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Protein

Alcohol dehydrogenase [NADP(+)]

Gene

Akr1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).By similarity

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton donorBy similarity1
Sitei80Lowers pKa of active site TyrBy similarity1
Binding sitei113SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 20NADPSequence analysis10
Nucleotide bindingi211 – 273NADPBy similarityAdd BLAST63

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: GO_Central
  • alditol:NADP+ 1-oxidoreductase activity Source: MGI
  • L-glucuronate reductase activity Source: MGI
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.2 3474
ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-5661270 Formation of xylulose-5-phosphate
SABIO-RKiQ9JII6

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene namesi
Name:Akr1a1
Synonyms:Akr1a4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1929955 Akr1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001246182 – 325Alcohol dehydrogenase [NADP(+)]Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Modified residuei4PhosphoserineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Modified residuei127N6-acetyllysine; alternateCombined sources1
Modified residuei127N6-succinyllysine; alternateCombined sources1
Modified residuei145N6-succinyllysineCombined sources1
Modified residuei211PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JII6
MaxQBiQ9JII6
PaxDbiQ9JII6
PRIDEiQ9JII6

2D gel databases

REPRODUCTION-2DPAGEiIPI00466128
Q9JII6

PTM databases

iPTMnetiQ9JII6
PhosphoSitePlusiQ9JII6
SwissPalmiQ9JII6

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Detected at high levels in several tissues including neural ectoderm, gut endoderm, somites, branchial arches, otic vesicles, limb buds and tail bud.

Inductioni

Fear memory increases expression 7-fold.1 Publication

Gene expression databases

BgeeiENSMUSG00000028692 Expressed in 339 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9JII6 baseline and differential
GenevisibleiQ9JII6 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ9JII6, 6 interactors
MINTiQ9JII6
STRINGi10090.ENSMUSP00000030455

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JII6
SMRiQ9JII6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOVERGENiHBG000020
InParanoidiQ9JII6
KOiK00002
OMAiIVPMITV
OrthoDBiEOG091G0D69
PhylomeDBiQ9JII6
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JII6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASSVLLHT GQKMPLIGLG TWKSEPGQVK AAIKHALSAG YRHIDCASVY
60 70 80 90 100
GNETEIGEAL KESVGSGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA
110 120 130 140 150
DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTVRYDSTHY KETWKALEVL
160 170 180 190 200
VAKGLVKALG LSNFNSRQID DVLSVASVRP AVLQVECHPY LAQNELIAHC
210 220 230 240 250
HARGLEVTAY SPLGSSDRAW RHPDEPVLLE EPVVLALAEK HGRSPAQILL
260 270 280 290 300
RWQVQRKVIC IPKSINPSRI LQNIQVFDFT FSPEEMKQLD ALNKNWRYIV
310 320
PMITVDGKRV PRDAGHPLYP FNDPY
Length:325
Mass (Da):36,587
Last modified:January 23, 2007 - v3
Checksum:i0097939061DA34CB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AXW3B1AXW3_MOUSE
Alcohol dehydrogenase [NADP(+)]
Akr1a1
203Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54T → A in BAB27586 (PubMed:16141072).Curated1
Sequence conflicti60L → P in BAB27915 (PubMed:16141072).Curated1
Sequence conflicti95L → I in BAB27883 (PubMed:16141072).Curated1
Sequence conflicti95L → I in BAB27767 (PubMed:16141072).Curated1
Sequence conflicti120R → L in BAB27909 (PubMed:16141072).Curated1
Sequence conflicti284E → G in BAB27437 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225564 mRNA Translation: AAF67111.1
AK011906 mRNA Translation: BAB27907.1
AK009462 mRNA Translation: BAB26303.1
AK011321 mRNA Translation: BAB27543.1
AK011794 mRNA Translation: BAB27846.1
AK011908 mRNA Translation: BAB27909.1
AK011918 mRNA Translation: BAB27915.1
AK011856 mRNA Translation: BAB27883.1
AK011667 mRNA Translation: BAB27767.1
AK011388 mRNA Translation: BAB27586.1
AK011157 mRNA Translation: BAB27437.1
AK011209 mRNA Translation: BAB27469.1
AK005162 mRNA Translation: BAB23853.1
AK011221 mRNA No translation available.
BC039926 mRNA Translation: AAH39926.1
CCDSiCCDS18514.1
RefSeqiNP_067448.1, NM_021473.3
UniGeneiMm.30085
Mm.467921
Mm.489607

Genome annotation databases

EnsembliENSMUST00000030455; ENSMUSP00000030455; ENSMUSG00000028692
GeneIDi58810
KEGGimmu:58810
UCSCiuc008uha.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225564 mRNA Translation: AAF67111.1
AK011906 mRNA Translation: BAB27907.1
AK009462 mRNA Translation: BAB26303.1
AK011321 mRNA Translation: BAB27543.1
AK011794 mRNA Translation: BAB27846.1
AK011908 mRNA Translation: BAB27909.1
AK011918 mRNA Translation: BAB27915.1
AK011856 mRNA Translation: BAB27883.1
AK011667 mRNA Translation: BAB27767.1
AK011388 mRNA Translation: BAB27586.1
AK011157 mRNA Translation: BAB27437.1
AK011209 mRNA Translation: BAB27469.1
AK005162 mRNA Translation: BAB23853.1
AK011221 mRNA No translation available.
BC039926 mRNA Translation: AAH39926.1
CCDSiCCDS18514.1
RefSeqiNP_067448.1, NM_021473.3
UniGeneiMm.30085
Mm.467921
Mm.489607

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GACX-ray1.64A/B2-325[»]
ProteinModelPortaliQ9JII6
SMRiQ9JII6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JII6, 6 interactors
MINTiQ9JII6
STRINGi10090.ENSMUSP00000030455

PTM databases

iPTMnetiQ9JII6
PhosphoSitePlusiQ9JII6
SwissPalmiQ9JII6

2D gel databases

REPRODUCTION-2DPAGEiIPI00466128
Q9JII6

Proteomic databases

EPDiQ9JII6
MaxQBiQ9JII6
PaxDbiQ9JII6
PRIDEiQ9JII6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030455; ENSMUSP00000030455; ENSMUSG00000028692
GeneIDi58810
KEGGimmu:58810
UCSCiuc008uha.2 mouse

Organism-specific databases

CTDi10327
MGIiMGI:1929955 Akr1a1

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOVERGENiHBG000020
InParanoidiQ9JII6
KOiK00002
OMAiIVPMITV
OrthoDBiEOG091G0D69
PhylomeDBiQ9JII6
TreeFamiTF106492

Enzyme and pathway databases

BRENDAi1.1.1.2 3474
ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-5661270 Formation of xylulose-5-phosphate
SABIO-RKiQ9JII6

Miscellaneous databases

ChiTaRSiAkr1a1 mouse
PROiPR:Q9JII6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028692 Expressed in 339 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9JII6 baseline and differential
GenevisibleiQ9JII6 MM

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAK1A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JII6
Secondary accession number(s): Q9CQI5
, Q9CQT8, Q9CT53, Q9D012, Q9D016, Q9D0I7, Q9D0P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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