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Protein

DNA cross-link repair 1A protein

Gene

Dclre1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
DNA cross-link repair 1A protein
Alternative name(s):
SNM1 homolog A
Gene namesi
Name:Dclre1a
Synonyms:Kiaa0086, Snm1, Snm1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1930042 Dclre1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002091171 – 1026DNA cross-link repair 1A proteinAdd BLAST1026

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki522Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei574PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JIC3
PRIDEiQ9JIC3

PTM databases

iPTMnetiQ9JIC3
PhosphoSitePlusiQ9JIC3

Interactioni

Subunit structurei

Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026063

Structurei

3D structure databases

ProteinModelPortaliQ9JIC3
SMRiQ9JIC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 189Nuclear localization regionBy similarityAdd BLAST189
Regioni401 – 602Nuclear focus formationBy similarityAdd BLAST202

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1361 Eukaryota
COG1236 LUCA
HOGENOMiHOG000168450
HOVERGENiHBG081418
InParanoidiQ9JIC3
PhylomeDBiQ9JIC3

Family and domain databases

Gene3Di3.60.15.10, 2 hits
InterProiView protein in InterPro
IPR011084 DRMBL
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF07522 DRMBL, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JIC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEDTWEEEI WEYKSKRKPK PVHPNNCSEN ISESVEKSTD GKHQSKGNEK
60 70 80 90 100
RTSENPGKTK DHKVCLAETD SQISAGSSQS SSCRDESQQS QNKETTPKKQ
110 120 130 140 150
HRTRRGKQVT PKVRPVYDGY CPSCQMPFSS LLGQTPQWHV FECLDSPPIS
160 170 180 190 200
DTECPEGLLC TSTIPSHYKK YTHILLAQSR DSKEPLGSPS DALAGLFAAA
210 220 230 240 250
APGSPCNLEE RRSMTLKTEN LRKVSDHSLL MMQYLETSQP SAEINRKNVS
260 270 280 290 300
SPCSQTSPVP QCAEFVKRDQ LVGGGSPLAE VALNSQSKSG SMGLPLPEND
310 320 330 340 350
TDSCEISYSP LHSDEETYDI DQELDDSQQE LFFTQSSKDS SLEEDGSAIF
360 370 380 390 400
ENLHGPSPKE AEGIRPTAKS LVAQARCSAP SEGSTLSDSF LLLSYTSNRL
410 420 430 440 450
SQEDLPHTDA AFHLLSPALA VGGAASNYQT SKAKLDEPEK FLSLASSHQQ
460 470 480 490 500
QKIETSAVGN QTSLPLLTRA RSKPLEKEGG KCLPLHPTQS QTRGSPRKGL
510 520 530 540 550
GAPGANCACR NAQKRSSMPL DKPLGTSPSS PKCSPSQPSK KVMKQMDIGV
560 570 580 590 600
FFGLPPKRQE TSLRESASEG PNVSPVVSPN QKRPRLCKRK AQSSLSDLEF
610 620 630 640 650
DAKNLNESQH SVGLSGEKRQ HRRKRHKTSN SPREGPCQRR SGHLMNNPEL
660 670 680 690 700
GPVSLSKAFV RRTRGRTQRG NMNISESSGA GEVRRTCPFY KRIPGTGFTV
710 720 730 740 750
DAFQYGEIEG CTAYFLTHFH SDHYAGLSKD FTRPVYCSEI TGNLLKKKLR
760 770 780 790 800
VQEQYIRQLP MDTECVVDSV KVVLLDANHC PGATMILFQL PNGAVILHTG
810 820 830 840 850
DFRADPSMER SRLAGRKVHT LFLDTTYCSP EYTFPSQQEV IQFAINTAFE
860 870 880 890 900
AVTLNPRALV VCGTYCIGKE KVFLAIADVL GSKVGMSQEK YKTLQCLNIP
910 920 930 940 950
EVSSLITTDM CDSLVHLLPM MQINFKGLQS HLKKCGGKYD QILAFRPTGW
960 970 980 990 1000
THSNNITSTA DIIPQTRGNI SIYGIPYSEH SSYLEMKRFV QWLKPQKIIP
1010 1020
TVNVGSFRSR NTMEKYFKEW RLEAGY
Length:1,026
Mass (Da):113,567
Last modified:August 16, 2005 - v2
Checksum:iBFDB4E03135FB901
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1N2S4R1N2_MOUSE
DNA cross-link repair 1A protein
Dclre1a
1,047Annotation score:
S4R1T3S4R1T3_MOUSE
DNA cross-link repair 1A protein
Dclre1a
97Annotation score:
S4R284S4R284_MOUSE
DNA cross-link repair 1A protein
Dclre1a
314Annotation score:

Sequence cautioni

The sequence AAH72667 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5T → TF in AAH72667 (PubMed:15489334).Curated1
Sequence conflicti52T → A in AAF64472 (PubMed:10848582).Curated1
Sequence conflicti188S → N in BAD90139 (Ref. 3) Curated1
Sequence conflicti241S → P in BAD90139 (Ref. 3) Curated1
Sequence conflicti268 – 269RD → KT in AAF64472 (PubMed:10848582).Curated2
Sequence conflicti291 – 293SMG → YVA in AAF64472 (PubMed:10848582).Curated3
Sequence conflicti296 – 306LPENDTDSCEI → EMTLTAVV in AAF64472 (PubMed:10848582).CuratedAdd BLAST11
Sequence conflicti322 – 324QEL → PRA in AAF64472 (PubMed:10848582).Curated3
Sequence conflicti346G → C in AAF64472 (PubMed:10848582).Curated1
Sequence conflicti361A → G in AAF64472 (PubMed:10848582).Curated1
Sequence conflicti373A → P in AAF64472 (PubMed:10848582).Curated1
Sequence conflicti394S → F in AAH72667 (PubMed:15489334).Curated1
Sequence conflicti525G → R in AAF64472 (PubMed:10848582).Curated1
Sequence conflicti654S → I in AAH72667 (PubMed:15489334).Curated1
Sequence conflicti657K → KGK in AAH72667 (PubMed:15489334).Curated1
Sequence conflicti774 – 775LL → FV in AAF64472 (PubMed:10848582).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241240 mRNA Translation: AAF64472.1
BC072667 mRNA Translation: AAH72667.1 Sequence problems.
AK220214 mRNA Translation: BAD90139.1
UniGeneiMm.2805

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241240 mRNA Translation: AAF64472.1
BC072667 mRNA Translation: AAH72667.1 Sequence problems.
AK220214 mRNA Translation: BAD90139.1
UniGeneiMm.2805

3D structure databases

ProteinModelPortaliQ9JIC3
SMRiQ9JIC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026063

PTM databases

iPTMnetiQ9JIC3
PhosphoSitePlusiQ9JIC3

Proteomic databases

PaxDbiQ9JIC3
PRIDEiQ9JIC3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1930042 Dclre1a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1361 Eukaryota
COG1236 LUCA
HOGENOMiHOG000168450
HOVERGENiHBG081418
InParanoidiQ9JIC3
PhylomeDBiQ9JIC3

Miscellaneous databases

PROiPR:Q9JIC3
SOURCEiSearch...

Family and domain databases

Gene3Di3.60.15.10, 2 hits
InterProiView protein in InterPro
IPR011084 DRMBL
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF07522 DRMBL, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCR1A_MOUSE
AccessioniPrimary (citable) accession number: Q9JIC3
Secondary accession number(s): Q571H5, Q6GQR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: February 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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