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Entry version 156 (29 Sep 2021)
Sequence version 2 (27 May 2002)
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Protein

General transcription factor II-I repeat domain-containing protein 1

Gene

Gtf2ird1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General transcription factor II-I repeat domain-containing protein 1
Short name:
GTF2I repeat domain-containing protein 1
Alternative name(s):
Binding factor for early enhancer
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gtf2ird1
Synonyms:Ben
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1861942, Gtf2ird1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000023079

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000838711 – 1104General transcription factor II-I repeat domain-containing protein 1Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki436Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448PhosphoserineBy similarity1
Cross-linki567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki588Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki638Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki669Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki717Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki757Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki759Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki772Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki841Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki901Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JI57

PRoteomics IDEntifications database

More...
PRIDEi
Q9JI57

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
271358 [Q9JI57-1]
271359 [Q9JI57-2]
271360 [Q9JI57-3]
271361 [Q9JI57-4]
271362 [Q9JI57-5]
271363 [Q9JI57-6]
271364 [Q9JI57-7]
271365 [Q9JI57-8]
271366 [Q9JI57-9]
271367 [Q9JI57-10]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JI57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JI57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in somites, neural tube and brain at 8-8.5 dpc. Expression remains constant from 9.5-12.5 dpc with highest expression levels in the limb buds, branchial arches, crainofacial area, brain and spinal cord.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023079, Expressed in ear vesicle and 306 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JI57, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the retinoblastoma protein (RB1) via its C-terminus.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JI57, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9JI57

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098217

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9JI57, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JI57

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati119 – 213GTF2I-like 1Add BLAST95
Repeati342 – 436GTF2I-like 2Add BLAST95
Repeati556 – 650GTF2I-like 3Add BLAST95
Repeati681 – 775GTF2I-like 4Add BLAST95
Repeati805 – 899GTF2I-like 5Add BLAST95
Repeati908 – 1002GTF2I-like 6Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni509 – 559DisorderedSequence analysisAdd BLAST51
Regioni783 – 802DisorderedSequence analysisAdd BLAST20
Regioni1001 – 1044DisorderedSequence analysisAdd BLAST44
Regioni1058 – 1104DisorderedSequence analysisAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1012 – 1019Nuclear localization signalBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi543 – 559Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi785 – 802Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1022 – 1044Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFII-I family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPVX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159414

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014412_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JI57

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSHRIQF

Database of Orthologous Groups

More...
OrthoDBi
115381at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JI57

TreeFam database of animal gene trees

More...
TreeFami
TF352524

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1460.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR016659, TF_II-I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02946, GTF2I, 6 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016441, TF_II-I, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117773, SSF117773, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51139, GTF2I, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9JI57-1) [UniParc]FASTAAdd to basket
Also known as: Beta, 3b7

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLGKHCDI PTNGCGSERW NSTFARKDEL INSLVSALDS MCSALSKLNT
60 70 80 90 100
EVACVAVHNE SVFVMGTEKG RVFLNTRKEL QSDFLRFCRG PLWNDPEAGH
110 120 130 140 150
PKKVQRCEGG GRSLPRSSLE QCSDVYLLQK MVEEVFDVLY SEAMGRATVV
160 170 180 190 200
PLPYERLLRE PGLLAVQGLP EGLAFRRPAE YDPKALMAIL EHSHRIRFKL
210 220 230 240 250
RRPPDDGGQD TKALVEMNGI SLLPKGSRDC GLHGQASKVA PQDLTPTATP
260 270 280 290 300
SSMANFLYST SMPNHTIREL KQEVPTCPLT PSDLGMGWPV PEPHVPSTQD
310 320 330 340 350
FSDCCGQTPA GPAGPLIQNV HASKRILFSI VHDKSEKWDP FIKEMEDINT
360 370 380 390 400
LRECVQILFN SRYAEALGLD HMVPVPYRKI ACDPEAVEIV GIPDKIPFKR
410 420 430 440 450
PCTYGVPKLK RILEERHSIH FIIKRMFDER IFTGNKFTKD PMKLEPASPP
460 470 480 490 500
EDTSTEVCRD SMLDLAGTAW SDMSSVSEDC GPGTSGEIAM LRPIKIEPEE
510 520 530 540 550
LDIIQVTVSD PSPTSEEMTD SLPGHLPSED SGYGMEMPAD KGPSEEPWSE
560 570 580 590 600
ERPAEESPGD VIRPLRKQVE MLFNTKYAKA IGTSEPVKVP YSKFLMHPEE
610 620 630 640 650
LFVLGLPEGI SLRRPNCFGI AKLRKILEAS NSIQFVIKRP ELLTDGVKEP
660 670 680 690 700
VLDTQERDSW DRLVDETPKR QGLQENYNTR LSRIDIANTL REQVQDLFNK
710 720 730 740 750
KYGEALGIKY PVQVPYKRIK SNPGSVIIEG LPPGIPFRKP CTFGSQNLER
760 770 780 790 800
ILSVADKIKF TVTRPFQGLI PKPETKILTT GHEAGKTTRP RRLQQDTWQP
810 820 830 840 850
DEDDANRLGE KVILREQVKE LFNEKYGEAL GLNRPVLVPY KLIRDSPDAV
860 870 880 890 900
EVKGLPDDIP FRNPNTYDIH RLEKILKARE HVRMVIINQL QPFAEVCNDP
910 920 930 940 950
KVPEEDDSNK LGKKVILREQ VKELFNEKYG EALGLNRPVL VPYKLIRDSP
960 970 980 990 1000
DAVEVKGLPD DIPFRNPNTY DIHRLEKILK AREHVRMVII NQLQPFGDVC
1010 1020 1030 1040 1050
NNAKVPAKDN IPKRKRKRVS EGNSVSSSSS SSSSSSNPES VASTNQISLV
1060 1070 1080 1090 1100
VKSRGSELHP NSVWPLPLPR AGPSTAPGTG RHWALRGTQP TTEGQAHPLV

LPTR
Length:1,104
Mass (Da):123,483
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC76B2AF3CD1BCD73
GO
Isoform 1 (identifier: Q9JI57-2) [UniParc]FASTAAdd to basket
Also known as: Alpha, 3a7

The sequence of this isoform differs from the canonical sequence as follows:
     1051-1104: VKSRGSELHP...QAHPLVLPTR → QWPVYMVDYSGLNVQLPGPLDY

Show »
Length:1,072
Mass (Da):120,267
Checksum:i9E82AA6D7D6D02FC
GO
Isoform 3 (identifier: Q9JI57-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, 1a1

The sequence of this isoform differs from the canonical sequence as follows:
     774-800: Missing.
     864-966: Missing.
     1051-1104: VKSRGSELHP...QAHPLVLPTR → QWPVYMVDYSGLNVQLPGPLDY

Show »
Length:942
Mass (Da):105,235
Checksum:i699A0ECFF01933EF
GO
Isoform 4 (identifier: Q9JI57-4) [UniParc]FASTAAdd to basket
Also known as: 1b1

The sequence of this isoform differs from the canonical sequence as follows:
     774-800: Missing.
     864-966: Missing.

Show »
Length:974
Mass (Da):108,452
Checksum:i243952898632E546
GO
Isoform 5 (identifier: Q9JI57-5) [UniParc]FASTAAdd to basket
Also known as: 3b5

The sequence of this isoform differs from the canonical sequence as follows:
     774-800: Missing.

Show »
Length:1,077
Mass (Da):120,352
Checksum:iA577262306C14333
GO
Isoform 6 (identifier: Q9JI57-6) [UniParc]FASTAAdd to basket
Also known as: 3b3

The sequence of this isoform differs from the canonical sequence as follows:
     657-675: Missing.
     774-800: Missing.

Show »
Length:1,058
Mass (Da):118,041
Checksum:i99AA5EFF06E36681
GO
Isoform 7 (identifier: Q9JI57-7) [UniParc]FASTAAdd to basket
Also known as: 3a3

The sequence of this isoform differs from the canonical sequence as follows:
     657-675: Missing.
     774-800: Missing.
     1051-1104: VKSRGSELHP...QAHPLVLPTR → QWPVYMVDYSGLNVQLPGPLDY

Show »
Length:1,026
Mass (Da):114,825
Checksum:i035A62B8AE290EC9
GO
Isoform 8 (identifier: Q9JI57-8) [UniParc]FASTAAdd to basket
Also known as: 1b4

The sequence of this isoform differs from the canonical sequence as follows:
     864-966: Missing.

Show »
Length:1,001
Mass (Da):111,584
Checksum:iFCEC832BCAD242BE
GO
Isoform 9 (identifier: Q9JI57-9) [UniParc]FASTAAdd to basket
Also known as: 2a5

The sequence of this isoform differs from the canonical sequence as follows:
     703-800: Missing.
     1051-1104: VKSRGSELHP...QAHPLVLPTR → QWPVYMVDYSGLNVQLPGPLDY

Show »
Length:974
Mass (Da):109,349
Checksum:i4A312EAE7E473D2A
GO
Isoform 10 (identifier: Q9JI57-10) [UniParc]FASTAAdd to basket
Also known as: 1a4

The sequence of this isoform differs from the canonical sequence as follows:
     864-966: Missing.
     1051-1104: VKSRGSELHP...QAHPLVLPTR → QWPVYMVDYSGLNVQLPGPLDY

Show »
Length:969
Mass (Da):108,367
Checksum:i9BF42994545C256B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PD35Q6PD35_MOUSE
General transcription factor II I r...
Gtf2ird1
1,045Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTX7A0A0J9YTX7_MOUSE
General transcription factor II-I r...
Gtf2ird1
942Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80ZG9Q80ZG9_MOUSE
General transcription factor II-I r...
Gtf2ird1
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YV00A0A0J9YV00_MOUSE
General transcription factor II-I r...
Gtf2ird1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YV21A0A0J9YV21_MOUSE
General transcription factor II-I r...
Gtf2ird1
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUI9A0A0J9YUI9_MOUSE
General transcription factor II-I r...
Gtf2ird1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUK2A0A0J9YUK2_MOUSE
General transcription factor II-I r...
Gtf2ird1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUW7A0A0J9YUW7_MOUSE
General transcription factor II-I r...
Gtf2ird1
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YV59A0A0J9YV59_MOUSE
General transcription factor II-I r...
Gtf2ird1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YV72A0A0J9YV72_MOUSE
General transcription factor II-I r...
Gtf2ird1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF78367 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79E → V in AAM02923 (PubMed:12780350).Curated1
Sequence conflicti94N → D in AAF78367 (PubMed:10861001).Curated1
Sequence conflicti134E → K in AAM02920 (PubMed:12780350).Curated1
Sequence conflicti252S → F in AAF78367 (PubMed:10861001).Curated1
Sequence conflicti258Y → H in AAF78367 (PubMed:10861001).Curated1
Sequence conflicti261S → L in AAF78367 (PubMed:10861001).Curated1
Sequence conflicti283D → G in AAF78367 (PubMed:10861001).Curated1
Sequence conflicti399K → R in AAL68980 (PubMed:12780350).Curated1
Sequence conflicti821L → F in AAM02920 (PubMed:12780350).Curated1
Sequence conflicti821L → F in AAP30731 (PubMed:12780350).Curated1
Sequence conflicti881H → Y in AAM02923 (PubMed:12780350).Curated1
Sequence conflicti1058L → P in AAP30733 (PubMed:12780350).Curated1
Sequence conflicti1058L → P in AAM02922 (PubMed:12780350).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021376657 – 675Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_021377703 – 800Missing in isoform 9. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_003874774 – 800Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_003875864 – 966Missing in isoform 3, isoform 4, isoform 8 and isoform 10. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_0038761051 – 1104VKSRG…VLPTR → QWPVYMVDYSGLNVQLPGPL DY in isoform 1, isoform 3, isoform 7, isoform 9 and isoform 10. 3 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF260133 mRNA Translation: AAF78367.1 Frameshift.
AF257475 mRNA Translation: AAG44655.1
AY030287 mRNA Translation: AAK49782.1
AY030288 mRNA Translation: AAK49783.1
AY030289 mRNA Translation: AAK49784.1
AF247161 mRNA Translation: AAL68980.1
AF343348 mRNA Translation: AAM02920.1
AF343349 mRNA Translation: AAM02921.1
AF343350 mRNA Translation: AAM02922.1
AF343351 mRNA Translation: AAM02923.1
AF497637 mRNA Translation: AAP30728.1
AF497638 mRNA Translation: AAP30729.1
AF497639 mRNA Translation: AAP30730.1
AF497640 mRNA Translation: AAP30731.1
AF497641 mRNA Translation: AAP30732.1
AF497642 mRNA Translation: AAP30733.1
AF289666 Genomic DNA Translation: AAF99337.1
AF289667 Genomic DNA Translation: AAF99339.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39302.1 [Q9JI57-7]
CCDS39303.1 [Q9JI57-9]
CCDS39305.1 [Q9JI57-2]
CCDS39306.1 [Q9JI57-5]
CCDS39307.1 [Q9JI57-1]
CCDS51657.1 [Q9JI57-8]
CCDS80420.1 [Q9JI57-10]
CCDS84967.1 [Q9JI57-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001074931.1, NM_001081462.2 [Q9JI57-1]
NP_001074932.1, NM_001081463.2 [Q9JI57-5]
NP_001074935.1, NM_001081466.2 [Q9JI57-7]
NP_001074936.1, NM_001081467.2 [Q9JI57-8]
NP_001074938.1, NM_001081469.2 [Q9JI57-10]
NP_001074939.1, NM_001081470.2 [Q9JI57-3]
NP_001231865.1, NM_001244936.1 [Q9JI57-4]
NP_001334417.1, NM_001347488.1 [Q9JI57-6]
NP_065064.2, NM_020331.3 [Q9JI57-2]
XP_017176527.1, XM_017321038.1 [Q9JI57-1]
XP_017176528.1, XM_017321039.1 [Q9JI57-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000073161; ENSMUSP00000072904; ENSMUSG00000023079 [Q9JI57-2]
ENSMUST00000074114; ENSMUSP00000073752; ENSMUSG00000023079 [Q9JI57-8]
ENSMUST00000100650; ENSMUSP00000098215; ENSMUSG00000023079 [Q9JI57-5]
ENSMUST00000100652; ENSMUSP00000098217; ENSMUSG00000023079 [Q9JI57-1]
ENSMUST00000100654; ENSMUSP00000098219; ENSMUSG00000023079 [Q9JI57-9]
ENSMUST00000111245; ENSMUSP00000106876; ENSMUSG00000023079 [Q9JI57-7]
ENSMUST00000167084; ENSMUSP00000132882; ENSMUSG00000023079 [Q9JI57-10]
ENSMUST00000200944; ENSMUSP00000143848; ENSMUSG00000023079 [Q9JI57-10]
ENSMUST00000202554; ENSMUSP00000143809; ENSMUSG00000023079 [Q9JI57-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57080

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:57080

UCSC genome browser

More...
UCSCi
uc008zvv.2, mouse [Q9JI57-2]
uc008zvw.2, mouse [Q9JI57-7]
uc008zvx.2, mouse [Q9JI57-3]
uc008zvy.2, mouse [Q9JI57-10]
uc008zvz.2, mouse [Q9JI57-9]
uc008zwa.2, mouse [Q9JI57-8]
uc008zwb.2, mouse [Q9JI57-6]
uc008zwc.2, mouse [Q9JI57-4]
uc008zwd.2, mouse [Q9JI57-5]
uc008zwe.2, mouse [Q9JI57-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260133 mRNA Translation: AAF78367.1 Frameshift.
AF257475 mRNA Translation: AAG44655.1
AY030287 mRNA Translation: AAK49782.1
AY030288 mRNA Translation: AAK49783.1
AY030289 mRNA Translation: AAK49784.1
AF247161 mRNA Translation: AAL68980.1
AF343348 mRNA Translation: AAM02920.1
AF343349 mRNA Translation: AAM02921.1
AF343350 mRNA Translation: AAM02922.1
AF343351 mRNA Translation: AAM02923.1
AF497637 mRNA Translation: AAP30728.1
AF497638 mRNA Translation: AAP30729.1
AF497639 mRNA Translation: AAP30730.1
AF497640 mRNA Translation: AAP30731.1
AF497641 mRNA Translation: AAP30732.1
AF497642 mRNA Translation: AAP30733.1
AF289666 Genomic DNA Translation: AAF99337.1
AF289667 Genomic DNA Translation: AAF99339.1
CCDSiCCDS39302.1 [Q9JI57-7]
CCDS39303.1 [Q9JI57-9]
CCDS39305.1 [Q9JI57-2]
CCDS39306.1 [Q9JI57-5]
CCDS39307.1 [Q9JI57-1]
CCDS51657.1 [Q9JI57-8]
CCDS80420.1 [Q9JI57-10]
CCDS84967.1 [Q9JI57-6]
RefSeqiNP_001074931.1, NM_001081462.2 [Q9JI57-1]
NP_001074932.1, NM_001081463.2 [Q9JI57-5]
NP_001074935.1, NM_001081466.2 [Q9JI57-7]
NP_001074936.1, NM_001081467.2 [Q9JI57-8]
NP_001074938.1, NM_001081469.2 [Q9JI57-10]
NP_001074939.1, NM_001081470.2 [Q9JI57-3]
NP_001231865.1, NM_001244936.1 [Q9JI57-4]
NP_001334417.1, NM_001347488.1 [Q9JI57-6]
NP_065064.2, NM_020331.3 [Q9JI57-2]
XP_017176527.1, XM_017321038.1 [Q9JI57-1]
XP_017176528.1, XM_017321039.1 [Q9JI57-5]

3D structure databases

SMRiQ9JI57
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JI57, 2 interactors
MINTiQ9JI57
STRINGi10090.ENSMUSP00000098217

PTM databases

iPTMnetiQ9JI57
PhosphoSitePlusiQ9JI57

Proteomic databases

PaxDbiQ9JI57
PRIDEiQ9JI57
ProteomicsDBi271358 [Q9JI57-1]
271359 [Q9JI57-2]
271360 [Q9JI57-3]
271361 [Q9JI57-4]
271362 [Q9JI57-5]
271363 [Q9JI57-6]
271364 [Q9JI57-7]
271365 [Q9JI57-8]
271366 [Q9JI57-9]
271367 [Q9JI57-10]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14624, 383 antibodies

The DNASU plasmid repository

More...
DNASUi
57080

Genome annotation databases

EnsembliENSMUST00000073161; ENSMUSP00000072904; ENSMUSG00000023079 [Q9JI57-2]
ENSMUST00000074114; ENSMUSP00000073752; ENSMUSG00000023079 [Q9JI57-8]
ENSMUST00000100650; ENSMUSP00000098215; ENSMUSG00000023079 [Q9JI57-5]
ENSMUST00000100652; ENSMUSP00000098217; ENSMUSG00000023079 [Q9JI57-1]
ENSMUST00000100654; ENSMUSP00000098219; ENSMUSG00000023079 [Q9JI57-9]
ENSMUST00000111245; ENSMUSP00000106876; ENSMUSG00000023079 [Q9JI57-7]
ENSMUST00000167084; ENSMUSP00000132882; ENSMUSG00000023079 [Q9JI57-10]
ENSMUST00000200944; ENSMUSP00000143848; ENSMUSG00000023079 [Q9JI57-10]
ENSMUST00000202554; ENSMUSP00000143809; ENSMUSG00000023079 [Q9JI57-6]
GeneIDi57080
KEGGimmu:57080
UCSCiuc008zvv.2, mouse [Q9JI57-2]
uc008zvw.2, mouse [Q9JI57-7]
uc008zvx.2, mouse [Q9JI57-3]
uc008zvy.2, mouse [Q9JI57-10]
uc008zvz.2, mouse [Q9JI57-9]
uc008zwa.2, mouse [Q9JI57-8]
uc008zwb.2, mouse [Q9JI57-6]
uc008zwc.2, mouse [Q9JI57-4]
uc008zwd.2, mouse [Q9JI57-5]
uc008zwe.2, mouse [Q9JI57-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9569
MGIiMGI:1861942, Gtf2ird1
VEuPathDBiHostDB:ENSMUSG00000023079

Phylogenomic databases

eggNOGiENOG502QPVX, Eukaryota
GeneTreeiENSGT00940000159414
HOGENOMiCLU_014412_0_0_1
InParanoidiQ9JI57
OMAiQSHRIQF
OrthoDBi115381at2759
PhylomeDBiQ9JI57
TreeFamiTF352524

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57080, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gtf2ird1, mouse

Protein Ontology

More...
PROi
PR:Q9JI57
RNActiQ9JI57, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023079, Expressed in ear vesicle and 306 other tissues
GenevisibleiQ9JI57, MM

Family and domain databases

Gene3Di3.90.1460.10, 6 hits
InterProiView protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
IPR016659, TF_II-I
PfamiView protein in Pfam
PF02946, GTF2I, 6 hits
PIRSFiPIRSF016441, TF_II-I, 1 hit
SUPFAMiSSF117773, SSF117773, 6 hits
PROSITEiView protein in PROSITE
PS51139, GTF2I, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGT2D1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JI57
Secondary accession number(s): Q547E0
, Q80WJ8, Q80WJ9, Q80WK0, Q80WK1, Q8R4X5, Q8R4X6, Q8R4X7, Q8R4X8, Q8VHD5, Q8VI58, Q9EQE7, Q9ESZ6, Q9ESZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: September 29, 2021
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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