Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor Sp5

Gene

Sp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp5
Gene namesi
Name:Sp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927715 Sp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471471 – 398Transcription factor Sp5Add BLAST398

Proteomic databases

MaxQBiQ9JHX2
PaxDbiQ9JHX2
PRIDEiQ9JHX2

PTM databases

PhosphoSitePlusiQ9JHX2

Expressioni

Gene expression databases

BgeeiENSMUSG00000075304 Expressed in 138 organ(s), highest expression level in presumptive midbrain
CleanExiMM_SP5
GenevisibleiQ9JHX2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097620

Structurei

3D structure databases

ProteinModelPortaliQ9JHX2
SMRiQ9JHX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 51Poly-Ala4
Compositional biasi164 – 173Poly-Pro10
Compositional biasi224 – 235Poly-AlaAdd BLAST12

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG014797
InParanoidiQ9JHX2
KOiK09195
OMAiEDIPWWS
OrthoDBiEOG091G0HX6
PhylomeDBiQ9JHX2
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9JHX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA
60 70 80 90 100
APDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH
110 120 130 140 150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA
160 170 180 190 200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP APAPDDLPWW SIPQSGAGPG
210 220 230 240 250
SSGVPGTSLS SACAGPPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY
260 270 280 290 300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
310 320 330 340 350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH
360 370 380 390
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KRENPRDL
Length:398
Mass (Da):42,052
Last modified:October 1, 2000 - v1
Checksum:iB359853755B6B5C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279479 mRNA Translation: AAF87798.1
AK036234 mRNA Translation: BAC29355.1
BC116691 mRNA Translation: AAI16692.1
BC117505 mRNA Translation: AAI17506.1
CCDSiCCDS16106.1
RefSeqiNP_071880.1, NM_022435.2
UniGeneiMm.423397

Genome annotation databases

EnsembliENSMUST00000100043; ENSMUSP00000097620; ENSMUSG00000075304
GeneIDi64406
KEGGimmu:64406
UCSCiuc008jzg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279479 mRNA Translation: AAF87798.1
AK036234 mRNA Translation: BAC29355.1
BC116691 mRNA Translation: AAI16692.1
BC117505 mRNA Translation: AAI17506.1
CCDSiCCDS16106.1
RefSeqiNP_071880.1, NM_022435.2
UniGeneiMm.423397

3D structure databases

ProteinModelPortaliQ9JHX2
SMRiQ9JHX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097620

PTM databases

PhosphoSitePlusiQ9JHX2

Proteomic databases

MaxQBiQ9JHX2
PaxDbiQ9JHX2
PRIDEiQ9JHX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100043; ENSMUSP00000097620; ENSMUSG00000075304
GeneIDi64406
KEGGimmu:64406
UCSCiuc008jzg.1 mouse

Organism-specific databases

CTDi389058
MGIiMGI:1927715 Sp5

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG014797
InParanoidiQ9JHX2
KOiK09195
OMAiEDIPWWS
OrthoDBiEOG091G0HX6
PhylomeDBiQ9JHX2
TreeFamiTF350150

Miscellaneous databases

PROiPR:Q9JHX2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075304 Expressed in 138 organ(s), highest expression level in presumptive midbrain
CleanExiMM_SP5
GenevisibleiQ9JHX2 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP5_MOUSE
AccessioniPrimary (citable) accession number: Q9JHX2
Secondary accession number(s): Q149T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again