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Protein

Progressive ankylosis protein

Gene

Ankh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

GO - Molecular functioni

GO - Biological processi

  • regulation of bone mineralization Source: UniProtKB

Keywordsi

Biological processPhosphate transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Progressive ankylosis protein
Alternative name(s):
Fn54 protein
Gene namesi
Name:Ankh
Synonyms:Ank
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3045421 Ank

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 85CytoplasmicSequence analysisAdd BLAST85
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 131ExtracellularSequence analysisAdd BLAST25
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 158CytoplasmicSequence analysis6
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189ExtracellularSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 326CytoplasmicSequence analysisAdd BLAST116
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 350ExtracellularSequence analysis3
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 403CytoplasmicSequence analysisAdd BLAST32
Transmembranei404 – 426HelicalSequence analysisAdd BLAST23
Topological domaini427 – 429ExtracellularSequence analysis3
Transmembranei430 – 452HelicalSequence analysisAdd BLAST23
Topological domaini453 – 492CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Ankh are the cause of a generalized, progressive form of arthritis. In ank mice hydroxyapatite crystals develop in articular surfaces and synovial fluid leading to joint space narrowing, cartilage erosion, and formation of bony outgrowths or osteophytes that cause fusion and joint immobility and destruction.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374681 – 492Progressive ankylosis proteinAdd BLAST492

Proteomic databases

MaxQBiQ9JHZ2
PaxDbiQ9JHZ2
PRIDEiQ9JHZ2

PTM databases

iPTMnetiQ9JHZ2
PhosphoSitePlusiQ9JHZ2

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, spleen, lung, muscle, and kidney of adult animals. Strongly expressed in the developing articular cartilage of joints in the shoulder, elbow, wrist, and digits of the embryo.

Gene expression databases

BgeeiENSMUSG00000022265 Expressed in 299 organ(s), highest expression level in seminal vesicle
CleanExiMM_ANK
ExpressionAtlasiQ9JHZ2 baseline and differential
GenevisibleiQ9JHZ2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022875

Structurei

3D structure databases

ProteinModelPortaliQ9JHZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ANKH family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH1E Eukaryota
ENOG410ZCHM LUCA
GeneTreeiENSGT00390000012189
HOGENOMiHOG000033943
HOVERGENiHBG018728
InParanoidiQ9JHZ2
KOiK22734
OMAiYMGVHGA
OrthoDBiEOG091G0587
PhylomeDBiQ9JHZ2
TreeFamiTF333504

Family and domain databases

InterProiView protein in InterPro
IPR009887 ANKH
PANTHERiPTHR28384 PTHR28384, 2 hits
PfamiView protein in Pfam
PF07260 ANKH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKFPALTHY WPLIRFLVPL GITNIAIDFG EQALNRGIAA VKEDAVEMLA
60 70 80 90 100
SYGLAYSLMK FFTGPMSDFK NVGLVFVNSK RDRAKAVLCM VVAGAIAAVF
110 120 130 140 150
HTLIAYSDLG YYIINKLHHV DESVGSKTRR AFLYLAAFPF MDAMAWTHAG
160 170 180 190 200
ILLKHKYSFL VGCASISDVI AQVVFVAILL HSHLECREPL LIPILSLYMG
210 220 230 240 250
ALVRCTTLCL GYYRNIHDII PDRSGPELGG DATIRKMLSF WWPLALILAT
260 270 280 290 300
QRISRPIVNL FVSRDLGGSS AATEAVAILT ATYPVGHMPY GWLTEIRAVY
310 320 330 340 350
PAFDKNNPSN KLANTSNTVT SAHIKKFTFV CMALSLTLCF VMFWTPNVSE
360 370 380 390 400
KILIDIIGVD FAFAELCVIP LRIFSFFPVP VTVRAHLTGW LMTLKKTFVL
410 420 430 440 450
APSSVLRIIV LITSLVVLPY LGVHGATLGV GSLLAGFVGE STMVALAACY
460 470 480 490
VYRKQKKKME NESATEGEDS AMTDMPPTEE VTDIVEMREE NE
Length:492
Mass (Da):54,298
Last modified:October 1, 2000 - v1
Checksum:i8792B248C875688E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti201A → V in strain: C3H. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274752 mRNA Translation: AAF88038.1
AF001532 mRNA Translation: AAB65653.1
AF001533 mRNA Translation: AAB65654.2
BC054379 mRNA Translation: AAH54379.1
CCDSiCCDS27402.1
RefSeqiNP_065065.3, NM_020332.4
UniGeneiMm.265264

Genome annotation databases

EnsembliENSMUST00000022875; ENSMUSP00000022875; ENSMUSG00000022265
GeneIDi11732
KEGGimmu:11732
UCSCiuc007vjo.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274752 mRNA Translation: AAF88038.1
AF001532 mRNA Translation: AAB65653.1
AF001533 mRNA Translation: AAB65654.2
BC054379 mRNA Translation: AAH54379.1
CCDSiCCDS27402.1
RefSeqiNP_065065.3, NM_020332.4
UniGeneiMm.265264

3D structure databases

ProteinModelPortaliQ9JHZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022875

PTM databases

iPTMnetiQ9JHZ2
PhosphoSitePlusiQ9JHZ2

Proteomic databases

MaxQBiQ9JHZ2
PaxDbiQ9JHZ2
PRIDEiQ9JHZ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022875; ENSMUSP00000022875; ENSMUSG00000022265
GeneIDi11732
KEGGimmu:11732
UCSCiuc007vjo.2 mouse

Organism-specific databases

CTDi11732
MGIiMGI:3045421 Ank

Phylogenomic databases

eggNOGiENOG410IH1E Eukaryota
ENOG410ZCHM LUCA
GeneTreeiENSGT00390000012189
HOGENOMiHOG000033943
HOVERGENiHBG018728
InParanoidiQ9JHZ2
KOiK22734
OMAiYMGVHGA
OrthoDBiEOG091G0587
PhylomeDBiQ9JHZ2
TreeFamiTF333504

Enzyme and pathway databases

ReactomeiR-MMU-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRSiAnk mouse
PROiPR:Q9JHZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022265 Expressed in 299 organ(s), highest expression level in seminal vesicle
CleanExiMM_ANK
ExpressionAtlasiQ9JHZ2 baseline and differential
GenevisibleiQ9JHZ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR009887 ANKH
PANTHERiPTHR28384 PTHR28384, 2 hits
PfamiView protein in Pfam
PF07260 ANKH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANKH_MOUSE
AccessioniPrimary (citable) accession number: Q9JHZ2
Secondary accession number(s): O35138, O35139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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