UniProtKB - Q9JHY7 (BIRC5_RAT)
Baculoviral IAP repeat-containing protein 5
Birc5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 57 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 60 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 77 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 84 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- chaperone binding Source: RGD
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- enzyme binding Source: RGD
- identical protein binding Source: RGD
- microtubule binding Source: UniProtKB
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: UniProtKB
- Ran GTPase binding Source: RGD
- tubulin binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB
- cellular response to ethanol Source: RGD
- cellular response to stem cell factor stimulus Source: RGD
- chromosome segregation Source: UniProtKB-KW
- establishment of chromosome localization Source: UniProtKB
- G2/M transition of mitotic cell cycle Source: UniProtKB
- microtubule cytoskeleton organization Source: RGD
- mitotic cytokinesis Source: UniProtKB
- mitotic spindle assembly checkpoint Source: UniProtKB
- negative regulation of apoptotic process Source: RGD
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of neuron apoptotic process Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of cell cycle Source: RGD
- positive regulation of exit from mitosis Source: UniProtKB
- positive regulation of mitotic cell cycle Source: UniProtKB
- protein-containing complex localization Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
- regulation of mitotic cell cycle Source: RGD
- regulation of type B pancreatic cell proliferation Source: RGD
- response to drug Source: RGD
- response to glucocorticoid Source: RGD
- response to peptide hormone Source: RGD
- sensory perception of sound Source: RGD
Keywordsi
Molecular function | Protease inhibitor, Repressor, Thiol protease inhibitor |
Biological process | Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | I32.005 |
Names & Taxonomyi
Protein namesi | Recommended name: Baculoviral IAP repeat-containing protein 5Alternative name(s): Apoptosis inhibitor survivin |
Gene namesi | Name:Birc5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70499, Birc5 |
Subcellular locationi
Cytoskeleton
- spindle By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
- Chromosome By similarity
- centromere By similarity
- kinetochore By similarity
- Midbody By similarity
Note: Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes (By similarity).By similarity
Cytoskeleton
- centriole Source: UniProtKB
- chromosome passenger complex Source: UniProtKB
- cytoplasmic microtubule Source: UniProtKB
- interphase microtubule organizing center Source: UniProtKB
- spindle microtubule Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nuclear chromosome Source: RGD
- nucleus Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
Other locations
- chromosome, centromeric region Source: UniProtKB
- condensed chromosome kinetochore Source: UniProtKB
- cytoplasm Source: RGD
- midbody Source: UniProtKB
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122360 | 1 – 142 | Baculoviral IAP repeat-containing protein 5Add BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 34 | Phosphothreonine; by CDK1 and CDK15By similarity | 1 | |
Modified residuei | 48 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 90 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 110 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 112 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 115 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 117 | Phosphothreonine; by AURKBBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9JHY7 |
PRIDEi | Q9JHY7 |
PTM databases
PhosphoSitePlusi | Q9JHY7 |
Interactioni
Subunit structurei
Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently.
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8.
Interacts with JTB.
Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3).
Interacts with EVI5.
Interacts with GTP-bound RAN in both the S and M phases of the cell cycle.
Interacts with USP9X.
Interacts with tubulin.
Interacts with BIRC2/c-IAP1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC.
Interacts with BIRC6/bruce.
Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 126 | Interaction with FBXL7By similarity | 1 |
GO - Molecular functioni
- chaperone binding Source: RGD
- enzyme binding Source: RGD
- identical protein binding Source: RGD
- microtubule binding Source: UniProtKB
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: UniProtKB
- Ran GTPase binding Source: RGD
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065784 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 18 – 88 | BIRAdd BLAST | 71 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1101, Eukaryota |
InParanoidi | Q9JHY7 |
OrthoDBi | 1404665at2759 |
PhylomeDBi | Q9JHY7 |
Family and domain databases
CDDi | cd00022, BIR, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt |
Pfami | View protein in Pfam PF00653, BIR, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 1 hit |
PROSITEi | View protein in PROSITE PS50143, BIR_REPEAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGATALPPIW QMYLKDHRIY TFKNWPFLED CSCTPERMAE AGFIHCPTEN
60 70 80 90 100
EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQVEELTVSE
110 120 130 140
FLKLDKQRAK NKIAKETNNK QKEFEETRRT VRQSIEQLAA LR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R8I8 | M0R8I8_RAT | Baculoviral IAP repeat-containing 5... | Birc5 rCG_35216 | 142 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF276775 mRNA Translation: AAF82586.1 |
RefSeqi | NP_071610.1, NM_022274.1 |
Genome annotation databases
GeneIDi | 64041 |
KEGGi | rno:64041 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF276775 mRNA Translation: AAF82586.1 |
RefSeqi | NP_071610.1, NM_022274.1 |
3D structure databases
SMRi | Q9JHY7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065784 |
Protein family/group databases
MEROPSi | I32.005 |
PTM databases
PhosphoSitePlusi | Q9JHY7 |
Proteomic databases
PaxDbi | Q9JHY7 |
PRIDEi | Q9JHY7 |
Genome annotation databases
GeneIDi | 64041 |
KEGGi | rno:64041 |
Organism-specific databases
CTDi | 332 |
RGDi | 70499, Birc5 |
Phylogenomic databases
eggNOGi | KOG1101, Eukaryota |
InParanoidi | Q9JHY7 |
OrthoDBi | 1404665at2759 |
PhylomeDBi | Q9JHY7 |
Miscellaneous databases
PROi | PR:Q9JHY7 |
Family and domain databases
CDDi | cd00022, BIR, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt |
Pfami | View protein in Pfam PF00653, BIR, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 1 hit |
PROSITEi | View protein in PROSITE PS50143, BIR_REPEAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIRC5_RAT | |
Accessioni | Q9JHY7Primary (citable) accession number: Q9JHY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families