UniProtKB - Q9JIG8 (PRAF2_MOUSE)
Protein
PRA1 family protein 2
Gene
Praf2
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).By similarity
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: PRA1 family protein 2 |
Gene namesi | Name:Praf2 Synonyms:DXImx39e |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859607, Praf2 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein By similarity
Endosome
- endosome membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 64 | ExtracellularSequence analysis | 2 | |
Transmembranei | 65 – 85 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 96 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 97 – 119 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 120 – 122 | ExtracellularSequence analysis | 3 | |
Transmembranei | 123 – 140 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 141 – 178 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220882 | 1 – 178 | PRA1 family protein 2Add BLAST | 178 |
Proteomic databases
EPDi | Q9JIG8 |
MaxQBi | Q9JIG8 |
PaxDbi | Q9JIG8 |
PeptideAtlasi | Q9JIG8 |
PRIDEi | Q9JIG8 |
PTM databases
iPTMneti | Q9JIG8 |
PhosphoSitePlusi | Q9JIG8 |
SwissPalmi | Q9JIG8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031149, Expressed in brain and 65 other tissues |
Genevisiblei | Q9JIG8, MM |
Interactioni
Subunit structurei
Interacts with CCR5 and GDE1.
By similarityProtein-protein interaction databases
BioGRIDi | 207700, 5 interactors |
IntActi | Q9JIG8, 1 interactor |
STRINGi | 10090.ENSMUSP00000033489 |
Miscellaneous databases
RNActi | Q9JIG8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PRA1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4050, Eukaryota |
GeneTreei | ENSGT00390000008631 |
HOGENOMi | CLU_097683_0_0_1 |
InParanoidi | Q9JIG8 |
OMAi | WNNRIIN |
OrthoDBi | 1288023at2759 |
PhylomeDBi | Q9JIG8 |
TreeFami | TF105479 |
Family and domain databases
InterProi | View protein in InterPro IPR004895, Prenylated_rab_accept_PRA1 |
Pfami | View protein in Pfam PF03208, PRA1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JIG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEVRLPPLR ALDDFVLGSA RLAAPDPGDP QRWCHRVINN LLYYQTNYLL
60 70 80 90 100
CFGISLALAG YIRPLHTLLS ALVVVVALGV LVWAAETRAA VRRCRRSHPA
110 120 130 140 150
ACLAAVLAIS LFILWAVGGA FTFLLSITAP VFLILLHASL RLRNLKNKIE
160 170
NKIESIGLKR TPMGLLLEAL GQEQEAGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF229636 mRNA Translation: AAF66950.1 AK003344 mRNA Translation: BAB22729.1 BC064757 mRNA Translation: AAH64757.1 |
CCDSi | CCDS29971.1 |
RefSeqi | NP_613068.1, NM_138602.4 |
Genome annotation databases
Ensembli | ENSMUST00000033489; ENSMUSP00000033489; ENSMUSG00000031149 |
GeneIDi | 54637 |
KEGGi | mmu:54637 |
UCSCi | uc009sme.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF229636 mRNA Translation: AAF66950.1 AK003344 mRNA Translation: BAB22729.1 BC064757 mRNA Translation: AAH64757.1 |
CCDSi | CCDS29971.1 |
RefSeqi | NP_613068.1, NM_138602.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 207700, 5 interactors |
IntActi | Q9JIG8, 1 interactor |
STRINGi | 10090.ENSMUSP00000033489 |
PTM databases
iPTMneti | Q9JIG8 |
PhosphoSitePlusi | Q9JIG8 |
SwissPalmi | Q9JIG8 |
Proteomic databases
EPDi | Q9JIG8 |
MaxQBi | Q9JIG8 |
PaxDbi | Q9JIG8 |
PeptideAtlasi | Q9JIG8 |
PRIDEi | Q9JIG8 |
Protocols and materials databases
Antibodypediai | 34944, 141 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033489; ENSMUSP00000033489; ENSMUSG00000031149 |
GeneIDi | 54637 |
KEGGi | mmu:54637 |
UCSCi | uc009sme.1, mouse |
Organism-specific databases
CTDi | 11230 |
MGIi | MGI:1859607, Praf2 |
Phylogenomic databases
eggNOGi | KOG4050, Eukaryota |
GeneTreei | ENSGT00390000008631 |
HOGENOMi | CLU_097683_0_0_1 |
InParanoidi | Q9JIG8 |
OMAi | WNNRIIN |
OrthoDBi | 1288023at2759 |
PhylomeDBi | Q9JIG8 |
TreeFami | TF105479 |
Miscellaneous databases
BioGRID-ORCSi | 54637, 1 hit in 17 CRISPR screens |
ChiTaRSi | Praf2, mouse |
PROi | PR:Q9JIG8 |
RNActi | Q9JIG8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031149, Expressed in brain and 65 other tissues |
Genevisiblei | Q9JIG8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004895, Prenylated_rab_accept_PRA1 |
Pfami | View protein in Pfam PF03208, PRA1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRAF2_MOUSE | |
Accessioni | Q9JIG8Primary (citable) accession number: Q9JIG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families