UniProtKB - Q9JIK1 (CDHR5_RAT)
Cadherin-related family member 5
Cdhr5
Functioni
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
1 PublicationGO - Molecular functioni
- beta-catenin binding Source: RGD
- calcium ion binding Source: UniProtKB
- cell adhesion molecule binding Source: UniProtKB
GO - Biological processi
- cell adhesion Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- intermicrovillar adhesion Source: UniProtKB
- regulation of microvillus length Source: UniProtKB
Keywordsi
Biological process | Differentiation |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-related family member 5CuratedAlternative name(s): GP1001 Publication Mu-protocadherin1 Publication |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620504, Cdhr5 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Single-pass type I membrane protein By similarity
- microvillus membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- brush border membrane Source: UniProtKB
- clathrin-coated pit Source: RGD
- integral component of plasma membrane Source: GO_Central
- microvillus membrane Source: UniProtKB
- spanning component of plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 671 | ExtracellularSequence analysisAdd BLAST | 643 | |
Transmembranei | 672 – 692 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 693 – 862 | CytoplasmicSequence analysisAdd BLAST | 170 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000004014 | 29 – 862 | Cadherin-related family member 5Add BLAST | 834 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 438 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Modified residuei | 729 | PhosphoserineCombined sources | 1 | |
Modified residuei | 751 | PhosphoserineBy similarity | 1 | |
Modified residuei | 755 | PhosphoserineBy similarity | 1 | |
Modified residuei | 758 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 766 | PhosphoserineBy similarity | 1 | |
Modified residuei | 783 | PhosphoserineBy similarity | 1 | |
Modified residuei | 825 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 832 | PhosphoserineBy similarity | 1 | |
Modified residuei | 834 | PhosphoserineBy similarity | 1 | |
Modified residuei | 836 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9JIK1 |
PTM databases
GlyGeni | Q9JIK1, 9 sites |
iPTMneti | Q9JIK1 |
PhosphoSitePlusi | Q9JIK1 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000017762, Expressed in jejunum and 21 other tissues |
Genevisiblei | Q9JIK1, RN |
Interactioni
Subunit structurei
Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5.
Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation.
By similarityGO - Molecular functioni
- beta-catenin binding Source: RGD
- cell adhesion molecule binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044906 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 127 | Cadherin 1PROSITE-ProRule annotationCuratedAdd BLAST | 88 | |
Domaini | 128 – 240 | Cadherin 2PROSITE-ProRule annotationCuratedAdd BLAST | 113 | |
Domaini | 252 – 357 | Cadherin 3PROSITE-ProRule annotationCuratedAdd BLAST | 106 | |
Domaini | 358 – 462 | Cadherin 4PROSITE-ProRule annotationCuratedAdd BLAST | 105 | |
Repeati | 545 – 575 | 1CuratedAdd BLAST | 31 | |
Repeati | 576 – 606 | 2CuratedAdd BLAST | 31 | |
Repeati | 607 – 636 | 3CuratedAdd BLAST | 30 | |
Repeati | 637 – 648 | 4; truncatedAdd BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 452 – 658 | DisorderedSequence analysisAdd BLAST | 207 | |
Regioni | 545 – 648 | 4 X 31 AA approximate tandem repeatsAdd BLAST | 104 | |
Regioni | 693 – 862 | Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organizationBy similarityAdd BLAST | 170 | |
Regioni | 706 – 803 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 821 – 862 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 467 – 653 | Polar residuesSequence analysisAdd BLAST | 187 | |
Compositional biasi | 735 – 771 | Pro residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 772 – 786 | Polar residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000162463 |
HOGENOMi | CLU_021415_0_0_1 |
InParanoidi | Q9JIK1 |
OMAi | FLPCAYS |
OrthoDBi | 1107941at2759 |
PhylomeDBi | Q9JIK1 |
TreeFami | TF350567 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR030326, Mucdhl |
PANTHERi | PTHR24028:SF243, PTHR24028:SF243, 1 hit |
SMARTi | View protein in SMART SM00112, CA, 3 hits |
SUPFAMi | SSF49313, SSF49313, 2 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 1 hit PS50268, CADHERIN_2, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAPALLWPP LLLPLLTVLF GHLPGTLAQA QVCSANQTVF TMNENTTVSG
60 70 80 90 100
PLADIFVPED QYVTLGQLST PNAFKVEGNK LFLIVTPDYE ENSLLEAVLE
110 120 130 140 150
CKRGDTLVTQ FRVFVAVLDI NDNAPEFPFT IKEYNVSEDT RVNTIVIPET
160 170 180 190 200
ELKATDADKD DILVYTLQEV TPNASKFFSL VGINSPALKL DQTLDYYKSP
210 220 230 240 250
NMTFRLLARD TREENVIPSH TATATVVLNV LPADLRTPWF LPCSFTDDYF
260 270 280 290 300
CIQAQYHTVI PTGHKLPSPL ILSPGPIYAV DGDQAINQPI VYSIMMGNTD
310 320 330 340 350
DTFIINKDDG NLTMAKSIPS PMTFTLVVRA EQADMARYSV TQAVVEARDV
360 370 380 390 400
TGNPLQFSQS LYFGTVVLGS EAGTAVKDKT FPSEILRIQA QYLGFPDLNS
410 420 430 440 450
AVTYQVTNSS EFIMNKDILL TTVPMETERT IRIEVEANNT VTKDIATTIV
460 470 480 490 500
EIQVSEREPP STESPTPPEA GGTTGPSSNT TLETPSTSGT SQGPATTSSG
510 520 530 540 550
GSAGPFPPAG TTLSPLTSAP TVPGGSPTLG ISTSPQTATP GGDATQTPKP
560 570 580 590 600
GTSQPMVPTP GASTSSQPAT PSGSSTQTPK PGTSQPMVPT PGASTSSQPA
610 620 630 640 650
TPSGSSTQTP RPGTSQPMVP TPGASTSSQP ATPSGSTQTP KPGTSQPTTT
660 670 680 690 700
GPISGVGELG DGQRFSTVDM AVLGGVLGAL LLLALIFLII LIHKHYRHRF
710 720 730 740 750
TCCSGKAKEP QPSGYDNLTF LPDNKAKWSP TSNRKPEPGP EPVQPPLRPP
760 770 780 790 800
SPMSSSPTPP SSMPPSPQPK ASGSPKTVQA GDSPSAVRSI LTKERRPEGE
810 820 830 840 850
GGYKAVWFGK DIGAEADVVV LNEPTADVDS ASASGSEGSD DDDDPDQKKS
860
LRLGAVADNT YV
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050688 | 464 – 655 | Missing in isoform 2. 1 PublicationAdd BLAST | 192 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221952 mRNA Translation: AAF70456.1 BC098904 mRNA Translation: AAH98904.1 |
RefSeqi | NP_612534.1, NM_138525.1 [Q9JIK1-1] |
Genome annotation databases
Ensembli | ENSRNOT00000044238; ENSRNOP00000044906; ENSRNOG00000017762 [Q9JIK1-1] |
GeneIDi | 171554 |
KEGGi | rno:171554 |
UCSCi | RGD:620504, rat [Q9JIK1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF221952 mRNA Translation: AAF70456.1 BC098904 mRNA Translation: AAH98904.1 |
RefSeqi | NP_612534.1, NM_138525.1 [Q9JIK1-1] |
3D structure databases
SMRi | Q9JIK1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044906 |
PTM databases
GlyGeni | Q9JIK1, 9 sites |
iPTMneti | Q9JIK1 |
PhosphoSitePlusi | Q9JIK1 |
Proteomic databases
PaxDbi | Q9JIK1 |
Genome annotation databases
Ensembli | ENSRNOT00000044238; ENSRNOP00000044906; ENSRNOG00000017762 [Q9JIK1-1] |
GeneIDi | 171554 |
KEGGi | rno:171554 |
UCSCi | RGD:620504, rat [Q9JIK1-1] |
Organism-specific databases
CTDi | 53841 |
RGDi | 620504, Cdhr5 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000162463 |
HOGENOMi | CLU_021415_0_0_1 |
InParanoidi | Q9JIK1 |
OMAi | FLPCAYS |
OrthoDBi | 1107941at2759 |
PhylomeDBi | Q9JIK1 |
TreeFami | TF350567 |
Miscellaneous databases
PROi | PR:Q9JIK1 |
Gene expression databases
Bgeei | ENSRNOG00000017762, Expressed in jejunum and 21 other tissues |
Genevisiblei | Q9JIK1, RN |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR030326, Mucdhl |
PANTHERi | PTHR24028:SF243, PTHR24028:SF243, 1 hit |
SMARTi | View protein in SMART SM00112, CA, 3 hits |
SUPFAMi | SSF49313, SSF49313, 2 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 1 hit PS50268, CADHERIN_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CDHR5_RAT | |
Accessioni | Q9JIK1Primary (citable) accession number: Q9JIK1 Secondary accession number(s): Q4FZY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |