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Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

Fibp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic fibroblast growth factor intracellular-binding protein
Short name:
aFGF intracellular-binding protein
Alternative name(s):
FGF-1 intracellular-binding protein
Gene namesi
Name:Fibp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1926233 Fibp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000872382 – 357Acidic fibroblast growth factor intracellular-binding proteinAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JI19
MaxQBiQ9JI19
PaxDbiQ9JI19
PRIDEiQ9JI19

PTM databases

iPTMnetiQ9JI19
PhosphoSitePlusiQ9JI19

Expressioni

Developmental stagei

Expressed throughout the development in embryo at 10.5 dpc. Expressed in the central nervous system at 12.5 dpc. Expressed in the ventral part of caudal diencephalon at 12.5 dpc. Expressed in the dorsal root ganglia at 12.5 dpc. Expressed in the kidney and lung at 12.5 dpc. Expressed in the dorsal and ventral midbrain at 18.5 dpc. Expressed uniformely in the cortex at 18.5 dpc.1 Publication

Gene expression databases

ExpressionAtlasiQ9JI19 baseline and differential

Interactioni

Subunit structurei

Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JI19, 2 interactors
STRINGi10090.ENSMUSP00000025847

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFMD Eukaryota
ENOG410ZCZH LUCA
GeneTreeiENSGT00390000015815
HOVERGENiHBG005728
InParanoidiQ9JI19

Family and domain databases

InterProiView protein in InterPro
IPR008614 FIBP
PANTHERiPTHR13223 PTHR13223, 1 hit
PfamiView protein in Pfam
PF05427 FIBP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JI19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSELDIFVG NTTLIDEDVY RLWLDGYSVN DAVALRVRSG ILEQTGATTG
60 70 80 90 100
VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQT LLIERYYTFD
110 120 130 140 150
EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE
160 170 180 190 200
MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA
210 220 230 240 250
FCAELMIQNW TLGAVDSQVD DMDVDLDKEF LQDLKELKVL VADKDLLDLH
260 270 280 290 300
KSLVCTALRG KLGVFSEMET NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV
310 320 330 340 350
EKFVEPCRSD HWPLSDVRLF LSQYSASVHS LDGFRHQALW DRYMGTLRGC

LLRLYHD
Length:357
Mass (Da):41,204
Last modified:October 1, 2000 - v1
Checksum:i51A6D28F5879D94B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8K2D8Q8K2D8_MOUSE
Acidic fibroblast growth factor int...
Fibp mCG_19865
364Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270700 mRNA Translation: AAF76201.1
AK012629 mRNA Translation: BAB28367.1
AK028029 mRNA Translation: BAC25708.1
RefSeqiNP_067413.1, NM_021438.4
UniGeneiMm.329656

Genome annotation databases

EnsembliENSMUST00000225141; ENSMUSP00000153409; ENSMUSG00000024911
GeneIDi58249
KEGGimmu:58249
UCSCiuc008gdg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270700 mRNA Translation: AAF76201.1
AK012629 mRNA Translation: BAB28367.1
AK028029 mRNA Translation: BAC25708.1
RefSeqiNP_067413.1, NM_021438.4
UniGeneiMm.329656

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JI19, 2 interactors
STRINGi10090.ENSMUSP00000025847

PTM databases

iPTMnetiQ9JI19
PhosphoSitePlusiQ9JI19

Proteomic databases

EPDiQ9JI19
MaxQBiQ9JI19
PaxDbiQ9JI19
PRIDEiQ9JI19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000225141; ENSMUSP00000153409; ENSMUSG00000024911
GeneIDi58249
KEGGimmu:58249
UCSCiuc008gdg.2 mouse

Organism-specific databases

CTDi9158
MGIiMGI:1926233 Fibp

Phylogenomic databases

eggNOGiENOG410IFMD Eukaryota
ENOG410ZCZH LUCA
GeneTreeiENSGT00390000015815
HOVERGENiHBG005728
InParanoidiQ9JI19

Miscellaneous databases

ChiTaRSiFibp mouse
PROiPR:Q9JI19
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ9JI19 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008614 FIBP
PANTHERiPTHR13223 PTHR13223, 1 hit
PfamiView protein in Pfam
PF05427 FIBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIBP_MOUSE
AccessioniPrimary (citable) accession number: Q9JI19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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