Sodium-coupled neutral amino acid transporter 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amino acid transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• antiporter activity Source: UniProtKB-KW
• L-alanine transmembrane transporter activity Source: RGD
• L-asparagine transmembrane transporter activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.2

    "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• L-glutamine transmembrane transporter activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.2

    "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• L-histidine transmembrane transporter activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• symporter activity Source: UniProtKB-KW

GO - Biological processⁱ

• amino acid transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• asparagine transport Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.2

    "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• brain development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain."
    Boulland J.L., Rafiki A., Levy L.M., Storm-Mathisen J., Chaudhry F.A.
    Glia 41:260-275(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to potassium ion starvation Source: RGD
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Expression and role of SNAT3 in the placenta."
    Yoshioka C., Yasuda S., Kimura F., Kobayashi M., Itagaki S., Hirano T., Iseki K.
    Placenta 30:1071-1077(2009) [PubMed] [Europe PMC] [Abstract]
• glutamine transport Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  • Ref.2

    "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• histidine transport Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• L-alanine transport Source: RGD
• positive regulation of glutamine transport Source: RGDInferred from direct assayⁱ
  • "Heterologous expression of the glutamine transporter SNAT3 in Xenopus oocytes is associated with four modes of uncoupled transport."
    Schneider H.P., Broer S., Broer A., Deitmer J.W.
    J Biol Chem 282:3788-3798(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: RGD
• sodium ion transport Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGMPTA DTQRAEDAQH CGEGKGFLQQ 
        60         70         80         90        100
SSSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF 
       110        120        130        140        150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL 
       160        170        180        190        200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP TPVWYMDGNY LVILVSVIII 
       210        220        230        240        250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLVNATG 
       260        270        280        290        300
NFSHMVVVEE KSQLQSEPDT AEAFCTPSYF TLNSQTAYTI PIMAFAFVCH 
       310        320        330        340        350
PEVLPIYTEL KDPSKRKMQH ISNLSIAVMY VMYFLAALFG YLTFYDGVES 
       360        370        380        390        400
ELLHTYSKVD PFDVLILCVR VAVLIAVTLT VPIVLFPVRR AIQQMLFQNQ 
       410        420        430        440        450
EFSWLRHVLI ATGLLTCINL LVIFAPNILG IFGIIGATSA PCLIFIFPAI 
       460        470        480        490        500
FYFRIMPTEK EPVRSTPKIL ALCFAAVGFL LMTMSLSFII TDWVSGTSQH 

GGNH                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families