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Protein

NF-kappa-B inhibitor beta

Gene

Nfkbib

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

GO - Molecular functioni

  • NF-kappaB binding Source: RGD

GO - Biological processi

  • cytoplasmic sequestering of NF-kappaB Source: RGD
  • signal transduction Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor beta
Short name:
NF-kappa-BIB
Alternative name(s):
I-kappa-B-beta
Short name:
IkB-B
Short name:
IkB-beta
Short name:
IkappaBbeta
Gene namesi
Name:Nfkbib
Synonyms:Ikbb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621887 Nfkbib

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670061 – 359NF-kappa-B inhibitor betaAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphoserine; by RPS6KA11 Publication1
Modified residuei23Phosphoserine; by RPS6KA11 Publication1
Modified residuei318PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JIA3
PRIDEiQ9JIA3

PTM databases

iPTMnetiQ9JIA3
PhosphoSitePlusiQ9JIA3

Interactioni

Subunit structurei

Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1. Interacts with inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2.By similarity

GO - Molecular functioni

  • NF-kappaB binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027212

Structurei

3D structure databases

ProteinModelPortaliQ9JIA3
SMRiQ9JIA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 86ANK 1Add BLAST30
Repeati93 – 122ANK 2Add BLAST30
Repeati126 – 155ANK 3Add BLAST30
Repeati206 – 235ANK 4Add BLAST30
Repeati240 – 269ANK 5Add BLAST30
Repeati273 – 302ANK 6Add BLAST30

Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
HOGENOMiHOG000137336
HOVERGENiHBG019039
InParanoidiQ9JIA3
PhylomeDBiQ9JIA3

Family and domain databases

CDDicd00204 ANK, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequencei

Sequence statusi: Complete.

Q9JIA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVACLGKT ADADEWCDSG LGSLGPDAAA PGGPGLVAEL SPELSWAPLV
60 70 80 90 100
FGYVTEDGDT ALHLAVIHQH EPFLDFLLGF SAGTEYLDLQ NDLGQTALHL
110 120 130 140 150
AAILGEASTV EKLYAAGAGV LVTERGGHTA LHLACRVRAH TCAYVLLQPR
160 170 180 190 200
PSHPRDASDT YLTQSQDHTP DTSHAPVATD PQPNPGNEEE LRDEDWRLQL
210 220 230 240 250
EAENYDGHTP LHVAVIHKDA EMVQLLRDAG ADLNKPEPTC GRTPLHLAVE
260 270 280 290 300
GQAAGVLALL LKAGADPTAR MYGGRTPLGS ALLRPNPVLA RLLRAHGAPE
310 320 330 340 350
PEDKDDKLSP CSNSSSDSDS DNRDEGDEYD DIVVHSRRSQ NQPPPSPAAK

PLPDDPNPA
Length:359
Mass (Da):38,081
Last modified:October 1, 2000 - v1
Checksum:iB8602C815C72B1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246634 mRNA Translation: AAF64191.1
UniGeneiRn.8395

Genome annotation databases

UCSCiRGD:621887 rat

Similar proteinsi

Entry informationi

Entry nameiIKBB_RAT
AccessioniPrimary (citable) accession number: Q9JIA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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