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Entry version 173 (10 Feb 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Delta-like protein 4

Gene

Dll4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600). During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation, Neurogenesis, Notch signaling pathway, Sensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like protein 4
Alternative name(s):
Drosophila Delta homolog 4
Short name:
Delta4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dll4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1859388, Dll4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 532ExtracellularSequence analysisAdd BLAST506
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 686CytoplasmicSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional knockdowns in retinal progenitors have thinner retinas with occasional regions abnormally organized into rosette-like structures in the outer nuclear layer and an optic nerve with a reduced diameter.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000751327 – 686Delta-like protein 4Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 55By similarity
Disulfide bondi62 ↔ 75By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi109N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi162N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi176 ↔ 185PROSITE-ProRule annotationBy similarity
Disulfide bondi189 ↔ 201PROSITE-ProRule annotationBy similarity
Disulfide bondi209 ↔ 218PROSITE-ProRule annotationBy similarity
Disulfide bondi223 ↔ 234PROSITE-ProRule annotationBy similarity
Disulfide bondi227 ↔ 240PROSITE-ProRule annotationBy similarity
Disulfide bondi242 ↔ 251PROSITE-ProRule annotationBy similarity
Disulfide bondi254 ↔ 265By similarity
Disulfide bondi260 ↔ 271By similarity
Disulfide bondi273 ↔ 282PROSITE-ProRule annotationBy similarity
Disulfide bondi289 ↔ 301By similarity
Disulfide bondi295 ↔ 311By similarity
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 322By similarity
Disulfide bondi329 ↔ 340By similarity
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi351 ↔ 360By similarity
Disulfide bondi367 ↔ 378By similarity
Disulfide bondi372 ↔ 389By similarity
Disulfide bondi391 ↔ 400By similarity
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi407 ↔ 418By similarity
Disulfide bondi412 ↔ 427By similarity
Disulfide bondi429 ↔ 438By similarity
Disulfide bondi445 ↔ 456By similarity
Disulfide bondi450 ↔ 465By similarity
Disulfide bondi467 ↔ 476By similarity
Disulfide bondi485 ↔ 496By similarity
Disulfide bondi490 ↔ 507By similarity
Disulfide bondi509 ↔ 518By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JI71

PRoteomics IDEntifications database

More...
PRIDEi
Q9JI71

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9JI71, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JI71

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JI71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in vascular endothelium. Expressed in retina at least during embryogenesis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 14.5, expressed within the retina outer neuroblastic layer.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027314, Expressed in entire extraembryonic component and 203 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JI71, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NOTCH4.

Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei111Interaction with Notch1By similarity1
Sitei217Interaction with Notch1By similarity1

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207669, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9JI71, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099575

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JI71, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JI71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 218DSLPROSITE-ProRule annotationAdd BLAST45
Domaini219 – 252EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini253 – 283EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini285 – 323EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini325 – 361EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini364 – 401EGF-like 5PROSITE-ProRule annotationAdd BLAST38
Domaini403 – 439EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini441 – 477EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini481 – 519EGF-like 8PROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 188Interaction with Notch1By similarity3
Regioni192 – 196Interaction with Notch1By similarity5

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157441

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012574_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JI71

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDECIPH

Database of Orthologous Groups

More...
OrthoDBi
406049at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR011651, Notch_ligand_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF07657, MNNL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 9 hits
SM00179, EGF_CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS51051, DSL, 1 hit
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPASRSACR WALLLLAVLW PQQRAAGSGI FQLRLQEFVN QRGMLANGQS
60 70 80 90 100
CEPGCRTFFR ICLKHFQATF SEGPCTFGNV STPVLGTNSF VVRDKNSGSG
110 120 130 140 150
RNPLQLPFNF TWPGTFSLNI QAWHTPGDDL RPETSPGNSL ISQIIIQGSL
160 170 180 190 200
AVGKIWRTDE QNDTLTRLSY SYRVICSDNY YGESCSRLCK KRDDHFGHYE
210 220 230 240 250
CQPDGSLSCL PGWTGKYCDQ PICLSGCHEQ NGYCSKPDEC ICRPGWQGRL
260 270 280 290 300
CNECIPHNGC RHGTCSIPWQ CACDEGWGGL FCDQDLNYCT HHSPCKNGST
310 320 330 340 350
CSNSGPKGYT CTCLPGYTGE HCELGLSKCA SNPCRNGGSC KDQENSYHCL
360 370 380 390 400
CPPGYYGQHC EHSTLTCADS PCFNGGSCRE RNQGSSYACE CPPNFTGSNC
410 420 430 440 450
EKKVDRCTSN PCANGGQCQN RGPSRTCRCR PGFTGTHCEL HISDCARSPC
460 470 480 490 500
AHGGTCHDLE NGPVCTCPAG FSGRRCEVRI THDACASGPC FNGATCYTGL
510 520 530 540 550
SPNNFVCNCP YGFVGSRCEF PVGLPPSFPW VAVSLGVGLV VLLVLLVMVV
560 570 580 590 600
VAVRQLRLRR PDDESREAMN NLSDFQKDNL IPAAQLKNTN QKKELEVDCG
610 620 630 640 650
LDKSNCGKLQ NHTLDYNLAP GLLGRGGMPG KYPHSDKSLG EKVPLRLHSE
660 670 680
KPECRISAIC SPRDSMYQSV CLISEERNEC VIATEV
Length:686
Mass (Da):74,991
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7DD4FC15C4AFFBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti419Q → L in AAF76428 (PubMed:10837024).Curated1
Sequence conflicti419Q → L in AAF78785 (Ref. 3) Curated1
Sequence conflicti527 – 528SF → CS in AAF78785 (Ref. 3) Curated2
Sequence conflicti627G → S in AAF76428 (PubMed:10837024).Curated1
Sequence conflicti627G → S in AAF78785 (Ref. 3) Curated1
Sequence conflicti639 – 649LGEKVPLRLHS → IGQGATSVTH in AAF78785 (Ref. 3) CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF253469 mRNA Translation: AAF76428.1
AF273454 mRNA Translation: AAF78785.1
AB043893 mRNA Translation: BAB18580.1
AK004739 mRNA Translation: BAB23520.1
AL929318 Genomic DNA No translation available.
BC042497 mRNA Translation: AAH42497.1
BC049130 mRNA Translation: AAH49130.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16600.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7569

NCBI Reference Sequences

More...
RefSeqi
NP_062327.2, NM_019454.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000102517; ENSMUSP00000099575; ENSMUSG00000027314

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:54485

UCSC genome browser

More...
UCSCi
uc008ltr.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253469 mRNA Translation: AAF76428.1
AF273454 mRNA Translation: AAF78785.1
AB043893 mRNA Translation: BAB18580.1
AK004739 mRNA Translation: BAB23520.1
AL929318 Genomic DNA No translation available.
BC042497 mRNA Translation: AAH42497.1
BC049130 mRNA Translation: AAH49130.1
CCDSiCCDS16600.1
PIRiJC7569
RefSeqiNP_062327.2, NM_019454.3

3D structure databases

SMRiQ9JI71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207669, 3 interactors
IntActiQ9JI71, 4 interactors
STRINGi10090.ENSMUSP00000099575

PTM databases

GlyGeniQ9JI71, 5 sites
iPTMnetiQ9JI71
PhosphoSitePlusiQ9JI71

Proteomic databases

PaxDbiQ9JI71
PRIDEiQ9JI71

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9JI71, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
5995, 850 antibodies

Genome annotation databases

EnsembliENSMUST00000102517; ENSMUSP00000099575; ENSMUSG00000027314
GeneIDi54485
KEGGimmu:54485
UCSCiuc008ltr.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54567
MGIiMGI:1859388, Dll4

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000157441
HOGENOMiCLU_012574_1_0_1
InParanoidiQ9JI71
OMAiCDECIPH
OrthoDBi406049at2759
TreeFamiTF351835

Enzyme and pathway databases

ReactomeiR-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54485, 1 hit in 17 CRISPR screens

Protein Ontology

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PROi
PR:Q9JI71
RNActiQ9JI71, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000027314, Expressed in entire extraembryonic component and 203 other tissues
GenevisibleiQ9JI71, MM

Family and domain databases

InterProiView protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR011651, Notch_ligand_N
PfamiView protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF07657, MNNL, 1 hit
SMARTiView protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 9 hits
SM00179, EGF_CA, 6 hits
SUPFAMiSSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS51051, DSL, 1 hit
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLL4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JI71
Secondary accession number(s): Q9DBU9, Q9JHZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: February 10, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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