UniProtKB - Q9JII9 (CXCR3_RAT)
Protein
C-X-C chemokine receptor type 3
Gene
Cxcr3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity).By similarity
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: RGD
- C-X-C chemokine binding Source: UniProtKB
- C-X-C chemokine receptor activity Source: RGD
- identical protein binding Source: RGD
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- angiogenesis Source: UniProtKB-KW
- calcium-mediated signaling Source: RGD
- cell chemotaxis Source: GO_Central
- cell surface receptor signaling pathway Source: RGD
- chemokine (C-C motif) ligand 11 production Source: UniProtKB
- chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: GO_Central
- inflammatory response Source: InterPro
- negative regulation of angiogenesis Source: RGD
- negative regulation of endothelial cell proliferation Source: RGD
- negative regulation of execution phase of apoptosis Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of chemotaxis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of execution phase of apoptosis Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of cell adhesion Source: RGD
- regulation of leukocyte migration Source: InterPro
- T cell chemotaxis Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Angiogenesis, Chemotaxis |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 3Short name: CXC-R3 Short name: CXCR-3 Alternative name(s): Interferon-inducible protein 10 receptor Short name: IP-10 receptor CD_antigen: CD183 |
Gene namesi | Name:Cxcr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621528, Cxcr3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | ExtracellularSequence analysisAdd BLAST | 56 | |
Transmembranei | 57 – 77 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 89 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 90 – 110 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 125 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 126 – 146 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 147 – 168 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 169 – 189 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 190 – 222 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 223 – 243 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 255 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 256 – 276 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 300 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 301 – 321 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 322 – 367 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069348 | 1 – 367 | C-X-C chemokine receptor type 3Add BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 27 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 29 | SulfotyrosineBy similarity | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 202 | PROSITE-ProRule annotation | ||
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, SulfationProteomic databases
PaxDbi | Q9JII9 |
PRIDEi | Q9JII9 |
PTM databases
GlyGeni | Q9JII9, 3 sites |
PhosphoSitePlusi | Q9JII9 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000003305, Expressed in spleen and 19 other tissues |
ExpressionAtlasi | Q9JII9, baseline and differential |
Genevisiblei | Q9JII9, RN |
Interactioni
Subunit structurei
Homomer. Forms heteromers with ACKR4 (By similarity).
By similarityGO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: RGD
- C-X-C chemokine binding Source: UniProtKB
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000004406 |
Chemistry databases
BindingDBi | Q9JII9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | Q9JII9 |
OMAi | VWGLCLF |
OrthoDBi | 794531at2759 |
PhylomeDBi | Q9JII9 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR004070, Chemokine_CXCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01532, CXCCHMKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9JII9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF
60 70 80 90 100
DRTFLPVLYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL
110 120 130 140 150
LVLTLPLWAV DAAAQWVFGS GLCKVAGALF NINFYAGAFL LACISFDRYL
160 170 180 190 200
SIVHATQIYR RDPWVRVALT CIVVWGLCVL FALPDFIFLS ASHDQRLNAT
210 220 230 240 250
HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV LLVSRGQRRF
260 270 280 290 300
RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS
310 320 330 340 350
VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS
360
RRESSWSETT EASYLGL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A096MIV9 | A0A096MIV9_RAT | C-X-C chemokine receptor type 3 | Cxcr3 | 33 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF223642 mRNA Translation: AAF76982.1 BC091136 mRNA Translation: AAH91136.1 |
RefSeqi | NP_445867.1, NM_053415.1 |
Genome annotation databases
Ensembli | ENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305 |
GeneIDi | 84475 |
KEGGi | rno:84475 |
UCSCi | RGD:621528, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF223642 mRNA Translation: AAF76982.1 BC091136 mRNA Translation: AAH91136.1 |
RefSeqi | NP_445867.1, NM_053415.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000004406 |
Chemistry databases
BindingDBi | Q9JII9 |
ChEMBLi | CHEMBL1075172 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9JII9, 3 sites |
PhosphoSitePlusi | Q9JII9 |
Proteomic databases
PaxDbi | Q9JII9 |
PRIDEi | Q9JII9 |
Genome annotation databases
Ensembli | ENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305 |
GeneIDi | 84475 |
KEGGi | rno:84475 |
UCSCi | RGD:621528, rat |
Organism-specific databases
CTDi | 2833 |
RGDi | 621528, Cxcr3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | Q9JII9 |
OMAi | VWGLCLF |
OrthoDBi | 794531at2759 |
PhylomeDBi | Q9JII9 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:Q9JII9 |
Gene expression databases
Bgeei | ENSRNOG00000003305, Expressed in spleen and 19 other tissues |
ExpressionAtlasi | Q9JII9, baseline and differential |
Genevisiblei | Q9JII9, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004070, Chemokine_CXCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01532, CXCCHMKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR3_RAT | |
Accessioni | Q9JII9Primary (citable) accession number: Q9JII9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries