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UniProtKB - Q9JIF5 (PECR_CAVPO)
Protein
Peroxisomal trans-2-enoyl-CoA reductase
Gene
PECR
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.
1 PublicationCatalytic activityi
- EC:1.3.1.381 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=11 µM for decenoyl-CoA1 Publication
- KM=53 µM for NADPH1 Publication
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 178 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 23 – 47 | NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
- trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniPathway
- phytol metabolic process Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.3.1.38, 1225 |
SABIO-RKi | Q9JIF5 |
UniPathwayi | UPA00094 |
Chemistry databases
SwissLipidsi | SLP:000001093 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PECR |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Peroxisome
- Peroxisome 1 Publication
Mitochondrion
- mitochondrion Source: UniProtKB
Peroxisome
- peroxisomal membrane Source: UniProtKB
Other locations
- intracellular membrane-bounded organelle Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000054739 | 2 – 302 | Peroxisomal trans-2-enoyl-CoA reductaseAdd BLAST | 301 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycineBy similarity | 1 | |
Modified residuei | 32 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 49 | PhosphoserineBy similarity | 1 | |
Modified residuei | 83 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 178 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinExpressioni
Tissue specificityi
Expressed in liver.1 Publication
Gene expression databases
Bgeei | ENSCPOG00000011717, Expressed in liver and 14 other tissues |
Interactioni
Subunit structurei
Interacts with PEX5, probably required to target it into peroxisomes.
By similarityGO - Molecular functioni
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000010538 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 300 – 302 | Microbody targeting signalBy similarity | 3 |
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
GeneTreei | ENSGT00940000156882 |
HOGENOMi | CLU_010194_1_2_1 |
InParanoidi | Q9JIF5 |
OMAi | RIWDSKV |
OrthoDBi | 1194344at2759 |
TreeFami | TF315256 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9JIF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSWTKCQSC LAPGLLQNRA AIVTGGGTGI GKAIAKELLH LGCNVVIASR
60 70 80 90 100
KFDRLRAAAE ELKATLPPSN KAEVTPIQCN IRKEEEVNNL MKSTLALYGK
110 120 130 140 150
IDFLVNNGGG QFWSSPEHIS SKGWHAVIET NLTGTFYMCK AAYNSWMKEH
160 170 180 190 200
GGAIVNIIIL LNGQPFVAHS GAARGGVYNL TKSLALGWAR SGIRINCVAP
210 220 230 240 250
GTVYSQTAMD NYGDMGKTLF ADAFQKIPAK RLGVPEEVSS LVCFLLSPAA
260 270 280 290 300
SFITGQLVNV DGGQSLYCQN HDIPDHDNWP EGVGDLSTVK KMKESFKQKA
KL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF232010 mRNA Translation: AAF69799.1 |
RefSeqi | XP_003462124.1, XM_003462076.3 |
Genome annotation databases
Ensembli | ENSCPOT00000011831; ENSCPOP00000010538; ENSCPOG00000011717 |
GeneIDi | 100725791 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF232010 mRNA Translation: AAF69799.1 |
RefSeqi | XP_003462124.1, XM_003462076.3 |
3D structure databases
AlphaFoldDBi | Q9JIF5 |
SMRi | Q9JIF5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000010538 |
Chemistry databases
SwissLipidsi | SLP:000001093 |
Genome annotation databases
Ensembli | ENSCPOT00000011831; ENSCPOP00000010538; ENSCPOG00000011717 |
GeneIDi | 100725791 |
Organism-specific databases
CTDi | 55825 |
Phylogenomic databases
eggNOGi | KOG0725, Eukaryota |
GeneTreei | ENSGT00940000156882 |
HOGENOMi | CLU_010194_1_2_1 |
InParanoidi | Q9JIF5 |
OMAi | RIWDSKV |
OrthoDBi | 1194344at2759 |
TreeFami | TF315256 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BRENDAi | 1.3.1.38, 1225 |
SABIO-RKi | Q9JIF5 |
Gene expression databases
Bgeei | ENSCPOG00000011717, Expressed in liver and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PECR_CAVPO | |
Accessioni | Q9JIF5Primary (citable) accession number: Q9JIF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families