UniProtKB - Q9JIK9 (RT34_MOUSE)
Protein
28S ribosomal protein S34, mitochondrial
Gene
Mrps34
Organism
Mus musculus (Mouse)
Status
Functioni
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.1 Publication
GO - Molecular functioni
- structural constituent of ribosome Source: MGI
GO - Biological processi
- mitochondrial translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-MMU-5389840, Mitochondrial translation elongation R-MMU-5419276, Mitochondrial translation termination |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S34, mitochondrialShort name: MRP-S34 Short name: S34mt Alternative name(s): T-complex expressed gene 2 protein |
Gene namesi | Name:Mrps34 Synonyms:Tce2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1930188, Mrps34 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial small ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 68 | L → P: Decreases protein expression. Decreases mitochondrial ribosomal subunits and translationally competent mitoribosomes. Mutant mice show heart hypertrophy and liver steatosis. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087731 | 1 – 218 | 28S ribosomal protein S34, mitochondrialAdd BLAST | 218 |
Proteomic databases
EPDi | Q9JIK9 |
jPOSTi | Q9JIK9 |
MaxQBi | Q9JIK9 |
PaxDbi | Q9JIK9 |
PeptideAtlasi | Q9JIK9 |
PRIDEi | Q9JIK9 |
PTM databases
iPTMneti | Q9JIK9 |
PhosphoSitePlusi | Q9JIK9 |
SwissPalmi | Q9JIK9 |
Expressioni
Tissue specificityi
Widely expressed (at protein liver).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000038880, Expressed in tibialis anterior and 299 other tissues |
Genevisiblei | Q9JIK9, MM |
Interactioni
Subunit structurei
Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Protein-protein interaction databases
BioGRIDi | 219729, 3 interactors |
ComplexPortali | CPX-5301, 28S mitochondrial small ribosomal subunit |
IntActi | Q9JIK9, 2 interactors |
MINTi | Q9JIK9 |
STRINGi | 10090.ENSMUSP00000045111 |
Miscellaneous databases
RNActi | Q9JIK9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mitochondrion-specific ribosomal protein mS34 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSI0, Eukaryota |
GeneTreei | ENSGT00390000008964 |
HOGENOMi | CLU_116794_0_0_1 |
InParanoidi | Q9JIK9 |
OMAi | AWGILTY |
OrthoDBi | 1475824at2759 |
PhylomeDBi | Q9JIK9 |
TreeFami | TF320386 |
Family and domain databases
InterProi | View protein in InterPro IPR032053, MRP-S34 |
PANTHERi | PTHR28589, PTHR28589, 1 hit |
Pfami | View protein in Pfam PF16053, MRP-S34, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JIK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARKKVRPRL IAELARRVRA LREQRNQPRD SQLYALDYET LTRPHSGRRL
60 70 80 90 100
PVRAWADVRR ESRLLQLLAR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV
110 120 130 140 150
RPDYTAQNLD HGRAWGILTF KGKSEDTARE IEQVMYHDWR LVPKHEEEAF
160 170 180 190 200
TAFTAKPEDR LNSVPYPPLL RAMILAERQK NGDTSVQEPL LNLERTRMRP
210
WDYPAKQETK GRAKGTPV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | K → E in BAB24970 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220294 Genomic DNA Translation: AAF69478.1 AK002285 mRNA Translation: BAB21988.1 AK004049 mRNA Translation: BAB23142.1 AK007337 mRNA Translation: BAB24970.1 AK019922 mRNA No translation available. BC024336 mRNA Translation: AAH24336.1 |
CCDSi | CCDS28502.1 |
RefSeqi | NP_075749.1, NM_023260.1 |
Genome annotation databases
Ensembli | ENSMUST00000043907; ENSMUSP00000045111; ENSMUSG00000038880 ENSMUST00000154236; ENSMUSP00000120985; ENSMUSG00000038880 |
GeneIDi | 79044 |
KEGGi | mmu:79044 |
UCSCi | uc008ayy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF220294 Genomic DNA Translation: AAF69478.1 AK002285 mRNA Translation: BAB21988.1 AK004049 mRNA Translation: BAB23142.1 AK007337 mRNA Translation: BAB24970.1 AK019922 mRNA No translation available. BC024336 mRNA Translation: AAH24336.1 |
CCDSi | CCDS28502.1 |
RefSeqi | NP_075749.1, NM_023260.1 |
3D structure databases
SMRi | Q9JIK9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 219729, 3 interactors |
ComplexPortali | CPX-5301, 28S mitochondrial small ribosomal subunit |
IntActi | Q9JIK9, 2 interactors |
MINTi | Q9JIK9 |
STRINGi | 10090.ENSMUSP00000045111 |
PTM databases
iPTMneti | Q9JIK9 |
PhosphoSitePlusi | Q9JIK9 |
SwissPalmi | Q9JIK9 |
Proteomic databases
EPDi | Q9JIK9 |
jPOSTi | Q9JIK9 |
MaxQBi | Q9JIK9 |
PaxDbi | Q9JIK9 |
PeptideAtlasi | Q9JIK9 |
PRIDEi | Q9JIK9 |
Protocols and materials databases
Antibodypediai | 23234, 282 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000043907; ENSMUSP00000045111; ENSMUSG00000038880 ENSMUST00000154236; ENSMUSP00000120985; ENSMUSG00000038880 |
GeneIDi | 79044 |
KEGGi | mmu:79044 |
UCSCi | uc008ayy.1, mouse |
Organism-specific databases
CTDi | 65993 |
MGIi | MGI:1930188, Mrps34 |
Phylogenomic databases
eggNOGi | ENOG502QSI0, Eukaryota |
GeneTreei | ENSGT00390000008964 |
HOGENOMi | CLU_116794_0_0_1 |
InParanoidi | Q9JIK9 |
OMAi | AWGILTY |
OrthoDBi | 1475824at2759 |
PhylomeDBi | Q9JIK9 |
TreeFami | TF320386 |
Enzyme and pathway databases
Reactomei | R-MMU-5389840, Mitochondrial translation elongation R-MMU-5419276, Mitochondrial translation termination |
Miscellaneous databases
BioGRID-ORCSi | 79044, 9 hits in 18 CRISPR screens |
ChiTaRSi | Mrps34, mouse |
PROi | PR:Q9JIK9 |
RNActi | Q9JIK9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038880, Expressed in tibialis anterior and 299 other tissues |
Genevisiblei | Q9JIK9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR032053, MRP-S34 |
PANTHERi | PTHR28589, PTHR28589, 1 hit |
Pfami | View protein in Pfam PF16053, MRP-S34, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT34_MOUSE | |
Accessioni | Q9JIK9Primary (citable) accession number: Q9JIK9 Secondary accession number(s): Q9D2B0, Q9D957 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries