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Entry version 121 (03 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Plectin

Gene

PLEC

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plectin
Short name:
PCN
Short name:
PLTN
Alternative name(s):
300 kDa intermediate filament-associated protein
IFAP300
Plectin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEC
Synonyms:PLEC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000078134‹1 – 4473PlectinAdd BLAST›4473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei509PhosphoserineBy similarity1
Modified residuei604PhosphothreonineBy similarity1
Modified residuei836PhosphoserineBy similarity1
Modified residuei1224PhosphoserineBy similarity1
Modified residuei1510PhosphoserineBy similarity1
Modified residuei1514N6-acetyllysineBy similarity1
Modified residuei2420PhosphoserineBy similarity1
Modified residuei2425N6-acetyllysineBy similarity1
Modified residuei2563PhosphoserineBy similarity1
Modified residuei2591PhosphoserineBy similarity1
Modified residuei2675PhosphothreonineBy similarity1
Modified residuei2822PhosphotyrosineBy similarity1
Modified residuei2842N6-acetyllysineBy similarity1
Modified residuei2880N6-acetyllysineBy similarity1
Modified residuei3151PhosphotyrosineBy similarity1
Modified residuei3209N6-acetyllysineBy similarity1
Modified residuei3574PhosphothreonineBy similarity1
Modified residuei3579PhosphotyrosineBy similarity1
Modified residuei3819PhosphothreonineBy similarity1
Modified residuei3843PhosphoserineBy similarity1
Modified residuei4171PhosphoserineBy similarity1
Modified residuei4173PhosphoserineBy similarity1
Modified residuei4174PhosphoserineBy similarity1
Modified residuei4175PhosphoserineBy similarity1
Modified residuei4178PhosphoserineBy similarity1
Modified residuei4179PhosphoserineBy similarity1
Modified residuei4180PhosphoserineBy similarity1
Modified residuei4181PhosphoserineBy similarity1
Modified residuei4182PhosphotyrosineBy similarity1
Modified residuei4185PhosphoserineBy similarity1
Modified residuei4189PhosphoserineBy similarity1
Modified residuei4195PhosphoserineBy similarity1
Modified residuei4200PhosphothreonineBy similarity1
Modified residuei4328Phosphothreonine; by CDK11 Publication1
Modified residuei4396PhosphoserineBy similarity1
Modified residuei4402PhosphoserineBy similarity1
Modified residuei4404PhosphotyrosineBy similarity1
Modified residuei4405PhosphoserineBy similarity1
Modified residuei4407PhosphoserineBy similarity1
Modified residuei4411PhosphoserineBy similarity1
Modified residuei4412PhosphothreonineBy similarity1
Modified residuei4415PhosphoserineBy similarity1
Modified residuei4416Omega-N-methylarginineBy similarity1
Modified residuei4429Omega-N-methylarginineBy similarity1
Modified residuei4431PhosphoserineBy similarity1
Modified residuei4464PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9JI55

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JI55

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homotetramer (By similarity).

Interacts (via actin-binding domain) with SYNE3.

Interacts (via calponin-homology (CH) 1 domain) with VIM (via rod region).

Interacts (via N-terminus) with DST isoform 2 (via N-terminus).

Interacts with FER.

Interacts with TOR1A (By similarity).

Interacts with ANK3 (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity).

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JI55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 74Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST›74
Domaini87 – 192Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati449 – 508Spectrin 1Add BLAST60
Repeati529 – 613Spectrin 2Add BLAST85
Repeati626 – 719Spectrin 3Add BLAST94
Domaini730 – 787SH3PROSITE-ProRule annotationAdd BLAST58
Repeati1104 – 1204Spectrin 4Add BLAST101
Repeati2615 – 2652Plectin 1Add BLAST38
Repeati2653 – 2690Plectin 2Add BLAST38
Repeati2691 – 2728Plectin 3Add BLAST38
Repeati2729 – 2766Plectin 4Add BLAST38
Repeati2770 – 2804Plectin 5Add BLAST35
Repeati2905 – 2942Plectin 6Add BLAST38
Repeati2943 – 2980Plectin 7Add BLAST38
Repeati2981 – 3018Plectin 8Add BLAST38
Repeati3019 – 3056Plectin 9Add BLAST38
Repeati3057 – 3094Plectin 10Add BLAST38
Repeati3274 – 3311Plectin 11Add BLAST38
Repeati3312 – 3349Plectin 12Add BLAST38
Repeati3350 – 3387Plectin 13Add BLAST38
Repeati3388 – 3425Plectin 14Add BLAST38
Repeati3429 – 3463Plectin 15Add BLAST35
Repeati3609 – 3646Plectin 16Add BLAST38
Repeati3647 – 3684Plectin 17Add BLAST38
Repeati3685 – 3722Plectin 18Add BLAST38
Repeati3723 – 3760Plectin 19Add BLAST38
Repeati3764 – 3797Plectin 20Add BLAST34
Repeati3800 – 3834Plectin 21Add BLAST35
Repeati3852 – 3889Plectin 22Add BLAST38
Repeati3890 – 3927Plectin 23Add BLAST38
Repeati3928 – 3965Plectin 24Add BLAST38
Repeati3966 – 4003Plectin 25Add BLAST38
Repeati4007 – 4041Plectin 26Add BLAST35
Repeati4043 – 4094Plectin 27Add BLAST52
Repeati4197 – 4234Plectin 28Add BLAST38
Repeati4235 – 4272Plectin 29Add BLAST38
Repeati4273 – 4310Plectin 30Add BLAST38
Repeati4311 – 4348Plectin 31Add BLAST38
Repeati4349 – 4386Plectin 32Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni‹1 – 1259Globular 1Add BLAST›1259
Regioni‹1 – 192Actin-bindingAdd BLAST›192
Regioni1260 – 2544Central fibrous rod domainAdd BLAST1285
Regioni2545 – 4473Globular 2Add BLAST1929
Regioni4039 – 4089Binding to intermediate filamentsBy similarityAdd BLAST51
Regioni4414 – 44294 X 4 AA tandem repeats of G-S-R-XAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1258 – 2548Sequence analysisAdd BLAST1291

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.90.1290.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR035915 Plakin_repeat_sf
IPR030269 Plectin
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF20 PTHR23169:SF20, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF00681 Plectin, 18 hits
PF17902 SH3_10, 1 hit
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00250 PLEC, 34 hits
SM00150 SPEC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9JI55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DGHNLISLLE VLSGDSLPRE KGRMRFHKLQ NVQIALDYLR HRQVKLVNIR
60 70 80 90 100
NDDIADGNPK LTLGLIWTII LHFQISDIQV SGQSEDMTAK EKLLLWSQRM
110 120 130 140 150
VEGYQGLRCD NFTTSWRDGR LFNAIIHRHK PMLIDMNKVY RQTNLENLDQ
160 170 180 190 200
AFSVAERDLG VTRLLDPEDV DVPQPDEKSI ITYVSSLYDA MPRVPGAQNG
210 220 230 240 250
VRANELQLRW QEYRELVLLL LQWIRHHTAA FEERKFPSSF EEIEILWCQF
260 270 280 290 300
LKFKETELPA KEADKSRSKG IYQSLEGAVQ AGQLQIPPGF HPLDVEKEWG
310 320 330 340 350
KLHVAILERE KQLRGEFERL ECLQRIVSKL QMEAGLCEEQ LNQADSLLQS
360 370 380 390 400
DIRLLASGKV AQRAGEVERD LDKADGMIRL LFNDVQTLKD GRHPQGEQMY
410 420 430 440 450
RRVYRLHERL VAIRTEYNLR LKAGVAAPVT QVTVQSTQRR PELEDSTLRY
460 470 480 490 500
LQDLLAWVEE NQRRIDSAEW GVDLPSVEAQ LGSHRGMHQS IEEFRAKIER
510 520 530 540 550
ARNDESQLSP ATRGAYRECL GRLDLQYAKL LNSSKARLRS LESLHGFVAA
560 570 580 590 600
ATKELMWLNE KEEEEVGFDW SDRNTNMAAK KESYSALMRE LEMKEKKIKE
610 620 630 640 650
TQNTGDRLLR EDHHARPTVE SFQAALQTQW SWMLQLCCCI EAHLKENTAY
660 670 680 690 700
FQFFSDVREA EEQLQKLQET MRREYSCDRS ITVTRLEDLL QDAQDEREQL
710 720 730 740 750
NEYKGHLSGL AKRAKAIVQL KPRNPAHPVR GHVPLMAVCD YKQVEVTVHK
760 770 780 790 800
GDQCQLVGPA QPSHWKVLRG PSSEAAVPSV CFLVPPPNQE AQEAVARLEA
810 820 830 840 850
QHQALVTLWH QLHVDMKSLL AWQNLSRDIQ LIRSWSLVTF RTLKPEEQRQ
860 870 880 890 900
ALRNLELHYQ AFLRDSQDAG GFGPEDRLVA EREYGSCSRH YQQLLQSLEQ
910 920 930 940 950
GEQEESRCQR CISELKDIRL QLEACETRTV HRLRLPLDKE PARECAQRIA
960 970 980 990 1000
EQQKAQAEVE GLGKGVARLS AEAEKVLALP EPSPAAPTLR SELELTLGKL
1010 1020 1030 1040 1050
EQVRSLSAIY LEKLKTISLV IRSTQGAEEV LKAHEEQLKE AQAVPATLQE
1060 1070 1080 1090 1100
LEATKASLKK LRAQAEAQQP VFDTLRDELR GAQEVGERLQ QRHGERDVEV
1110 1120 1130 1140 1150
ERWRERVNQL LERWQAVLAQ IDVRQRELEQ LGRQLRYYRE SADPLSSWLQ
1160 1170 1180 1190 1200
DAKRRQEQIQ AVPIPNSQAA REQLRQEKAL LEEIERHGEK VEECQKFAKQ
1210 1220 1230 1240 1250
YINAIKDYEL QLVTYKAQLE PVASPAKKPK VQSGSESVIQ EYVDLRTRYS
1260 1270 1280 1290 1300
ELTTLTSQYI KFISETLRRM EEEERLAEQQ RAEERERLAE GEAALEKQRQ
1310 1320 1330 1340 1350
LAEAHAQAKA QAELEAQELQ RRMQEEVARR EEAAVNAQQQ KRSIQEELQH
1360 1370 1380 1390 1400
LRQSSEAEIQ AKAQQVEAAE RSRMRIEEEI RVVRLQLETT ERQRGGAEGE
1410 1420 1430 1440 1450
LQALRARAEE AEAQKRQAQE EAERLRRQVQ DESQRKRQAE AELALRVKAQ
1460 1470 1480 1490 1500
AEAAQEKQRA LQALEELRLQ AEEAERRLRQ AQAERARQVQ VALETAQRSA
1510 1520 1530 1540 1550
EVELQSKRAS FAEKTAQLER TLQEEHVTVT QLREKAERRA QQQAEAERAR
1560 1570 1580 1590 1600
EEAERELERW QLKANEALRL RLQAEEVAQQ RSLAQADAEK QKEEAEREAR
1610 1620 1630 1640 1650
RRGKAEEQAV RQRELAEQEL EKQRQLAEGT AQQRLAAEQE LIRLRAETEQ
1660 1670 1680 1690 1700
GEQQRQLLEE ELARLQREAT AATHKRQELE AELAKVRAEM EVLLASKARA
1710 1720 1730 1740 1750
EEESRSTSEK SKQRLEAEAD RFRELAEEAA RLRALAEEAK RQRQLAEEDA
1760 1770 1780 1790 1800
ARQRAEAERV LTEKLAAISE ATRLKTEAEI ALKEKEAENE RLRRLAEDEA
1810 1820 1830 1840 1850
FQRRRLEEQA ALHKADIEER LAQLRKASES ELERQKGLVE DTLRQRRQVE
1860 1870 1880 1890 1900
EEILALKVSF EKAAAGKAEL ELELGRIRSS AEDTMRSKEQ AEQEAARQRQ
1910 1920 1930 1940 1950
LAAEEEQRRR EAEERVQKSL AAEEEAARQR KAALEEVERL KAKVEEARRL
1960 1970 1980 1990 2000
RERAEQESAR QLQLAQEAAQ KRLQAEEKAH AFVVQQREEE LQQTLQQEQS
2010 2020 2030 2040 2050
MLERLRGEAE AARRAAEEAE EAREQAEREA AQSRKQVEEA ERLKQSAEEQ
2060 2070 2080 2090 2100
AQARAQAQAA AEKLRKEAEQ EAARRAQAEQ AALKQKQAAD AEMEKHKKFA
2110 2120 2130 2140 2150
EQTLRQKAQV EQELTTLRLQ LEETDHQKSI LDEELQRLKA EVTEAARQRS
2160 2170 2180 2190 2200
QVEEELFSVR VQMEELGKLK ARIEAENRAL ILRDKDNTQR FLEEEAEKMK
2210 2220 2230 2240 2250
QVAEEAARLS VAAQEAARLR QLAEEDLAQQ RALAEKMLKE KMQAVQEATR
2260 2270 2280 2290 2300
LKAEAELLQQ QKELAQEQAR RLQEDKEQMA QQLVEETQGF QRTLEVERQR
2310 2320 2330 2340 2350
QLEMSAEAER LKLRMAEMSR AQARAEEDAQ RFRKQAEEIG EKLHRTELAT
2360 2370 2380 2390 2400
QEKVTLVQTL EIQRQQSDHD AERLREAIAE LEREKEKLKQ EAKLLQLKSE
2410 2420 2430 2440 2450
EMQTVQQEQI LQETQALQKS FLSEKDSLLQ RERFIEQEKA KLEQLFQDEV
2460 2470 2480 2490 2500
AKAQQLREEQ QRQQRQMEQE KQELVASMEE ARRRQCEAEE AVRRKQEELQ
2510 2520 2530 2540 2550
HLELQRQQQE KLLAEENQRL RERLQRLEEE HRAALAHSEE IAATQAAAAK
2560 2570 2580 2590 2600
ALPNGRDALD GPSMEVEPEH AFEGLRQKVP ALQLREAGIL SAEELQRLEQ
2610 2620 2630 2640 2650
GHTTVAELSQ REDVRQYLQG RSSIAGLLLK PTDEKLSVYT ALQRQLLSPG
2660 2670 2680 2690 2700
TALILLEAQA ASGFLLDPVR NRRLTVNEPV KEGVVGPELH HKLLSAERAV
2710 2720 2730 2740 2750
TGYKDPYTGE QISLFQAMKK DLLVRDHAIR LLEAQIATGG IIDTVHSHRV
2760 2770 2780 2790 2800
PVDVAYQRGY FDEEMSRILA DPGDDTKGFF DPNTHENLTY LQLLERCVED
2810 2820 2830 2840 2850
PETGLHLLPL TDKAAKGGEL VYTDTEARDV FEKATVSAPF GKFQGKTVTI
2860 2870 2880 2890 2900
WEIINSEYFT AEQRRDLLRQ FRTGRITVEK IIKIVITVVE EQERKGQLCF
2910 2920 2930 2940 2950
EGLRALVPAA ELLESGVISH ELYQQLQRGE RSVREVAEAD SVRRALRGAS
2960 2970 2980 2990 3000
VIAGVWLEEA GQKLSIYEAL KKDLLQPDVA VALLEAQAGT GHIIDPATSA
3010 3020 3030 3040 3050
RLTVDEAVRA GLVGPELHEK LLSAEKAVTG YRDPYSGQSV SLFQALKKGL
3060 3070 3080 3090 3100
IPREQGLRLL DAQLSTGGMV DPSKSHRVPL DVAYARGYLD KETNRALTSP
3110 3120 3130 3140 3150
RNDARVYLDP SSQEPATYSQ LQQRCRADQL TGLSLLPVSE KAVRARQEEV
3160 3170 3180 3190 3200
YSELQARETL EKARVEVPVG GFKGRTMTVW ELISSEYFTQ EQRQELLRQF
3210 3220 3230 3240 3250
RTGKVTVEKV IRIVITIVEE VETQRQERLS FSGLRAPVPA SELLAAKILS
3260 3270 3280 3290 3300
RAQFDQLKEG KTSVKDLSEV GSVRTLLQGS GCLAGVYLED SKEKVTIYEA
3310 3320 3330 3340 3350
MRRGLLRPST ATLLLEAQAA TGFLVDPVRN QRLYVHEAVK AGVVGPELHE
3360 3370 3380 3390 3400
KLLSAEKAVT GYKDPYSGTT ISLFQAMKKG LVLREHAIRL LEAQIATGGI
3410 3420 3430 3440 3450
IDPVHSHRLP VDVAYQRGYF DEEMSRILAD PSDDTKGFFD PNTHENLTYL
3460 3470 3480 3490 3500
QLLERCVEDP ETGLRLLPLK GAEKTEVVET TQVYTEEETR RAFEETQIDI
3510 3520 3530 3540 3550
PGGGSHGGSS MSLWEVMQSD MIPEDQRARL MADFQAGRVT KERMIIIIIE
3560 3570 3580 3590 3600
IIEKTEIIRQ QNLASYDYVR RRLTAEDLYE ARIISLETYN LFREGTKSLR
3610 3620 3630 3640 3650
EVLEMESAWR YLYGTGSVAG VYLPGSRQTL TIYQALKKGL LSAEVARLLL
3660 3670 3680 3690 3700
EAQAATGFLL DPVKGERLTV DEAVRKGLVG PELHDRLLSA ERAVTGYRDP
3710 3720 3730 3740 3750
YTEQTISLFQ AMKKELIPAE EALRLLDAQL ATGGIVDPRL GFHLPLEVAY
3760 3770 3780 3790 3800
QRGYLNKDTH DQLSEPSEVR SYVDPSTDER LSYTQLLKRC RRDDGSGQML
3810 3820 3830 3840 3850
LPLSDARRLT FRGLRKQITV EELVRSQVMD EATALQLQEG LTSIEEVTKT
3860 3870 3880 3890 3900
LQKFLEGTSC IAGVFVDATK ERLSVYQAMK KGIIRPGTAF ELLEAQAATG
3910 3920 3930 3940 3950
YVIDPIKGLK LTVEEAVRMG IVGPEFKDRL LSAERAVTGY KDPYSGKLIS
3960 3970 3980 3990 4000
LFQAMKKGLI LKDHGIRLLE AQIATGGIID PEESHRLPVE VAYKRGLFDE
4010 4020 4030 4040 4050
EMNEILTDPS DDTKGFFDPN TEENLTYLQL MERCITDPQT GLRLLPLKEK
4060 4070 4080 4090 4100
KRERKTSSKS SVRKRRVVIV DPETSKEMSV YEAYRKGLID HQTYLELSEQ
4110 4120 4130 4140 4150
ECEWEEITIS SSDGVVKSMI IDRRSGRQYD IDDAITENLI DRSALDQYRA
4160 4170 4180 4190 4200
GTLSITEFAD MLSGNAGGFR SRSSSVGSSS SYPISPAVSR TQLASWSDPT
4210 4220 4230 4240 4250
EETGPVAGIL DTETLEKVSI TEAMHRNLVD NITGQRLLEA QACTGGIIDP
4260 4270 4280 4290 4300
STGERFPVTE AVNKGLVDKI MVDRINLAQK AFCGFEDPRT KTKMSAAQAL
4310 4320 4330 4340 4350
KKGWLYYEAG QRFLEVQYLT GGLIEPDTPG RVPLDEALQR GTVDARTAQK
4360 4370 4380 4390 4400
LRDVSAYSKY LTCPKTKLKI SYKDALDRSM VEEGTGLRLL EAAAQSSKGY
4410 4420 4430 4440 4450
YSPYSVSGSG STTGSRTGSR TGSRAGSRRG SFDATGSGFS MTFSSSSYSS
4460 4470
SGYGRRYASG PPASLGGPES AVA
Length:4,473
Mass (Da):509,020
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE144615D361E3484
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF260753 mRNA Translation: AAF70372.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260753 mRNA Translation: AAF70372.1

3D structure databases

SMRiQ9JI55
ModBaseiSearch...

PTM databases

iPTMnetiQ9JI55

Proteomic databases

PRIDEiQ9JI55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
3.90.1290.10, 6 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR035915 Plakin_repeat_sf
IPR030269 Plectin
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR23169:SF20 PTHR23169:SF20, 3 hits
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00681 Plectin, 18 hits
PF17902 SH3_10, 1 hit
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00250 PLEC, 34 hits
SM00150 SPEC, 6 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 7 hits
PROSITEiView protein in PROSITE
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLEC_CRIGR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JI55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: July 3, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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