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Protein

Cyclin-dependent kinase 20

Gene

Cdk20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
CDK-activating kinase p42
Short name:
CAK-kinase p42
CDK-related protein kinase PNQLARE
Cell cycle-related kinase
Cell division protein kinase 20
Cyclin-dependent protein kinase H
Cyclin-kinase-activating kinase p42
Gene namesi
Name:Cdk20
Synonyms:Ccrk, Cdch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145349 Cdk20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857031 – 346Cyclin-dependent kinase 20Add BLAST346

Proteomic databases

PaxDbiQ9JHU3
PRIDEiQ9JHU3

PTM databases

iPTMnetiQ9JHU3
PhosphoSitePlusiQ9JHU3

Expressioni

Gene expression databases

BgeeiENSMUSG00000021483
CleanExiMM_CCRK
ExpressionAtlasiQ9JHU3 baseline and differential
GenevisibleiQ9JHU3 MM

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with MAK (By similarity). Interacts with TBC1D32.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021939

Structurei

3D structure databases

ProteinModelPortaliQ9JHU3
SMRiQ9JHU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0659 Eukaryota
ENOG410XQDH LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ9JHU3
KOiK08817
OMAiLWGSQKY
OrthoDBiEOG091G0CI9
PhylomeDBiQ9JHU3
TreeFamiTF327240

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JHU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR
60 70 80 90 100
EIKALQEIED SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
PAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGGRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG
210 220 230 240 250
SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI SFKEQAPVPL
260 270 280 290 300
EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRPGGPA PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG
Length:346
Mass (Da):38,379
Last modified:October 1, 2000 - v1
Checksum:iACCACE0C3FC4B833
GO
Isoform 2 (identifier: Q9JHU3-2) [UniParc]FASTAAdd to basket
Also known as: Cardiac CCRK

The sequence of this isoform differs from the canonical sequence as follows:
     168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
     244-346: Missing.

Show »
Length:243
Mass (Da):26,974
Checksum:iB9EFCE73BAC18AC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44I → F in AAW82351 (Ref. 2) Curated1
Sequence conflicti58I → M in AAW82351 (Ref. 2) Curated1
Sequence conflicti61S → N in AAW82351 (Ref. 2) Curated1
Sequence conflicti75A → G in AAW82351 (Ref. 2) Curated1
Sequence conflicti101P → Q in AAW82351 (Ref. 2) Curated1
Sequence conflicti157G → S in AAW82351 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016753168 – 243WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_016754244 – 346Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005133 mRNA Translation: AAF89089.1
AY904369 mRNA Translation: AAW82351.1
BC031907 mRNA Translation: AAH31907.1
CCDSiCCDS26601.1 [Q9JHU3-1]
RefSeqiNP_444410.1, NM_053180.2 [Q9JHU3-1]
UniGeneiMm.74982

Genome annotation databases

EnsembliENSMUST00000021939; ENSMUSP00000021939; ENSMUSG00000021483 [Q9JHU3-1]
GeneIDi105278
KEGGimmu:105278
UCSCiuc007qyx.1 mouse [Q9JHU3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDK20_MOUSE
AccessioniPrimary (citable) accession number: Q9JHU3
Secondary accession number(s): Q5EDC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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