F11r

Functionⁱ

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration.By similarity

GO - Molecular functionⁱ

PDZ domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actomyosin structure organization Source: Ensembl
cell adhesion Source: Ensembl
cell differentiation
Source: RGD
Inferred from expression patternⁱ
- 18506084
establishment of endothelial intestinal barrier Source: Ensembl
intestinal absorption Source: Ensembl
negative regulation of GTPase activity Source: Ensembl
positive regulation of blood pressure
Source: RGD
Inferred from direct assayⁱ
- 17420334
positive regulation of GTPase activity Source: Ensembl
protein localization to plasma membrane Source: Ensembl
regulation of actin cytoskeleton reorganization Source: Ensembl
regulation of cytokine production Source: Ensembl
regulation of membrane permeability Source: Ensembl
response to radiation
Source: RGD
Inferred from expression patternⁱ
- 20180397

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-202733 Cell surface interactions at the vascular wall R-RNO-216083 Integrin cell surface interactions R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-RNO-420029 Tight junction interactions

Reactomeⁱ

R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-216083 Integrin cell surface interactions
R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-420029 Tight junction interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Junctional adhesion molecule A Short name: JAM-A Alternative name(s): Junctional adhesion molecule 1 Short name: JAM-1 CD_antigen: CD321
Gene namesⁱ	Name:F11r Synonyms:Jam1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	621842 F11r

RGDⁱ

621842 F11r

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 238	ExtracellularSequence analysisAdd BLAST	212
Transmembraneⁱ	239 – 259	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	260 – 300	CytoplasmicSequence analysisAdd BLAST	41

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000015068	27 – 300	Junctional adhesion molecule AAdd BLAST		274

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 108	PROSITE-ProRule annotation
Disulfide bondⁱ	152 ↔ 212	PROSITE-ProRule annotation
Glycosylationⁱ	185	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	282	PhosphoserineBy similarity	1
Modified residueⁱ	285	PhosphoserineCombined sources	1
Modified residueⁱ	288	PhosphoserineBy similarity	1

Post-translational modificationⁱ

N-glycosylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9JHY1
PRIDEⁱ	Q9JHY1

PTM databases

iPTMnetⁱ	Q9JHY1
PhosphoSitePlusⁱ	Q9JHY1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000004414
Genevisibleⁱ	Q9JHY1 RN

Interactionⁱ

Subunit structureⁱ

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Afdn	O35889	2	EBI-4306794,EBI-6654073
inaD	Q24008	2	EBI-4306794,EBI-195326	From Drosophila melanogaster.
Pard3	Q9Z340	2	EBI-4306794,EBI-349441

Show more details

GO - Molecular functionⁱ

PDZ domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q9JHY1, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9JHY1
STRINGⁱ	10116.ENSRNOP00000006141

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JHY1
SMRⁱ	Q9JHY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 122	Ig-like V-type 1Add BLAST		95
Domainⁱ	134 – 228	Ig-like V-type 2Add BLAST		95

Domainⁱ

The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.By similarity

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWUE Eukaryota ENOG410YHHV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110678
HOGENOMⁱ	HOG000247041
HOVERGENⁱ	HBG000518
InParanoidⁱ	Q9JHY1
KEGG Orthology (KO) More...KOⁱ	K06089
OMAⁱ	NRAFSNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q9JHY1
TreeFamⁱ	TF331459

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9JHY1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTEGKAGSK LLFLFTSMIL GSLVQGKGSV YSPQTAVQVP ENDSVKLPCI 
        60         70         80         90        100
YSGFSSPRVE WKFVQGSTTA LVCYNNQITV PYADRVTFSS SGITFSSVTR 
       110        120        130        140        150
KDNGEYTCMV SEDGGQNYGE VSIHLTVLVP PSKPTVSIPS SVTIGNRAVL 
       160        170        180        190        200
TCSEHDGSPP SEYSWFKDGV PMLTADAKKT RAFINSSYTI DPKSGDLVFD 
       210        220        230        240        250
PVSAFDSGEY YCEAQNGYGT AMRSEAVRME AVELNVGGIV AAVLVTLILL 
       260        270        280        290        300
GLLIFGIWFA YSRGYFERTK KGTAPGKKVI YSQPSARSEG EFKQTSSFLV

Length:300

Mass (Da):32,370

Last modified:October 1, 2000 - v1

Checksum:ⁱ45AE362A96158BFA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276998 mRNA Translation: AAF78250.1 BC065309 mRNA Translation: AAH65309.1
NCBI Reference Sequences More...RefSeqⁱ	NP_446248.1, NM_053796.1
UniGeneⁱ	Rn.107273

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414
GeneIDⁱ	116479
KEGGⁱ	rno:116479
UCSC genome browser More...UCSCⁱ	RGD:621842 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9JHY1	Junctional adhesion molecule A	)	MOUSE		300
Junctional adhesion molecule (Fragment)		RAT		173
UPI000A30E6A4		MUSPA		300
UPI000A319FFF		MUSCR		300
UPI0000111576		MOUSE		212

Protein	Similar proteins		Species	Score	Length
Q9JHY1	Junctional adhesion molecule A	)	MOUSE		300
UPI000A30E6A4		MUSPA		300
UPI000A319FFF		MUSCR		300
Junctional adhesion molecule (Fragment)		RAT		173
F11 receptor		MANLE		274
+101

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF276998 mRNA Translation: AAF78250.1 BC065309 mRNA Translation: AAH65309.1
NCBI Reference Sequences More...RefSeqⁱ	NP_446248.1, NM_053796.1
UniGeneⁱ	Rn.107273

3D structure databases

ProteinModelPortalⁱ	Q9JHY1
SMRⁱ	Q9JHY1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9JHY1, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9JHY1
STRINGⁱ	10116.ENSRNOP00000006141

PTM databases

iPTMnetⁱ	Q9JHY1
PhosphoSitePlusⁱ	Q9JHY1

Proteomic databases

PaxDbⁱ	Q9JHY1
PRIDEⁱ	Q9JHY1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414
GeneIDⁱ	116479
KEGGⁱ	rno:116479
UCSC genome browser More...UCSCⁱ	RGD:621842 rat

Organism-specific databases

CTDⁱ	50848
Rat genome database More...RGDⁱ	621842 F11r

Phylogenomic databases

eggNOGⁱ	ENOG410IWUE Eukaryota ENOG410YHHV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110678
HOGENOMⁱ	HOG000247041
HOVERGENⁱ	HBG000518
InParanoidⁱ	Q9JHY1
KEGG Orthology (KO) More...KOⁱ	K06089
OMAⁱ	NRAFSNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q9JHY1
TreeFamⁱ	TF331459

Enzyme and pathway databases

Reactomeⁱ	R-RNO-202733 Cell surface interactions at the vascular wall R-RNO-216083 Integrin cell surface interactions R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-RNO-420029 Tight junction interactions

Reactomeⁱ

R-RNO-202733 Cell surface interactions at the vascular wall
R-RNO-216083 Integrin cell surface interactions
R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-420029 Tight junction interactions

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JHY1

PROⁱ

PR:Q9JHY1

Gene expression databases

Bgeeⁱ	ENSRNOG00000004414
Genevisibleⁱ	Q9JHY1 RN

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JAM1_RAT
Accessionⁱ	Q9JHY1Primary (citable) accession number: Q9JHY1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	October 1, 2000
	Last modified:	July 18, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - Q9JHY1 (JAM1_RAT)

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Junctional adhesion molecule A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ