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UniProtKB - Q9JHZ9 (S38A3_RAT)
Protein
Sodium-coupled neutral amino acid transporter 3
Gene
Slc38a3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine and asparagine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
1 Publication2 PublicationsGO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- antiporter activity Source: UniProtKB-KW
- L-alanine transmembrane transporter activity Source: RGD
- L-asparagine transmembrane transporter activity Source: UniProtKB
- L-glutamine transmembrane transporter activity Source: UniProtKB
- L-histidine transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- asparagine transport Source: UniProtKB
- brain development Source: RGD
- cellular response to potassium ion starvation Source: RGD
- female pregnancy Source: RGD
- glutamine transport Source: UniProtKB
- histidine transport Source: UniProtKB
- L-alanine transport Source: RGD
- positive regulation of glutamine transport Source: RGD
- positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: RGD
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-352230, Amino acid transport across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-coupled neutral amino acid transporter 3Alternative name(s): N-system amino acid transporter 1 Na(+)-coupled neutral amino acid transporter 3 Solute carrier family 38 member 3 System N amino acid transporter 1 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628620, Slc38a3 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- apical plasma membrane Source: RGD
- basolateral plasma membrane Source: RGD
- integral component of plasma membrane Source: UniProtKB
Other locations
- membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 143 – 163 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 324 – 344 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 408 – 428 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 431 – 451 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 469 – 489 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093830 | 1 – 504 | Sodium-coupled neutral amino acid transporter 3Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 239 ↔ 275 | PROSITE-ProRule annotation | ||
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9JHZ9 |
PTM databases
GlyGeni | Q9JHZ9, 4 sites |
iPTMneti | Q9JHZ9 |
PhosphoSitePlusi | Q9JHZ9 |
Expressioni
Tissue specificityi
Expressed in skeletal muscle, liver, kidney, heart and brain. Not detected in gut, lung or spleen. Expressed ubiquitously in hepatocytes in liver whereas in kidney expression is restricted to the medulla. Within brain, expressed in glial cells. In the cerebellum, expressed on Bergmann glial fibers in the molecular layer and astrocytes in the granule layer.2 Publications
Gene expression databases
Bgeei | ENSRNOG00000016827, Expressed in liver and 21 other tissues |
Genevisiblei | Q9JHZ9, RN |
Interactioni
Protein-protein interaction databases
BioGRIDi | 251668, 1 interactor |
STRINGi | 10116.ENSRNOP00000023623 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid/polyamine transporter 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1305, Eukaryota |
GeneTreei | ENSGT00940000157127 |
HOGENOMi | CLU_009020_0_2_1 |
InParanoidi | Q9JHZ9 |
OMAi | CWGVAVM |
OrthoDBi | 697331at2759 |
PhylomeDBi | Q9JHZ9 |
TreeFami | TF328787 |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JHZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIPRQTEMV ELVPNGKHLE GLLPVGMPTA DTQRAEDAQH CGEGKGFLQQ
60 70 80 90 100
SSSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP TPVWYMDGNY LVILVSVIII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLVNATG
260 270 280 290 300
NFSHMVVVEE KSQLQSEPDT AEAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKRKMQH ISNLSIAVMY VMYFLAALFG YLTFYDGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLIAVTLT VPIVLFPVRR AIQQMLFQNQ
410 420 430 440 450
EFSWLRHVLI ATGLLTCINL LVIFAPNILG IFGIIGATSA PCLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPVRSTPKIL ALCFAAVGFL LMTMSLSFII TDWVSGTSQH
GGNH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF273025 mRNA Translation: AAF81797.1 BC081717 mRNA Translation: AAH81717.1 |
RefSeqi | NP_665719.1, NM_145776.1 |
Genome annotation databases
Ensembli | ENSRNOT00000023623; ENSRNOP00000023623; ENSRNOG00000016827 |
GeneIDi | 252919 |
KEGGi | rno:252919 |
UCSCi | RGD:628620, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF273025 mRNA Translation: AAF81797.1 BC081717 mRNA Translation: AAH81717.1 |
RefSeqi | NP_665719.1, NM_145776.1 |
3D structure databases
AlphaFoldDBi | Q9JHZ9 |
SMRi | Q9JHZ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251668, 1 interactor |
STRINGi | 10116.ENSRNOP00000023623 |
PTM databases
GlyGeni | Q9JHZ9, 4 sites |
iPTMneti | Q9JHZ9 |
PhosphoSitePlusi | Q9JHZ9 |
Proteomic databases
PaxDbi | Q9JHZ9 |
Genome annotation databases
Ensembli | ENSRNOT00000023623; ENSRNOP00000023623; ENSRNOG00000016827 |
GeneIDi | 252919 |
KEGGi | rno:252919 |
UCSCi | RGD:628620, rat |
Organism-specific databases
CTDi | 10991 |
RGDi | 628620, Slc38a3 |
Phylogenomic databases
eggNOGi | KOG1305, Eukaryota |
GeneTreei | ENSGT00940000157127 |
HOGENOMi | CLU_009020_0_2_1 |
InParanoidi | Q9JHZ9 |
OMAi | CWGVAVM |
OrthoDBi | 697331at2759 |
PhylomeDBi | Q9JHZ9 |
TreeFami | TF328787 |
Enzyme and pathway databases
Reactomei | R-RNO-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
PROi | PR:Q9JHZ9 |
Gene expression databases
Bgeei | ENSRNOG00000016827, Expressed in liver and 21 other tissues |
Genevisiblei | Q9JHZ9, RN |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S38A3_RAT | |
Accessioni | Q9JHZ9Primary (citable) accession number: Q9JHZ9 Secondary accession number(s): Q66HS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families