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Protein

Stathmin-3

Gene

Stmn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • tubulin binding Source: RGD

GO - Biological processi

  • cytoplasmic microtubule organization Source: HGNC
  • microtubule depolymerization Source: GO_Central
  • negative regulation of Rac protein signal transduction Source: HGNC
  • neuron projection development Source: HGNC
  • regulation of cytoskeleton organization Source: HGNC
  • regulation of GTPase activity Source: HGNC
  • regulation of microtubule polymerization or depolymerization Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
SCG10-like protein
Gene namesi
Name:Stmn3
Synonyms:Sclip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3628 Stmn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824041 – 180Stathmin-3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22S-palmitoyl cysteineBy similarity1
Lipidationi24S-palmitoyl cysteineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei65PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei81PhosphoserineCombined sources1

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ9JHU6

PTM databases

iPTMnetiQ9JHU6
PhosphoSitePlusiQ9JHU6

Expressioni

Tissue specificityi

Neuron specific.

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi247922, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9JHU6
SMRiQ9JHU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 180SLDPROSITE-ProRule annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ9JHU6

Family and domain databases

InterProiView protein in InterPro
IPR028835 Stathmin-3
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF17 PTHR10104:SF17, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTVSAYKE KMKELSVLSL ICSCFYSQPH PNTIYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPV LSSPPKRKDA SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSP LAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):20,895
Last modified:October 1, 2000 - v1
Checksum:iA7C0D0D7DCB0A765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004290 mRNA Translation: AAF86617.1
RefSeqiNP_077322.1, NM_024346.1
UniGeneiRn.14961

Genome annotation databases

GeneIDi29246
KEGGirno:29246

Similar proteinsi

Entry informationi

Entry nameiSTMN3_RAT
AccessioniPrimary (citable) accession number: Q9JHU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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