UniProtKB - Q9JIE6 (TSLP_MOUSE)
Protein
Thymic stromal lymphopoietin
Gene
Tslp
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 37 | Inserts into a conserved IL7R hydrophobic pocket, important for IL7R-binding1 Publication | 1 |
GO - Molecular functioni
- cytokine activity Source: MGI
- interleukin-7 receptor binding Source: MGI
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- defense response to fungus Source: MGI
- defense response to Gram-negative bacterium Source: MGI
- negative regulation of apoptotic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of chemokine (C-C motif) ligand 1 production Source: MGI
- positive regulation of chemokine production Source: MGI
- positive regulation of cytokine-mediated signaling pathway Source: MGI
- positive regulation of granulocyte colony-stimulating factor production Source: MGI
- positive regulation of inflammatory response Source: MGI
- positive regulation of interleukin-10 production Source: MGI
- positive regulation of interleukin-13 production Source: MGI
- positive regulation of interleukin-5 production Source: MGI
- positive regulation of interleukin-6 production Source: MGI
- positive regulation of mast cell activation Source: MGI
- positive regulation of receptor signaling pathway via STAT Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
Reactomei | R-MMU-1266695, Interleukin-7 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Thymic stromal lymphopoietinAlternative name(s): Thymic stroma-derived lymphopoietin |
Gene namesi | Name:Tslp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1855696, Tslp |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000300874 | 20 – 140 | Thymic stromal lymphopoietinAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 25 ↔ 98 | 1 Publication | ||
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 57 ↔ 63 | 1 Publication | ||
Disulfide bondi | 78 ↔ 121 | 1 Publication | ||
Glycosylationi | 123 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JIE6 |
PRIDEi | Q9JIE6 |
PTM databases
GlyGeni | Q9JIE6, 3 sites |
PhosphoSitePlusi | Q9JIE6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024379, Expressed in heart left ventricle and 120 other tissues |
Genevisiblei | Q9JIE6, MM |
Interactioni
Subunit structurei
Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
1 PublicationBinary interactionsi
Q9JIE6
With | #Exp. | IntAct |
---|---|---|
Crlf2 [Q8CII9] | 9 | EBI-16096402,EBI-15887886 |
GO - Molecular functioni
- cytokine activity Source: MGI
- interleukin-7 receptor binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-60842N |
IntActi | Q9JIE6, 2 interactors |
STRINGi | 10090.ENSMUSP00000025237 |
Miscellaneous databases
RNActi | Q9JIE6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9JIE6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TEM0, Eukaryota |
GeneTreei | ENSGT00390000012541 |
HOGENOMi | CLU_143224_0_0_1 |
InParanoidi | Q9JIE6 |
OMAi | NPTPRCA |
OrthoDBi | 1389326at2759 |
PhylomeDBi | Q9JIE6 |
TreeFami | TF338216 |
Family and domain databases
Gene3Di | 1.20.1250.90, 1 hit |
InterProi | View protein in InterPro IPR029189, TSLP IPR038329, TSLP_sf |
PANTHERi | PTHR38003, PTHR38003, 1 hit |
Pfami | View protein in Pfam PF15216, TSLP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9JIE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK
60 70 80 90 100
FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG
110 120 130 140
YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF232937 mRNA Translation: AAF81677.1 BC130230 mRNA Translation: AAI30231.1 |
CCDSi | CCDS29121.1 |
RefSeqi | NP_067342.1, NM_021367.2 |
Genome annotation databases
Ensembli | ENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379 |
GeneIDi | 53603 |
KEGGi | mmu:53603 |
UCSCi | uc008ejl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF232937 mRNA Translation: AAF81677.1 BC130230 mRNA Translation: AAI30231.1 |
CCDSi | CCDS29121.1 |
RefSeqi | NP_067342.1, NM_021367.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4NN5 | X-ray | 1.90 | A | 20-140 | [»] | |
4NN6 | X-ray | 2.54 | A | 20-140 | [»] | |
4NN7 | X-ray | 3.78 | A | 20-140 | [»] | |
SMRi | Q9JIE6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-60842N |
IntActi | Q9JIE6, 2 interactors |
STRINGi | 10090.ENSMUSP00000025237 |
PTM databases
GlyGeni | Q9JIE6, 3 sites |
PhosphoSitePlusi | Q9JIE6 |
Proteomic databases
PaxDbi | Q9JIE6 |
PRIDEi | Q9JIE6 |
Protocols and materials databases
Antibodypediai | 25309, 818 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379 |
GeneIDi | 53603 |
KEGGi | mmu:53603 |
UCSCi | uc008ejl.2, mouse |
Organism-specific databases
CTDi | 85480 |
MGIi | MGI:1855696, Tslp |
Phylogenomic databases
eggNOGi | ENOG502TEM0, Eukaryota |
GeneTreei | ENSGT00390000012541 |
HOGENOMi | CLU_143224_0_0_1 |
InParanoidi | Q9JIE6 |
OMAi | NPTPRCA |
OrthoDBi | 1389326at2759 |
PhylomeDBi | Q9JIE6 |
TreeFami | TF338216 |
Enzyme and pathway databases
Reactomei | R-MMU-1266695, Interleukin-7 signaling |
Miscellaneous databases
BioGRID-ORCSi | 53603, 0 hits in 17 CRISPR screens |
PROi | PR:Q9JIE6 |
RNActi | Q9JIE6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024379, Expressed in heart left ventricle and 120 other tissues |
Genevisiblei | Q9JIE6, MM |
Family and domain databases
Gene3Di | 1.20.1250.90, 1 hit |
InterProi | View protein in InterPro IPR029189, TSLP IPR038329, TSLP_sf |
PANTHERi | PTHR38003, PTHR38003, 1 hit |
Pfami | View protein in Pfam PF15216, TSLP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSLP_MOUSE | |
Accessioni | Q9JIE6Primary (citable) accession number: Q9JIE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references