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Protein

Ragulator complex protein LAMTOR2

Gene

Lamtor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2
Alternative name(s):
Endosomal adaptor protein p14
Late endosomal/lysosomal Mp1-interacting protein
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
Mitogen-activated protein-binding protein-interacting protein
Roadblock domain-containing protein 3
Gene namesi
Name:Lamtor2
Synonyms:Mapbpip, Robld3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1932697 Lamtor2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209611 – 125Ragulator complex protein LAMTOR2Add BLAST125

Proteomic databases

EPDiQ9JHS3
MaxQBiQ9JHS3
PaxDbiQ9JHS3
PeptideAtlasiQ9JHS3
PRIDEiQ9JHS3

PTM databases

iPTMnetiQ9JHS3
PhosphoSitePlusiQ9JHS3

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000028062 Expressed in 288 organ(s), highest expression level in brain
ExpressionAtlasiQ9JHS3 baseline and differential
GenevisibleiQ9JHS3 MM

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:15016825, PubMed:15263099, PubMed:15740743, PubMed:19177150). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1 (PubMed:11266467).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219917, 1 interactor
CORUMiQ9JHS3
IntActiQ9JHS3, 4 interactors
MINTiQ9JHS3
STRINGi10090.ENSMUSP00000029698

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9JHS3
SMRiQ9JHS3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JHS3

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 70Required for location at endosomesAdd BLAST14

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
HOVERGENiHBG004518
InParanoidiQ9JHS3
KOiK20398
OMAiIWSAYEK
OrthoDBiEOG091G0W0V
PhylomeDBiQ9JHS3
TreeFamiTF313929

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9JHS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS
60 70 80 90 100
NIWAAYDRNG NQAFNEDSLK FILMDCMEGR VAITRVANLL LCMYAKETVG
110 120
FGMLKAKAQA LVQYLEEPLT QVAAS
Length:125
Mass (Da):13,480
Last modified:October 1, 2000 - v1
Checksum:i69448F11DFD6C03D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTS4D3YTS4_MOUSE
Ragulator complex protein LAMTOR2
Lamtor2
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277386 mRNA Translation: CAB97177.1
AK019006 mRNA Translation: BAB31506.1
BC031816 mRNA Translation: AAH31816.1
CCDSiCCDS17478.1
RefSeqiNP_112538.1, NM_031248.3
UniGeneiMm.41680

Genome annotation databases

EnsembliENSMUST00000029698; ENSMUSP00000029698; ENSMUSG00000028062
GeneIDi83409
KEGGimmu:83409
UCSCiuc008pvo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277386 mRNA Translation: CAB97177.1
AK019006 mRNA Translation: BAB31506.1
BC031816 mRNA Translation: AAH31816.1
CCDSiCCDS17478.1
RefSeqiNP_112538.1, NM_031248.3
UniGeneiMm.41680

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SKOX-ray2.00B2-124[»]
1SZVNMR-A1-125[»]
1VETX-ray1.90B1-125[»]
1VEUX-ray2.15B1-125[»]
2ZL1X-ray2.00B2-125[»]
3CPTX-ray1.90B2-125[»]
ProteinModelPortaliQ9JHS3
SMRiQ9JHS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219917, 1 interactor
CORUMiQ9JHS3
IntActiQ9JHS3, 4 interactors
MINTiQ9JHS3
STRINGi10090.ENSMUSP00000029698

PTM databases

iPTMnetiQ9JHS3
PhosphoSitePlusiQ9JHS3

Proteomic databases

EPDiQ9JHS3
MaxQBiQ9JHS3
PaxDbiQ9JHS3
PeptideAtlasiQ9JHS3
PRIDEiQ9JHS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029698; ENSMUSP00000029698; ENSMUSG00000028062
GeneIDi83409
KEGGimmu:83409
UCSCiuc008pvo.1 mouse

Organism-specific databases

CTDi28956
MGIiMGI:1932697 Lamtor2

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
HOVERGENiHBG004518
InParanoidiQ9JHS3
KOiK20398
OMAiIWSAYEK
OrthoDBiEOG091G0W0V
PhylomeDBiQ9JHS3
TreeFamiTF313929

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

EvolutionaryTraceiQ9JHS3
PROiPR:Q9JHS3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028062 Expressed in 288 organ(s), highest expression level in brain
ExpressionAtlasiQ9JHS3 baseline and differential
GenevisibleiQ9JHS3 MM

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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