, NM_001205396.1 [Q9JIL6-1] NP_444348.1, NM_053118.1 [Q9JIL6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107553 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q9JIL6 |
Proteomic databases
PaxDbi | Q9JIL6 |
PRIDEi | Q9JIL6 |
Protocols and materials databases
Antibodypediai | 11949, 197 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032327; ENSMUSP00000032327; ENSMUSG00000030205 [Q9JIL6-1] ENSMUST00000111922; ENSMUSP00000107553; ENSMUSG00000030205 [Q9JIL6-2] |
GeneIDi | 93746 |
KEGGi | mmu:93746 |
UCSCi | uc009elg.1, mouse [Q9JIL6-1] |
Organism-specific databases
CTDi | 55507 |
MGIi | MGI:1935037, Gprc5d |
Phylogenomic databases
eggNOGi | ENOG502SKRS, Eukaryota |
GeneTreei | ENSGT00950000182961 |
HOGENOMi | CLU_044162_0_1_1 |
InParanoidi | Q9JIL6 |
OMAi | RSCKQDC |
PhylomeDBi | Q9JIL6 |
TreeFami | TF321410 |
Miscellaneous databases
BioGRID-ORCSi | 93746, 0 hits in 17 CRISPR screens |
PROi | PR:Q9JIL6 |
RNActi | Q9JIL6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030205, Expressed in skin of back and 38 other tissues |
ExpressionAtlasi | Q9JIL6, baseline and differential |
Genevisiblei | Q9JIL6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC5D_MOUSE | |
Accessioni | Q9JIL6Primary (citable) accession number: Q9JIL6 Secondary accession number(s): Q8CJI0, Q8CJI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries