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Protein

Inositol-3-phosphate synthase 1

Gene

Isyna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.

Cofactori

NAD+By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol monophosphatase 1 (Impa1), Inositol monophosphatase 3 (Impad1), Inositol monophosphatase 2 (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

  • inositol biosynthetic process Source: GO_Central
  • phospholipid biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionIsomerase
Biological processInositol biosynthesis, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayi
UPA00823;UER00787

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-3-phosphate synthase 1 (EC:5.5.1.4)
Short name:
IPS 1
Alternative name(s):
Myo-inositol 1-phosphate synthase
Short name:
MI-1-P synthase
Short name:
MIP synthase
Gene namesi
Name:Isyna1
Synonyms:Ino1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919030 Isyna1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246301 – 557Inositol-3-phosphate synthase 1Add BLAST557

Proteomic databases

EPDiQ9JHU9
MaxQBiQ9JHU9
PaxDbiQ9JHU9
PeptideAtlasiQ9JHU9
PRIDEiQ9JHU9

2D gel databases

REPRODUCTION-2DPAGEiIPI00119886
Q9JHU9

PTM databases

iPTMnetiQ9JHU9
PhosphoSitePlusiQ9JHU9
SwissPalmiQ9JHU9

Expressioni

Tissue specificityi

In testis, it is expressed in Sertoli cells. Highly expressed in 2 types of germ cells, pachytene spermatocytes and round spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000019139 Expressed in 258 organ(s), highest expression level in embryo
CleanExiMM_ISYNA1
ExpressionAtlasiQ9JHU9 baseline and differential
GenevisibleiQ9JHU9 MM

Interactioni

Protein-protein interaction databases

BioGridi214923, 1 interactor
IntActiQ9JHU9, 4 interactors
MINTiQ9JHU9
STRINGi10090.ENSMUSP00000019283

Structurei

3D structure databases

ProteinModelPortaliQ9JHU9
SMRiQ9JHU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0693 Eukaryota
COG1260 LUCA
GeneTreeiENSGT00390000018395
HOGENOMiHOG000013469
HOVERGENiHBG061200
InParanoidiQ9JHU9
KOiK01858
OMAiEGWDNID
OrthoDBiEOG091G05DF
PhylomeDBiQ9JHU9
TreeFamiTF300382

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11510 PTHR11510, 1 hit
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9JHU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPAAEILVD SPDVVYSPET IEARYEYRTT RVSREGGVLR VQPRATRFTF
60 70 80 90 100
RTARQVPRLG VMLVGWGGNN GSTLTAAVLA NRLRLTWPTR TGRKEANYYG
110 120 130 140 150
SLTQAGTVNL GLDENGREVF VPFSALLPMV APNDLVFDGW DISSLNLAEA
160 170 180 190 200
MRRAQVLDCG LQEQLWPHME SLRPRPSVYI PEFIAANQTA RADNLIPGTR
210 220 230 240 250
AQQLEQIRKD IRDFRSSAGL DKVIVLWTAN TERFCEVVPG RNDTAENLLH
260 270 280 290 300
TIQLGLEVSP STLFAVASIL EDCAFLNGSP QNTLVPGALE LASQRHVFVG
310 320 330 340 350
GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG QNLSAPLQFR
360 370 380 390 400
SKEVTKSSVV DDMVHSNHVL YAPGERPDHC VVIKYVPYVG DSKRALDEYT
410 420 430 440 450
SELMLGGTNT LVLHNTCEDS LLAAPIMLDL VLLTELCQRV SFCTDSDPEP
460 470 480 490 500
QGFHTVLSLL SFLFKAPLVP PGSPVVNALF RQRSCIENIF RACVGLPPQN
510 520 530 540 550
HMLLEHKMER PGPGIKPGEV VATSPLPCKK EPTPATNGCT GDANGHPQAP

TPKLSTA
Length:557
Mass (Da):60,932
Last modified:October 1, 2000 - v1
Checksum:i91166BD2A2C53ADA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSW6A0A1B0GSW6_MOUSE
Inositol-3-phosphate synthase 1
Isyna1
41Annotation score:
A0A1B0GS86A0A1B0GS86_MOUSE
Inositol-3-phosphate synthase 1
Isyna1
146Annotation score:
A0A1B0GR94A0A1B0GR94_MOUSE
Inositol-3-phosphate synthase 1
Isyna1
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288525 mRNA Translation: AAF90201.1
AK005029 mRNA Translation: BAB23756.1
AK079323 mRNA Translation: BAC37607.1
BC003458 mRNA Translation: AAH03458.1
CCDSiCCDS22373.1
RefSeqiNP_076116.1, NM_023627.1
UniGeneiMm.29357

Genome annotation databases

EnsembliENSMUST00000019283; ENSMUSP00000019283; ENSMUSG00000019139
ENSMUST00000210005; ENSMUSP00000148077; ENSMUSG00000019139
GeneIDi71780
KEGGimmu:71780
UCSCiuc009mav.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288525 mRNA Translation: AAF90201.1
AK005029 mRNA Translation: BAB23756.1
AK079323 mRNA Translation: BAC37607.1
BC003458 mRNA Translation: AAH03458.1
CCDSiCCDS22373.1
RefSeqiNP_076116.1, NM_023627.1
UniGeneiMm.29357

3D structure databases

ProteinModelPortaliQ9JHU9
SMRiQ9JHU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214923, 1 interactor
IntActiQ9JHU9, 4 interactors
MINTiQ9JHU9
STRINGi10090.ENSMUSP00000019283

PTM databases

iPTMnetiQ9JHU9
PhosphoSitePlusiQ9JHU9
SwissPalmiQ9JHU9

2D gel databases

REPRODUCTION-2DPAGEiIPI00119886
Q9JHU9

Proteomic databases

EPDiQ9JHU9
MaxQBiQ9JHU9
PaxDbiQ9JHU9
PeptideAtlasiQ9JHU9
PRIDEiQ9JHU9

Protocols and materials databases

DNASUi71780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019283; ENSMUSP00000019283; ENSMUSG00000019139
ENSMUST00000210005; ENSMUSP00000148077; ENSMUSG00000019139
GeneIDi71780
KEGGimmu:71780
UCSCiuc009mav.1 mouse

Organism-specific databases

CTDi51477
MGIiMGI:1919030 Isyna1

Phylogenomic databases

eggNOGiKOG0693 Eukaryota
COG1260 LUCA
GeneTreeiENSGT00390000018395
HOGENOMiHOG000013469
HOVERGENiHBG061200
InParanoidiQ9JHU9
KOiK01858
OMAiEGWDNID
OrthoDBiEOG091G05DF
PhylomeDBiQ9JHU9
TreeFamiTF300382

Enzyme and pathway databases

UniPathwayi
UPA00823;UER00787

ReactomeiR-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

ChiTaRSiIsyna1 mouse
PROiPR:Q9JHU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019139 Expressed in 258 organ(s), highest expression level in embryo
CleanExiMM_ISYNA1
ExpressionAtlasiQ9JHU9 baseline and differential
GenevisibleiQ9JHU9 MM

Family and domain databases

InterProiView protein in InterPro
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11510 PTHR11510, 1 hit
PfamiView protein in Pfam
PF01658 Inos-1-P_synth, 1 hit
PF07994 NAD_binding_5, 1 hit
PIRSFiPIRSF015578 Myoinos-ppht_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINO1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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