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Entry version 116 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Collagen alpha-1(V) chain

Gene

Col5a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1442490, Collagen degradation
R-RNO-1474244, Extracellular matrix organization
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-186797, Signaling by PDGF
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-216083, Integrin cell surface interactions
R-RNO-3000171, Non-integrin membrane-ECM interactions
R-RNO-3000178, ECM proteoglycans
R-RNO-419037, NCAM1 interactions
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(V) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col5a1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
70920, Col5a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004176231 – 1840Collagen alpha-1(V) chainAdd BLAST1810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei234SulfotyrosineSequence analysis1
Modified residuei236SulfotyrosineSequence analysis1
Modified residuei240SulfotyrosineSequence analysis1
Modified residuei262SulfotyrosineSequence analysis1
Modified residuei263SulfotyrosineSequence analysis1
Modified residuei336SulfotyrosineSequence analysis1
Modified residuei338SulfotyrosineSequence analysis1
Modified residuei344SulfotyrosineSequence analysis1
Modified residuei5724-hydroxyprolineBy similarity1
Modified residuei5784-hydroxyprolineBy similarity1
Modified residuei6234-hydroxyprolineBy similarity1
Modified residuei6295-hydroxylysineBy similarity1
Modified residuei6414-hydroxyprolineBy similarity1
Modified residuei6445-hydroxylysineBy similarity1
Modified residuei6504-hydroxyprolineBy similarity1
Modified residuei6564-hydroxyprolineBy similarity1
Modified residuei6594-hydroxyprolineBy similarity1
Modified residuei6774-hydroxyprolineBy similarity1
Modified residuei6804-hydroxyprolineBy similarity1
Modified residuei6823-hydroxyprolineBy similarity1
Modified residuei6883-hydroxyprolineBy similarity1
Modified residuei6924-hydroxyprolineBy similarity1
Modified residuei6984-hydroxyprolineBy similarity1
Modified residuei7074-hydroxyprolineBy similarity1
Modified residuei7105-hydroxylysineBy similarity1
Modified residuei7194-hydroxyprolineBy similarity1
Modified residuei7224-hydroxyprolineBy similarity1
Modified residuei7284-hydroxyprolineBy similarity1
Modified residuei7344-hydroxyprolineBy similarity1
Modified residuei7465-hydroxylysineBy similarity1
Modified residuei7524-hydroxyprolineBy similarity1
Modified residuei7584-hydroxyprolineBy similarity1
Modified residuei7644-hydroxyprolineBy similarity1
Modified residuei7674-hydroxyprolineBy similarity1
Modified residuei7734-hydroxyprolineBy similarity1
Modified residuei7765-hydroxylysineBy similarity1
Modified residuei7824-hydroxyprolineBy similarity1
Modified residuei7914-hydroxyprolineBy similarity1
Modified residuei7975-hydroxylysineBy similarity1
Modified residuei8065-hydroxylysineBy similarity1
Modified residuei8095-hydroxylysineBy similarity1
Modified residuei8125-hydroxylysineBy similarity1
Modified residuei8184-hydroxyprolineBy similarity1
Modified residuei8215-hydroxylysineBy similarity1
Modified residuei8364-hydroxyprolineBy similarity1
Modified residuei8485-hydroxylysineBy similarity1
Modified residuei8665-hydroxylysineBy similarity1
Modified residuei8724-hydroxyprolineBy similarity1
Modified residuei8754-hydroxyprolineBy similarity1
Modified residuei8784-hydroxyprolineBy similarity1
Modified residuei8845-hydroxylysineBy similarity1
Modified residuei8904-hydroxyprolineBy similarity1
Modified residuei8934-hydroxyprolineBy similarity1
Modified residuei8995-hydroxylysineBy similarity1
Modified residuei9054-hydroxyprolineBy similarity1
Modified residuei9084-hydroxyprolineBy similarity1
Modified residuei9324-hydroxyprolineBy similarity1
Modified residuei9474-hydroxyprolineBy similarity1
Modified residuei10194-hydroxyprolineBy similarity1
Modified residuei10224-hydroxyprolineBy similarity1
Modified residuei10254-hydroxyprolineBy similarity1
Modified residuei10314-hydroxyprolineBy similarity1
Modified residuei12234-hydroxyprolineBy similarity1
Modified residuei12264-hydroxyprolineBy similarity1
Modified residuei14694-hydroxyprolineBy similarity1
Modified residuei14724-hydroxyprolineBy similarity1
Modified residuei1603SulfotyrosineSequence analysis1
Modified residuei1606SulfotyrosineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity
Sulfated on 40% of tyrosines.By similarity
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Hydroxylation, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JI03

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JI03

PRoteomics IDEntifications database

More...
PRIDEi
Q9JI03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

A high molecular weight form was detected in Schwann cells and peripheral nerve. A lower, probably processed form, is detected in all other tissues tested (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.

Interacts with CSPG4 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9JI03, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000012334

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9JI03

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 244Laminin G-likeAdd BLAST173
Domaini1611 – 1839Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni231 – 445Nonhelical regionBy similarityAdd BLAST215
Regioni446 – 560Interrupted collagenous regionBy similarityAdd BLAST115
Regioni561 – 1572Triple-helical regionBy similarityAdd BLAST1012
Regioni1573 – 1607Nonhelical regionBy similarityAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JI03

KEGG Orthology (KO)

More...
KOi
K19721

Database of Orthologous Groups

More...
OrthoDBi
199083at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JI03

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 6 hits
PF02210, Laminin_G_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038, COLFI, 1 hit
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461, NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9JI03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVHTRWKAP RPGAPLLSSP LLLLLLLLWA PPPSRAAQPT DLLEMLDFHN
60 70 80 90 100
LPSGVTKTTG FCATRRSSKE PDVAYRVSKD AQLSMPTKQL YPESDFPEDF
110 120 130 140 150
SILTTVKAKK GSQAFLVSVY NEQGIQQLGL ELGRSPVFLY EDHTGKPGPE
160 170 180 190 200
EYPLFPGINL SDGKWHRIAI SVYKKNVTLI LDCKKKITKF LNRGDHPIID
210 220 230 240 250
VNGIIMFGSR ILDDEIFEGD IQQLLFVSDH RAAYDYCEHY SPDCDTAVPD
260 270 280 290 300
TPQSQDPNPD EYYPEGEGET YYYEYPYYED PEDPGKEPAP SQKPVEAARE
310 320 330 340 350
TTEVPEEQTQ PPSEAPTVPE TSDTAGKEDN PGIGDYDYVP TDDYYTTSPY
360 370 380 390 400
EDFGYGEGVE NPDQPTNPDS GAEIPTSTSV TSNSSNPAPS PEEGKDDLGG
410 420 430 440 450
EFTEETIKNL DENYYDPYFD PDSDSNVSPS EIGPGMPANQ DTIYEGIGGP
460 470 480 490 500
RGEKGQKGEP AIIEPGMLIE GPPGPEGPAG LPGPPGTTGP TGQMGDPGER
510 520 530 540 550
GPPGRPGLPG ADGLPGPPGT MLMLPFRFGG GGDAGSKGPM VSAQESQAQA
560 570 580 590 600
ILQQARLALR GPAGPMGLTG RPGPMGPPGS GGLKGEPGDM GPQGPRGVQG
610 620 630 640 650
PPGPTGKPGR RGRAGSDGAR GMPGQTGPKG DRGFDGLAGL PGEKGHRGDP
660 670 680 690 700
GPSGPPGLPG DDGERGDDGE VGPRGLPGEP GPRGLLGPKG PPGPPGPPGV
710 720 730 740 750
TGMDGQPGPK GNVGPQGEPG PPGQQGNPGA QGLPGPQGAI GPPGEKGPLG
760 770 780 790 800
KPGLPGMPGA DGPPGHPGKE GPPGEKGGQG PPGPQGPIGY PGPRGVKGAD
810 820 830 840 850
GIRGLKGTKG EKGEDGFPGF KGDMGIKGDR GEIGPPGPRG EDGPEGPKGR
860 870 880 890 900
GGPNGDPGPL GPTGEKGKLG VPGLPGYPGR QGPKGSIGFP GFPGANGEKG
910 920 930 940 950
GRGTPGKPGP RGQRGPTGPR GERGPRGITG KPGPKGNSGG DGPAGPPGER
960 970 980 990 1000
GPNGPQGPTG FPGPKGPPGP PGKDGLPGHP GQRGETGFQG KTGPPGPPGV
1010 1020 1030 1040 1050
VGPQGPTGET GPMGERGHPG PPGPPGEQGL PGAAGKEGTK GDPGPAGLPG
1060 1070 1080 1090 1100
KDGPPGLRGF PGDRGLPGPV GALGLKGSEG PPGPPGPAGS PGERGPAGAA
1110 1120 1130 1140 1150
GPIGIPGRPG PQGPPGPAGE KGVPGEEGPQ GPAGRDGLQG PVGLPGPAGP
1160 1170 1180 1190 1200
VGPPGEDGDK GEIGEPGQKG SKGDKGEQGP PGPTGPQGPT GQPGPSGADG
1210 1220 1230 1240 1250
EPGPRGQQGL FGQKGDEGSR GFPGPPGPVG LQGLPGPPGE KGETGDVGQM
1260 1270 1280 1290 1300
GPPGPPGPRG PSGAPGADGP QGPPGGIGNP GAVGEKGEPG EAGEPGLPGE
1310 1320 1330 1340 1350
GGPLGPKGER GEKGEAGPSG AAGPPGPKGP PGDDGPKGSP GPVGFPGDPG
1360 1370 1380 1390 1400
PPGEPGPAGQ DGPPGDKGDD GEPGQTGSPG PTGEPGPSGP PGKRGPPGPA
1410 1420 1430 1440 1450
GPEGRQGEKG AKGEAGLEGP PGKTGPIGPQ GAPGKPGPDG LRGIPGPVGE
1460 1470 1480 1490 1500
QGLPGSPGPD GPPGPMGPPG LPGLKGDSGP KGEKGHPGLI GLIGPPGEQG
1510 1520 1530 1540 1550
EKGDRGLPGP QGSSGPKGEQ GITGPSGPLG PPGPPGLPGP PGPKGAKGSS
1560 1570 1580 1590 1600
GPTGPKGEAG HPGLPGPPGP PGEVIQPLPI QASRTRRNID ASQLLDDGAG
1610 1620 1630 1640 1650
ESYVDYADGM EEIFGSLNSL KLEIEQMKRP LGTQQNPART CKDLQLCHPD
1660 1670 1680 1690 1700
FPDGEYWVDP NQGCSRDSFK VYCNFTAGGS TCVFPDKKSE GARITSWPKE
1710 1720 1730 1740 1750
NPGSWFSEFK RGKLLSYVDA EGNPVGVVQM TFLRLLSASA QQNITYNCYQ
1760 1770 1780 1790 1800
SVAWQDAATG SYDKAIRFLG SNDEEMSYDN NPYIRALVDG CATKKGYQKT
1810 1820 1830 1840
VLEIDTPKVE QVPIVDIMFT DFGEASQKFG FEVGPACFLG
Length:1,840
Mass (Da):183,987
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD38F5FF886B923C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V763G3V763_RAT
Collagen alpha-1(V) chain
Col5a1 rCG_45497
1,840Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JX47A0A0G2JX47_RAT
Collagen alpha-1(V) chain
Col5a1
1,788Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF272662 mRNA Translation: AAF76433.1

NCBI Reference Sequences

More...
RefSeqi
NP_604447.1, NM_134452.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85490

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:85490

UCSC genome browser

More...
UCSCi
RGD:70920, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272662 mRNA Translation: AAF76433.1
RefSeqiNP_604447.1, NM_134452.1

3D structure databases

SMRiQ9JI03
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9JI03, 1 interactor
STRINGi10116.ENSRNOP00000012334

Proteomic databases

jPOSTiQ9JI03
PaxDbiQ9JI03
PRIDEiQ9JI03

Genome annotation databases

GeneIDi85490
KEGGirno:85490
UCSCiRGD:70920, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1289
RGDi70920, Col5a1

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
InParanoidiQ9JI03
KOiK19721
OrthoDBi199083at2759
PhylomeDBiQ9JI03

Enzyme and pathway databases

ReactomeiR-RNO-1442490, Collagen degradation
R-RNO-1474244, Extracellular matrix organization
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-186797, Signaling by PDGF
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-216083, Integrin cell surface interactions
R-RNO-3000171, Non-integrin membrane-ECM interactions
R-RNO-3000178, ECM proteoglycans
R-RNO-419037, NCAM1 interactions
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8948216, Collagen chain trimerization

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9JI03

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR013320, ConA-like_dom_sf
IPR000885, Fib_collagen_C
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 6 hits
PF02210, Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00038, COLFI, 1 hit
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461, NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO5A1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JI03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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