UniProtKB - Q9JI35 (HRH3_CAVPO)
Histamine H3 receptor
HRH3
Functioni
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
GO - Molecular functioni
- histamine receptor activity Source: InterPro
GO - Biological processi
- regulation of neurotransmitter levels Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Histamine H3 receptorShort name: H3R Short name: HH3R |
Gene namesi | Name:HRH3 |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 40 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 41 – 61 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 62 – 71 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 72 – 92 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 109 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 110 – 130 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 157 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 158 – 178 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 197 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 198 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 359 | CytoplasmicSequence analysisAdd BLAST | 141 | |
Transmembranei | 360 – 380 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 381 – 398 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 399 – 419 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 420 – 445 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069689 | 1 – 445 | Histamine H3 receptorAdd BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinExpressioni
Tissue specificityi
Interactioni
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000020710 |
Chemistry databases
BindingDBi | Q9JI35 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 236 – 264 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 288 – 336 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 247 – 261 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 299 – 314 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q9JI35 |
OrthoDBi | 614573at2759 |
Family and domain databases
CDDi | cd15296, 7tmA_Histamine_H3R, 1 hit |
InterProi | View protein in InterPro IPR041998, 7tmA_HRH3 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAPPDGLM NASGALAGEA AAAAGGARTF SAAWTAVLAA LMALLIVATV
60 70 80 90 100
LGNALVMLAF VADSSLRTQN NFFLLNLAIS DFLVGVFCIP LYVPYVLTGR
110 120 130 140 150
WTFGRGLCKL WLVVDYLLCT SSVFNIVLIS YDRFLSVTRA VSYRAQQGDT
160 170 180 190 200
RRAVRKMVLV WVLAFLLYGP AILSWEYLSG GSSIPEGHCY AEFFYNWYFL
210 220 230 240 250
ITASTLEFFT PFLSVTFFNL SIYLNIQRRT RLRLDGGARE AGPDPLPEAQ
260 270 280 290 300
SSPPQPPPGC WGCWPKGQGE SMPLHRYGVG EAGPGAEAGE AALGGGSGAA
310 320 330 340 350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL
360 370 380 390 400
SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL
410 420 430 440
LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHSSL EHCWK
The sequence of this isoform differs from the canonical sequence as follows:
276-305: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001880 | 276 – 305 | Missing in isoform Short. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267537 mRNA Translation: AAF78947.1 AF267538 mRNA Translation: AAF78950.1 |
RefSeqi | NP_001166208.1, NM_001172737.1 [Q9JI35-1] |
Genome annotation databases
GeneIDi | 100135541 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267537 mRNA Translation: AAF78947.1 AF267538 mRNA Translation: AAF78950.1 |
RefSeqi | NP_001166208.1, NM_001172737.1 [Q9JI35-1] |
3D structure databases
AlphaFoldDBi | Q9JI35 |
SMRi | Q9JI35 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000020710 |
Chemistry databases
BindingDBi | Q9JI35 |
ChEMBLi | CHEMBL5076 |
DrugCentrali | Q9JI35 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
GeneIDi | 100135541 |
Organism-specific databases
CTDi | 11255 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | Q9JI35 |
OrthoDBi | 614573at2759 |
Family and domain databases
CDDi | cd15296, 7tmA_Histamine_H3R, 1 hit |
InterProi | View protein in InterPro IPR041998, 7tmA_HRH3 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR003980, Histamine_H3_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01471, HISTAMINEH3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HRH3_CAVPO | |
Accessioni | Q9JI35Primary (citable) accession number: Q9JI35 Secondary accession number(s): Q9JI36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 16, 2001 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families