Rgs2

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity

GO - Molecular functionⁱ

beta-tubulin binding
Source: RGD
Inferred from physical interactionⁱ
- 16820281
G-protein alpha-subunit binding Source: Ensembl
GTPase activator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: RGD
Inferred from expression patternⁱ
- 11906535
brown fat cell differentiation Source: Ensembl
cell cycle Source: UniProtKB-KW
maternal process involved in female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 12712095
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Source: Ensembl
negative regulation of cAMP-mediated signaling Source: Ensembl
negative regulation of cell growth involved in cardiac muscle cell development
Source: RGD
Inferred from mutant phenotypeⁱ
- 16380388
negative regulation of glycine import across plasma membrane
Source: RGD
Inferred from mutant phenotypeⁱ
- 21798518
negative regulation of G protein-coupled receptor signaling pathway
Source: RGD
Inferred from mutant phenotypeⁱ
- 21798518
negative regulation of MAP kinase activity Source: Ensembl
negative regulation of phospholipase activity Source: Ensembl
negative regulation of translation
Source: RGD
Inferred from mutant phenotypeⁱ
- 24576550
ovulation
Source: RGD
Inferred from expression patternⁱ
- 11058559
positive regulation of cardiac muscle contraction Source: Ensembl
positive regulation of neuron projection development
Source: RGD
Inferred from mutant phenotypeⁱ
- 16820281
regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
relaxation of cardiac muscle Source: Ensembl
relaxation of vascular smooth muscle Source: Ensembl
response to amphetamine
Source: RGD
Inferred from expression patternⁱ
- 26321241
response to ethanol
Source: RGD
Inferred from expression patternⁱ
- 28736108
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Signal transduction inhibitor
Biological process	Cell cycle, Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 2 Short name: RGS2
Gene namesⁱ	Name:Rgs2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	621665 Rgs2

RGDⁱ

621665 Rgs2

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204181	1 – 211	Regulator of G-protein signaling 2Add BLAST		211

Post-translational modificationⁱ

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9JHX0
PRIDEⁱ	Q9JHX0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000003687 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	Q9JHX0 RN

Interactionⁱ

Subunit structureⁱ

Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

GO - Molecular functionⁱ

beta-tubulin binding
Source: RGD
Inferred from physical interactionⁱ
- 16820281
G-protein alpha-subunit binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000005156

STRINGⁱ

10116.ENSRNOP00000005156

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9JHX0
SMRⁱ	Q9JHX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	83 – 199	RGSPROSITE-ProRule annotationAdd BLAST		117

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	32 – 66	Necessary for membrane associationBy similarityAdd BLAST		35
Regionⁱ	79 – 116	Necessary to inhibit protein synthesisBy similarityAdd BLAST		38

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q9JHX0
KEGG Orthology (KO) More...KOⁱ	K18154
OMAⁱ	TIIKDWK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q9JHX0
TreeFamⁱ	TF315837

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034947 RGS2 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF43 PTHR10845:SF43, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9JHX0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ 
        60         70         80         90        100
NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF 
       110        120        130        140        150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI 
       160        170        180        190        200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK 
       210 
KPQITTEPHA T

Length:211

Mass (Da):24,323

Last modified:October 1, 2000 - v1

Checksum:ⁱ84B5525CB41EA964

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279918 mRNA Translation: AAF85981.1 AF321837 mRNA Translation: AAK09375.1 AY043246 mRNA Translation: AAK85309.1 BC061969 mRNA Translation: AAH61969.1 AJ318489 mRNA Translation: CAC44900.1
NCBI Reference Sequences More...RefSeqⁱ	NP_445905.1, NM_053453.2
UniGeneⁱ	Rn.1892

Genome annotation databases

Ensemblⁱ	ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687
GeneIDⁱ	84583
KEGGⁱ	rno:84583
UCSC genome browser More...UCSCⁱ	RGD:621665 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9JHX0	regulator of G-protein signaling 2		MESAU		207	UniRef100_Q9JHX0
Regulator of G-protein signaling 2		CRIGR		207

Protein	Similar proteins		Species	Score	Length	Source
Q9JHX0	Regulator of G-protein signaling 2	)	HUMAN		211	UniRef90_P41220
Regulator of G-protein signaling 2		PIG		212
Regulator of G-protein signaling 2		MOUSE		211
Regulator of G-protein signaling 2		BOVIN		211
Uncharacterized protein		PANPA		211
+113

Protein	Similar proteins		Species	Score	Length	Source
Q9JHX0	Regulator of G-protein signaling 2	)	HUMAN		211	UniRef50_P41220
Regulator of G-protein signaling 2		PIG		212
Regulator of G-protein signaling 2		MOUSE		211
Regulator of G-protein signaling 2		BOVIN		211
Uncharacterized protein		PANPA		211
+238

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279918 mRNA Translation: AAF85981.1 AF321837 mRNA Translation: AAK09375.1 AY043246 mRNA Translation: AAK85309.1 BC061969 mRNA Translation: AAH61969.1 AJ318489 mRNA Translation: CAC44900.1
RefSeqⁱ	NP_445905.1, NM_053453.2
UniGeneⁱ	Rn.1892

3D structure databases

ProteinModelPortalⁱ	Q9JHX0
SMRⁱ	Q9JHX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000005156

STRINGⁱ

10116.ENSRNOP00000005156

Proteomic databases

PaxDbⁱ	Q9JHX0
PRIDEⁱ	Q9JHX0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687
GeneIDⁱ	84583
KEGGⁱ	rno:84583
UCSCⁱ	RGD:621665 rat

Organism-specific databases

CTDⁱ	5997
RGDⁱ	621665 Rgs2

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000118903
HOGENOMⁱ	HOG000233512
HOVERGENⁱ	HBG013233
InParanoidⁱ	Q9JHX0
KOⁱ	K18154
OMAⁱ	TIIKDWK
OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	Q9JHX0
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9JHX0

PROⁱ

PR:Q9JHX0

Gene expression databases

Bgeeⁱ	ENSRNOG00000003687 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	Q9JHX0 RN

Family and domain databases

Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR016137 RGS IPR034947 RGS2 IPR036305 RGS_sf IPR024066 RGS_subdom1/3
PANTHERⁱ	PTHR10845:SF43 PTHR10845:SF43, 1 hit
Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS2_RAT
Accessionⁱ	Q9JHX0Primary (citable) accession number: Q9JHX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9JHX0 (RGS2_RAT)

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Regulator of G-protein signaling 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ