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Protein

Junctional adhesion molecule B

Gene

Jam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • negative regulation of cell adhesion Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule B
Short name:
JAM-B
Alternative name(s):
Junctional adhesion molecule 2
Short name:
JAM-2
Vascular endothelial junction-associated molecule
Short name:
VE-JAM
CD_antigen: CD322
Gene namesi
Name:Jam2
Synonyms:Vejam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1933820 Jam2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 236ExtracellularSequence analysisAdd BLAST208
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 298CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001507029 – 298Junctional adhesion molecule BAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 110PROSITE-ProRule annotation
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JI59
PaxDbiQ9JI59
PeptideAtlasiQ9JI59
PRIDEiQ9JI59

PTM databases

iPTMnetiQ9JI59
PhosphoSitePlusiQ9JI59
SwissPalmiQ9JI59

Expressioni

Gene expression databases

BgeeiENSMUSG00000053062 Expressed in 258 organ(s), highest expression level in brain blood vessel
CleanExiMM_JAM2
ExpressionAtlasiQ9JI59 baseline and differential
GenevisibleiQ9JI59 MM

Interactioni

Subunit structurei

Interacts with JAM3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61078N
IntActiQ9JI59, 1 interactor
STRINGi10090.ENSMUSP00000109833

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JI59
SMRiQ9JI59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 128Ig-like V-typeAdd BLAST97
Domaini135 – 238Ig-like C2-typeAdd BLAST104

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXS Eukaryota
ENOG41100KX LUCA
GeneTreeiENSGT00730000110678
HOGENOMiHOG000247041
HOVERGENiHBG000518
InParanoidiQ9JI59
KOiK06735
OMAiHRRCPGK
OrthoDBiEOG091G05PI
PhylomeDBiQ9JI59
TreeFamiTF331459

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JI59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSPQGLLM LLLLHYLIVA LDYHKANGFS ASKDHRQEVT VIEFQEAILA
60 70 80 90 100
CKTPKKTTSS RLEWKKVGQG VSLVYYQQAL QGDFKDRAEM IDFNIRIKNV
110 120 130 140 150
TRSDAGEYRC EVSAPTEQGQ NLQEDKVMLE VLVAPAVPAC EVPTSVMTGS
160 170 180 190 200
VVELRCQDKE GNPAPEYIWF KDGTSLLGNP KGGTHNNSSY TMNTKSGILQ
210 220 230 240 250
FNMISKMDSG EYYCEARNSV GHRRCPGKRM QVDVLNISGI IATVVVVAFV
260 270 280 290
ISVCGLGTCY AQRKGYFSKE TSFQKGSPAS KVTTMSENDF KHTKSFII
Length:298
Mass (Da):33,047
Last modified:October 1, 2000 - v1
Checksum:i1124E0F07E6CF751
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CWD9Q9CWD9_MOUSE
Junctional adhesion molecule B
Jam2
181Annotation score:
A0A338P721A0A338P721_MOUSE
Junctional adhesion molecule B
Jam2
322Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133V → M in BAC26102 (PubMed:16141072).Curated1
Sequence conflicti174T → H in BAC37139 (PubMed:16141072).Curated1
Sequence conflicti183G → R in BAC37139 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255911 mRNA Translation: AAF81224.1
AJ291757 mRNA Translation: CAC20699.1
AK010616 mRNA Translation: BAB27064.1
AK013914 mRNA Translation: BAB29053.1
AK028757 mRNA Translation: BAC26102.1
AK078128 mRNA Translation: BAC37139.1
CT027693, AC164162 Genomic DNA Translation: CAO78081.1
BC028778 mRNA Translation: AAH28778.1
CCDSiCCDS37381.1
RefSeqiNP_076333.3, NM_023844.5
UniGeneiMm.41758

Genome annotation databases

EnsembliENSMUST00000114195; ENSMUSP00000109833; ENSMUSG00000053062
GeneIDi67374
KEGGimmu:67374
UCSCiuc007ztg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255911 mRNA Translation: AAF81224.1
AJ291757 mRNA Translation: CAC20699.1
AK010616 mRNA Translation: BAB27064.1
AK013914 mRNA Translation: BAB29053.1
AK028757 mRNA Translation: BAC26102.1
AK078128 mRNA Translation: BAC37139.1
CT027693, AC164162 Genomic DNA Translation: CAO78081.1
BC028778 mRNA Translation: AAH28778.1
CCDSiCCDS37381.1
RefSeqiNP_076333.3, NM_023844.5
UniGeneiMm.41758

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GMJX-ray2.99C/D280-298[»]
ProteinModelPortaliQ9JI59
SMRiQ9JI59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61078N
IntActiQ9JI59, 1 interactor
STRINGi10090.ENSMUSP00000109833

PTM databases

iPTMnetiQ9JI59
PhosphoSitePlusiQ9JI59
SwissPalmiQ9JI59

Proteomic databases

MaxQBiQ9JI59
PaxDbiQ9JI59
PeptideAtlasiQ9JI59
PRIDEiQ9JI59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114195; ENSMUSP00000109833; ENSMUSG00000053062
GeneIDi67374
KEGGimmu:67374
UCSCiuc007ztg.2 mouse

Organism-specific databases

CTDi58494
MGIiMGI:1933820 Jam2

Phylogenomic databases

eggNOGiENOG410IDXS Eukaryota
ENOG41100KX LUCA
GeneTreeiENSGT00730000110678
HOGENOMiHOG000247041
HOVERGENiHBG000518
InParanoidiQ9JI59
KOiK06735
OMAiHRRCPGK
OrthoDBiEOG091G05PI
PhylomeDBiQ9JI59
TreeFamiTF331459

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions

Miscellaneous databases

PROiPR:Q9JI59
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053062 Expressed in 258 organ(s), highest expression level in brain blood vessel
CleanExiMM_JAM2
ExpressionAtlasiQ9JI59 baseline and differential
GenevisibleiQ9JI59 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJAM2_MOUSE
AccessioniPrimary (citable) accession number: Q9JI59
Secondary accession number(s): A6X955, Q8C5K9, Q8CE95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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