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1 to 25 of 26  Show
  1. 1
    "WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II."
    Xu B.-E., English J.M., Wilsbacher J.L., Stippec S., Goldsmith E.J., Cobb M.H.
    J. Biol. Chem. 275:16795-16801(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ACTIVITY REGULATION, SUBCELLULAR LOCATION, CAUTION, ACTIVE SITE, MUTAGENESIS OF LYS-233; CYS-250; LYS-256; LYS-259 AND ASP-368.
    Category: Function, Subcellular Location, Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform."
    Subramanya A.R., Yang C.L., Zhu X., Ellison D.H.
    Am. J. Physiol. 290:F619-F624(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), ALTERNATIVE SPLICING, FUNCTION (ISOFORM 5), SUBUNIT (ISOFORM 5).
    Category: Function, Interaction, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 18 other entries.

  3. 3
    "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 312-2126.
    Category: Sequences.
    Strain: Brown Norway.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 22748 other entries.

  4. 4
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 8 other entries.

  5. 5
    "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation."
    Xu B.-E., Min X., Stippec S., Lee B.H., Goldsmith E.J., Cobb M.H.
    J. Biol. Chem. 277:48456-48462(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, CAUTION, PHOSPHORYLATION AT SER-378 AND SER-382, REGION, MUTAGENESIS OF LYS-233; CYS-250; SER-378; SER-382; PHE-524 AND PHE-526.
    Category: Function, Pathology & Biotech, PTM / Processing, Family & Domains.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 9 other entries.

  6. 6
    "The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex."
    Yang C.L., Zhu X., Ellison D.H.
    J. Clin. Invest. 117:3403-3411(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH WNK3 AND WNK4.
    Category: Function, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 and mapped to 6 other entries.

  7. 7
    "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members."
    Heise C.J., Xu B.E., Deaton S.L., Cha S.K., Cheng C.J., Earnest S., Sengupta S., Juang Y.C., Stippec S., Xu Y., Zhao Y., Huang C.L., Cobb M.H.
    J. Biol. Chem. 285:25161-25167(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 7 and mapped to 23 other entries.

  8. 8
    "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-172; SER-1773 AND SER-1776, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: PTM / Processing, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 6815 other entries.

  9. 9
    "Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension."
    Min X., Lee B.-H., Cobb M.H., Goldsmith E.J.
    Structure 12:1303-1311(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 194-483 OF MUTANT ALA-382.
    Category: Pathology & Biotech, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  10. 10
    "Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain."
    Moon T.M., Correa F., Kinch L.N., Piala A.T., Gardner K.H., Goldsmith E.J.
    J. Mol. Biol. 425:1245-1252(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 480-572.
    Category: Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  11. 11
    "Chloride sensing by WNK1 involves inhibition of autophosphorylation."
    Piala A.T., Moon T.M., Akella R., He H., Cobb M.H., Goldsmith E.J.
    Sci. Signal. 7:RA41-RA41(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 194-480 OF MUTANT ALA-382, FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, PHOSPHORYLATION AT SER-382, MUTAGENESIS OF LEU-369 AND LEU-371.
    Category: Function, Pathology & Biotech, PTM / Processing, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 9 other entries.

  12. 12
    Category: Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  13. 13
    "WNK kinases regulate thiazide-sensitive Na-Cl cotransport."
    Yang C.-L., Angell J., Mitchell R., Ellison D.H.
    J. Clin. Invest. 111:1039-1045(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: WNK1 has a role in the sodium regulatory pathway of the distalImported.
    Source: GeneRIF:116477.

    This publication is cited by 1 and mapped to 22 other entries.

  14. 14
    "Comparison of WNK4 and WNK1 kinase and inhibiting activities."
    Wang Z., Yang C.L., Ellison D.H.
    Biochem. Biophys. Res. Commun. 317:939-944(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: RGD:621141.

    This publication is mapped to 1 other entry.

  15. 15
    "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding."
    Lee B.H., Min X., Heise C.J., Xu B.E., Chen S., Shu H., Luby-Phelps K., Goldsmith E.J., Cobb M.H.
    Mol. Cell 15:741-751(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q9JIH7, RGD:621141.

    This publication is mapped to 57 other entries.

  16. 16
    "The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport."
    Naray-Fejes-Toth A., Snyder P.M., Fejes-Toth G.
    Proc. Natl. Acad. Sci. U.S.A. 101:17434-17439(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: stimulation of KS-WNK1 expression might be an important element of aldosterone-induced Na(+) retention and hypertensionImported.
    Source: GeneRIF:116477.

    This publication is mapped to 10 other entries.

  17. 17
    "Properties of WNK1 and implications for other family members."
    Lenertz L.Y., Lee B.H., Min X., Xu B.E., Wedin K., Earnest S., Goldsmith E.J., Cobb M.H.
    J. Biol. Chem. 280:26653-26658(2005) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Source: PhosphoSitePlus:Q9JIH7.

    This publication is mapped to 11 other entries.

  18. 18
    "The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases."
    Vitari A.C., Deak M., Morrice N.A., Alessi D.R.
    Biochem. J. 391:17-24(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: WNK1 and WNK4 both interacted with SPAK as well as a closely related kinase termed oxidative stress response kinase-1 (OSR1).Imported.
    Source: RGD:621141, GeneRIF:116477.

    This publication is mapped to 8 other entries.

  19. 19
    "Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms."
    Lazrak A., Liu Z., Huang C.L.
    Proc. Natl. Acad. Sci. U.S.A. 103:1615-1620(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: ROMK is antagonistically regulated by long and kidney-specific WNK1 isoformsImported.
    Source: GeneRIF:116477.

    This publication is mapped to 16 other entries.

  20. 20
    "WNK1 affects surface expression of the ROMK potassium channel independent of WNK4."
    Cope G., Murthy M., Golbang A.P., Hamad A., Liu C.H., Cuthbert A.W., O'Shaughnessy K.M.
    J. Am. Soc. Nephrol. 17:1867-1874(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: RGD:621141.

    This publication is mapped to 1 other entry.

  21. 21
    "WNK1 and WNK4 modulate CFTR activity."
    Yang C.L., Liu X., Paliege A., Zhu X., Bachmann S., Dawson D.C., Ellison D.H.
    Biochem. Biophys. Res. Commun. 353:535-540(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: the effect of WNK1 on CFTR activity requires intact WNK1 kinase activity. Moreover WNK1 and WNK4 exhibit additive CFTR inhibitionImported.
    Source: GeneRIF:116477.

    This publication is mapped to 1 other entry.

  22. 22
    "Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II."
    Shekarabi M., Girard N., Riviere J.B., Dion P., Houle M., Toulouse A., Lafreniere R.G., Vercauteren F., Hince P., Laganiere J., Rochefort D., Faivre L., Samuels M., Rouleau G.A.
    J. Clin. Invest. 118:2496-2505(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).Imported.
    Source: GeneRIF:116477.

    This publication is cited by 1 and mapped to 24 other entries.

  23. 23
    "Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice."
    Xie J., Wu T., Xu K., Huang I.K., Cleaver O., Huang C.L.
    Am. J. Pathol. 175:1315-1327(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: a novel function of WNK1 in endothelial cells that is critical for angiogenesis and heart developmentImported.
    Source: GeneRIF:116477.

    This publication is mapped to 89 other entries.

  24. 24
    "Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses."
    Vorontsova I., Lam L., Delpire E., Lim J., Donaldson P.
    Invest. Ophthalmol. Vis. Sci. 56:310-321(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Source: RGD:621141.

    This publication is mapped to 23 other entries.

  25. 25
    "WNK1 is involved in Nogo66 inhibition of OPC differentiation."
    Zhang Z.H., Li J.J., Wang Q.J., Zhao W.Q., Hong J., Lou S.J., Xu X.H.
    Mol. Cell. Neurosci. 65:135-142(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: WNK1 interacts with LINGO1 in oligodendrocytes. Knockdown WNK1 attenuated Nogo66-induced inhibition of OPC maturation.Imported.
    Source: GeneRIF:116477.
1 to 25 of 26  Show
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