UniProtKB - Q9JHX0 (RGS2_RAT)
Protein
Regulator of G-protein signaling 2
Gene
Rgs2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity
GO - Molecular functioni
- beta-tubulin binding Source: RGD
- G-protein alpha-subunit binding Source: RGD
- GTPase activator activity Source: UniProtKB
GO - Biological processi
- brain development Source: RGD
- brown fat cell differentiation Source: RGD
- cell cycle Source: UniProtKB-KW
- maternal process involved in female pregnancy Source: RGD
- negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Source: RGD
- negative regulation of cAMP-mediated signaling Source: RGD
- negative regulation of cardiac muscle hypertrophy Source: RGD
- negative regulation of cell growth involved in cardiac muscle cell development Source: RGD
- negative regulation of glycine import across plasma membrane Source: RGD
- negative regulation of G protein-coupled receptor signaling pathway Source: RGD
- negative regulation of MAP kinase activity Source: RGD
- negative regulation of phospholipase activity Source: RGD
- negative regulation of translation Source: RGD
- ovulation Source: RGD
- positive regulation of cardiac muscle contraction Source: RGD
- positive regulation of neuron projection development Source: RGD
- regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
- relaxation of cardiac muscle Source: RGD
- relaxation of vascular associated smooth muscle Source: RGD
- response to amphetamine Source: RGD
- response to ethanol Source: RGD
- spermatogenesis Source: RGD
Keywordsi
Molecular function | GTPase activation, Signal transduction inhibitor |
Biological process | Cell cycle, Translation regulation |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 2Short name: RGS2 |
Gene namesi | Name:Rgs2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621665, Rgs2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Nucleus
- nucleolus By similarity
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: RGD
Nucleus
Plasma Membrane
- cytoplasmic side of plasma membrane Source: BHF-UCL
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
- neuron projection Source: RGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204181 | 1 – 211 | Regulator of G-protein signaling 2Add BLAST | 211 |
Post-translational modificationi
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9JHX0 |
PRIDEi | Q9JHX0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000003687, Expressed in lung and 21 other tissues |
Genevisiblei | Q9JHX0, RN |
Interactioni
Subunit structurei
Interacts with GNAQ. Does not interact with GNAI1 and GNAI3.
Interacts with EIF2B5.
Interacts with PRKG1 (isoform alpha).
By similarityGO - Molecular functioni
- beta-tubulin binding Source: RGD
- G-protein alpha-subunit binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005156 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 199 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 66 | Necessary for membrane associationBy similarityAdd BLAST | 35 | |
Regioni | 79 – 116 | Necessary to inhibit protein synthesisBy similarityAdd BLAST | 38 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157937 |
HOGENOMi | CLU_059863_3_2_1 |
InParanoidi | Q9JHX0 |
OMAi | IKRKNWR |
OrthoDBi | 1246872at2759 |
PhylomeDBi | Q9JHX0 |
TreeFami | TF315837 |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR034947, RGS2 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF43, PTHR10845:SF43, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9JHX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279918 mRNA Translation: AAF85981.1 AF321837 mRNA Translation: AAK09375.1 AY043246 mRNA Translation: AAK85309.1 BC061969 mRNA Translation: AAH61969.1 AJ318489 mRNA Translation: CAC44900.1 |
RefSeqi | NP_445905.1, NM_053453.2 |
Genome annotation databases
Ensembli | ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687 |
GeneIDi | 84583 |
KEGGi | rno:84583 |
UCSCi | RGD:621665, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279918 mRNA Translation: AAF85981.1 AF321837 mRNA Translation: AAK09375.1 AY043246 mRNA Translation: AAK85309.1 BC061969 mRNA Translation: AAH61969.1 AJ318489 mRNA Translation: CAC44900.1 |
RefSeqi | NP_445905.1, NM_053453.2 |
3D structure databases
SMRi | Q9JHX0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000005156 |
Proteomic databases
PaxDbi | Q9JHX0 |
PRIDEi | Q9JHX0 |
Genome annotation databases
Ensembli | ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687 |
GeneIDi | 84583 |
KEGGi | rno:84583 |
UCSCi | RGD:621665, rat |
Organism-specific databases
CTDi | 5997 |
RGDi | 621665, Rgs2 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157937 |
HOGENOMi | CLU_059863_3_2_1 |
InParanoidi | Q9JHX0 |
OMAi | IKRKNWR |
OrthoDBi | 1246872at2759 |
PhylomeDBi | Q9JHX0 |
TreeFami | TF315837 |
Enzyme and pathway databases
Reactomei | R-RNO-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:Q9JHX0 |
Gene expression databases
Bgeei | ENSRNOG00000003687, Expressed in lung and 21 other tissues |
Genevisiblei | Q9JHX0, RN |
Family and domain databases
Gene3Di | 1.10.196.10, 2 hits |
InterProi | View protein in InterPro IPR016137, RGS IPR034947, RGS2 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF43, PTHR10845:SF43, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS2_RAT | |
Accessioni | Q9JHX0Primary (citable) accession number: Q9JHX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |