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Protein

Something about silencing protein 10

Gene

Utp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain.By similarity1 Publication

GO - Biological processi

  • brain development Source: UniProtKB
  • chromatin organization Source: UniProtKB-KW
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central

Keywordsi

Molecular functionChromatin regulator, Developmental protein

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Something about silencing protein 10
Alternative name(s):
Charged amino acid-rich leucine zipper 1
Short name:
Crl-1
Disrupter of silencing SAS10
UTP3 homolog
Gene namesi
Name:Utp3
Synonyms:Crl1, Crlz1, Sas10Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919230 Utp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143271 – 469Something about silencing protein 10Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8Omega-N-methylarginineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei140N6-acetyllysine; alternateCombined sources1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei146PhosphoserineBy similarity1
Modified residuei375Citrulline1 Publication1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JI13
PaxDbiQ9JI13
PeptideAtlasiQ9JI13
PRIDEiQ9JI13

PTM databases

iPTMnetiQ9JI13
PhosphoSitePlusiQ9JI13

Expressioni

Tissue specificityi

Detected mainly in subsets of neuronal cells of the brain. In the 17.5 dpc embryo, mainly expressed in the olfactory bulb and cerebral cortex. Postnatally, additionally expressed in the cerebellar cortex, most strongly in the hippocampus.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiENSMUSG00000070697 Expressed in 305 organ(s), highest expression level in mandibular prominence
GenevisibleiQ9JI13 MM

Interactioni

Protein-protein interaction databases

BioGridi211158, 1 interactor
IntActiQ9JI13, 3 interactors
MINTiQ9JI13
STRINGi10090.ENSMUSP00000087896

Structurei

3D structure databases

ProteinModelPortaliQ9JI13
SMRiQ9JI13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 160Glu-richAdd BLAST95

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Phylogenomic databases

eggNOGiKOG3118 Eukaryota
ENOG410XSPX LUCA
GeneTreeiENSGT00500000044947
HOGENOMiHOG000047611
HOVERGENiHBG074329
InParanoidiQ9JI13
KOiK14767
OMAiEEYIRPQ
OrthoDBiEOG091G0LB8
PhylomeDBiQ9JI13
TreeFamiTF315177

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
IPR018972 Sas10_C_dom
PfamiView protein in Pfam
PF09368 Sas10, 1 hit
PF04000 Sas10_Utp3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q9JI13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKKSRRRGA AQWAAVRAQA GLTATDENED DLGLPPSPGD SSYYQDQVDE
60 70 80 90 100
FHEARSRAVL AKGWNEVESG EEDGDEEEEV LPLDIDDGDD EDGESSEEEE
110 120 130 140 150
VGEDDDGGSS VQSEAEASVD PSLSWGQRKK LYYDTDYGSK SRGRQSQQEV
160 170 180 190 200
EEEEREEEEE AQIIQRRLAQ ALQEDDFGVA WVEAFAKPVP QVDEAETRVV
210 220 230 240 250
KDLAKVSVKE KLKMLKKESP ELLELIEDLQ AKLTEVKDEL EPLLQLVEKG
260 270 280 290 300
VIPTGRGSEY LKTKYNLYLN YCANISFYLI LKARRVPAHG HPVIERLVTY
310 320 330 340 350
RNLINKLSVV DQKLSSEIRH LLTAKDGAVK KEMTPKAKLT KTKPKSVKQA
360 370 380 390 400
AAVALTDEPD FDGAALKYYK EMEDRQELKR KKEENSAEEQ ALEEQNAKRA
410 420 430 440 450
ITYQIAKNRG LTPRRKKIDR NPRVKHREKF RKAKIRRRGQ VREVRREEQR
460
YSGELSGIRA GVKKSIKLK
Length:469
Mass (Da):53,399
Last modified:October 1, 2000 - v1
Checksum:iD469094FF0AB9632
GO
Isoform 21 Publication (identifier: Q9JI13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-412: T → P
     414-469: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:413
Mass (Da):46,544
Checksum:i81B5FEE55C6F53C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → R in AAF80256 (PubMed:11404095).Curated1
Sequence conflicti14 – 15AA → RP in AAF80256 (PubMed:11404095).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051655412T → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_051656414 – 469Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155362 mRNA Translation: AAF80256.2
AF271213 mRNA Translation: AAF91409.1
AK010316 mRNA Translation: BAB26848.1
AK145637 mRNA Translation: BAE26555.1
BC022994 mRNA Translation: AAH22994.1
CCDSiCCDS19402.1 [Q9JI13-1]
RefSeqiNP_075541.1, NM_023054.1 [Q9JI13-1]
UniGeneiMm.490364

Genome annotation databases

EnsembliENSMUST00000090413; ENSMUSP00000087896; ENSMUSG00000070697 [Q9JI13-1]
GeneIDi65961
KEGGimmu:65961
UCSCiuc008xzv.1 mouse [Q9JI13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155362 mRNA Translation: AAF80256.2
AF271213 mRNA Translation: AAF91409.1
AK010316 mRNA Translation: BAB26848.1
AK145637 mRNA Translation: BAE26555.1
BC022994 mRNA Translation: AAH22994.1
CCDSiCCDS19402.1 [Q9JI13-1]
RefSeqiNP_075541.1, NM_023054.1 [Q9JI13-1]
UniGeneiMm.490364

3D structure databases

ProteinModelPortaliQ9JI13
SMRiQ9JI13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211158, 1 interactor
IntActiQ9JI13, 3 interactors
MINTiQ9JI13
STRINGi10090.ENSMUSP00000087896

PTM databases

iPTMnetiQ9JI13
PhosphoSitePlusiQ9JI13

Proteomic databases

EPDiQ9JI13
PaxDbiQ9JI13
PeptideAtlasiQ9JI13
PRIDEiQ9JI13

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090413; ENSMUSP00000087896; ENSMUSG00000070697 [Q9JI13-1]
GeneIDi65961
KEGGimmu:65961
UCSCiuc008xzv.1 mouse [Q9JI13-1]

Organism-specific databases

CTDi57050
MGIiMGI:1919230 Utp3

Phylogenomic databases

eggNOGiKOG3118 Eukaryota
ENOG410XSPX LUCA
GeneTreeiENSGT00500000044947
HOGENOMiHOG000047611
HOVERGENiHBG074329
InParanoidiQ9JI13
KOiK14767
OMAiEEYIRPQ
OrthoDBiEOG091G0LB8
PhylomeDBiQ9JI13
TreeFamiTF315177

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q9JI13
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070697 Expressed in 305 organ(s), highest expression level in mandibular prominence
GenevisibleiQ9JI13 MM

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
IPR018972 Sas10_C_dom
PfamiView protein in Pfam
PF09368 Sas10, 1 hit
PF04000 Sas10_Utp3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAS10_MOUSE
AccessioniPrimary (citable) accession number: Q9JI13
Secondary accession number(s): Q3UL95, Q8R5C6, Q9JJ12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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