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Entry version 162 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Alpha 4 type V collagen

Gene

Col5a3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1442490, Collagen degradation
R-RNO-1474244, Extracellular matrix organization
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-186797, Signaling by PDGF
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-216083, Integrin cell surface interactions
R-RNO-3000171, Non-integrin membrane-ECM interactions
R-RNO-3000178, ECM proteoglycans
R-RNO-419037, NCAM1 interactions
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha 4 type V collagenImported
Submitted name:
Collagen type V alpha 3 chainImported
Submitted name:
Procollagen, type V, alpha 3, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col5a3Imported
ORF Names:rCG_31726Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
70922, Col5a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501410809330 – 1737Sequence analysisAdd BLAST1708

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000020525, Expressed in quadriceps femoris and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000027897

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JI04

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1507 – 1736Fibrillar collagen NC1InterPro annotationAdd BLAST230

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 307DisorderedSequence analysisAdd BLAST83
Regioni321 – 351DisorderedSequence analysisAdd BLAST31
Regioni385 – 429DisorderedSequence analysisAdd BLAST45
Regioni473 – 1493DisorderedSequence analysisAdd BLAST1021

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi247 – 269Basic residuesSequence analysisAdd BLAST23
Compositional biasi270 – 290Polar residuesSequence analysisAdd BLAST21
Compositional biasi399 – 415Pro residuesSequence analysisAdd BLAST17
Compositional biasi656 – 677Pro residuesSequence analysisAdd BLAST22
Compositional biasi722 – 743Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi872 – 889Pro residuesSequence analysisAdd BLAST18
Compositional biasi930 – 944Pro residuesSequence analysisAdd BLAST15
Compositional biasi1076 – 1090Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1314 – 1328Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1364 – 1385Pro residuesSequence analysisAdd BLAST22
Compositional biasi1472 – 1486Pro residuesSequence analysisAdd BLAST15

Keywords - Domaini

CollagenImported, RepeatARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001074_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGHQGKD

Database of Orthologous Groups

More...
OrthoDBi
1018065at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JI04

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038, COLFI, 1 hit
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461, NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9JI04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSCRRLDQL QAGLCLLLAS LQLVSWTLAA EPVDVLETLG VHRDKAGVTK
60 70 80 90 100
GPGFCPQRIP QGDRAFRVGK SSLLSVPTWQ LFPDGHFPEN FSVLLTLRAQ
110 120 130 140 150
PANQSVLLSI YDENGVRQMG LALGPALGLL GDSFRSLPKQ INLMDGRWHR
160 170 180 190 200
VAVSISGDKV TLVVDCEPQP PMFGQGPRVI STAGLTVMGT QELGEESFEG
210 220 230 240 250
DIQELLLIPD PQAALQACEL YLPDCETPDS TTTGVTKEEP ETPAPRRRKG
260 270 280 290 300
KGKKKDRGRK GKGRKKNKTS RLSPTPGAPE NQTSLHTPET EKPSPHLPPT
310 320 330 340 350
PTPLAITTTV TMGGNATVLQ GLDSSTETEQ MTPEMDATEE SEGGGPTMGP
360 370 380 390 400
EFRAAEQSLQ TEFQIFPGAG EKGAKGEPAT IEQGQQFEGP AGAPGPRGIS
410 420 430 440 450
GPSGPPGPPG FPGDRGLPGP AGLPGIPGID GVRGLPGTVI MMPFHFASGS
460 470 480 490 500
MKGPPVSFQQ AQAQAVLQQA QLSMKGPPGP VGLTGRPGPV GLPGYPGLKG
510 520 530 540 550
ELGEAGPQGP RGLQGPPGPP GREGKTGRAG ADGARGLPGD TGPKGDRGFD
560 570 580 590 600
GLPGLPGEKG QRGDFGPVGQ PGPPGEDGIK GLQGPPGPTG QAGEPGPRGL
610 620 630 640 650
IGPRGPPGPL GRPGVTGSDG APGAKGNVGP PGEPGPPGQQ GNHGSQGIPG
660 670 680 690 700
PQGPIGTPGE KGPPGNPGIP GVPGSEGPPG HPGHEGPTGE KGAQGPPGSA
710 720 730 740 750
GPQGYPGPRG VKGTSGNRGL QGEKGERGED GFPGFKGDEG PKGDRGNPGL
760 770 780 790 800
PGPRGEDGPE GQKGPEGLPG DEGPPGAAGE KGKLGVPGLP GYPGRPGPKG
810 820 830 840 850
SIGFPGPLGP LGEKGKRGKA GQPGEEGERG TPGTRGDRGQ PGATGQPGPK
860 870 880 890 900
GDVGQNGSPG APGEKGLPGL QGPPGFPGPK GPPGPQGKDG IPGHPGQRGE
910 920 930 940 950
LGFQGQTGPP GPAGVLGPQG KVGDVGPLGE RGPPGPPGPP GEPGLPGIEG
960 970 980 990 1000
REGAKGELGP LGSLGKEGPP GPMGFPGPQG APGDPGPIGL KGDKGPPGPL
1010 1020 1030 1040 1050
GANGSPGERG PVGPSGGIGL PGQSGGQGPI GPAGEKGSPG ERGVPGPTGK
1060 1070 1080 1090 1100
DGIPGPPGLQ GPPGAAGPSG EEGDKGEVGM PGHKGSKGDK GDAGPPGPTG
1110 1120 1130 1140 1150
IRGPAGHPGP PGADGAQGRR GPPGLFGQKG DDGVRGFVGV IGPPGLQGLP
1160 1170 1180 1190 1200
GPPGEKGEVG DVGSMGPHGA PGPRGPPGPS GSAGSPGLPG GVGQPGAVGE
1210 1220 1230 1240 1250
KGEPGNAGDA GPPGVPGIPG PKGEIGEKGD SGPSGAAGPP GKKGPPGEDG
1260 1270 1280 1290 1300
AKGNMGPTGL PGDLGPPGDP GVPGTDGIPG EKGNAGDIGG PGPPGASGEP
1310 1320 1330 1340 1350
GARGLPGKRG SPGRMGPEGK EGEKGAKGDA GPDGPPGRTG PIGARGPPGR
1360 1370 1380 1390 1400
VGPDGLPGIP GPVGEPGLLG PPGLIGPPGP LGPPGLPGLK GDAGLKGEKG
1410 1420 1430 1440 1450
HIGLIGLIGP PGEAGEKGDQ GLPGVQGPPG LQGDPGLPGP VGSLGHPGPP
1460 1470 1480 1490 1500
GVVGPLGQKG SKGSPGSLGP RGDPGPAGPP GPPGSPAEVH GLRRRRSVLD
1510 1520 1530 1540 1550
TPEGGLEEVM ASLNSLSLEL EQLQRPPGTA ESPGLICHEL HRNHPHLPDG
1560 1570 1580 1590 1600
EYWIDPNQGC ARDAFKVFCN FTAGGETCLY PDKKFETVKL ASWSREKPGG
1610 1620 1630 1640 1650
WYSTFRRGKK FSYVDADGSP VNVVQLTFLK LLSAAAHQRF TYTCQNSAAW
1660 1670 1680 1690 1700
LDEASGDHRH SIRFQGTNWE ELSFNQTTAA TIKVPHDGCR VRKGQAKTLF
1710 1720 1730
EFSSSVGFLP LWDVAAVDFG QTNQKFGFEL GSVCFSS
Length:1,737
Mass (Da):171,575
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD635D5D57481C257
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07073370 Genomic DNA No translation available.
AC135310 Genomic DNA No translation available.
AF272661 mRNA Translation: AAF76432.1
CH473993 Genomic DNA Translation: EDL78352.1

NCBI Reference Sequences

More...
RefSeqi
NP_068528.1, NM_021760.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000027897; ENSRNOP00000027897; ENSRNOG00000020525

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60379

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:60379

UCSC genome browser

More...
UCSCi
RGD:70922, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073370 Genomic DNA No translation available.
AC135310 Genomic DNA No translation available.
AF272661 mRNA Translation: AAF76432.1
CH473993 Genomic DNA Translation: EDL78352.1
RefSeqiNP_068528.1, NM_021760.1

3D structure databases

SMRiQ9JI04
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027897

Genome annotation databases

EnsembliENSRNOT00000027897; ENSRNOP00000027897; ENSRNOG00000020525
GeneIDi60379
KEGGirno:60379
UCSCiRGD:70922, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50509
RGDi70922, Col5a3

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000162394
HOGENOMiCLU_001074_2_0_1
OMAiPGHQGKD
OrthoDBi1018065at2759
PhylomeDBiQ9JI04
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-RNO-1442490, Collagen degradation
R-RNO-1474244, Extracellular matrix organization
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-186797, Signaling by PDGF
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-216083, Integrin cell surface interactions
R-RNO-3000171, Non-integrin membrane-ECM interactions
R-RNO-3000178, ECM proteoglycans
R-RNO-419037, NCAM1 interactions
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8948216, Collagen chain trimerization

Gene expression databases

BgeeiENSRNOG00000020525, Expressed in quadriceps femoris and 22 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 2 hits
SMARTiView protein in SMART
SM00038, COLFI, 1 hit
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461, NC1_FIB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9JI04_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JI04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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